A Kinetic Model Explains Why Shorter and Less Affine Enzyme-recruiting Oligonucleotides Can Be More Potent (Q38261831)

1 September 2017

A Kinetic Model Explains Why Shorter and Less Affine Enzyme-recruiting Oligonucleotides Can Be More Potent (English)

1 reference

1 September 2017

Marie Wickström Lindholm

3

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author name string

Lykke Pedersen

1

1 reference

1 September 2017

Peter H Hagedorn

2

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1 September 2017

Morten Lindow

4

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1 September 2017

18 February 2014

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Molecular Therapy. Nucleic acids

1 September 2017

1 reference

1 September 2017

3

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1 September 2017

e149

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Efficacy and safety of mipomersen sodium (Kynamro).

1 September 2017

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6 September 2017

ViennaRNA Package 2.0

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3951909

Stability and mismatch discrimination of locked nucleic acid-DNA duplexes

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3951909

Silencing of microRNA families by seed-targeting tiny LNAs

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3951909

mRNA turnover rate limits siRNA and microRNA efficacy

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3951909

Short locked nucleic acid antisense oligonucleotides potently reduce apolipoprotein B mRNA and serum cholesterol in mice and non-human primates

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3951909

Target mRNA abundance dilutes microRNA and siRNA activity

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3951909

RNA targeting therapeutics: molecular mechanisms of antisense oligonucleotides as a therapeutic platform

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3951909

Calorimetry and thermodynamics in drug design

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3951909

Molecular and cellular barriers limiting the effectiveness of antisense oligonucleotides

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3951909

Analysis of thermal melting curves.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3951909

Statistical mechanical approaches to models with many poorly known parameters

6 September 2017

1 reference

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Decay rates of human mRNAs: correlation with functional characteristics and sequence attributes

6 September 2017

1 reference

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Stopped-flow kinetics of locked nucleic acid (LNA)-oligonucleotide duplex formation: studies of LNA-DNA and DNA-DNA interactions

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3951909

2'-carbohydrate modifications in antisense oligonucleotide therapy: importance of conformation, configuration and conjugation

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3951909

A unified view of polymer, dumbbell, and oligonucleotide DNA nearest-neighbor thermodynamics

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3951909

Enzyme from calf thymus degrading the RNA moiety of DNA-RNA Hybrids: effect on DNA-dependent RNA polymerase

6 September 2017

1 reference

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Role of RNase H in hybrid-arrested translation by antisense oligonucleotides

6 September 2017

1 reference

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Physicochemical properties of phosphorothioate oligodeoxynucleotides

6 September 2017

1 reference

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Implications of ribozyme kinetics for targeting the cleavage of specific RNA molecules in vivo: more isn't always better

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3951909

Inhibition of Rous sarcoma virus replication and cell transformation by a specific oligodeoxynucleotide

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3951909

Chemical modification study of antisense gapmers

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3951909

Short antisense oligonucleotides with novel 2'-4' conformationaly restricted nucleoside analogues show improved potency without increased toxicity in animals

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3951909

Expanding the design horizon of antisense oligonucleotides with alpha-L-LNA.

14 September 2017

1 reference

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Implication of RNA structure on antisense oligonucleotide hybridization kinetics

14 September 2017

1 reference

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Kinetics and thermodynamics of DNA, RNA, and hybrid duplex formation.

23 June 2018

1 reference

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Single-fluorophore monitoring of DNA hybridization for investigating the effect of secondary structure on the nucleation step.

31 August 2018

1 reference

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Sequence-dependent thermodynamic parameters for locked nucleic acid (LNA)-DNA duplex formation

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3951909

Theoretical and experimental selection parameters for HBV-directed antisense RNA are related to increased RNA-RNA annealing

31 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24549300

12 December 2020

inferred from PubMed ID database lookup

Thermodynamic parameters to predict stability of RNA/DNA hybrid duplexes

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24549300

12 December 2020

inferred from PubMed ID database lookup

Synthesis of 2′-O,4′-C-methyleneuridine and -cytidine. Novel bicyclic nucleosides having a fixed C3, -endo sugar puckering

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FMTNA.2013.72

7 January 2021

inferred from DOI database lookup

LNA (Locked Nucleic Acids): Synthesis of the adenine, cytosine, guanine, 5-methylcytosine, thymine and uracil bicyclonucleoside monomers, oligomerisation, and unprecedented nucleic acid recognition

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FMTNA.2013.72

7 January 2021

inferred from DOI database lookup

Exact stochastic simulation of coupled chemical reactions

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FMTNA.2013.72

7 January 2021

inferred from DOI database lookup

Identifiers

DOI

10.1038/MTNA.2013.72

1 reference

1 September 2017

1 reference

1 September 2017

PubMed publication ID

24549300

1 reference