Roles of p38α mitogen-activated protein kinase in mouse models of inflammatory diseases and cancer. (Q38366515)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25728574%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

review article

2 references

8 February 2021

Roles of p38α mitogen-activated protein kinase in mouse models of inflammatory diseases and cancer (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25728574%20AND%20SRC:MED&resulttype=core&format=json

p38 mitogen-activated protein kinases

1 March 2020

main subject

1 reference

20 November 2019

1 reference

8 February 2021

1 reference

PubMed publication ID

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25728574%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

author name string

Angel R Nebreda

series ordinal

2

1 reference

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1 March 2020

language of work or name

English

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publication date

16 March 2015

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1 March 2020

1 May 2015

1 reference

8 February 2021

5 references

3 April 2019

28 September 2019

20 November 2019

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25728574%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

8 February 2021

282

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1 March 2020

issue

10

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1 March 2020

page(s)

1841-1857

1 reference

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Creative Commons Attribution-NonCommercial-NoDerivatives

1 March 2020

copyright license

4 references

3 April 2019

28 September 2019

20 November 2019

8 February 2021

on focus list of Wikimedia project

ScienceSource

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cites work

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p38γ and p38δ kinases regulate the Toll-like receptor 4 (TLR4)-induced cytokine production by controlling ERK1/2 protein kinase pathway activation

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Antiinflammatory functions of p38 in mouse models of rheumatoid arthritis: advantages of targeting upstream kinases MKK-3 or MKK-6

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6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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Essential role for p38alpha mitogen-activated protein kinase in placental angiogenesis

6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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A benzothiophene inhibitor of mitogen-activated protein kinase-activated protein kinase 2 inhibits tumor necrosis factor alpha production and has oral anti-inflammatory efficacy in acute and chronic models of inflammation

6 September 2017

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14 September 2017

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p38alpha blockade inhibits colorectal cancer growth in vivo by inducing a switch from HIF1alpha- to FoxO-dependent transcription

14 September 2017

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14 September 2017

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Selective p38 activation in human non-small cell lung cancer

14 September 2017

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A paracrine network regulates the cross-talk between human lung stem cells and the stroma.

27 September 2017

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Critical role for apoptosis signal-regulating kinase 1 in the development of inflammatory K/BxN serum-induced arthritis

23 June 2018

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Pro-oncogenic role of alternative p38 mitogen-activated protein kinases p38γ and p38δ, linking inflammation and cancer in colitis-associated colon cancer.

23 June 2018

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31 August 2018

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Colon cancer cells colonize the lung from established liver metastases through p38 MAPK signalling and PTHLH.

31 August 2018

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Dual function of p38α MAPK in colon cancer: suppression of colitis-associated tumor initiation but requirement for cancer cell survival

31 August 2018

1 reference

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p38 Mitogen-activated protein kinase accelerates emphysema in mouse model of chronic obstructive pulmonary disease.

31 August 2018

1 reference

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Activation of p38 mitogen-activated protein kinase in ovalbumin and ozone-induced mouse model of asthma

31 August 2018

1 reference

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SnapShot: p38 MAPK substrates.

31 August 2018

1 reference

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SnapShot: p38 MAPK signaling.

31 August 2018

1 reference

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Phosphorylated p38 and JNK MAPK proteins in hepatocellular carcinoma.

31 August 2018

1 reference

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Mice lacking MSK1 and MSK2 show reduced skin tumor development in a two-stage chemical carcinogenesis model.

31 August 2018

1 reference

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Down-regulation of p38 mitogen-activated protein kinase activation and proinflammatory cytokine production by mitogen-activated protein kinase inhibitors in inflammatory bowel disease.

31 August 2018

1 reference

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Selective p38alpha inhibitors clinically evaluated for the treatment of chronic inflammatory disorders

31 August 2018

1 reference

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p38delta Mitogen-activated protein kinase is essential for skin tumor development in mice.

31 August 2018

1 reference

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Efficacy, pharmacodynamics, and safety of VX-702, a novel p38 MAPK inhibitor, in rheumatoid arthritis: results of two randomized, double-blind, placebo-controlled clinical studies.

31 August 2018

1 reference

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Evaluation of the efficacy and safety of pamapimod, a p38 MAP kinase inhibitor, in a double-blind, methotrexate-controlled study of patients with active rheumatoid arthritis

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5006851

The kinases MSK1 and MSK2 act as negative regulators of Toll-like receptor signaling

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5006851

Relative corticosteroid insensitivity of alveolar macrophages in severe asthma compared with non-severe asthma

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5006851

Macrophage deletion of p38alpha partially impairs lipopolysaccharide-induced cellular activation.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5006851

p38alpha-selective mitogen-activated protein kinase inhibitor SD-282 reduces inflammation in a subchronic model of tobacco smoke-induced airway inflammation

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5006851

The mitogen-activated protein kinase (MAPK)-activated protein kinases MK2 and MK3 cooperate in stimulation of tumor necrosis factor biosynthesis and stabilization of p38 MAPK.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5006851

The role of the MKK6/p38 MAPK pathway in Wip1-dependent regulation of ErbB2-driven mammary gland tumorigenesis.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5006851

Gadd45a suppresses Ras-driven mammary tumorigenesis by activation of c-Jun NH2-terminal kinase and p38 stress signaling resulting in apoptosis and senescence.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5006851

Attenuated phosphorylation of heat shock protein 27 correlates with tumor progression in patients with hepatocellular carcinoma

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5006851

Molecular changes in tamoxifen-resistant breast cancer: relationship between estrogen receptor, HER-2, and p38 mitogen-activated protein kinase

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5006851

Inhaled p38alpha mitogen-activated protein kinase antisense oligonucleotide attenuates asthma in mice.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5006851

Inactivation of the Wip1 phosphatase inhibits mammary tumorigenesis through p38 MAPK-mediated activation of the p16(Ink4a)-p19(Arf) pathway

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5006851

Prognostic significance of phosphorylated P38 mitogen-activated protein kinase and HER-2 expression in lymph node-positive breast carcinoma

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5006851

Systemic Deficiency of the MAP Kinase–Activated Protein Kinase 2 Reduces Atherosclerosis in Hypercholesterolemic Mice

31 August 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13250

Apoptosis Signal-Regulating Kinase 1 Regulates Colitis and Colitis-Associated Tumorigenesis by the Innate Immune Responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13250

p38α suppresses normal and cancer cell proliferation by antagonizing the JNK–c-Jun pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13250

Increased activation of p38 MAPK in COPD

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13250

Activation, differential localization, and regulation of the stress-activated protein kinases, extracellular signal-regulated kinase, c-JUN N-terminal kinase, and p38 mitogen-activated protein kinase, in synovial tissue and cells in rheumatoid arthr

21 January 2018

1 reference

12 December 2020

No Evidence for an Involvement of the P38 and JNK Mitogen-Activated Protein in Inflammatory Bowel Diseases

1 reference

12 December 2020

Essential role of p38alpha MAP kinase in placental but not embryonic cardiovascular development

1 reference

12 December 2020

Anti-inflammatory effects of LASSBio-998, a new drug candidate designed to be a p38 MAPK inhibitor, in an experimental model of acute lung inflammation

1 reference

12 December 2020

Oral p38 mitogen-activated protein kinase inhibition with BIRB 796 for active Crohn's disease: a randomized, double-blind, placebo-controlled trial

1 reference

12 December 2020

Dysregulation of phosphatidylinositol 3-kinase and downstream effectors in human breast cancer

1 reference

12 December 2020

p38 mitogen-activated protein kinase is activated and linked to TNF-alpha signaling in inflammatory bowel disease

1 reference

12 December 2020

MAPKAP kinase 2-deficient mice are resistant to collagen-induced arthritis

1 reference

12 December 2020

Genetic background determines the extent of atherosclerosis in ApoE-deficient mice

1 reference

12 December 2020

NF-kappaB, p38 MAPK and JNK are highly expressed and active in the stroma of human colonic adenomatous polyps

1 reference

12 December 2020

Chronic Obstructive Pulmonary Disease and Risk of Lung Cancer: The Importance of Smoking and Timing of Diagnosis

1 reference

12 December 2020

Chemical genetics define the roles of p38alpha and p38beta in acute and chronic inflammation

1 reference

12 December 2020

p38α MAP kinase is essential in lung stem and progenitor cell proliferation and differentiation

1 reference

12 December 2020

Involvement of the p38 mitogen-activated protein kinase cascade in hepatocellular carcinoma

1 reference

12 December 2020

Gadd45a protects against UV irradiation-induced skin tumors, and promotes apoptosis and stress signaling via MAPK and p53

1 reference

12 December 2020

A selective p38 alpha mitogen-activated protein kinase inhibitor reverses cartilage and bone destruction in mice with collagen-induced arthritis

1 reference

12 December 2020

Identifiers

DOI

10.1111/FEBS.13250

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25728574%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25728574%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

PubMed publication ID

25728574

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25728574%20AND%20SRC:MED&resulttype=core&format=json