PEGylation of Biopharmaceuticals: A Review of Chemistry and Nonclinical Safety Information of Approved Drugs (Q38730623)

5 September 2017

title

PEGylation of Biopharmaceuticals: A Review of Chemistry and Nonclinical Safety Information of Approved Drugs (English)

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5 September 2017

1

Peter L Turecek

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5 September 2017

Mary J Bossard

2

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5 September 2017

Freddy Schoetens

series ordinal

3

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5 September 2017

Inge A Ivens

series ordinal

4

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5 September 2017

language of work or name

English

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publication date

1 February 2016

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Journal of Pharmaceutical Sciences

5 September 2017

published in

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5 September 2017

volume

105

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5 September 2017

issue

2

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5 September 2017

page(s)

460-475

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Protein, peptide and non-peptide drug PEGylation for therapeutic application

5 September 2017

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7 January 2021

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Effects of monomethoxypoly(ethylene glycol) modification of ribonuclease on antibody recognition, substrate accessibility and conformational stability

7 January 2021

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Preferential Interactions and the Effect of Protein PEGylation.

7 January 2021

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Effects of PEG size on structure, function and stability of PEGylated BSA.

7 January 2021

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Characterisation and physical stability of PEGylated glucagon

7 January 2021

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Stabilization of alpha-chymotrypsin upon PEGylation correlates with reduced structural dynamics

7 January 2021

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Structural and biologic characterization of pegylated recombinant IFN-alpha2b

7 January 2021

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Structure-Function Perturbation and Dissociation of Tetrameric Urate Oxidase by High Hydrostatic Pressure

7 January 2021

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PEGylation enhancement of pH stability of uricase via inhibitive tetramer dissociation.

7 January 2021

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Biochemical and biopharmaceutical properties of PEGylated uricase.

7 January 2021

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Biophysical characterisation of GlycoPEGylated recombinant human factor VIIa.

7 January 2021

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Characterization and stability of N-terminally PEGylated rhG-CSF.

7 January 2021

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The effect of protein PEGylation on physical stability in liquid formulation

7 January 2021

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Evaluation of a new reagent for covalent attachment of polyethylene glycol to proteins

7 January 2021

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The pharmacology of PEGylation: balancing PD with PK to generate novel therapeutics

7 January 2021

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Protein carboxyl amidation increases the potential extent of protein polyethylene glycol conjugation

7 January 2021

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A simple modified carbodiimide method for conjugation of small-molecular-weight compounds to immunoglobulin G with minimal protein crosslinking

7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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A novel B-domain O-glycoPEGylated FVIII (N8-GP) demonstrates full efficacy and prolonged effect in hemophilic mice models

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7 January 2021

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7 January 2021

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Generation and biochemical characterization of glycoPEGylated factor VIIa derivatives.

7 January 2021

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Prolonged half-life and preserved enzymatic properties of factor IX selectively PEGylated on native N-glycans in the activation peptide

7 January 2021

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Treatment of adenosine deaminase deficiency with polyethylene glycol-modified adenosine deaminase

7 January 2021

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Induced and pre-existing anti-polyethylene glycol antibody in a trial of every 3-week dosing of pegloticase for refractory gout, including in organ transplant recipients

7 January 2021

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Anti-cancer PEG-enzymes: 30 years old, but still a current approach

7 January 2021

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PEG conjugates in clinical development or use as anticancer agents: an overview

7 January 2021

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Amino acid sequence of L-asparaginase from Escherichia coli

7 January 2021

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Instability of succinyl ester linkages in O2'-monosuccinyl cyclic AMP-protein conjugates at neutral pH.

7 January 2021

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L-asparaginase and PEG asparaginase--past, present, and future

7 January 2021

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Pegaspargase: a review of clinical studies

7 January 2021

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PEG-uricase in the management of treatment-resistant gout and hyperuricemia

7 January 2021

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Structural and biological characterization of pegylated recombinant interferon alpha-2b and its therapeutic implications

7 January 2021

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Identification of the major positional isomer of pegylated interferon alpha-2b

7 January 2021

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Carboxyalkylated histidine is a pH-dependent product of pegylation with SC-PEG.

7 January 2021

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Pegylating IFNs at his-34 improves the in vitro antiviral activity through the JAK/STAT pathway

7 January 2021

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Site of pegylation and polyethylene glycol molecule size attenuate interferon-alpha antiviral and antiproliferative activities through the JAK/STAT signaling pathway.

7 January 2021

1 reference

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Use of an indirect pharmacodynamic stimulation model of MX protein induction to compare in vivo activity of interferon alfa-2a and a polyethylene glycol-modified derivative in healthy subjects

7 January 2021

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Positional isomers of monopegylated interferon alpha-2a: isolation, characterization, and biological activity

7 January 2021

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A branched monomethoxypoly(ethylene glycol) for protein modification

7 January 2021

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Anchimeric assistance effect on regioselective hydrolysis of branched PEGs: a mechanistic investigation

7 January 2021

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Use of peginterferon alfa-2a (40 KD) (Pegasys) for the treatment of hepatitis C.

7 January 2021

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Rational design of a potent, long-lasting form of interferon: a 40 kDa branched polyethylene glycol-conjugated interferon alpha-2a for the treatment of hepatitis C.

7 January 2021

1 reference

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Structural, kinetic, and thermodynamic analysis of the binding of the 40 kDa PEG-interferon-alpha2a and its individual positional isomers to the extracellular domain of the receptor IFNAR2.

7 January 2021

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Pegvisomant in the treatment of acromegaly.

7 January 2021

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Long-acting growth hormones produced by conjugation with polyethylene glycol.

7 January 2021

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Management of viral hepatitis: clinical and public health perspectives--a consensus statement. CASL Hepatitis Consensus Group. Canadian Association for Study of the Liver

7 January 2021

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2'-Fluoropyrimidine RNA-based aptamers to the 165-amino acid form of vascular endothelial growth factor (VEGF165). Inhibition of receptor binding and VEGF-induced vascular permeability through interactions requiring the exon 7-encoded domain

7 January 2021

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Detection and plasma pharmacokinetics of an anti-vascular endothelial growth factor oligonucleotide-aptamer (NX1838) in rhesus monkeys

7 January 2021

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Pharmacokinetics and safety of an anti-vascular endothelial growth factor aptamer (NX1838) following injection into the vitreous humor of rhesus monkeys

7 January 2021

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The design and development of pegfilgrastim (PEG-rmetHuG-CSF, Neulasta).

7 January 2021

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A new form of Filgrastim with sustained duration in vivo and enhanced ability to mobilize PBPC in both mice and humans

7 January 2021

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Mono-N-terminal poly(ethylene glycol)-protein conjugates

7 January 2021

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Formulation of Neulasta (pegfilgrastim).

7 January 2021

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N-terminally PEGylated human interferon-beta-1a with improved pharmacokinetic properties and in vivo efficacy in a melanoma angiogenesis model.

7 January 2021

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PEGylated antibodies and antibody fragments for improved therapy: a review

7 January 2021

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Therapeutic antibody fragments with prolonged in vivo half-lives

7 January 2021

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Mechanism of action of certolizumab pegol (CDP870): in vitro comparison with other anti-tumor necrosis factor alpha agents

7 January 2021

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Certolizumab pegol for the treatment of rheumatoid arthritis

7 January 2021

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Pharmacokinetics, metabolism and distribution of PEGs and PEGylated proteins: quo vadis?

7 January 2021

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The structure of 2Zn pig insulin crystals at 1.5 A resolution

7 January 2021

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inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1016/J.XPHS.2015.11.015

1 reference

5 September 2017

1 reference