Emerging roles of RAC1 in treating lung cancer patients (Q38993407)

8 September 2017

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title

Emerging roles of RAC1 in treating lung cancer patients (English)

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8 September 2017

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T Zou

1

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8 September 2017

X Mao

2

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8 September 2017

J Yin

3

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8 September 2017

X Li

4

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8 September 2017

J Chen

5

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8 September 2017

T Zhu

6

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8 September 2017

Q Li

7

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8 September 2017

H Zhou

8

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8 September 2017

Z Liu

9

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8 September 2017

publication date

27 October 2016

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8 September 2017

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8 September 2017

volume

91

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8 September 2017

issue

4

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8 September 2017

page(s)

520-528

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Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia

8 September 2017

cites work

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Rho GTPases in cell biology

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The Ins and Outs of Small GTPase Rac1 in the Vasculature.

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The redox mechanism for vascular barrier dysfunction associated with metabolic disorders: Glutathionylation of Rac1 in endothelial cells.

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RAC1 inhibition as a therapeutic target for gefitinib-resistant non-small-cell lung cancer

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Regulation of Rac1 translocation and activation by membrane domains and their boundaries

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Proteins regulating Ras and its relatives

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Ras and Rho GTPases: a family reunion

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Cancer statistics, 2015

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Prognostic factors for long term survival in patients with advanced non-small cell lung cancer

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Radical treatment of non-small cell lung cancer during the last 5 years

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Long-term results of the international adjuvant lung cancer trial evaluating adjuvant Cisplatin-based chemotherapy in resected lung cancer

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Association of positively selected eIF3a polymorphisms with toxicity of platinum-based chemotherapy in NSCLC patients

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WISP1 polymorphisms contribute to platinum-based chemotherapy toxicity in lung cancer patients

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Rac1 targeting suppresses human non-small cell lung adenocarcinoma cancer stem cell activity

21 January 2018

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The Regulation of Cellular Responses to Mechanical Cues by Rho GTPases

21 January 2018

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The role of class I, II and III PI 3-kinases in platelet production and activation and their implication in thrombosis

21 January 2018

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Epidermal growth factor receptor signaling in nonsmall cell lung cancer

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RAS and RHO families of GTPases directly regulate distinct phosphoinositide 3-kinase isoforms

21 January 2018

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The emerging mechanisms of isoform-specific PI3K signalling

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Phosphoinositide 3-kinase p110beta activity: key role in metabolism and mammary gland cancer but not development

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Basic fibroblast growth factor promotes melanocyte migration via activating PI3K/Akt-Rac1-FAK-JNK and ERK signaling pathways

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PI 3-kinase p110beta: a new target for antithrombotic therapy

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Temporal-specific roles of Rac1 during vascular development and retinal angiogenesis.

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Function and regulation of Rnd proteins

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Regulation of the cytoskeleton by Rho-family GTPases: implications for tumour cell invasion

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Characterizing the initial encounter complex in cadherin adhesion

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Signaling interplay in Ras superfamily function

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The on-off relationship of Rho and Rac during integrin-mediated adhesion and cell migration

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Coevolution of RAC Small GTPases and their Regulators GEF Proteins

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Rho proteins: linking signaling with membrane trafficking

21 January 2018

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Regulation of receptor-mediated endocytosis by Rho and Rac.

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PtdIns(3,4,5)P3 binding is necessary for WAVE2-induced formation of lamellipodia

21 January 2018

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The PI3K p110alpha isoform regulates endothelial adherens junctions via Pyk2 and Rac1.

21 January 2018

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The Rac1 splice form Rac1b promotes K-ras-induced lung tumorigenesis

21 January 2018

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The role of Rac1 in the regulation of NF-κB activity, cell proliferation, and cell migration in non-small cell lung carcinoma

21 January 2018

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Non-small cell lung cancer stem/progenitor cells are enriched in multiple distinct phenotypic subpopulations and exhibit plasticity

21 January 2018

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Rac1 GTPase-deficient HeLa cells present reduced DNA repair, proliferation, and survival under UV or gamma irradiation

21 January 2018

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Rho GTPases: Novel Players in the Regulation of the DNA Damage Response?

21 January 2018

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Rho GTPases: RAC1 polymorphisms affected platinum-based chemotherapy toxicity in lung cancer patients.

21 January 2018

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Matrix metalloproteinase induction of Rac1b, a key effector of lung cancer progression

21 January 2018

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Rac1b and reactive oxygen species mediate MMP-3-induced EMT and genomic instability

21 January 2018

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Genome and transcriptome sequencing of lung cancers reveal diverse mutational and splicing events.

21 January 2018

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Deregulation of Rho GTPases in cancer

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Rho GTPases and actin dynamics in membrane protrusions and vesicle trafficking

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An EGFR/PI3K/AKT axis promotes accumulation of the Rac1-GEF Tiam1 that is critical in EGFR-driven tumorigenesis.

21 January 2018

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Endothelial Rac1 is essential for hematogenous metastasis to the lung

21 January 2018

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Armus is a Rac1 effector that inactivates Rab7 and regulates E-cadherin degradation

21 January 2018

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Different roles of the small GTPases Rac1, Cdc42, and RhoG in CALEB/NGC-induced dendritic tree complexity

21 January 2018

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Vimentin regulates lung cancer cell adhesion through a VAV2-Rac1 pathway to control focal adhesion kinase activity

21 January 2018

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PARD3 Inactivation in Lung Squamous Cell Carcinomas Impairs STAT3 and Promotes Malignant Invasion.

21 January 2018

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RhoB loss induces Rac1-dependent mesenchymal cell invasion in lung cells through PP2A inhibition

21 January 2018

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Curcumin inhibits lung cancer cell migration and invasion through Rac1-dependent signaling pathway

21 January 2018

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Ect2 links the PKCiota-Par6alpha complex to Rac1 activation and cellular transformation

21 January 2018

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KAI1/CD82 decreases Rac1 expression and cell proliferation through PI3K/Akt/mTOR pathway in H1299 lung carcinoma cells

21 January 2018

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PED interacts with Rac1 and regulates cell migration/invasion processes in human non-small cell lung cancer cells.

21 January 2018

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Signaling through Rho GTPase pathway as viable drug target

21 January 2018

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Drugging Ras GTPase: a comprehensive mechanistic and signaling structural view

21 January 2018

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Phosphorylation of Threonine 794 on Tie1 by Rac1/PAK1 Reveals a Novel Angiogenesis Regulatory Pathway

21 January 2018

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Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma

21 January 2018

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Inhibition of RAC1-GEF DOCK3 by miR-512-3p contributes to suppression of metastasis in non-small cell lung cancer

21 January 2018

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Inhibition of Rac1 activity in the hippocampus impaired extinction of contextual fear

21 January 2018

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Rac1-regulated endothelial radiation response stimulates extravasation and metastasis that can be blocked by HMG-CoA reductase inhibitors

21 January 2018

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Hypoxia/reoxygenation-experienced cancer cell migration and metastasis are regulated by Rap1- and Rac1-GTPase activation via the expression of thymosin beta-4.

21 January 2018

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The involvement of mutant Rac1 in the formation of invadopodia in cultured melanoma cells

21 January 2018

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Inhibition of migration and invasion of colorectal cancer cells via deletion of Rac1 with RNA interference

21 January 2018

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RAC1 GTPase promotes the survival of breast cancer cells in response to hyper-fractionated radiation treatment

21 January 2018

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Implications of Rho GTPase Signaling in Glioma Cell Invasion and Tumor Progression

21 January 2018

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Risk assessment of lung resection for lung cancer according to pulmonary function: republication of systematic review and proposals by guideline committee of the Japanese association for chest surgery 2014.

21 January 2018

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Radiotherapy plus chemotherapy with or without surgical resection for stage III non-small-cell lung cancer: a phase III randomised controlled trial

21 January 2018

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American Society of Clinical Oncology Clinical Practice Guideline Update on Chemotherapy for Stage IV Non-Small-Cell Lung Cancer

21 January 2018

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Metastatic non-small-cell lung cancer (NSCLC): ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up

21 January 2018

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Phase III study comparing cisplatin plus gemcitabine with cisplatin plus pemetrexed in chemotherapy-naive patients with advanced-stage non-small-cell lung cancer

21 January 2018

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Chemotherapy in non-small cell lung cancer: opportunities for advancement

21 January 2018

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Randomized phase II trial comparing bevacizumab plus carboplatin and paclitaxel with carboplatin and paclitaxel alone in previously untreated locally advanced or metastatic non-small-cell lung cancer

21 January 2018

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Rociletinib in EGFR-mutated non-small-cell lung cancer

21 January 2018

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Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer

21 January 2018

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KRAS mutation is an important predictor of resistance to therapy with epidermal growth factor receptor tyrosine kinase inhibitors in non-small-cell lung cancer

21 January 2018

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Randomized, phase III trial of first-line figitumumab in combination with paclitaxel and carboplatin versus paclitaxel and carboplatin alone in patients with advanced non-small-cell lung cancer

21 January 2018

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DNA damage response (DDR) pathway engagement in cisplatin radiosensitization of non-small cell lung cancer

21 January 2018

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The Future of Immunotherapy in the Treatment of Small Cell Lung Cancer

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Effect of transporter and DNA repair gene polymorphisms to lung cancer chemotherapy toxicity

21 January 2018

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21 January 2018

Identifiers

DOI

10.1111/CGE.12908

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8 September 2017

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