Targeting inhibitor 2 of protein phosphatase 2A as a therapeutic strategy for prostate cancer treatment (Q39097201)

9 September 2017

Targeting inhibitor 2 of protein phosphatase 2A as a therapeutic strategy for prostate cancer treatment (English)

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9 September 2017

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Archana Mukhopadhyay

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9 September 2017

Kayann Tabanor

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2

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9 September 2017

Rathnam Chaguturu

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3

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9 September 2017

Jane V Aldrich

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4

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9 September 2017

5 August 2013

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Cancer Biology and Therapy

9 September 2017

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9 September 2017

14

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9 September 2017

10

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9 September 2017

962-972

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describes a project that uses

9 September 2017

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3926893/fullTextXML

inferred from PubMed Central ID database lookup

cites work

The changing landscape in the treatment of metastatic castration-resistant prostate cancer

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Ceramide-orchestrated signalling in cancer cells.

9 September 2017

1 reference

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Ceramide--antiestrogen nanoliposomal combinations--novel impact of hormonal therapy in hormone-insensitive breast cancer

9 September 2017

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Rac1 activation driven by 14-3-3ζ dimerization promotes prostate cancer cell-matrix interactions, motility and transendothelial migration

9 September 2017

1 reference

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Castration-resistant prostate cancer: mechanisms, targets, and treatment.

9 September 2017

1 reference

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Reducing prohibitin increases histone acetylation, and promotes androgen independence in prostate tumours by increasing androgen receptor activation by adrenal androgens

9 September 2017

1 reference

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Cabazitaxel for the treatment of prostate cancer

9 September 2017

1 reference

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C6-ceramide synergistically potentiates the anti-tumor effects of histone deacetylase inhibitors via AKT dephosphorylation and α-tubulin hyperacetylation both in vitro and in vivo

9 September 2017

1 reference

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Targeting SET/I(2)PP2A oncoprotein functions as a multi-pathway strategy for cancer therapy

9 September 2017

1 reference

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Targeted therapy for advanced prostate cancer: inhibition of the PI3K/Akt/mTOR pathway

9 September 2017

1 reference

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Direct interaction between the inhibitor 2 and ceramide via sphingolipid-protein binding is involved in the regulation of protein phosphatase 2A activity and signaling

9 September 2017

1 reference

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Multiple pathways regulated by the tumor suppressor PP2A in transformation

9 September 2017

1 reference

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A tumor suppressor role for PP2A-B56alpha through negative regulation of c-Myc and other key oncoproteins

9 September 2017

1 reference

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Principles of bioactive lipid signalling: lessons from sphingolipids

9 September 2017

1 reference

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Protein phosphatase 2A (PP2A), a drugable tumor suppressor in Ph1(+) leukemias

9 September 2017

1 reference

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Rac1-induced cell migration requires membrane recruitment of the nuclear oncogene SET

9 September 2017

1 reference

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Sphingolipids in cancer: regulation of pathogenesis and therapy

9 September 2017

1 reference

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Sphingolipid targets in cancer therapy

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3926893

The histone chaperone TAF-I/SET/INHAT is required for transcription in vitro of chromatin templates

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3926893

Biologically active sphingolipids in cancer pathogenesis and treatment

9 September 2017

1 reference

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Tumor suppressor NM23-H1 is a granzyme A-activated DNase during CTL-mediated apoptosis, and the nucleosome assembly protein SET is its inhibitor

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3926893

Protein phosphatase 2A and phosphoprotein SET regulate androgen production by P450c17

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3926893

Focus on prostate cancer.

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3926893

The development of androgen-independent prostate cancer

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3926893

Regulation of histone acetylation and transcription by INHAT, a human cellular complex containing the set oncoprotein

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3926893

Expression of SET, an inhibitor of protein phosphatase 2A, in renal development and Wilms' tumor

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3926893

The myeloid leukemia-associated protein SET is a potent inhibitor of protein phosphatase 2A

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3926893

Identification and characterization of SET, a nuclear phosphoprotein encoded by the translocation break point in acute undifferentiated leukemia

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3926893

Replication factor encoded by a putative oncogene, set, associated with myeloid leukemogenesis

9 September 2017

1 reference

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The Akt-inhibitor Erufosine induces apoptotic cell death in prostate cancer cells and increases the short term effects of ionizing radiation

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3926893

Hyperacetylation in prostate cancer induces cell cycle aberrations, chromatin reorganization and altered gene expression profiles.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3926893

Ceramide inhibition of MMP-2 expression and human cancer bronchial cell invasiveness involve decreased histone acetylation.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3926893

Glyceraldehyde 3-phosphate dehydrogenase is a SET-binding protein and regulates cyclin B-cdk1 activity

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3926893

The tumor suppressor PP2A is functionally inactivated in blast crisis CML through the inhibitory activity of the BCR/ABL-regulated SET protein

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3926893

PCOTH, a novel gene overexpressed in prostate cancers, promotes prostate cancer cell growth through phosphorylation of oncoprotein TAF-Ibeta/SET.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3926893

Systemic delivery of liposomal short-chain ceramide limits solid tumor growth in murine models of breast adenocarcinoma.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3926893

Role of ceramide in mediating apoptosis of irradiated LNCaP prostate cancer cells

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3926893

Novel role for the nuclear phosphoprotein SET in transcriptional activation of P450c17 and initiation of neurosteroidogenesis

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3926893

Enzalutamide: a novel antiandrogen for patients with castrate-resistant prostate cancer

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3926893

Neuronal and glioma-derived stem cell factor induces angiogenesis within the brain

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3926893

Protein phosphatase 2A regulatory subunit B56alpha associates with c-myc and negatively regulates c-myc accumulation

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3926893

Global histone modification patterns predict risk of prostate cancer recurrence

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3926893

Identification of a gene expression signature associated with recurrent disease in squamous cell carcinoma of the head and neck

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3926893

C16 ceramide accumulates following androgen ablation in LNCaP prostate cancer cells

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3926893

Elevation of de novo ceramide synthesis in tumor masses and the role of microsomal dihydroceramide synthase

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3926893

Ceramide levels are inversely associated with malignant progression of human glial tumors.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3926893

SET complex in serous epithelial ovarian cancer

21 August 2018

1 reference

Crossref

https://api.crossref.org/works/10.4161%2FCBT.25943

Simultaneous quantitative analysis of bioactive sphingolipids by high-performance liquid chromatography-tandem mass spectrometry

21 January 2018

1 reference

12 December 2020

Comparative investigation of sphingoid bases and fatty acids in ceramides and sphingomyelins from human ovarian malignant tumors and normal ovary

1 reference

12 December 2020

Down-regulation of stem cell genes, including those in a 200-kb gene cluster at 12p13.31, is associated with in vivo differentiation of human male germ cell tumors

1 reference

12 December 2020

The SET Protein Regulates G2/M Transition by Modulating Cyclin B-Cyclin-dependent Kinase 1 Activity

1 reference

12 December 2020

Purification and characterization of two potent heat-stable protein inhibitors of protein phosphatase 2A from bovine kidney

1 reference

12 December 2020

Increased levels of nm23 H1/nucleoside diphosphate kinase A mRNA associated with adenocarcinoma of the prostate

1 reference

12 December 2020

Identifiers

DOI

10.4161/CBT.25943

1 reference

9 September 2017

1 reference

9 September 2017

PubMed publication ID

24025258

1 reference