AEG-1 is a target of perifosine and is over-expressed in gastric dysplasia and cancers (Q39115952)

9 September 2017

title

AEG-1 is a target of perifosine and is over-expressed in gastric dysplasia and cancers (English)

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9 September 2017

Wenbin Huang

1

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9 September 2017

Li Yang

2

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9 September 2017

Song Liang

3

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9 September 2017

Dongxiao Liu

4

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9 September 2017

Xi Chen

5

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9 September 2017

Zhuo Ma

6

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9 September 2017

Sulan Zhai

7

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9 September 2017

Ping Li

8

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9 September 2017

Xuerong Wang

9

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9 September 2017

publication date

4 August 2013

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Digestive Diseases and Sciences

9 September 2017

published in

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9 September 2017

volume

58

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9 September 2017

issue

10

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9 September 2017

page(s)

2873-2880

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9 September 2017

cites work

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Perifosine, an oral bioactive novel alkylphospholipid, inhibits Akt and induces in vitro and in vivo cytotoxicity in human multiple myeloma cells

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The alkylphospholipid perifosine induces apoptosis of human lung cancer cells requiring inhibition of Akt and activation of the extrinsic apoptotic pathway

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Proapoptotic activity and chemosensitizing effect of the novel Akt inhibitor perifosine in acute myelogenous leukemia cells

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Synergistic proapoptotic activity of recombinant TRAIL plus the Akt inhibitor Perifosine in acute myelogenous leukemia cells

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Perifosine inhibits mammalian target of rapamycin signaling through facilitating degradation of major components in the mTOR axis and induces autophagy

21 January 2018

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https://api.crossref.org/works/10.1007%2FS10620-013-2735-5

Coadministration of histone deacetylase inhibitors and perifosine synergistically induces apoptosis in human leukemia cells through Akt and ERK1/2 inactivation and the generation of ceramide and reactive oxygen species

21 January 2018

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In vitro combination treatment with perifosine and UCN-01 demonstrates synergism against prostate (PC-3) and lung (A549) epithelial adenocarcinoma cell lines

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Akt down-modulation induces apoptosis of human prostate cancer cells and synergizes with EGFR tyrosine kinase inhibitors

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Identification and cloning of human astrocyte genes displaying elevated expression after infection with HIV-1 or exposure to HIV-1 envelope glycoprotein by rapid subtraction hybridization, RaSH.

21 January 2018

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Astrocyte elevated gene-1 (AEG-1) is a target gene of oncogenic Ha-ras requiring phosphatidylinositol 3-kinase and c-Myc

21 January 2018

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Enhancing mammalian target of rapamycin (mTOR)-targeted cancer therapy by preventing mTOR/raptor inhibition-initiated, mTOR/rictor-independent Akt activation

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Smoothened as a new therapeutic target for human osteosarcoma

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The role of PTEN/Akt/PI3K signaling in the maintenance and viability of prostate cancer stem-like cell populations

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Perifosine: update on a novel Akt inhibitor.

21 January 2018

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Astrocyte elevated gene-1 activates cell survival pathways through PI3K-Akt signaling

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Glycogen synthase kinase 3 beta: can it be a target for oral cancer

21 January 2018

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Astrocyte-elevated gene-1 overexpression is associated with poor prognosis in gastric cancer

21 January 2018

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Synergistic induction of apoptosis in human leukemia T cells by the Akt inhibitor perifosine and etoposide through activation of intrinsic and Fas-mediated extrinsic cell death pathways

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Perifosine, a novel alkylphospholipid, inhibits protein kinase B activation

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12 December 2020

Upregulation of the eIF4E signaling pathway contributes to the progression of gastric cancer, and targeting eIF4E by perifosine inhibits cell growth

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12 December 2020

MicroRNA-27a inhibitors alone or in combination with perifosine suppress the growth of gastric cancer cells

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12 December 2020

Downregulation of IRS-1 promotes metastasis of head and neck squamous cell carcinoma

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12 December 2020

10.1007/S10620-013-2735-5

Identifiers

DOI

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9 September 2017

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