Dual blockade of angiotensin-II and aldosterone suppresses the progression of a non-diabetic rat model of steatohepatitis. (Q39517819)

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18 February 2020

title

Dual blockade of angiotensin-II and aldosterone suppresses the progression of a non-diabetic rat model of steatohepatitis (English)

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18 February 2020

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1

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18 February 2020

author name string

Hitoshi Yoshiji

2

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18 February 2020

Yasuhide Ikenaka

3

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18 February 2020

Kosuke Kaji

4

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18 February 2020

Yosuke Aihara

5

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18 February 2020

Yusaku Shirai

6

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18 February 2020

Tadashi Namisaki

7

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18 February 2020

Mitsuteru Kitade

8

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18 February 2020

Akitoshi Douhara

9

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Kei Moriya

10

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18 February 2020

Hiroshi Fukui

11

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publication date

20 November 2012

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18 February 2020

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18 February 2020

volume

43

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issue

7

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18 February 2020

page(s)

765-774

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Inhibition of renin-angiotensin system attenuates liver enzyme-altered preneoplastic lesions and fibrosis development in rats.

18 February 2020

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Angiotensin-I-converting enzyme inhibitors may be an alternative anti-angiogenic strategy in the treatment of liver fibrosis and hepatocellular carcinoma. Possible role of vascular endothelial growth factor

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Impact of inhibitors of the Renin-Angiotensin-aldosterone system on liver fibrosis and portal hypertension

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Selective aldosterone blocker, eplerenone, attenuates hepatocellular carcinoma growth and angiogenesis in mice.

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ERK1/2 MAPKs and Wnt signaling pathways are independently involved in adipocytokine-mediated aldosterone secretion

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Extrarenal effects of aldosterone.

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Mineralocorticoid receptor blockade improves diastolic function independent of blood pressure reduction in a transgenic model of RAAS overexpression.

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Therapeutic efficacy of an angiotensin II receptor antagonist in patients with nonalcoholic steatohepatitis

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The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized Aldactone Evaluation Study Investigators

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Serum potassium and clinical outcomes in the Eplerenone Post-Acute Myocardial Infarction Heart Failure Efficacy and Survival Study (EPHESUS).

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Eplerenone shows renoprotective effect by reducing LOX-1-mediated adhesion molecule, PKCepsilon-MAPK-p90RSK, and Rho-kinase pathway

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Angiotensin-II type 1 receptor interaction is a major regulator for liver fibrosis development in rats.

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Synergistic effect of basic fibroblast growth factor and vascular endothelial growth factor in murine hepatocellular carcinoma

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Combination of vitamin K2 and the angiotensin-converting enzyme inhibitor, perindopril, attenuates the liver enzyme-altered preneoplastic lesions in rats via angiogenesis suppression

21 January 2018

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Combination treatment of angiotensin II type I receptor blocker and new oral iron chelator attenuates progression of nonalcoholic steatohepatitis in rats

21 January 2018

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Addition of eplerenone to an angiotensin-converting enzyme inhibitor effectively improves nitric oxide bioavailability

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Mineralocorticoid receptor blockade enhances the antiproteinuric effect of an angiotensin II blocker through inhibiting podocyte injury in type 2 diabetic rats.

21 January 2018

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Disparate effects of eplerenone, amlodipine and telmisartan on podocyte injury in aldosterone-infused rats

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Aldosterone and angiotensin II synergistically stimulate migration in vascular smooth muscle cells through c-Src-regulated redox-sensitive RhoA pathways.

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Hypoxia, angiogenesis and liver fibrogenesis in the progression of chronic liver diseases

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Vascular endothelial growth factor and receptor interaction is a prerequisite for murine hepatic fibrogenesis

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Leptin-mediated neovascularization is a prerequisite for progression of nonalcoholic steatohepatitis in rats.

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Involvement of the vascular endothelial growth factor receptor-1 in murine hepatocellular carcinoma development.

21 January 2018

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Angiotensin-I converting enzyme inhibitors as potential anti-angiogenic agents for cancer therapy.

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Endothelial cell marker expression in dysplastic lesions of the liver: an immunohistochemical study.

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Efficacy and safety of the selective aldosterone blocker eplerenone in Japanese patients with hypertension: a randomized, double-blind, placebo-controlled, dose-ranging study

21 January 2018

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21 January 2018

Identifiers

DOI

10.1111/HEPR.12008

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23163573%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

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