Molecular dissection of the human alpha2-macroglobulin subunit reveals domains with antagonistic activities in cell signaling. (Q39979231)

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7 January 2020

title

Molecular dissection of the human alpha2-macroglobulin subunit reveals domains with antagonistic activities in cell signaling (English)

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7 January 2020

1

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7 January 2020

Gatambwa Mukandala

2

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7 January 2020

author name string

Xiaoqing Li

3

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7 January 2020

W Marie Campana

4

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7 January 2020

Steven L Gonias

5

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7 January 2020

language of work or name

English

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publication date

22 May 2008

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Journal of Biological Chemistry

7 January 2020

published in

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7 January 2020

volume

283

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7 January 2020

issue

29

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7 January 2020

page(s)

19904-19911

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Human alpha2-macroglobulin is composed of multiple domains, as predicted by homology with complement component C3

7 January 2020

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22 September 2017

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Selective mutations in cloned and expressed alpha-macroglobulin receptor binding fragment alter binding to either the alpha2-macroglobulin signaling receptor or the low density lipoprotein receptor-related protein/alpha2-macroglobulin receptor

22 September 2017

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Activated alpha 2-macroglobulin promotes mitogenesis in rat vascular smooth muscle cells by a mechanism that is independent of growth-factor-carrier activity.

22 September 2017

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Native and activated forms of alpha 2-macroglobulin increase expression of platelet-derived growth factor alpha-receptor in vascular smooth muscle cells. Evidence for autocrine transforming growth factor-beta activity

22 September 2017

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22 September 2017

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22 September 2017

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22 September 2017

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22 September 2017

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22 September 2017

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25 September 2017

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17 June 2018

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17 June 2018

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17 June 2018

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The acute phase protein alpha2-macroglobulin induces rat ventricular cardiomyocyte hypertrophy via ERK1,2 and PI3-kinase/Akt pathways

17 June 2018

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20 August 2018

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Limited mutations in full-length tetrameric human alpha2-macroglobulin abrogate binding of platelet-derived growth factor-BB and transforming growth factor-beta1.

20 August 2018

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A positive role of the PI3-K/Akt signaling pathway in PC12 cell differentiation.

20 August 2018

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Apolipoprotein E receptors mediate neurite outgrowth through activation of p44/42 mitogen-activated protein kinase in primary neurons

20 August 2018

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20 August 2018

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Mice lacking alpha(2)-macroglobulin show an increased host defense against Gram-negative bacterial sepsis, but are more susceptible to endotoxic shock.

20 August 2018

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20 August 2018

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20 August 2018

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20 August 2018

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12 December 2020

Human alpha-2-macroglobulin. Studies on the electrophoretic heterogeneity

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12 December 2020

Chemical and structural modifications of alpha 2-macroglobulin: effects on receptor binding and endocytosis studied in an in vivo model

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12 December 2020

Mitogen activated protein kinase-dependent activation of c-Jun and c-Fos is required for neuronal differentiation but not for growth and stress response in PC12 cells

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12 December 2020

Rat alpha1-macroglobulin enhances nerve growth factor-promoted neurite outgrowth, TrkA phosphorylation, and gene expression of pheochromocytoma PC12 cells

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Reaction of alpha 2-macroglobulin with plasmin increases binding of transforming growth factors-beta 1 and beta 2

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12 December 2020

Interaction of transforming growth factor-beta 1 with alpha 2-macroglobulin. Role in transforming growth factor-beta 1 clearance

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12 December 2020

Targeted inactivation of the mouse alpha 2-macroglobulin gene

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12 December 2020

Identification of residues in alpha-macroglobulins important for binding to the alpha2-macroglobulin receptor/Low density lipoprotein receptor-related protein

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12 December 2020

Low-density lipoprotein receptor-related protein mediates in PC12 cell cultures the inhibition of nerve growth factor-promoted neurite outgrowth by pregnancy zone protein and alpha2-macroglobulin

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Identifiers

DOI

10.1074/JBC.M801762200

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18499670%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18499670%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

PubMed publication ID

18499670

1 reference