Generation of potent and stable human CD4+ T regulatory cells by activation-independent expression of FOXP3. (Q40055892)

16 September 2017

title

Generation of potent and stable human CD4+ T regulatory cells by activation-independent expression of FOXP3. (English)

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16 September 2017

7

Luigi Naldini

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Mario Amendola

Mario Amendola

5

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Alicia N McMurchy

Alicia N Alstad

2

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Megan K. Levings

Megan K Levings

10

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Maria Grazia Roncarolo

Maria Grazia Roncarolo

8

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Hugo Soudeyns

9

Hugo Soudeyns

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16 September 2017

Sarah E Allan

1

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16 September 2017

Natacha Merindol

3

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16 September 2017

Natasha K Crellin

4

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16 September 2017

Rosa Bacchetta

6

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16 September 2017

language of work or name

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6 November 2007

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16 September 2017

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16 September 2017

volume

16

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16 September 2017

issue

1

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16 September 2017

page(s)

194-202

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Human regulatory T cells and their role in autoimmune disease

16 September 2017

cites work

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In vitro expanded human CD4+CD25+ regulatory T cells suppress effector T cell proliferation.

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In vitro-expanded human CD4(+)CD25(+) T-regulatory cells can markedly inhibit allogeneic dendritic cell-stimulated MLR cultures

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Large-scale in vitro expansion of polyclonal human CD4(+)CD25high regulatory T cells.

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Human cd25(+)cd4(+) t regulatory cells suppress naive and memory T cell proliferation and can be expanded in vitro without loss of function.

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Only the CD45RA+ subpopulation of CD4+CD25high T cells gives rise to homogeneous regulatory T-cell lines upon in vitro expansion.

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CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells

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Expression of interleukin (IL)-2 and IL-7 receptors discriminates between human regulatory and activated T cells

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MHC class II expression identifies functionally distinct human regulatory T cells

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Induction of FoxP3 and acquisition of T regulatory activity by stimulated human CD4+CD25– T cells

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Differentiation and expansion of T cells with regulatory function from human peripheral lymphocytes by stimulation in the presence of TGF-{beta}.

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Generation ex vivo of TGF-beta-producing regulatory T cells from CD4+CD25- precursors.

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Rapamycin promotes expansion of functional CD4+CD25+FOXP3+ regulatory T cells of both healthy subjects and type 1 diabetic patients

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FOXP3: of mice and men.

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The role of 2 FOXP3 isoforms in the generation of human CD4+ Tregs.

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UBD, a downstream element of FOXP3, allows the identification of LGALS3, a new marker of human regulatory T cells

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Crucial role of FOXP3 in the development and function of human CD25+CD4+ regulatory T cells

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Potential of allospecific gene-engineered T cells in transplantation gene therapy: specific T cell activation determines transgene expression in vitro and in vivo

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Costimulation of transduced T lymphocytes via T cell receptor-CD3 complex and CD28 leads to increased transcription of integrated retrovirus

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Enhanced transgene expression in quiescent and activated human CD8+ T cells

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Single-cell analysis of normal and FOXP3-mutant human T cells: FOXP3 expression without regulatory T cell development

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7 January 2021

Molecular mechanisms underlying FOXP3 induction in human T cells

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7 January 2021

Transient regulatory T-cells: a state attained by all activated human T-cells.

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Transient expression of FOXP3 in human activated nonregulatory CD4+ T cells

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Activation-induced FOXP3 in human T effector cells does not suppress proliferation or cytokine production

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HIV infection of naturally occurring and genetically reprogrammed human regulatory T-cells

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Altered proximal T cell receptor (TCR) signaling in human CD4+CD25+ regulatory T cells

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7 January 2021

The clonal composition of human CD4+CD25+Foxp3+ cells determined by a comprehensive DNA-based multiplex PCR for TCRB gene rearrangements

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7 January 2021

Transient T cell receptor beta-chain variable region-specific expansions of CD4+ and CD8+ T cells during the early phase of pediatric human immunodeficiency virus infection: characterization of expanded cell populations by T cell receptor phenotypin

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7 January 2021

Retrovirus-mediated gene transfer in primary T lymphocytes: influence of the transduction/selection process and of ex vivo expansion on the T cell receptor beta chain hypervariable region repertoire

1 reference

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7 January 2021

Human CD25+CD4+ T suppressor cell clones produce transforming growth factor beta, but not interleukin 10, and are distinct from type 1 T regulatory cells.

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7 January 2021

FOXP3 controls regulatory T cell function through cooperation with NFAT

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7 January 2021

Hematopoietic stem cell gene transfer in a tumor-prone mouse model uncovers low genotoxicity of lentiviral vector integration

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7 January 2021

Human CD4+ T Cells Express TLR5 and Its Ligand Flagellin Enhances the Suppressive Capacity and Expression of FOXP3 in CD4+CD25+ T Regulatory Cells

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7 January 2021

IMGT/V-QUEST, an integrated software program for immunoglobulin and T cell receptor V-J and V-D-J rearrangement analysis

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7 January 2021

Antigen-specific development of primary and memory T cells in vivo.

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7 January 2021

Identifiers

DOI

10.1038/SJ.MT.6300341

1 reference

16 September 2017

1 reference