The use of molecular technology in the differentiation of pancreatic cancer and chronic pancreatitis (Q40855140)

24 September 2017

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title

The use of molecular technology in the differentiation of pancreatic cancer and chronic pancreatitis (English)

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24 September 2017

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Bramhall SR

1

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24 September 2017

publication date

1 April 1998

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International Journal of Pancreatology

24 September 2017

published in

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24 September 2017

volume

23

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24 September 2017

issue

2

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24 September 2017

page(s)

83-100

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Soluble normal and mutated DNA sequences from single-copy genes in human blood

24 September 2017

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Expression of p53 tumor suppressor gene, oncoprotein c-erbB-2, cellular proliferation and differentiation in malignant and benign pancreatic lesions.

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Implications of peritoneal cytology for staging of early pancreatic cancer

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Detection of ras gene mutations in pancreatic juice and peripheral blood of patients with pancreatic adenocarcinoma.

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Diabetes mellitus as a risk factor for pancreatic cancer. A meta-analysis

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Molecular and immunochemical analyses of RB1 and cyclin D1 in human ductal pancreatic carcinomas and cell lines

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Overexpression of c-Ki-ras and c-fos in human pancreatic carcinomas

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12 December 2020

Localization of expression of fibroblast growth-factors and their receptors in pancreatic adenocarcinoma by in-situ hybridization

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Direct growth stimulation of normal human epithelial cells by mutant p53.

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12 December 2020

CEA concentration and cytology in duodenal fluid collected during the Secretin-Pancreozymin test. Attempt at an early diagnosis of pancreatic carcinoma by means of simple procedure

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12 December 2020

Cytologic studies for the diagnosis of pancreatic cancer

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12 December 2020

Identification of a chromosome 18q gene that is altered in colorectal cancers

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12 December 2020

Partnership between DPC4 and SMAD proteins in TGF-beta signalling pathways.

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12 December 2020

Abnormalities affecting the APC and MCC tumour suppressor gene loci on chromosome 5q occur frequently in gastric cancer but not in pancreatic cancer

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12 December 2020

Genetic instability in pancreatic cancer and poorly differentiated type of gastric cancer.

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12 December 2020

Detection of K-ras mutations by denaturing gradient gel electrophoresis (DGGE): a study on pancreatic cancer

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12 December 2020

Transforming growth factor alpha and epidermal growth factor in human pancreatic cancer

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12 December 2020

K-ras mutation is an early event in pancreatic duct carcinogenesis in the Syrian golden hamster

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12 December 2020

The subunit structures of two distinct receptors for insulin-like growth factors I and II and their relationship to the insulin receptor

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12 December 2020

Diagnosis of pancreatic lesions using fine needle aspiration cytology: detection of K-ras point mutations using solid phase minisequencing

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12 December 2020

p53 mutations in pancreatic carcinoma and evidence of common involvement of homocopolymer tracts in DNA microdeletions

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12 December 2020

Detection of c-Ki-ras gene codon 12 mutations from pancreatic duct brushings in the diagnosis of pancreatic tumours

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12 December 2020

Molecular cloning of a new transforming gene from a chemically transformed human cell line.

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12 December 2020

Germline BRCA2 gene mutations in patients with apparently sporadic pancreatic carcinomas

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12 December 2020

K-ras oncogene activation in adenocarcinoma of the human pancreas. A study of 82 carcinomas using a combination of mutant-enriched polymerase chain reaction analysis and allele-specific oligonucleotide hybridization

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12 December 2020

Growth regulation of a cellular tumour antigen, p53, in nontransformed cells

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12 December 2020

p53 immunostaining as a marker of malignant disease in diagnostic cytopathology

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12 December 2020

Endoscopic evaluation of cancer of the pancreas

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12 December 2020

Polymerase chain reaction-based K-ras mutation detection of pancreatic adenocarcinoma in routine cytology smears

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12 December 2020

Diagnosis of pancreatic carcinoma. Imaging techniques and tumor markers

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12 December 2020

Expression of cellular oncogenes in human malignancies

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Prognostic value of proliferating cell nuclear antigen in gastric carcinoma

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Expression of cripto in human pancreatic tumors.

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12 December 2020

NIH conference. Insulin-like growth factors in health and disease

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12 December 2020

Binding proteins for the insulin-like growth factors: structure, regulation and function

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12 December 2020

Clinical application of ras gene mutation for diagnosis of pancreatic adenocarcinoma

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12 December 2020

High frequency of Ki-ras codon 12 mutations in pancreatic adenocarcinomas

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12 December 2020

Regulation of matrix metalloproteinases - their role in tumor invasion and metastasis

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12 December 2020

Diagnosis of pancreatic adenocarcinoma by polymerase chain reaction from pancreatic secretions

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12 December 2020

Pancreatitis and the risk of pancreatic cancer. International Pancreatitis Study Group.

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12 December 2020

Allelotype of pancreatic adenocarcinoma using xenograft enrichment

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12 December 2020

A subgroup of patients with chronic pancreatitis overexpress the c-erb B-2 protooncogene

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12 December 2020

Percutaneous fine needle aspiration cytology of the pancreas: advantages and pitfalls

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12 December 2020

Transforming growth factor beta 1 is present at sites of extracellular matrix gene expression in human pulmonary fibrosis

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12 December 2020

Assignment of a locus for familial melanoma, MLM, to chromosome 9p13-p22

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12 December 2020

Epidermal growth factor (EGF/URO) induces expression of regulatory peptides in damaged human gastrointestinal tissues

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12 December 2020

Allelic loss on chromosome 11 in hereditary and sporadic tumors related to familial multiple endocrine neoplasia type 1

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12 December 2020

Ras gene mutations in intraductal papillary neoplasms of the pancreas. Analysis in five cases

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12 December 2020

Amplifications of both c-Ki-ras with a point mutation and c-myc in a primary pancreatic cancer and its metastatic tumors in lymph nodes.

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12 December 2020

Frequency and types of point mutation at the 12th codon of the c-Ki-ras gene found in pancreatic cancers from Japanese patients.

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12 December 2020

Scatter factor: molecular characteristics and effect on the invasiveness of epithelial cells

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12 December 2020

Localization of transforming growth factor beta 1 and its latent binding protein in human chronic pancreatitis

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12 December 2020

A matrix metalloproteinase expressed on the surface of invasive tumour cells

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12 December 2020

Mutated c-K-ras in small pancreatic adenocarcinomas

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12 December 2020

p53 mutations are common in pancreatic cancer and are absent in chronic pancreatitis

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12 December 2020

Enhanced expression of the type II transforming growth factor beta receptor in human pancreatic cancer cells without alteration of type III receptor expression.

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12 December 2020

Allelotype of pancreatic adenocarcinoma

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12 December 2020

Frequent somatic mutations of the APC gene in human pancreatic cancer

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12 December 2020

Assessment of endoscopic retrograde cholangio-pancreatography (ERCP) and pure pancreatic juice cytology in patients with pancreatic disease

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12 December 2020

Abnormalities of the RB1 and DCC tumor suppressor genes: Uncommon in human pancreatic adenocarcinoma

1 reference

12 December 2020

The epidermal growth factor receptor in human pancreatic cancer

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12 December 2020

Detection of c-K-ras mutations in fine needle aspirates from human pancreatic adenocarcinomas.

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12 December 2020

Enhancement of transforming growth factor β1 expression in the rat pancreas during regeneration from caerulein-induced pancreatitis

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12 December 2020

Human retinoblastoma susceptibility gene: cloning, identification, and sequence

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12 December 2020

Epidermal growth factor and its receptors in human pancreatic carcinoma

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12 December 2020

Expression of and response to growth regulatory peptides by two human pancreatic carcinoma cell lines

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12 December 2020

Cytological diagnosis of pancreatic tumors

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12 December 2020

Transforming growth factor-beta (TGF-beta 1) inhibits pancreatic acinar cell growth

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12 December 2020

Expression and in-situ localization of genes coding for extracellular matrix proteins and extracellular matrix degrading proteases in pancreatic cancer.

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12 December 2020

Detection of k-ras mutations in nonsmall cell lung-carcinoma

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12 December 2020

Enhanced expression of transforming growth factor beta isoforms in pancreatic cancer correlates with decreased survival

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12 December 2020

Direct sequencing analysis of exon 1 of the c-K-ras gene shows a low frequency of mutations in human pancreatic adenocarcinomas

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12 December 2020

Detection of melanoma cells in peripheral blood by means of reverse transcriptase and polymerase chain reaction

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12 December 2020

Loss of heterozygosity on chromosomes 1 and 11 in carcinoma of the pancreas

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12 December 2020

Microsatellite instability in cancer of the proximal colon

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12 December 2020

Frequent alterations of the tumor suppressor genes p53 and DCC in human pancreatic carcinoma.

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12 December 2020

Coexpression of the c-met proto-oncogene and hepatocyte growth factor in human pancreatic cancer

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12 December 2020

Insulin-like growth factors I and II.

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12 December 2020

KRAS codon 12 mutations occur very frequently in pancreatic adenocarcinomas

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12 December 2020

The assessment of proliferating cell nuclear antigen (PCNA) immunostaining in primary gastrointestinal lymphomas and its relationship to histological grade, S+G2+M phase fraction (flow cytometric analysis) and prognosis

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12 December 2020

Insulin-like growth factor I and transforming growth factor alpha as autocrine growth factors in human pancreatic cancer cell growth

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12 December 2020

Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis

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12 December 2020

Crude isolation of DNA from unselected human pancreatic tissue and amplification by the polymerase chain reaction of Ki-ras oncogene to detect point mutations in pancreatic cancer

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12 December 2020

Differential binding and biological activities of epidermal growth factor and transforming growth factor alpha in a human pancreatic cancer cell line

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12 December 2020

Treatment and survival in 13560 patients with pancreatic cancer, and incidence of the disease, in the West Midlands: An epidemiological study

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12 December 2020

Molecular pathology of primary and metastatic ductal pancreatic lesions: analyses of mutations and expression of the p53, mdm-2, and p21/WAF-1 genes in sporadic and familial lesions

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12 December 2020

The point mutation of c-Ki-ras at codon 12 in carcinoma of the pancreatic head region and in intraductal mucin-hypersecreting neoplasm of the pancreas

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12 December 2020

Intraoperative fine needle aspiration cytologic examination of pancreatic lesions.

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12 December 2020

Increased expression of acidic and basic fibroblast growth factors in chronic pancreatitis.

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12 December 2020

Diabetes and the Risk of Pancreatic Cancer

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12 December 2020

Insulin-like growth factor I (IGF-I)-binding protein complex is a better mitogen than free IGF-I

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12 December 2020

Detection of c-Ki-ras mutation by PCR/RFLP analysis and diagnosis of pancreatic adenocarcinomas

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12 December 2020

Immunohistochemistry in district general hospitals in England and Wales

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12 December 2020

Epidemiology of pancreatic cancer in Japan

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12 December 2020

Cell cycle analysis of a cell proliferation-associated human nuclear antigen defined by the monoclonal antibody Ki-67

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12 December 2020

Overexpression of HER2/neu oncogene in human pancreatic carcinoma

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12 December 2020

Endoscopic cytology of the esophagus, stomach and pancreas

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12 December 2020

Ki-ras oncogene activation in preinvasive pancreatic cancer

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12 December 2020

Identification of a Gene Located at Chromosome 5q21 that Is Mutated in Colorectal Cancers

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12 December 2020

Detection of c-Ki-ras point mutation from pancreatic juice. A useful diagnostic approach for pancreatic carcinoma

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12 December 2020

ras oncogenes in human cancer: a review

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12 December 2020

[Ki-ras mutation as a molecular tumor marker for carcinoma of the pancreas]

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12 December 2020

Pancreatic cancer in Europe: Ki-ras gene mutation pattern shows geographical differences

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12 December 2020

Clonal loss of INT-2 alleles in sporadic and familial pancreatic endocrine tumours

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12 December 2020

Mutations of chromosome 5q21 genes in FAP and colorectal cancer patients

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12 December 2020

Cripto, a member of the epidermal growth factor family, is over-expressed in human pancreatic cancer and chronic pancreatitis

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12 December 2020

The possible autocrine/paracrine and endocrine roles of insulin-like growth factors of human tumors

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12 December 2020

Localization of a breast cancer susceptibility gene, BRCA2, to chromosome 13q12-13.

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12 December 2020

Frequent loss of expression of the potential tumor suppressor gene DCC in ductal pancreatic adenocarcinoma

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12 December 2020

Chronic pancreatitis is associated with increased concentrations of epidermal growth factor receptor, transforming growth factor alpha, and phospholipase C gamma

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12 December 2020

Growth factors and oncogenes in pancreatic cancer

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12 December 2020

Immunohistochemical analysis of p53 expression in human pancreatic carcinomas.

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12 December 2020

Pancreatic adenocarcinomas frequently show p53 gene mutations.

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12 December 2020

K-ras and p53 gene mutations in pancreatic cancer: ductal and nonductal tumors progress through different genetic lesions.

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12 December 2020

Functional identity of proliferating cell nuclear antigen and a DNA polymerase-delta auxiliary protein

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12 December 2020

Clinicopathological features and prognostic significance of nucleoside diphosphate kinase/nm23 gene product in human pancreatic exocrine neoplasms

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12 December 2020

Detection of K-ras mutations in mucinous pancreatic duct hyperplasia from a patient with a family history of pancreatic carcinoma.

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12 December 2020

Human pancreatic carcinomas and cell lines reveal frequent and multiple alterations in the p53 and Rb-1 tumor-suppressor genes

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12 December 2020

Detection of ras gene mutations in human lung cancers by single-strand conformation polymorphism analysis of polymerase chain reaction products

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12 December 2020

Loss of heterozygosity involving the APC and MCC genetic loci occurs in the majority of human esophageal cancers

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12 December 2020

C-myc proto-oncogene expression and prognosis in early carcinoma of the uterine cervix

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12 December 2020

p53 and K-RAS alterations in pancreatic epithelial cell lesions

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12 December 2020

Abnormalities of the p53 tumour suppressor gene in human pancreatic cancer.

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12 December 2020

Detection of K-ras mutations in the stool of patients with pancreatic adenocarcinoma and pancreatic ductal hyperplasia

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12 December 2020

Enhanced expression of epidermal growth factor receptor correlates with alterations of chromosome 7 in human pancreatic cancer

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12 December 2020

Expression of c-erbB-2 in Human Pancreatic Adenocarcinomas

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12 December 2020

Islet amyloid polypeptide in patients with pancreatic cancer and diabetes.

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12 December 2020

Mortality in relation to smoking: 20 years' observations on male British doctors

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12 December 2020

Overexpression of HER2/neu oncogene in pancreatic cancer correlates with shortened survival

1 reference

12 December 2020

Values of CA 19-9 in the serum, pure pancreatic juice, and aspirated pancreatic material in the diagnosis of malignant pancreatic tumor

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12 December 2020

Transforming growth factors beta 1 and alpha in chronic liver disease. Effects of interferon alfa therapy

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12 December 2020

Do insulin and the insulin like growth factors (IGFs) stimulate growth of the exocrine pancreas?

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12 December 2020

Comparison of mutations of ras oncogene in human pancreatic exocrine and endocrine tumors

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12 December 2020

Alterations in serum levels of insulin-like growth factors and insulin-like growth-factor-binding proteins in patients with colorectal cancer

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12 December 2020

Cytologic brushings of ductal lesions during ERCP

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12 December 2020

Life-style risk factors for pancreatic cancer in Louisiana: a case-control study

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12 December 2020

Genetic and immunochemical analysis of mutant p53 in human breast cancer cell lines

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12 December 2020

Evolution of tumours and the impact of molecular oncology

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12 December 2020

Pancreatic tumor pathogenesis reflects the causative genetic lesion

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12 December 2020

Pancreatic ductal adenocarcinomas induced in Syrian hamsters by N-nitrosobis(2-oxopropyl)amine contain a c-Ki-ras oncogene with a point-mutated codon 12.

1 reference

12 December 2020

Evidence for a new tumor-suppressor gene involved in gastrointestinal malignancies

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12 December 2020

Cytodiagnosis of pancreatic malignant tumors by aspiration, under direct vision, using a duodenal fiberscope

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12 December 2020

Insulin-like growth factor I overexpression in human pancreatic cancer: evidence for autocrine and paracrine roles.

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12 December 2020

Mutational activation of the c-K-ras gene in human pancreatic carcinoma.

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12 December 2020

DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1

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12 December 2020

Insulin-like growth factor-I, interleukin-1 alpha and beta in pancreatic cancer: role in tumor invasiveness and associated diabetes

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12 December 2020

Identification of K-ras oncogene mutations in the pure pancreatic juice of patients with ductal pancreatic cancers.

1 reference

12 December 2020

Cytologic criteria for the diagnosis of pancreatic carcinoma

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12 December 2020

Structure and expression in breast tumors of human TIMP-3, a new member of the metalloproteinase inhibitor family

1 reference

12 December 2020

The diagnosis of pancreatic cancer by pancreatic juice cytology

1 reference

12 December 2020

Cytologic examination of pure pancreatic juice in the diagnosis of pancreatic carcinoma. The endoscopic retrograde intraductal catheter aspiration cytologic technique

1 reference

12 December 2020

Enhanced levels of insulin-like growth factor messenger RNA in human colon carcinomas and liposarcomas

1 reference

12 December 2020

Identification of a fibroblast-derived epithelial morphogen as hepatocyte growth factor

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12 December 2020

DPC4 gene in various tumor types

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12 December 2020

Expression of the antimetastatic gene nm23 in human breast cancer: an association with good prognosis

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12 December 2020

Enhanced erbB-3 expression in human pancreatic cancer correlates with tumor progression

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12 December 2020

Growth inhibition of human pancreatic carcinoma cells by transforming growth factor beta-1.

1 reference

12 December 2020

The prognostic value of Ki67 immunostaining in non-Hodgkin's lymphoma

1 reference

12 December 2020

Tissue inhibitor of metalloproteinase (TIMP-2). A new member of the metalloproteinase inhibitor family

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12 December 2020

Frequent c-Ki-ras oncogene activation in mucous cell hyperplasias of pancreas suffering from chronic inflammation

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12 December 2020

Detection of point mutations in the K-ras oncogene at codon 12 in pure pancreatic juice for diagnosis of pancreatic carcinoma

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12 December 2020

Ultrasound-guided core biopsy

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12 December 2020

Betacellulin, a member of the epidermal growth-factor family, is overexpressed in human pancreatic-cancer

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12 December 2020

The immunohistochemical expressions of epidermal growth factors, epidermal growth factor receptors and c-erbB-2 oncoprotein in human pancreatic cancer.

1 reference

12 December 2020

Betacellulin activates the epidermal growth factor receptor and erbB-4, and induces cellular response patterns distinct from those stimulated by epidermal growth factor or neuregulin-beta

1 reference

12 December 2020

Expression of nucleoside diphosphate kinase/nm23 gene product in human pancreatic cancer: an association with lymph node metastasis and tumor invasion

1 reference

12 December 2020

Analysis of ras gene mutations in biliary and pancreatic tumors by polymerase chain reaction and direct sequencing

1 reference

12 December 2020

Overexpression of the epidermal growth factor receptor in human pancreatic cancer is associated with concomitant increases in the levels of epidermal growth factor and transforming growth factor alpha

1 reference

12 December 2020

CT-guided needle biopsy of the pancreas: a retrospective analysis of diagnostic accuracy

1 reference

12 December 2020

Detection of point mutations in the Kirsten-ras oncogene provides evidence for the multicentricity of pancreatic carcinoma

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12 December 2020

Analysis of c-Ki-ras mutations in human colon carcinoma by cell sorting, polymerase chain reaction, and DNA sequencing

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12 December 2020

Multiple K-ras codon 12 mutations in cholangiocarcinomas demonstrated with a sensitive polymerase chain reaction technique.

1 reference

12 December 2020

Distinguishing Pancreatic Carcinoma From Other Periampullary Carcinomas by Analysis of Mutations in the Kirsten-ras Oncogene

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12 December 2020

Point mutation of K-ras gene codon 12 in biliary tract tumors

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12 December 2020

Elevated expression of transforming growth factor-beta and proteoglycan production in experimental glomerulonephritis. Possible role in expansion of the mesangial extracellular matrix

1 reference

12 December 2020

Evidence for a common molecular pathogenesis in colorectal, gastric, and pancreatic cancer

1 reference

12 December 2020

The c-erb B-2 proto-oncogene in human pancreatic cancer

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12 December 2020

The erbB-3 gene in human pancreatic cancer

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12 December 2020

The role of Ras mutation in pancreatic cancer, precancerous lesions, and chronic pancreatitis

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12 December 2020

Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes

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12 December 2020

Intraoperative fine needle aspiration of pancreatic and extrahepatic biliary masses.

1 reference

12 December 2020

Detection of K-ras mutations in pancreatic and hepatic neoplasms by non-isotopic mismatched polymerase chain reaction

1 reference

12 December 2020

Deletion and mutation analyses of the P16/MTS-1 tumor suppressor gene in human ductal pancreatic cancer reveals a higher frequency of abnormalities in tumor-derived cell lines than in primary ductal adenocarcinomas

1 reference

12 December 2020

A cell cycle regulator potentially involved in genesis of many tumor types

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12 December 2020

Polymorphic sites within the MCC and APC loci reveal very frequent loss of heterozygosity in human small cell lung cancer

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12 December 2020

Evaluation of candidate tumour suppressor genes on chromosome 18 in colorectal cancers

1 reference

12 December 2020

Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells

1 reference

12 December 2020

Frequent somatic mutations and homozygous deletions of the p16 (MTS1) gene in pancreatic adenocarcinoma

1 reference

12 December 2020

Identifiers

DOI

10.1385/IJGC:23:2:83

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24 September 2017

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