Modification of rifamycin polyketide backbone leads to improved drug activity against rifampicin-resistant Mycobacterium tuberculosis. (Q42121206)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24923585%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

title

Modification of rifamycin polyketide backbone leads to improved drug activity against rifampicin-resistant Mycobacterium tuberculosis (English)

1 reference

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Mycobacterium tuberculosis

20 March 2020

main subject

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author

Taifo Mahmud

12

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20 March 2020

11

Yogendra Singh

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20 March 2020

author name string

Aeshna Nigam

1

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20 March 2020

Khaled H Almabruk

2

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20 March 2020

Anjali Saxena

3

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20 March 2020

Jongtae Yang

4

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20 March 2020

Udita Mukherjee

5

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20 March 2020

Hardeep Kaur

6

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20 March 2020

Puneet Kohli

7

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20 March 2020

Rashmi Kumari

8

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20 March 2020

Priya Singh

9

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20 March 2020

Lev N Zakharov

10

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20 March 2020

Rup Lal

13

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20 March 2020

language of work or name

English

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publication date

1 July 2014

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Journal of Biological Chemistry

20 March 2020

published in

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volume

289

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20 March 2020

issue

30

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20 March 2020

page(s)

21142-21152

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X-ray Crystal Structures of the Escherichia coli RNA Polymerase in Complex with Benzoxazinorifamycins

20 March 2020

cites work

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29 May 2018

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Controlled comparison of BacT/Alert MB system, manual Myco/F lytic procedure, and isolator 10 system for diagnosis of Mycobacterium tuberculosis Bacteremia

29 May 2018

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Shared Biosynthesis of the Saliniketals and Rifamycins in Salinispora arenicola is Controlled by the sare1259-Encoded Cytochrome P450

29 May 2018

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29 May 2018

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Revisiting the modularity of modular polyketide synthases

29 May 2018

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Combinatorial biosynthesis--potential and problems

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Identification of tailoring genes involved in the modification of the polyketide backbone of rifamycin B by Amycolatopsis mediterranei S699.

29 May 2018

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A Switch for the transfer of substrate between nonribosomal peptide and polyketide modules of the rifamycin synthetase assembly line

29 May 2018

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Structural mechanism for rifampicin inhibition of bacterial rna polymerase

29 May 2018

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Regulation and manipulation of the gene clusters encoding type-I PKSs

29 May 2018

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A multiplasmid approach to preparing large libraries of polyketides

29 May 2018

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Direct evidence that the rifamycin polyketide synthase assembles polyketide chains processively.

29 May 2018

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Contribution of rpoB mutations to development of rifamycin cross-resistance in Mycobacterium tuberculosis

29 May 2018

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Ethyl-substituted erythromycin derivatives produced by directed metabolic engineering

29 May 2018

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Biosynthesis of the ansamycin antibiotic rifamycin: deductions from the molecular analysis of the rif biosynthetic gene cluster of Amycolatopsis mediterranei S699.

29 May 2018

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Analysis of seven genes from the eryAI-eryK region of the erythromycin biosynthetic gene cluster in Saccharopolyspora erythraea

29 May 2018

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Acyltransferase domain substitutions in erythromycin polyketide synthase yield novel erythromycin derivatives

29 May 2018

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Engineering antibiotic producers to overcome the limitations of classical strain improvement programs

29 May 2018

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The biosynthetic gene cluster for the polyketide immunosuppressant rapamycin

29 May 2018

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Rifamycins: strain improvement program

29 May 2018

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Recent trends in rifamycin research

29 May 2018

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Construction of a hybrid plasmid capable of replication in Amycolatopsis mediterranei

29 May 2018

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In vitro and in vivo investigation of metabolic fate of rifampicin using an optimized sample preparation approach and modern tools of liquid chromatography-mass spectrometry.

29 May 2018

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Allosteric modulation of the RNA polymerase catalytic reaction is an essential component of transcription control by rifamycins

17 August 2018

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Isolation and characterization of 27-O-demethylrifamycin SV methyltransferase provides new insights into the post-PKS modification steps during the biosynthesis of the antitubercular drug rifamycin B by Amycolatopsis mediterranei S699.

17 August 2018

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Cloning and partial characterization of the putative rifamycin biosynthetic gene cluster from the actinomycete Amycolatopsis mediterranei DSM 46095.

17 August 2018

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The loading module of rifamycin synthetase is an adenylation-thiolation didomain with substrate tolerance for substituted benzoates

17 August 2018

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Knowledge-based design of bimodular and trimodular polyketide synthases based on domain and module swaps: a route to simple statin analogues

17 August 2018

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Dissecting the role of acyltransferase domains of modular polyketide synthases in the choice and stereochemical fate of extender units

17 August 2018

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Selection of suitable marker genes for the development of cloning vectors and electroporation in different strains of Amycolatopsis mediterranei.

17 August 2018

1 reference

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3-Amino-5-hydroxybenzoic acid synthase, the terminal enzyme in the formation of the precursor of mC7N units in rifamycin and related antibiotics.

17 August 2018

1 reference

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4-[2-(2-amino-2-oxoethyl)-2,7-dihydroxy-4-oxochroman-5-yl]-3-hydroxybut-2-enoic acid

17 August 2018

1 reference

Crossref

https://api.crossref.org/works/10.1074%2FJBC.M114.572636

A hybrid modular polyketide synthase obtained by domain swapping

21 January 2018

1 reference

12 December 2020

Cloning and sequence analysis of the putative rifamycin polyketide synthase gene cluster from Amycolatopsis mediterranei

1 reference

12 December 2020

Development of an improved cloning vector and transformation system in Amycolatopsis mediterranei (Nocardia mediterranei)

1 reference

12 December 2020

Precursor-directed biosynthesis of 12-ethyl erythromycin

1 reference

12 December 2020

The importance of homologous recombination in the generation of large deletions in hybrid plasmids in Amycolatopsis mediterranei

1 reference

12 December 2020

Intermediates of rifamycin polyketide synthase produced by an Amycolatopsis mediterranei mutant with inactivated rifF gene

1 reference

12 December 2020

Identifiers

DOI

10.1074/JBC.M114.572636

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24923585%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24923585%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

PubMed publication ID

24923585

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24923585%20AND%20SRC:MED&resulttype=core&format=json