Design of the novel protraction mechanism of insulin degludec, an ultra-long-acting basal insulin. (Q42240405)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22485010%20AND%20SRC:MED&resulttype=core&format=json

28 January 2020

title

Design of the novel protraction mechanism of insulin degludec, an ultra-long-acting basal insulin (English)

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28 January 2020

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4

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28 January 2020

author name string

Ib Jonassen

1

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28 January 2020

Svend Havelund

2

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28 January 2020

Thomas Hoeg-Jensen

3

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28 January 2020

Per-Olof Wahlund

5

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28 January 2020

Ulla Ribel

6

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28 January 2020

language of work or name

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7 April 2012

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28 January 2020

published in

Pharmaceutical Research

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28 January 2020

volume

29

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28 January 2020

issue

8

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28 January 2020

page(s)

2104-2114

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The future of basal insulin supplementation.

28 January 2020

cites work

1 reference

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26 October 2017

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A new-generation ultra-long-acting basal insulin with a bolus boost compared with insulin glargine in insulin-naive people with type 2 diabetes: a randomized, controlled trial

26 October 2017

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Insulin degludec in type 1 diabetes: a randomized controlled trial of a new-generation ultra-long-acting insulin compared with insulin glargine.

26 October 2017

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Strategies for the Assessment of Protein Aggregates in Pharmaceutical Biotech Product Development

26 October 2017

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Refining basal insulin therapy: what have we learned in the age of analogues?

26 October 2017

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Towards peakless, reproducible and long-acting insulins. An assessment of the basal analogues based on isoglycaemic clamp studies

26 October 2017

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Albumin-bound basal insulin analogues (insulin detemir and NN344): comparable time-action profiles but less variability than insulin glargine in type 2 diabetes

26 October 2017

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Effects of protein aggregates: an immunologic perspective

26 October 2017

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How to achieve a predictable basal insulin?

26 October 2017

1 reference

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New insulins in the treatment of diabetes mellitus

26 October 2017

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Size-exclusion chromatography with on-line light-scattering, absorbance, and refractive index detectors for studying proteins and their interactions.

26 October 2017

1 reference

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Albumin binding of insulins acylated with fatty acids: characterization of the ligand-protein interaction and correlation between binding affinity and timing of the insulin effect in vivo

26 October 2017

1 reference

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Estimation of molecular size and molecular weights of biological compounds by gel filtration

26 October 2017

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Comparison of solution structural flexibility and zinc binding domains for insulin, proinsulin, and miniproinsulin

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3399081

Insulin degludec, an ultra-long-acting basal insulin, once a day or three times a week versus insulin glargine once a day in patients with type 2 diabetes: a 16-week, randomised, open-label, phase 2 trial

26 October 2017

1 reference

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The specific refractive increment of some purified proteins

29 May 2018

1 reference

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Biochemical and physiological properties of a novel series of long-acting insulin analogs obtained by acylation with cholic acid derivatives

17 August 2018

1 reference

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Lower within-subject variability of insulin detemir in comparison to NPH insulin and insulin glargine in people with type 1 diabetes

17 August 2018

1 reference

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The allosteric transition of the insulin hexamer is modulated by homotropic and heterotropic interactions.

17 August 2018

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Structural effects of protein lipidation as revealed by LysB29-myristoyl, des(B30) insulin

17 August 2018

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12 December 2020

The Mechanism of Protraction of Insulin Detemir, a Long-Acting, Acylated Analog of Human Insulin

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12 December 2020

Cooperativity and intermediate states in the T----R-structural transformation of insulin

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12 December 2020

Insulin degludec: four times lower pharmacodynamic variability than insulin glargine under steady-state conditions in type 1 diabetes

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12 December 2020

Ultra-long-acting insulin degludec has a flat and stable glucose-lowering effect in type 2 diabetes

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12 December 2020

Monomeric insulins obtained by protein engineering and their medical implications

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12 December 2020

Three-dimensional atomic structure of insulin and its relationship to activity

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12 December 2020

Homogeneous mono-(125)i-insulins. Preparation and characterization of mono-(125)i-(tyr a14)-and mono-(125)i-(tyr a19)-insulin

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12 December 2020

Action Profile of Cobalt(III)-Insulin: A Novel Principle of Protraction of Potential Use for Basal Insulin Delivery

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12 December 2020

10.1007/S11095-012-0739-Z

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22485010%20AND%20SRC:MED&resulttype=core&format=json

28 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22485010%20AND%20SRC:MED&resulttype=core&format=json

28 January 2020

PubMed publication ID

22485010

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22485010%20AND%20SRC:MED&resulttype=core&format=json