Increased dynamic effects in a catalytically compromised variant of Escherichia coli dihydrofolate reductase. (Q42414532)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24252106%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

title

Increased dynamic effects in a catalytically compromised variant of Escherichia coli dihydrofolate reductase (English)

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1 March 2020

1 reference

José Javier Ruiz-Pernía

1

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1 March 2020

Louis Y P Luk

2

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1 March 2020

Rafael García-Meseguer

3

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1 March 2020

Sergio Martí

4

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1 March 2020

Edric Joel Loveridge

5

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1 March 2020

Iñaki Tuñón

6

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1 March 2020

Vicent Moliner

7

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1 March 2020

author name string

Rudolf K Allemann

8

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1 March 2020

language of work or name

English

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publication date

26 November 2013

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Journal of the American Chemical Society

1 March 2020

published in

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1 March 2020

volume

135

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1 March 2020

issue

49

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1 March 2020

page(s)

18689-18696

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Unraveling the role of protein dynamics in dihydrofolate reductase catalysis

1 March 2020

cites work

1 reference

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Automated identification of functional dynamic contact networks from X-ray crystallography

28 May 2018

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Studying the role of protein dynamics in an SN2 enzyme reaction using free-energy surfaces and solvent coordinates

28 May 2018

1 reference

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Functional significance of evolving protein sequence in dihydrofolate reductase from bacteria to humans

28 May 2018

1 reference

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Heavy-enzyme kinetic isotope effects on proton transfer in alanine racemase

28 May 2018

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Barrier Crossing in Dihydrofolate Reductasedoes not involve a rate-promoting vibration

28 May 2018

1 reference

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Evidence that a 'dynamic knockout' in Escherichia coli dihydrofolate reductase does not affect the chemical step of catalysis.

28 May 2018

1 reference

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Taking Ockham's razor to enzyme dynamics and catalysis

28 May 2018

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Femtosecond dynamics coupled to chemical barrier crossing in a Born-Oppenheimer enzyme

28 May 2018

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The role of large-scale motions in catalysis by dihydrofolate reductase.

28 May 2018

1 reference

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Mass-dependent bond vibrational dynamics influence catalysis by HIV-1 protease.

28 May 2018

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Catalysis by dihydrofolate reductase and other enzymes arises from electrostatic preorganization, not conformational motions

28 May 2018

1 reference

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A dynamic knockout reveals that conformational fluctuations influence the chemical step of enzyme catalysis

28 May 2018

1 reference

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Slow conformational motions that favor sub-picosecond motions important for catalysis

28 May 2018

1 reference

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Coupled motions in enzyme catalysis

28 May 2018

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Do dynamic effects play a significant role in enzymatic catalysis? A theoretical analysis of formate dehydrogenase

28 May 2018

1 reference

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Solvent effects on catalysis by Escherichia coli dihydrofolate reductase

28 May 2018

1 reference

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Enzyme millisecond conformational dynamics do not catalyze the chemical step

28 May 2018

1 reference

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A 21st century revisionist's view at a turning point in enzymology

28 May 2018

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Structural and mechanistic aspects of flavoproteins: probes of hydrogen tunnelling

28 May 2018

1 reference

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Probing coupled motions in enzymatic hydrogen tunnelling reactions

28 May 2018

1 reference

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Dynamic personalities of proteins

28 May 2018

1 reference

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A hierarchy of timescales in protein dynamics is linked to enzyme catalysis

28 May 2018

1 reference

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Conformational change of the methionine 20 loop of Escherichia coli dihydrofolate reductase modulates pKa of the bound dihydrofolate

28 May 2018

1 reference

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The dynamic energy landscape of dihydrofolate reductase catalysis

28 May 2018

1 reference

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Effects of a distal mutation on active site chemistry

28 May 2018

1 reference

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A perspective on enzyme catalysis.

28 May 2018

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A compelling experimental test of the hypothesis that enzymes have evolved to enhance quantum mechanical tunneling in hydrogen transfer reactions: the beta-neopentylcobalamin system combined with prior adocobalamin data

28 May 2018

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Barrier passage and protein dynamics in enzymatically catalyzed reactions

28 May 2018

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New insights into enzyme catalysis. Ground state tunnelling driven by protein dynamics

28 May 2018

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Loop and subdomain movements in the mechanism of Escherichia coli dihydrofolate reductase: crystallographic evidence

28 May 2018

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Dynamics of enzymatic reactions

28 May 2018

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Construction and evaluation of the kinetic scheme associated with dihydrofolate reductase from Escherichia coli

28 May 2018

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28 May 2018

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Fast protein motions are coupled to enzyme H-transfer reactions

28 May 2018

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Effect of pH on hydride transfer by Escherichia coli dihydrofolate reductase.

16 August 2018

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The temperature dependence of the kinetic isotope effects of dihydrofolate reductase from Thermotoga maritima is influenced by intersubunit interactions

16 August 2018

1 reference

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Dynamic effects on reaction rates in a Michael addition catalyzed by chalcone isomerase. Beyond the frozen environment approach.

16 August 2018

1 reference

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Origin of the temperature dependence of isotope effects in enzymatic reactions: the case of dihydrofolate reductase

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3949409

The catalytic effect of dihydrofolate reductase and its mutants is determined by reorganization energies

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3949409

Tunneling and coupled motion in the Escherichia coli dihydrofolate reductase catalysis

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3949409

Reaction-path energetics and kinetics of the hydride transfer reaction catalyzed by dihydrofolate reductase

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3949409

The first experimental test of the hypothesis that enzymes have evolved to enhance hydrogen tunneling

16 August 2018

1 reference

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Nuclear quantum tunneling in the light-activated enzyme protochlorophyllide oxidoreductase

16 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24252106

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Zur Quantentheorie der Molekeln

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COCI

https://opencitations.net/index/coci/api/v1/citations/10.1002/ANDP.19273892002

29 July 2023

Identifiers

DOI

10.1021/JA410519H

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release_onqkwycvtbcdtf7ik6qlkdvili

1 March 2020

Fatcat ID

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Fatcat

https://api.fatcat.wiki/v0/release/onqkwycvtbcdtf7ik6qlkdvili

mapped directly with Wikidata item

24 November 2022

based on heuristic

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1 March 2020

PubMed publication ID

24252106

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