A single mutation in the 729 residue modulates human DNA topoisomerase IB DNA binding and drug resistance. (Q42950337)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18772225%20AND%20SRC:MED&resulttype=core&format=json

13 January 2020

title

A single mutation in the 729 residue modulates human DNA topoisomerase IB DNA binding and drug resistance (English)

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13 January 2020

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1

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13 January 2020

Ilda D'Annessa

4

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13 January 2020

Giovanni Chillemi

5

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13 January 2020

author name string

Erica Cretaio

2

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13 January 2020

Paola Fiorani

3

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13 January 2020

Piero Benedetti

6

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13 January 2020

language of work or name

English

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publication date

4 September 2008

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13 January 2020

published in

Nucleic Acids Research

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13 January 2020

volume

36

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13 January 2020

issue

17

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13 January 2020

page(s)

5635-5644

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describes a project that uses

13 January 2020

ImageQuant

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11 June 2022

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inferred from PubMed Central ID database lookup

cites work

Mutation of Gly721 alters DNA topoisomerase I active site architecture and sensitivity to camptothecin

1 reference

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Topoisomerase I inhibitors: camptothecins and beyond

27 May 2018

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The different cleavage DNA sequence specificity explains the camptothecin resistance of the human topoisomerase I Glu418Lys mutant.

27 May 2018

1 reference

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Repair of and checkpoint response to topoisomerase I-mediated DNA damage

27 May 2018

1 reference

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Single mutation in the linker domain confers protein flexibility and camptothecin resistance to human topoisomerase I.

27 May 2018

1 reference

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Nonlinear partial differential equations and applications: The mechanism of topoisomerase I poisoning by a camptothecin analog

27 May 2018

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Tumor cell death induced by topoisomerase-targeting drugs.

27 May 2018

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Drug-induced stabilization of covalent DNA topoisomerase I-DNA intermediates. DNA cleavage assays

27 May 2018

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Clinical use of topoisomerase I inhibitors in anticancer treatment

27 May 2018

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A novel nuclear localization signal in human DNA topoisomerase I

27 May 2018

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A model for the mechanism of human topoisomerase I

27 May 2018

1 reference

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Crystal structures of human topoisomerase I in covalent and noncovalent complexes with DNA

27 May 2018

1 reference

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A camptothecin-resistant DNA topoisomerase I mutant exhibits altered sensitivities to other DNA topoisomerase poisons

27 May 2018

1 reference

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Mutation at the catalytic site of topoisomerase I in CEM/C2, a human leukemia cell line resistant to camptothecin

27 May 2018

1 reference

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SCT1 mutants suppress the camptothecin sensitivity of yeast cells expressing wild-type DNA topoisomerase I

27 May 2018

1 reference

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A high affinity topoisomerase I binding sequence is clustered at DNAase I hypersensitive sites in Tetrahymena R-chromatin.

27 May 2018

1 reference

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Detection of topoisomerase I gene point mutation in CPT-11 resistant lung cancer cell line

27 May 2018

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Supercoiling of intracellular DNA can occur in eukaryotic cells.

27 May 2018

1 reference

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Mechanisms of camptothecin resistance by human topoisomerase I mutations

27 May 2018

1 reference

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Regions within the N-terminal domain of human topoisomerase I exert important functions during strand rotation and DNA binding

16 August 2018

1 reference

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Topoisomerase I inhibitors: selectivity and cellular resistance.

16 August 2018

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Substitutions of Asn-726 in the active site of yeast DNA topoisomerase I define novel mechanisms of stabilizing the covalent enzyme-DNA intermediate.

16 August 2018

1 reference

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Domain interactions affecting human DNA topoisomerase I catalysis and camptothecin sensitivity.

16 August 2018

1 reference

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Reconstitution of enzymatic activity by the association of the cap and catalytic domains of human topoisomerase I

16 August 2018

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12 December 2020

Alterations in the catalytic activity of yeast DNA topoisomerase I result in cell cycle arrest and cell death

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12 December 2020

Alterations in linker flexibility suppress DNA topoisomerase I mutant-induced cell lethality

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12 December 2020

Expression of human DNA topoisomerase I in yeast cells lacking yeast DNA topoisomerase I: restoration of sensitivity of the cells to the antitumor drug camptothecin

1 reference

12 December 2020

Intragenic suppressors of mutant DNA topoisomerase I-induced lethality diminish enzyme binding of DNA

1 reference

12 December 2020

Camptothecin resistance from a single mutation changing glycine 363 of human DNA topoisomerase I to cysteine

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12 December 2020

Identifiers

DOI

10.1093/NAR/GKN557

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18772225%20AND%20SRC:MED&resulttype=core&format=json

release_gjd3gdmlkvhc7nq3jpyryxdcje

13 January 2020

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/gjd3gdmlkvhc7nq3jpyryxdcje

24 November 2022

mapped directly with Wikidata item

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18772225%20AND%20SRC:MED&resulttype=core&format=json

13 January 2020

PubMed publication ID

18772225

1 reference