NF-kappaB plays a key role in hypoxia-inducible factor-1-regulated erythropoietin gene expression (Q44249433)

1 December 2017

title

NF-kappaB plays a key role in hypoxia-inducible factor-1-regulated erythropoietin gene expression (English)

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1 December 2017

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Yanira G Figueroa

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1 December 2017

Anna K Chan

2

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1 December 2017

Rania Ibrahim

3

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1 December 2017

Yan Tang

4

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1 December 2017

Matthew E Burow

5

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1 December 2017

Jawed Alam

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1 December 2017

Aline B Scandurro

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1 December 2017

Barbara S Beckman

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1 December 2017

publication date

1 December 2002

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1 December 2017

published in

Experimental Hematology

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1 December 2017

volume

30

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1 December 2017

issue

12

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1 December 2017

page(s)

1419-1427

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Oxygen sensing and molecular adaptation to hypoxia

1 December 2017

cites work

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7 January 2021

A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation

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7 January 2021

Inducible operation of the erythropoietin 3' enhancer in multiple cell lines: evidence for a widespread oxygen-sensing mechanism

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7 January 2021

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension

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7 January 2021

Purification and characterization of hypoxia-inducible factor 1

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7 January 2021

Regulation of hypoxia-inducible factor 1alpha is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathway

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7 January 2021

Hypoxia-inducible factor 1alpha (HIF-1alpha) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. Its stabilization by hypoxia depends on redox-induced changes

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7 January 2021

Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation

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7 January 2021

HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

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7 January 2021

Protein kinase C alpha protein expression is necessary for sustained erythropoietin production in human hepatocellular carcinoma (Hep3B) cells exposed to hypoxia

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7 January 2021

p42/p44 mitogen-activated protein kinases phosphorylate hypoxia-inducible factor 1alpha (HIF-1alpha) and enhance the transcriptional activity of HIF-1.

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7 January 2021

Requirement for p38alpha in erythropoietin expression: a role for stress kinases in erythropoiesis

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7 January 2021

Phosphatidylinositol 3-kinase signaling mediates angiogenesis and expression of vascular endothelial growth factor in endothelial cells

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7 January 2021

New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway

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7 January 2021

PI3-K/AKT regulation of NF-kappaB signaling events in suppression of TNF-induced apoptosis

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7 January 2021

Cross-talk between phosphatidylinositol 3-kinase and sphingomyelinase pathways as a mechanism for cell survival/death decisions

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The PI3K-PDK1 connection: more than just a road to PKB

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The PTEN/MMAC1 tumor suppressor phosphatase functions as a negative regulator of the phosphoinositide 3-kinase/Akt pathway

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7 January 2021

Oxidative stress and gene regulation

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Oxidative stress and nuclear factor-kappaB activation: a reassessment of the evidence in the light of recent discoveries.

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7 January 2021

Oxygen regulation of gene expression: a study in opposites

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7 January 2021

Response of tumour cells to hypoxia: role of p53 and NFkB.

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7 January 2021

c-Jun does not mediate hepatocyte apoptosis following NFkappaB inhibition and partial hepatectomy

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7 January 2021

Liver regeneration 4: transcriptional control of liver regeneration.

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7 January 2021

Erythropoietin-mediated neuroprotection involves cross-talk between Jak2 and NF-kappaB signalling cascades

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7 January 2021

p38 MAPK and NF-kappa B collaborate to induce interleukin-6 gene expression and release. Evidence for a cytoprotective autocrine signaling pathway in a cardiac myocyte model system

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7 January 2021

An essential role of NFkappaB in tyrosine kinase signaling of p38 MAP kinase regulation of myocardial adaptation to ischemia

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7 January 2021

Activation of NF-kappa B and p38 MAP kinase is not sufficient for triggering efficient HIV gene expression in response to stress

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7 January 2021

Recent advances towards understanding redox mechanisms in the activation of nuclear factor kappaB.

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Coupling of a signal response domain in I kappa B alpha to multiple pathways for NF-kappa B activation

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7 January 2021

Post-transcriptional regulation of erythropoietin mRNA stability by erythropoietin mRNA-binding protein

1 reference

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7 January 2021

Development of a new radioimmunoassay for erythropoietin using recombinant erythropoietin

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7 January 2021

Lack of evidence for the involvement of the phosphoinositide 3-kinase/Akt pathway in the activation of hypoxia-inducible factors by low oxygen tension.

1 reference

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7 January 2021

Pyrrolidine dithiocarbamate, a potent inhibitor of nuclear factor kappa B (NF-kappa B) activation, prevents apoptosis in human promyelocytic leukemia HL-60 cells and thymocytes

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7 January 2021

HER2 (neu) signaling increases the rate of hypoxia-inducible factor 1alpha (HIF-1alpha) synthesis: novel mechanism for HIF-1-mediated vascular endothelial growth factor expression

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7 January 2021

HIF1A gene transcription is dependent on a core promoter sequence encompassing activating and inhibiting sequences located upstream from the transcription initiation site and cis elements located within the 5'UTR

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7 January 2021

The human erythropoietin-encoding gene contains a CAAT box, TATA boxes and other transcriptional regulatory elements in its 5' flanking region

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7 January 2021

Isolation and characterization of genomic and cDNA clones of human erythropoietin

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7 January 2021

10.1016/S0301-472X(02)00934-7

Identifiers

DOI

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1 December 2017

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