Rev1 is essential in generating G to C transversions downstream of the Ung2 pathway but not the Msh2+Ung2 hybrid pathway. (Q44658606)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23857323%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

title

Rev1 is essential in generating G to C transversions downstream of the Ung2 pathway but not the Msh2+Ung2 hybrid pathway (English)

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5 March 2020

6

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5 March 2020

Peter H L Krijger

1

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5 March 2020

author name string

Anastasia Tsaalbi-Shtylik

2

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5 March 2020

Niek Wit

3

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5 March 2020

Paul Cornelius Maria van den Berk

4

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5 March 2020

Niels de Wind

5

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5 March 2020

language of work or name

English

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publication date

5 August 2013

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European Journal of Immunology

5 March 2020

published in

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5 March 2020

volume

43

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5 March 2020

issue

10

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5 March 2020

page(s)

2765-2770

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Antibody diversification by somatic mutation: from Burnet onwards

5 March 2020

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Altered somatic hypermutation and reduced class-switch recombination in exonuclease 1-mutant mice

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DNA polymerase eta is an A-T mutator in somatic hypermutation of immunoglobulin variable genes

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Contribution of DNA polymerase eta to immunoglobulin gene hypermutation in the mouse

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Different mutation signatures in DNA polymerase eta- and MSH6-deficient mice suggest separate roles in antibody diversification

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DNA polymerase eta is the sole contributor of A/T modifications during immunoglobulin gene hypermutation in the mouse

21 January 2018

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A backup role of DNA polymerase kappa in Ig gene hypermutation only takes place in the complete absence of DNA polymerase eta.

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Dependence of nucleotide substitutions on Ung2, Msh2, and PCNA-Ub during somatic hypermutation.

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A/T mutagenesis in hypermutated immunoglobulin genes strongly depends on PCNAK164 modification

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Ubiquitylated PCNA plays a role in somatic hypermutation and class-switch recombination and is required for meiotic progression

21 January 2018

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PCNA ubiquitination-independent activation of polymerase η during somatic hypermutation and DNA damage tolerance.

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Immunoglobulin isotype switching is inhibited and somatic hypermutation perturbed in UNG-deficient mice

21 January 2018

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Strand-biased defect in C/G transversions in hypermutating immunoglobulin genes in Rev1-deficient mice

21 January 2018

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The catalytic activity of REV1 is employed during immunoglobulin gene diversification in DT40.

21 January 2018

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A critical role for REV1 in regulating the induction of C:G transitions and A:T mutations during Ig gene hypermutation.

21 January 2018

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A role for PCNA ubiquitination in immunoglobulin hypermutation

21 January 2018

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Analysis of mice deficient in both REV1 catalytic activity and POLH reveals an unexpected role for POLH in the generation of C to G and G to C transversions during Ig gene hypermutation.

21 January 2018

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Deoxycytidyl transferase activity of yeast REV1 protein

21 January 2018

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Mismatch recognition and uracil excision provide complementary paths to both Ig switching and the A/T-focused phase of somatic mutation

21 January 2018

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Somatic hypermutation and class switch recombination in Msh6(-/-)Ung(-/-) double-knockout mice

21 January 2018

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The concerted action of Msh2 and UNG stimulates somatic hypermutation at A . T base pairs

21 January 2018

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Rev1 recruits ung to switch regions and enhances du glycosylation for immunoglobulin class switch DNA recombination

21 January 2018

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Somatic Apc mutations are selected upon their capacity to inactivate the beta-catenin downregulating activity

21 January 2018

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Rapid methods for the analysis of immunoglobulin gene hypermutation: application to transgenic and gene targeted mice

21 January 2018

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