The neurotoxic MEC-4(d) DEG/ENaC sodium channel conducts calcium: implications for necrosis initiation (Q46229892)

20 December 2017

title

The neurotoxic MEC-4(d) DEG/ENaC sodium channel conducts calcium: implications for necrosis initiation (English)

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20 December 2017

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9

Monica Driscoll

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20 December 2017

Laura Bianchi

1

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20 December 2017

Beate Gerstbrein

2

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20 December 2017

Christian Frøkjaer-Jensen

3

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20 December 2017

Dewey C Royal

4

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20 December 2017

Gargi Mukherjee

5

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20 December 2017

Mary Anne Royal

6

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20 December 2017

Jian Xue

7

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20 December 2017

William R Schafer

8

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20 December 2017

language of work or name

English

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publication date

7 November 2004

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20 December 2017

published in

Nature Neuroscience

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20 December 2017

volume

7

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20 December 2017

issue

12

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20 December 2017

page(s)

1337-1344

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20 December 2017

Cell biology. Apoptosis--the calcium connection.

cites work

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Necrotic cell death in C. elegans requires the function of calreticulin and regulators of Ca(2+) release from the endoplasmic reticulum

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The mec-4 gene is a member of a family of Caenorhabditis elegans genes that can mutate to induce neuronal degeneration

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Insights from mouse models into the molecular basis of neurodegeneration

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Dying for a cause: invertebrate genetics takes on human neurodegeneration

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Sequence and transmembrane topology of MEC-4, an ion channel subunit required for mechanotransduction in Caenorhabditis elegans

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MEC-2 regulates C. elegans DEG/ENaC channels needed for mechanosensation

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The mechanosensory protein MEC-6 is a subunit of the C. elegans touch-cell degenerin channel

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In vivo imaging of C. elegans mechanosensory neurons demonstrates a specific role for the MEC-4 channel in the process of gentle touch sensation

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The mammalian degenerin MDEG, an amiloride-sensitive cation channel activated by mutations causing neurodegeneration in Caenorhabditis elegans

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Protons activate brain Na+ channel 1 by inducing a conformational change that exposes a residue associated with neurodegeneration.

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A transmembrane domain of the putative channel subunit MEC-4 influences mechanotransduction and neurodegeneration in C. elegans

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The mammalian sodium channel BNC1 is required for normal touch sensation

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The acid-activated ion channel ASIC contributes to synaptic plasticity, learning, and memory

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Specific aspartyl and calpain proteases are required for neurodegeneration in C. elegans

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Further characteristics of the Ca(2+)-inactivated Cl(-) channel in Xenopus laevis oocytes

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Ionic Blockage of Sodium Channels in Nerve

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Characterization of the selectivity filter of the epithelial sodium channel

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On the molecular basis of ion permeation in the epithelial Na+ channel

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Mutations in the alpha1 subunit of an L-type voltage-activated Ca2+ channel cause myotonia in Caenorhabditis elegans

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Acid-sensing ion channel 3 matches the acid-gated current in cardiac ischemia-sensing neurons

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Single channel properties of rat acid-sensitive ion channel-1alpha, -2a, and -3 expressed in Xenopus oocytes

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Calreticulin is essential for cardiac development

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Optical imaging of calcium transients in neurons and pharyngeal muscle of C. elegans

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Acid-sensing ion channel 1 is localized in brain regions with high synaptic density and contributes to fear conditioning.

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7 January 2021

In vivo structure-function analyses of Caenorhabditis elegans MEC-4, a candidate mechanosensory ion channel subunit.

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7 January 2021

Proton-gated channels in PC12 cells

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7 January 2021

A comparison of fluorescent Ca2+ indicator properties and their use in measuring elementary and global Ca2+ signals

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7 January 2021

Identifiers

DOI

10.1038/NN1347

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20 December 2017

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20 December 2017