Suppression of HIV replication using RNA interference against HIV-1 integrase (Q48078641)

8 February 2018

title

Suppression of HIV replication using RNA interference against HIV-1 integrase (English)

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8 February 2018

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3

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8 February 2018

author name string

Tat San Lau

1

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8 February 2018

Yonggang Li

2

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Tzi Bun Ng

4

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David Chi Cheong Wan

5

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8 February 2018

language of work or name

English

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publication date

15 June 2007

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8 February 2018

published in

FEBS Letters

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volume

581

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issue

17

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8 February 2018

page(s)

3253-3259

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describes a project that uses

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Retroviral integrases and their cousins

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.06.011

Requirement for integrase during reverse transcription of human immunodeficiency virus type 1 and the effect of cysteine mutations of integrase on its interactions with reverse transcriptase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.06.011

Interaction between human immunodeficiency virus type 1 reverse transcriptase and integrase proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.06.011

HIV-1 integrase inhibitors: a decade of research and two drugs in clinical trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.06.011

Inhibition of HIV-1 integration protein by aurintricarboxylic acid monomers, monomer analogs, and polymer fractions

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.06.011

Inhibitors of human immunodeficiency virus integrase

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.06.011

siRNA-mediated gene silencing in vitro and in vivo.

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.06.011

Killing the messenger: short RNAs that silence gene expression

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.06.011

Therapeutic potential of RNA interference against cancer

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.06.011

RNA interference in cancer

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.06.011

Dissecting HIV-1 through RNA interference

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.06.011

Silencing of HIV-1 with RNA interference: a multiple shRNA approach

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.06.011

The plant ribosome inactivating proteins luffin and saporin are potent inhibitors of HIV-1 integrase

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.06.011

Vpr is required for efficient replication of human immunodeficiency virus type-1 in mononuclear phagocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.06.011

RNA interference directed against Poly(ADP-Ribose) polymerase 1 efficiently suppresses human immunodeficiency virus type 1 replication in human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.06.011

Expression of human immunodeficiency virus type 1 (HIV-1) gag antigens on the surface of a cell line persistently infected with HIV-1 that highly expresses HIV-1 antigens

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.06.011

Nucleocytoplasmic transport: the soluble phase

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.06.011

HIV-1 infection requires a functional integrase NLS.

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.06.011

HIV-1 gag proteins: diverse functions in the virus life cycle

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.06.011

Initial cleavage of the human immunodeficiency virus type 1 GagPol precursor by its activated protease occurs by an intramolecular mechanism

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.06.011

Processing sites in the human immunodeficiency virus type 1 (HIV-1) Gag-Pro-Pol precursor are cleaved by the viral protease at different rates

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.06.011

The gene-silencing efficiency of siRNA is strongly dependent on the local structure of mRNA at the targeted region

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.06.011

Rational siRNA design for RNA interference

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.06.011

Enhancement of RNAi activity by improved siRNA duplexes.

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.06.011

Effects on RNAi of the tight structure, sequence and position of the targeted region.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.06.011

Multiple effects of HIV-1 trans-activator protein on the pathogenesis of HIV-1 infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.06.011

The multiple functions of HIV-1 Tat: proliferation versus apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.06.011

Angiogenic effects of extracellular human immunodeficiency virus type 1 Tat protein and its role in the pathogenesis of AIDS-associated Kaposi's sarcoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.06.011

The effects of arginine on refolding of aggregated proteins: not facilitate refolding, but suppress aggregation

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.06.011

Extensive regions of pol are required for efficient human immunodeficiency virus polyprotein processing and particle maturation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.06.011

Identification of a key target sequence to block human immunodeficiency virus type 1 replication within the gag-pol transframe domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.06.011

The virus-associated human immunodeficiency virus type 1 Gag-Pol carrying an active protease domain in the matrix region is severely defective both in autoprocessing and in trans processing of gag particles

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.06.011

Comprehensive bioinformatic analysis of the specificity of human immunodeficiency virus type 1 protease

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.06.011

The conformation of the mature dimeric human immunodeficiency virus type 1 RNA genome requires packaging of pol protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.06.011

Maintenance of the Gag/Gag-Pol ratio is important for human immunodeficiency virus type 1 RNA dimerization and viral infectivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.06.011

Characterization of human immunodeficiency virus type 1 Pr160 gag-pol mutants with truncations downstream of the protease domain

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.06.011

Gag regulates association of human immunodeficiency virus type 1 envelope with detergent-resistant membranes

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.06.011

Structural basis for targeting HIV-1 Gag proteins to the plasma membrane for virus assembly.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.06.011

Identification of an intracellular trafficking and assembly pathway for HIV-1 gag.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.06.011

Functional Surfaces of the Human Immunodeficiency Virus Type 1 Capsid Protein

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.06.011

Selected amino acid substitutions in the C-terminal region of human immunodeficiency virus type 1 capsid protein affect virus assembly and release.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.06.011

The conserved carboxy terminus of the capsid domain of human immunodeficiency virus type 1 gag protein is important for virion assembly and release

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.06.011

Targeting the assembly of the human immunodeficiency virus type I.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.06.011

Redundant roles for nucleocapsid and matrix RNA-binding sequences in human immunodeficiency virus type 1 assembly

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.06.011

Mutation in the loop C-terminal to the cyclophilin A binding site of HIV-1 capsid protein disrupts proper virus assembly and infectivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.06.011

Long-term inhibition of HIV-1 infection in primary hematopoietic cells by lentiviral vector delivery of a triple combination of anti-HIV shRNA, anti-CCR5 ribozyme, and a nucleolar-localizing TAR decoy

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.06.011

Effective suppression of human immunodeficiency virus type 1 through a combination of short- or long-hairpin RNAs targeting essential sequences for retroviral integration

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.06.011

10.1016/J.FEBSLET.2007.06.011

21 January 2018

Identifiers

DOI

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8 February 2018

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8 February 2018