Serine Synthesis Helps Hypoxic Cancer Stem Cells Regulate Redox. (Q51108335)

30 March 2018

title

Serine Synthesis Helps Hypoxic Cancer Stem Cells Regulate Redox. (English)

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30 March 2018

main subject

hypoxia

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neoplastic stem cells

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2

Gregg L Semenza

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30 March 2018

Debangshu Samanta

1

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30 March 2018

language of work or name

English

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publication date

3 November 2016

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30 March 2018

published in

Cancer Research

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30 March 2018

volume

76

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30 March 2018

issue

22

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30 March 2018

page(s)

6458-6462

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30 March 2018

PHGDH Expression Is Required for Mitochondrial Redox Homeostasis, Breast Cancer Stem Cell Maintenance, and Lung Metastasis.

cites work

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1158/0008-5472.CAN-16-1730

Metabolic enzyme expression highlights a key role for MTHFD2 and the mitochondrial folate pathway in cancer

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Identification of a small molecule inhibitor of 3-phosphoglycerate dehydrogenase to target serine biosynthesis in cancers.

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High level PHGDH expression in breast is predominantly associated with keratin 5-positive cell lineage independently of malignancy

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Chemotherapy triggers HIF-1-dependent glutathione synthesis and copper chelation that induces the breast cancer stem cell phenotype

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HIF-1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations

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https://opencitations.net/index/coci/api/v1/references/10.1158/0008-5472.CAN-16-1730

HIF-1-mediated suppression of acyl-CoA dehydrogenases and fatty acid oxidation is critical for cancer progression.

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https://opencitations.net/index/coci/api/v1/references/10.1158/0008-5472.CAN-16-1730

Quantitative flux analysis reveals folate-dependent NADPH production.

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https://opencitations.net/index/coci/api/v1/references/10.1158/0008-5472.CAN-16-1730

Regulation of cell proliferation by hypoxia-inducible factors

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https://opencitations.net/index/coci/api/v1/references/10.1158/0008-5472.CAN-16-1730

Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1158/0008-5472.CAN-16-1730

Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1158/0008-5472.CAN-16-1730

Phosphoglycerate dehydrogenase induces glioma cells proliferation and invasion by stabilizing forkhead box M1.

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1158/0008-5472.CAN-16-1730

Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1 alpha

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1158/0008-5472.CAN-16-1730

Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1158/0008-5472.CAN-16-1730

A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1158/0008-5472.CAN-16-1730

Hypoxia-inducible factor 1 mediates TAZ expression and nuclear localization to induce the breast cancer stem cell phenotype

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1158/0008-5472.CAN-16-1730

Hypoxia-inducible factors: mediators of cancer progression and targets for cancer therapy

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1158/0008-5472.CAN-16-1730

Adaptive and maladaptive cardiorespiratory responses to continuous and intermittent hypoxia mediated by hypoxia-inducible factors 1 and 2.

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12 October 2022

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Enhanced serine production by bone metastatic breast cancer cells stimulates osteoclastogenesis

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1158/0008-5472.CAN-16-1730

SHMT2 drives glioma cell survival in ischaemia but imposes a dependence on glycine clearance.

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1158/0008-5472.CAN-16-1730

Expression of serine/glycine metabolism-related proteins is different according to the thyroid cancer subtype.

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1158/0008-5472.CAN-16-1730

Psat1-Dependent Fluctuations in α-Ketoglutarate Affect the Timing of ESC Differentiation.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1158/0008-5472.CAN-16-1730

Phosphoglycerate dehydrogenase is dispensable for breast tumor maintenance and growth

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1158/0008-5472.CAN-16-1730

Serine catabolism regulates mitochondrial redox control during hypoxia

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1158/0008-5472.CAN-16-1730

Oxidative stress inhibits distant metastasis by human melanoma cells

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1158/0008-5472.CAN-16-1730

Hypoxia-inducible factors are required for chemotherapy resistance of breast cancer stem cells

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1158/0008-5472.CAN-16-1730

Expression and clinical significance of phosphoglycerate dehydrogenase and squamous cell carcinoma antigen in cervical cancer

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1158/0008-5472.CAN-16-1730

Antiangiogenic agents increase breast cancer stem cells via the generation of tumor hypoxia

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1158/0008-5472.CAN-16-1730

The hypoxic tumor microenvironment: A driving force for breast cancer progression

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1158/0008-5472.CAN-16-1730

Prospective identification of tumorigenic breast cancer cells

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1158/0008-5472.CAN-16-1730

HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1158/0008-5472.CAN-16-1730

Increased Expression of PHGDH and Prognostic Significance in Colorectal Cancer

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1158/0008-5472.CAN-16-1730

Detection and characterization of tumor hypoxia using pO2 histography

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1158/0008-5472.CAN-16-1730

Hypoxia Response Elements in the Aldolase A, Enolase 1, and Lactate Dehydrogenase A Gene Promoters Contain Essential Binding Sites for Hypoxia-inducible Factor 1

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1158/0008-5472.CAN-16-1730

Reactive oxygen species generated at mitochondrial complex III stabilize hypoxia-inducible factor-1alpha during hypoxia: a mechanism of O2 sensing

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1158/0008-5472.CAN-16-1730

NRF2 regulates serine biosynthesis in non-small cell lung cancer

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1158/0008-5472.CAN-16-1730

Metabolic regulation of hematopoietic stem cells in the hypoxic niche

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1158/0008-5472.CAN-16-1730

Antioxidants can increase melanoma metastasis in mice

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1158/0008-5472.CAN-16-1730

HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1158/0008-5472.CAN-16-1730

Functional genomics reveal that the serine synthesis pathway is essential in breast cancer

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1158/0008-5472.CAN-16-1730

Identifiers

DOI

10.1158/0008-5472.CAN-16-1730

1 reference

30 March 2018

1 reference

30 March 2018