Macrophages from nonobese diabetic mouse have a selective defect in IFN-γ but not IFN-α/β receptor pathway. (Q51806945)

12 April 2018

title

Macrophages from nonobese diabetic mouse have a selective defect in IFN-γ but not IFN-α/β receptor pathway. (English)

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12 April 2018

author name string

Myung-Shik Lee

series ordinal

1

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12 April 2018

Hyung-Joon Kwon

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2

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12 April 2018

Hun Sik Kim

series ordinal

3

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12 April 2018

publication date

7 March 2012

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Journal of Clinical Immunology

published in

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volume

32

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issue

4

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page(s)

753-761

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Role of innate immunity in triggering and tuning of autoimmune diabetes

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NOD macrophages produce high levels of inflammatory cytokines upon encounter of apoptotic or necrotic cells

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A defect in tryptophan catabolism impairs tolerance in nonobese diabetic mice

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Essential role of STAT1 in caspase-independent cell death of activated macrophages through the p38 mitogen-activated protein kinase/STAT1/reactive oxygen species pathway

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Transcriptionally active Stat1 is required for the antiproliferative effects of both interferon alpha and interferon gamma

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Interferon-alpha initiates type 1 diabetes in nonobese diabetic mice

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STAT1 as a key modulator of cell death

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The IFN gamma receptor: a paradigm for cytokine receptor signaling

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Ligand-induced autoregulation of IFN-gamma receptor beta chain expression in T helper cell subsets

21 January 2018

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In the absence of IGF-1 signaling, IFN-gamma suppresses human malignant T-cell growth

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Cellular responses to interferon-gamma

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IFN-gamma sensitizes MIN6N8 insulinoma cells to TNF-alpha-induced apoptosis by inhibiting NF-kappaB-mediated XIAP upregulation

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Innocuous IFNgamma induced by adjuvant-free antigen restores normoglycemia in NOD mice through inhibition of IL-17 production

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Transfer of dendritic cells (DC) ex vivo stimulated with interferon-gamma (IFN-gamma) down-modulates autoimmune diabetes in non-obese diabetic (NOD) mice.

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IL-12 administration accelerates autoimmune diabetes in both wild-type and IFN-gamma-deficient nonobese diabetic mice, revealing pathogenic and protective effects of IL-12-induced IFN-gamma

21 January 2018

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IFN-gamma/TNF-alpha synergism as the final effector in autoimmune diabetes: a key role for STAT1/IFN regulatory factor-1 pathway in pancreatic beta cell death

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Critical role for IFN-γ in natural killer cell-mediated protection from diabetes

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Essential Role for Signal Transducer and Activator of Transcription-1 in Pancreatic -Cell Death and Autoimmune Type 1 Diabetes of Nonobese Diabetic Mice

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Lipopolysaccharide and ceramide use divergent signaling pathways to induce cell death in murine macrophages.

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12 December 2020

Absolute requirement of macrophages for the development and activation of beta-cell cytotoxic CD8+ T-cells in T-cell receptor transgenic NOD mice

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Autoimmune diabetes results from genetic defects manifest by antigen presenting cells

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Sensitization of IFN-γ Jak-STAT signaling during macrophage activation

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Role of inflammatory infiltrate in activation and effector function of cloned islet reactive nonobese diabetic CD8+ T cells: involvement of a nitric oxide-dependent pathway.

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Gamma interferon paradoxically inhibits the development of diabetes in the NOD mouse

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Interferon-gamma receptor 2 expression as the deciding factor in human T, B, and myeloid cell proliferation or death

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Preferential infiltration of macrophages during early stages of insulitis in diabetes-prone BB rats

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12 December 2020

Studies on autoimmunity for initiation of beta-cell destruction. V. Decrease of macrophage-dependent T lymphocytes and natural killer cytotoxicity in silica-treated BB rats.

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12 December 2020

Defects in the differentiation and function of antigen presenting cells in NOD/Lt mice.

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12 December 2020

The role of interferon alpha in initiation of type I diabetes in the NOD mouse

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12 December 2020

Aberrant macrophage cytokine production is a conserved feature among autoimmune-prone mouse strains: elevated interleukin (IL)-12 and an imbalance in tumor necrosis factor-alpha and IL-10 define a unique cytokine profile in macrophages from young no

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12 December 2020

Splenic macrophages from the NOD mouse are defective in the ability to present antigen

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12 December 2020

10.1007/S10875-012-9682-3

Identifiers

DOI

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12 April 2018

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12 April 2018