All-trans-retinoyl-beta-glucuronide is a potent teratogen in the mouse because of extensive metabolism to all-trans-retinoic acid. (Q53005061)

10 May 2018

title

All-trans-retinoyl-beta-glucuronide is a potent teratogen in the mouse because of extensive metabolism to all-trans-retinoic acid. (English)

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10 May 2018

author name string

Nau H

1

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10 May 2018

Elmazar MM

2

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Rühl R

3

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Thiel R

4

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Sass JO

5

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10 May 2018

publication date

1 September 1996

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Birth Defects Research Part A: Clinical and Molecular Teratology

published in

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volume

54

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issue

3

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page(s)

150-156

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10 May 2018

Chemical synthesis and growth-promoting activity of all-trans-retinyl beta-D-glucuronide

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Chemical synthesis of all-trans-[11-3H]retinoyl beta-glucuronide and its metabolism in rats in vivo

21 January 2018

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The molecular and genetic dissection of the retinoid signalling pathway

21 January 2018

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Comparative teratology and transplacental pharmacokinetics of all-trans-retinoic acid, 13-cis-retinoic acid, and retinyl palmitate following daily administrations in rats

21 January 2018

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Characterization of oxidized and glucuronidated metabolites of retinol in monkey plasma by thermospray liquid chromatography/mass spectrometry.

21 January 2018

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Influence of dose and pharmaceutical formulation of vitamin A on plasma levels of retinyl esters and retinol and metabolic generation of retinoic acid compounds and beta-glucuronides in the cynomolgus monkey.

21 January 2018

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Comparative studies on effects of all-trans-retinoic acid and all-trans-retinoyl-beta-d-glucuronide on the development of foetal mouse thymus in an organ culture system.

21 January 2018

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Effects of Retinoid Glucuronides on Mammary Gland Development in Organ Culture

21 January 2018

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Retinoyl β-glucuronide: lack of binding to receptor proteins of retinoic acid as related to biological activity

21 January 2018

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Single-run analysis of isomers of retinoyl-beta-D-glucuronide and retinoic acid by reversed-phase high-performance liquid chromatography.

21 January 2018

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The high sensitivity of the rabbit to the teratogenic effects of 13-cis-retinoic acid (isotretinoin) is a consequence of prolonged exposure of the embryo to 13-cis-retinoic acid and 13-cis-4-oxo-retinoic acid, and not of isomerization to all-trans-r

21 January 2018

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Induction of differentiation of human promyelocytic leukemia cell line HL-60 by retinoyl glucuronide, a biologically active metabolite of vitamin A

21 January 2018

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Growth suppression of human breast carcinoma cells in culture by N-(4-hydroxyphenyl)retinamide and its glucuronide and through synergism with glucarate

21 January 2018

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4-Methylpyrazole partially ameliorated the teratogenicity of retinol and reduced the metabolic formation of all-trans-retinoic acid in the mouse

21 January 2018

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Single versus multiple dose administration of all-trans-retinoic acid during organogenesis: differential metabolism and transplacental kinetics in rat and rabbit

21 January 2018

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Isotretinoin (13-cis-retinoic acid) metabolism, cis-trans isomerization, glucuronidation, and transfer to the mouse embryo: consequences for teratogenicity

21 January 2018

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RETINOYL BETA-GLUCURONIC ACID: A MAJOR METABOLITE OF VITAMIN A IN RAT BILE

21 January 2018

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Comparative teratogenicity and metabolism of all-trans retinoic acid, all-trans retinoyl beta-glucose, and all-trans retinoyl beta-glucuronide in pregnant Sprague-Dawley rats

21 January 2018

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Maternal toxicokinetics, metabolism, and embryo exposure following a teratogenic dosing regimen with 13-cis-retinoic acid (isotretinoin) in the cynomolgus monkey

21 January 2018

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Teratogenic activity of retinoic acid.

21 January 2018

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13-cis-retinoic acid metabolism in vivo. The major tissue metabolites in the rat have the all-trans configuration

21 January 2018

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Correlation of transplacental and maternal pharmacokinetics of retinoids during organogenesis with teratogenicity

21 January 2018

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10.1002/(SICI)1096-9926(199609)54:3<150::AID-TERA5>3.0.CO;2-7

21 January 2018

Identifiers

DOI

1 reference

10 May 2018

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10 May 2018