Substitutions of Asn-726 in the active site of yeast DNA topoisomerase I define novel mechanisms of stabilizing the covalent enzyme-DNA intermediate. (Q54051610)

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English	Substitutions of Asn-726 in the active site of yeast DNA topoisomerase I define novel mechanisms of stabilizing the covalent enzyme-DNA intermediate.	scientific article

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scholarly article

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Europe PubMed Central

PubMed publication ID

24 May 2018

http://europepmc.org/abstract/MED/10809761

Substitutions of Asn-726 in the active site of yeast DNA topoisomerase I define novel mechanisms of stabilizing the covalent enzyme-DNA intermediate. (English)

1 reference

Europe PubMed Central

PubMed publication ID

24 May 2018

http://europepmc.org/abstract/MED/10809761

author name string

Fertala J

1

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Europe PubMed Central

PubMed publication ID

24 May 2018

http://europepmc.org/abstract/MED/10809761

Vance JR

2

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Europe PubMed Central

PubMed publication ID

24 May 2018

http://europepmc.org/abstract/MED/10809761

Pourquier P

3

1 reference

Europe PubMed Central

PubMed publication ID

24 May 2018

http://europepmc.org/abstract/MED/10809761

Pommier Y

4

1 reference

Europe PubMed Central

PubMed publication ID

24 May 2018

http://europepmc.org/abstract/MED/10809761

Bjornsti MA

5

1 reference

Europe PubMed Central

PubMed publication ID

24 May 2018

http://europepmc.org/abstract/MED/10809761

language of work or name

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publication date

1 May 2000

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Europe PubMed Central

PubMed publication ID

24 May 2018

http://europepmc.org/abstract/MED/10809761

number of pages

8

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Journal of Biological Chemistry

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Europe PubMed Central

PubMed publication ID

24 May 2018

http://europepmc.org/abstract/MED/10809761

275

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Europe PubMed Central

PubMed publication ID

24 May 2018

http://europepmc.org/abstract/MED/10809761

20

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Europe PubMed Central

PubMed publication ID

24 May 2018

http://europepmc.org/abstract/MED/10809761

15246-15253

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Europe PubMed Central

PubMed publication ID

24 May 2018

http://europepmc.org/abstract/MED/10809761

DNA topoisomerases

1 reference

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21 January 2018

Yeast as a model organism for studying the actions of DNA topoisomerase-targeted drugs

1 reference

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21 January 2018

DNA topoisomerases: essential enzymes and lethal targets

1 reference

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Clinical applications of the camptothecins.

1 reference

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21 January 2018

Crystal structures of human topoisomerase I in covalent and noncovalent complexes with DNA

1 reference

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21 January 2018

Structure of DNA topoisomerases

1 reference

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21 January 2018

Conservation of structure and mechanism between eukaryotic topoisomerase I and site-specific recombinases

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21 January 2018

Topoisomerase Poisons: Harnessing the Dark Side of Enzyme Mechanism

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21 January 2018

CDC45 and DPB11 are required for processive DNA replication and resistance to DNA topoisomerase I-mediated DNA damage.

1 reference

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21 January 2018

Replication-mediated DNA damage by camptothecin induces phosphorylation of RPA by DNA-dependent protein kinase and dissociates RPA:DNA-PK complexes

1 reference

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21 January 2018

DNA topoisomerase-targeting antitumor drugs can be studied in yeast

1 reference

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21 January 2018

Role of the 20-hydroxyl group in camptothecin binding by the topoisomerase I-DNA binary complex

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21 January 2018

A model for the mechanism of human topoisomerase I

1 reference

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21 January 2018

Eukaryotic DNA topoisomerases I.

1 reference

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21 January 2018

Peptide sequencing and site-directed mutagenesis identify tyrosine-727 as the active site tyrosine of Saccharomyces cerevisiae DNA topoisomerase I.

1 reference

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21 January 2018

A camptothecin-resistant DNA topoisomerase I mutant exhibits altered sensitivities to other DNA topoisomerase poisons

1 reference

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21 January 2018

Domain interactions affecting human DNA topoisomerase I catalysis and camptothecin sensitivity.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.20.15246

21 January 2018

SCT1 mutants suppress the camptothecin sensitivity of yeast cells expressing wild-type DNA topoisomerase I

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.20.15246

21 January 2018

Camptothecin sensitivity is mediated by the pleiotropic drug resistance network in yeast.

1 reference

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21 January 2018

Expression of yeast DNA topoisomerase I can complement a conditional-lethal DNA topoisomerase I mutation in Escherichia coli

1 reference

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21 January 2018

Supercoiling of intracellular DNA can occur in eukaryotic cells.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.20.15246

21 January 2018

The basis for camptothecin enhancement of DNA breakage by eukaryotic topoisomerase I.

1 reference

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21 January 2018

Molecular modeling studies of the DNA-topoisomerase I ternary cleavable complex with camptothecin

1 reference

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21 January 2018

Induction of reversible complexes between eukaryotic DNA topoisomerase I and DNA-containing oxidative base damages. 7, 8-dihydro-8-oxoguanine and 5-hydroxycytosine

1 reference

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21 January 2018

Mechanism of action of eukaryotic DNA topoisomerase I and drugs targeted to the enzyme

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21 January 2018

Structural insights into the function of type IB topoisomerases

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21 January 2018

Analysis of comptothecin resistance in yeast: relevance to cancer therapy

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21 January 2018

Structural modifications of camptothecin and effects on topoisomerase I inhibition

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.20.15246

21 January 2018

Alterations in the catalytic activity of yeast DNA topoisomerase I result in cell cycle arrest and cell death

1 reference

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21 January 2018

Intragenic suppressors of mutant DNA topoisomerase I-induced lethality diminish enzyme binding of DNA

1 reference

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21 January 2018

Increased camptothecin toxicity induced in mammalian cells expressing Saccharomyces cerevisiae DNA topoisomerase I

1 reference

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21 January 2018

Trapping of mammalian topoisomerase I and recombinations induced by damaged DNA containing nicks or gaps. Importance of DNA end phosphorylation and camptothecin effects

1 reference

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21 January 2018

Identifiers

10.1074/JBC.275.20.15246

1 reference

Europe PubMed Central

PubMed publication ID

24 May 2018

http://europepmc.org/abstract/MED/10809761

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

24 May 2018

http://europepmc.org/abstract/MED/10809761

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