MLN4924 is an efficient inhibitor of NEDD8 conjugation in plants (Q58021549)

1

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René Richter

2

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Esther Mirjam Natascha Dohmann

3

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Anthi Katsiarimpa

4

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Erika Isono

Creative Commons Attribution 4.0 International

5

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language of work or name

English

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publication date

June 2011

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published in

Plant Physiology

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volume

156

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issue

2

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page(s)

527-36

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copyright license

start time

25 January 2021

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

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The GATA-type transcription factors GNC and GNL/CGA1 repress gibberellin signaling downstream from DELLA proteins and PHYTOCHROME-INTERACTING FACTORS.

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MLN4924, a NEDD8-activating enzyme inhibitor, is active in diffuse large B-cell lymphoma models: rationale for treatment of NF-{kappa}B-dependent lymphoma

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Substrate-assisted inhibition of ubiquitin-like protein-activating enzymes: the NEDD8 E1 inhibitor MLN4924 forms a NEDD8-AMP mimetic in situ

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An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer

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30 November 2018

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Regulation of cullin RING ligases

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Ribosomal proteins are targets for the NEDD8 pathway

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Inhibition of APP intracellular domain (AICD) transcriptional activity via covalent conjugation with Nedd8.

30 November 2018

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AXL and AXR1 have redundant functions in RUB conjugation and growth and development in Arabidopsis.

30 November 2018

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Mutation of E1-CONJUGATING ENZYME-RELATED1 decreases RELATED TO UBIQUITIN conjugation and alters auxin response and development

30 November 2018

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The DELLA domain of GA INSENSITIVE mediates the interaction with the GA INSENSITIVE DWARF1A gibberellin receptor of Arabidopsis.

30 November 2018

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F-box proteins in rice. Genome-wide analysis, classification, temporal and spatial gene expression during panicle and seed development, and regulation by light and abiotic stress

30 November 2018

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Arabidopsis CULLIN4 Forms an E3 Ubiquitin Ligase with RBX1 and the CDD Complex in Mediating Light Control of Development.

30 November 2018

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30 November 2018

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Conjugation to Nedd8 instigates ubiquitylation and down-regulation of activated receptor tyrosine kinases

30 November 2018

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Analysis of Nedd8-associated polypeptides: a model for deciphering the pathway for ubiquitin-like modifications

30 November 2018

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The conserved protein DCN-1/Dcn1p is required for cullin neddylation in C. elegans and S. cerevisiae

30 November 2018

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The F-box protein TIR1 is an auxin receptor

30 November 2018

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Developmental specificity of auxin response by pairs of ARF and Aux/IAA transcriptional regulators

30 November 2018

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Arabidopsis has two redundant Cullin3 proteins that are essential for embryo development and that interact with RBX1 and BTB proteins to form multisubunit E3 ubiquitin ligase complexes in vivo

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3177256

Arabidopsis COP10 forms a complex with DDB1 and DET1 in vivo and enhances the activity of ubiquitin conjugating enzymes

30 November 2018

1 reference

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Mdm2-mediated NEDD8 conjugation of p53 inhibits its transcriptional activity

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3177256

The Arabidopsis F-box protein SLEEPY1 targets gibberellin signaling repressors for gibberellin-induced degradation

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3177256

pVHL modification by NEDD8 is required for fibronectin matrix assembly and suppression of tumor development

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3177256

DEN1 is a dual function protease capable of processing the C terminus of Nedd8 and deconjugating hyper-neddylated CUL1

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3177256

Identification and characterization of DEN1, a deneddylase of the ULP family

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3177256

Role of the Arabidopsis RING-H2 protein RBX1 in RUB modification and SCF function.

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3177256

Role of predicted metalloprotease motif of Jab1/Csn5 in cleavage of Nedd8 from Cul1.

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3177256

The F-box subunit of the SCF E3 complex is encoded by a diverse superfamily of genes in Arabidopsis

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3177256

Two interacting bZIP proteins are direct targets of COP1-mediated control of light-dependent gene expression in Arabidopsis

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3177256

AXR1-ECR1-dependent conjugation of RUB1 to the Arabidopsis Cullin AtCUL1 is required for auxin response

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3177256

Auxin regulates SCF(TIR1)-dependent degradation of AUX/IAA proteins

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3177256

Roles and activities of Aux/IAA proteins in Arabidopsis

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3177256

Promotion of NEDD-CUL1 conjugate cleavage by COP9 signalosome

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3177256

Interactions of the COP9 Signalosome with the E3 Ubiquitin Ligase SCFTIR1 in Mediating Auxin Response

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3177256

Targeted destabilization of HY5 during light-regulated development of Arabidopsis.

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3177256

The Arabidopsis cullin AtCUL1 is modified by the ubiquitin-related protein RUB1.

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3177256

Covalent modification of all members of human cullin family proteins by NEDD8

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3177256

An auxin-dependent distal organizer of pattern and polarity in the Arabidopsis root

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3177256

Identification of the activating and conjugating enzymes of the NEDD8 conjugation pathway

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3177256

Floral dip: a simplified method for Agrobacterium-mediated transformation of Arabidopsis thaliana

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3177256

The ubiquitin-related protein RUB1 and auxin response in Arabidopsis

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3177256

Modification of yeast Cdc53p by the ubiquitin-related protein rub1p affects function of the SCFCdc4 complex

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3177256

Arabidopsis auxin-resistance gene AXR1 encodes a protein related to ubiquitin-activating enzyme E1.

30 November 2018

1 reference

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Growth and development of the axr1 mutants of Arabidopsis.

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3177256

Neddylation of a breast cancer-associated protein recruits a class III histone deacetylase that represses NFkappaB-dependent transcription

30 November 2018

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12 December 2020

Degradation of the cyclin-dependent kinase inhibitor KRP1 is regulated by two different ubiquitin E3 ligases

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12 December 2020

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A glucocorticoid-mediated transcriptional induction system in transgenic plants

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12 December 2020

Plant development is regulated by a family of auxin receptor F box proteins

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12 December 2020