Dissecting the relative contribution of OATP1B1-mediated uptake of xenobiotics into human hepatocytes using siRNA (Q58073588)

1

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A. C. Soars

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P. White

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R. J. Riley

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M. G. Soars

Atu027, a liposomal small interfering RNA formulation targeting protein kinase N3, inhibits cancer progression.

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language of work or name

English

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publication date

6 March 2013

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published in

Xenobiotica

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volume

43

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issue

10

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page(s)

920-931

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cites work

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Bilateral pharmacokinetic interaction between cyclosporine A and atorvastatin in renal transplant recipients

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Hepatic uptake of bilirubin and its conjugates by the human organic anion transporter SLC21A6

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Interaction of three regiospecific amino acid residues is required for OATP1B1 gain of OATP1B3 substrate specificity

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Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans

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Xenobiotic transporters of the human organic anion transporting polypeptides (OATP) family

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HIV protease inhibitors are substrates for OATP1A2, OATP1B1 and OATP1B3 and lopinavir plasma concentrations are influenced by SLCO1B1 polymorphisms

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Pharmacokinetics and pharmacodynamics of pravastatin in pediatric and adolescent cardiac transplant recipients on a regimen of triple immunosuppression

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Contribution of OATP2 (OATP1B1) and OATP8 (OATP1B3) to the hepatic uptake of pitavastatin in humans

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Drug-drug interaction between pitavastatin and various drugs via OATP1B1.

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SLCO1B1 (OATP1B1, an uptake transporter) and ABCG2 (BCRP, an efflux transporter) variant alleles and pharmacokinetics of pitavastatin in healthy volunteers

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Mechanistic pharmacokinetic modeling for the prediction of transporter-mediated disposition in humans from sandwich culture human hepatocyte data

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Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions

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Involvement of multiple transporters in the hepatobiliary transport of rosuvastatin

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Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver

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Inhibition of hepatic organic anion-transporting polypeptide by RNA interference in sandwich-cultured human hepatocytes: an in vitro model to assess transporter-mediated drug-drug interactions

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The eighth and ninth transmembrane domains in organic anion transporting polypeptide 1B1 affect the transport kinetics of estrone-3-sulfate and estradiol-17beta-D-glucuronide

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Drug interactions with lipid-lowering drugs: mechanisms and clinical relevance

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Organic anion transporting polypeptide 1B1: a genetically polymorphic transporter of major importance for hepatic drug uptake

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Substrate-dependent drug-drug interactions between gemfibrozil, fluvastatin and other organic anion-transporting peptide (OATP) substrates on OATP1B1, OATP2B1, and OATP1B3.

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Prediction of the pharmacokinetics of atorvastatin, cerivastatin, and indomethacin using kinetic models applied to isolated rat hepatocytes

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Different Effects of SLCO1B1 Polymorphism on the Pharmacokinetics of Atorvastatin and Rosuvastatin

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Prediction of pharmacokinetic profile of valsartan in human based on in vitro uptake transport data

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Design, data analysis, and simulation of in vitro drug transport kinetic experiments using a mechanistic in vitro model

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A novel siRNA-lipoplex technology for RNA interference in the mouse vascular endothelium

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RNA interference in the mouse vascular endothelium by systemic administration of siRNA-lipoplexes for cancer therapy

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Transporters as a determinant of drug clearance and tissue distribution

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Rosuvastatin pharmacokinetics in heart transplant recipients administered an antirejection regimen including cyclosporine

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The development, characterization, and application of an OATP1B1 inhibition assay in drug discovery

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The pivotal role of hepatocytes in drug discovery

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Impact of hepatic uptake transporters on pharmacokinetics and drug-drug interactions: use of assays and models for decision making in the pharmaceutical industry

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Pharmacokinetic interaction between pravastatin and olmesartan in relation to SLCO1B1 polymorphism

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A status report on RNAi therapeutics

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Relative quantities of catalytically active CYP 2C9 and 2C19 in human liver microsomes: application of the relative activity factor approach

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Investigation of the rate-determining process in the hepatic elimination of HMG-CoA reductase inhibitors in rats and humans

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Kinetic characterization of rat hepatic uptake of 16 actively transported drugs

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Multiple human isoforms of drug transporters contribute to the hepatic and renal transport of olmesartan, a selective antagonist of the angiotensin II AT1-receptor

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Involvement of transporters in the hepatic uptake and biliary excretion of valsartan, a selective antagonist of the angiotensin II AT1-receptor, in humans

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Small interfering RNA in drug metabolism and transport

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Knocking down breast cancer resistance protein (Bcrp) by adenoviral vector-mediated RNA interference (RNAi) in sandwich-cultured rat hepatocytes: a novel tool to assess the contribution of Bcrp to drug biliary excretion

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