Early events in the thymus affect the balance of effector and regulatory T cells (Q59077338)

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Tobias Silberzahn

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Mónica Escórcio-Correia

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Martin J. Woodward

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Scott J. Roberts

6

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Adrian L. Smith

7

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P. Julian Dyson

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Adrian C. Hayday

Regulation of thymus size by competition for stromal niches among early T cell progenitors

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language of work or name

English

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publication date

12 November 2006

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published in

Nature

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volume

444

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issue

7122

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page(s)

1073-1077

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cites work

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Regulatory T cells overexpress a subset of Th2 gene transcripts

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Deficiency of the Src homology region 2 domain-containing phosphatase 1 (SHP-1) causes enrichment of CD4+CD25+ regulatory T cells

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CD4+ CD25+ regulatory T cell repertoire formation in response to varying expression of a neo-self-antigen

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Control of regulatory T cell development by the transcription factor Foxp3

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Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

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An essential role for Scurfin in CD4+CD25+ T regulatory cells

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Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide

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Origin of regulatory T cells with known specificity for antigen

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Regulatory T cell lineage specification by the forkhead transcription factor foxp3

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Lymphotoxin-mediated regulation of gammadelta cell differentiation by alphabeta T cell progenitors

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Origin of Thy-1+ dendritic epidermal cells of adult mice from fetal thymic precursors

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Resident skin-specific gammadelta T cells provide local, nonredundant regulation of cutaneous inflammation

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Alpha beta lineage-committed thymocytes can be rescued by the gamma delta T cell receptor (TCR) in the absence of TCR beta chain.

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Intrathymic delta selection events in gammadelta cell development.

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Role of different T cell receptors in the development of pre-T cells.

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Crucial role of the pre-T-cell receptor α gene in development of ap but not γδ T cells

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The biological activity of natural and mutant pTalpha alleles

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A function for interleukin 2 in Foxp3-expressing regulatory T cells

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Cytotoxic T lymphocyte-associated antigen 4 plays an essential role in the function of CD25(+)CD4(+) regulatory cells that control intestinal inflammation

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Immunologic self-tolerance maintained by CD25(+)CD4(+) regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4.

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Number of T reg cells that differentiate does not increase upon encounter of agonist ligand on thymic epithelial cells.

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Regulatory T cells mediate maternal tolerance to the fetus

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The lymphotoxin beta receptor controls organogenesis and affinity maturation in peripheral lymphoid tissues

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Mutations in T-cell antigen receptor genes alpha and beta block thymocyte development at different stages

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Peripheral T cell lymphopenia and concomitant enrichment in naturally arising regulatory T cells: the case of the pre-Talpha gene-deleted mouse

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