Mitochondrial type II NADH dehydrogenase of Plasmodium falciparum (PfNDH2) is dispensable in the asexual blood stages (Q64065041)

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2 May 2020

title

Mitochondrial type II NADH dehydrogenase of Plasmodium falciparum (PfNDH2) is dispensable in the asexual blood stages (English)

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2 May 2020

main subject

Plasmodium falciparum

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1

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2 May 2020

author name string

Suresh M Ganesan

2

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2 May 2020

Swati Dass

3

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2 May 2020

Joanne M Morrisey

4

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2 May 2020

Sovitj Pou

5

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2 May 2020

Aaron Nilsen

6

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2 May 2020

Michael K Riscoe

7

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2 May 2020

Michael W Mather

8

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2 May 2020

Akhil B Vaidya

9

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2 May 2020

language of work or name

English

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publication date

9 April 2019

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2 May 2020

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2 May 2020

volume

14

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issue

4

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2 May 2020

page(s)

e0214023

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Creative Commons Attribution 4.0 International

2 May 2020

copyright license

start time

9 April 2019

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April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

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Mitochondria of mammalian Plasmodium spp.

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Purification and characterization of a rotenone-insensitive NADH:Q6 oxidoreductase from mitochondria of Saccharomyces cerevisiae

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Arabidopsis genes encoding mitochondrial type II NAD(P)H dehydrogenases have different evolutionary origin and show distinct responses to light.

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Growth inhibition of Toxoplasma gondii and Plasmodium falciparum by nanomolar concentrations of 1-hydroxy-2-dodecyl-4(1H)quinolone, a high-affinity inhibitor of alternative (type II) NADH dehydrogenases

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The malaria parasite type II NADH:quinone oxidoreductase: an alternative enzyme for an alternative lifestyle

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Malaria-parasite mitochondrial dehydrogenases as drug targets: too early to write the obituary.

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A drug-selected Plasmodium falciparum lacking the need for conventional electron transport

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Triazolopyrimidine-based dihydroorotate dehydrogenase inhibitors with potent and selective activity against the malaria parasite Plasmodium falciparum.

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Identification of new inhibitors for alternative NADH dehydrogenase (NDH-II).

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Type II NADH dehydrogenase of the respiratory chain of Plasmodium falciparum and its inhibitors

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Chapter 17 Type II NADH: quinone oxidoreductases of Plasmodium falciparum and Mycobacterium tuberculosis kinetic and high-throughput assays.

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Hemozoin-free Plasmodium falciparum mitochondria for physiological and drug susceptibility studies.

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Variation among Plasmodium falciparum strains in their reliance on mitochondrial electron transport chain function

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12 December 2020

Arrested oocyst maturation in Plasmodium parasites lacking type II NADH:ubiquinone dehydrogenase

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12 December 2020

Two internal type II NADH dehydrogenases of Toxoplasma gondii are both required for optimal tachyzoite growth

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12 December 2020

Cytochrome b mutation Y268S conferring atovaquone resistance phenotype in malaria parasite results in reduced parasite bc1 catalytic turnover and protein expression

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12 December 2020

Identification, design and biological evaluation of bisaryl quinolones targeting Plasmodium falciparum type II NADH:quinone oxidoreductase (PfNDH2).

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12 December 2020

Identification, design and biological evaluation of heterocyclic quinolones targeting Plasmodium falciparum type II NADH:quinone oxidoreductase (PfNDH2).

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Identification of novel antimalarial chemotypes via chemoinformatic compound selection methods for a high-throughput screening program against the novel malarial target, PfNDH2: increasing hit rate via virtual screening methods.

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12 December 2020

HDQ, a potent inhibitor of Plasmodium falciparum proliferation, binds to the quinone reduction site of the cytochrome bc1 complex.

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12 December 2020

Generation of quinolone antimalarials targeting the Plasmodium falciparum mitochondrial respiratory chain for the treatment and prophylaxis of malaria

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12 December 2020

Critical roles of the mitochondrial complex II in oocyst formation of rodent malaria parasite Plasmodium berghei

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Mitochondrial disorders as windows into an ancient organelle

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Quinolone-3-diarylethers: a new class of antimalarial drug.

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Novel inhibitors of the Plasmodium falciparum electron transport chain

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Discovery, synthesis, and optimization of antimalarial 4(1H)-quinolone-3-diarylethers

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Mitochondrial ATP synthase is dispensable in blood-stage Plasmodium berghei rodent malaria but essential in the mosquito phase

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Genetic investigation of tricarboxylic acid metabolism during the Plasmodium falciparum life cycle

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A long-duration dihydroorotate dehydrogenase inhibitor (DSM265) for prevention and treatment of malaria

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Parasites resistant to the antimalarial atovaquone fail to transmit by mosquitoes

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Atovaquone and ELQ-300 Combination Therapy as a Novel Dual-Site Cytochrome bc1 Inhibition Strategy for Malaria

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The chaperonin TRiC forms an oligomeric complex in the malaria parasite cytosol

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12 December 2020

Target Elucidation by Cocrystal Structures of NADH-Ubiquinone Oxidoreductase of Plasmodium falciparum (PfNDH2) with Small Molecule To Eliminate Drug-Resistant Malaria

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12 December 2020

Structure and function of complex I in animals and plants - a comparative view

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12 December 2020

Type-II NADH Dehydrogenase (NDH-2): a promising therapeutic target for antitubercular and antibacterial drug discovery

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12 December 2020

Suppression of experimental cerebral malaria by disruption of malate:quinone oxidoreductase.

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12 December 2020

The mitochondrial ribosomal protein L13 is critical for the structural and functional integrity of the mitochondrion in Plasmodium falciparum.

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12 December 2020

Uncovering the essential genes of the human malaria parasitePlasmodium falciparumby saturation mutagenesis

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12 December 2020

Selection of cytochrome B mutants by putative PfNDH2 inhibitors

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12 December 2020

Antimalarial activity of single-dose DSM265, a novel plasmodium dihydroorotate dehydrogenase inhibitor, in patients with uncomplicated Plasmodium falciparum or Plasmodium vivax malaria infection: a proof-of-concept, open-label, phase 2a study

1 reference

12 December 2020

10.1371/JOURNAL.PONE.0214023

Identifiers

DOI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30964863%20AND%20SRC:MED&resulttype=core&format=json

2 May 2020

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2 May 2020

PubMed publication ID

30964863

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