Neurotoxicity of the 22 kDa thrombin-cleavage fragment of apolipoprotein E and related synthetic peptides is receptor-mediated (Q73507862)

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4 November 2019

title

Neurotoxicity of the 22 kDa thrombin-cleavage fragment of apolipoprotein E and related synthetic peptides is receptor-mediated (English)

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4 November 2019

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M Tolar

1

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4 November 2019

M A Marques

series ordinal

2

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4 November 2019

J A Harmony

series ordinal

3

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4 November 2019

K A Crutcher

series ordinal

4

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4 November 2019

publication date

1 August 1997

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4 November 2019

published in

Journal of Neuroscience

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4 November 2019

volume

17

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4 November 2019

issue

15

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4 November 2019

page(s)

5678-5686

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The presence of heparan sulfate proteoglycans in the neuritic plaques and congophilic angiopathy in Alzheimer's disease

4 November 2019

cites work

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12 December 2020

Localization of a Domain in Apolipoprotein E with both Cytostatic and Cytotoxic Activity

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Distribution of the alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein in human tissues

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alpha 2-Macroglobulin expression in neuritic-type plaques in patients with Alzheimer's disease

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Isoform-specific interactions of apolipoprotein E with the microtubule-associated protein MAP2c: implications for Alzheimer's disease.

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Astrocytes synthesize apolipoprotein E and metabolize apolipoprotein E-containing lipoproteins

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RAP, a specialized chaperone, prevents ligand-induced ER retention and degradation of LDL receptor-related endocytic receptors

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Primary structure of alpha 2-macroglobulin receptor-associated protein. Human homologue of a Heymann nephritis antigen

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Organ distribution in rats of two members of the low-density lipoprotein receptor gene family, gp330 and LRP/alpha 2MR, and the receptor-associated protein (RAP)

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Functional expression of low density lipoprotein receptor-related protein is controlled by receptor-associated protein in vivo

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12 December 2020

Structural features of synthetic peptides of apolipoprotein E that bind the LDL receptor

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12 December 2020

The chicken LDL receptor-related protein/alpha 2-macroglobulin receptor family

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12 December 2020

The alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein binds and internalizes Pseudomonas exotoxin A

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A new low density lipoprotein receptor homologue with 8 ligand binding repeats in brain of chicken and mouse

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12 December 2020

Isoform-specific binding of apolipoprotein E to beta-amyloid

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12 December 2020

A 70-kDa apolipoprotein designated ApoJ is a marker for subclasses of human plasma high density lipoproteins

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12 December 2020

Low Density Lipoprotein Receptor-related Protein/[IMAGE][IMAGE]-Macroglobulin Receptor Mediates the Cellular Internalization and Degradation of Thrombospondin

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12 December 2020

Neurite degeneration elicited by apolipoprotein E peptides

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12 December 2020

Low density lipoprotein receptor-related protein mediates apolipoprotein E-dependent neurite outgrowth in a central nervous system-derived neuronal cell line

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12 December 2020

Ischemia-induced death of astrocytes and neurons in primary culture: pitfalls in quantifying neuronal cell death

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The receptor-binding domain of human apolipoprotein E. Binding of apolipoprotein E fragments

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12 December 2020

Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families

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12 December 2020

Binding of human apolipoprotein E to synthetic amyloid beta peptide: isoform-specific effects and implications for late-onset Alzheimer disease

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12 December 2020

Multiple, diverse senile plaque-associated proteins are ligands of an apolipoprotein E receptor, the alpha 2-macroglobulin receptor/low-density-lipoprotein receptor-related protein.

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12 December 2020

The 39-kDa receptor-associated protein interacts with two members of the low density lipoprotein receptor family, alpha 2-macroglobulin receptor and glycoprotein 330

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12 December 2020

Apolipoprotein E epsilon 4 allele distributions in late-onset Alzheimer's disease and in other amyloid-forming diseases.

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12 December 2020

Human apolipoprotein E receptor 2. A novel lipoprotein receptor of the low density lipoprotein receptor family predominantly expressed in brain

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12 December 2020

Early accumulation of heparan sulfate in neurons and in the beta-amyloid protein-containing lesions of Alzheimer's disease and Down's syndrome

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12 December 2020

Autoimmune target in Heymann nephritis is a glycoprotein with homology to the LDL receptor

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12 December 2020

A synthetic peptide mimic of plasma apolipoprotein E that binds the LDL receptor

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12 December 2020

Effects of apolipoprotein E, beta-very low density lipoproteins, and cholesterol on the extension of neurites by rabbit dorsal root ganglion neurons in vitro

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12 December 2020

The cellular internalization and degradation of hepatic lipase is mediated by low density lipoprotein receptor-related protein and requires cell surface proteoglycans

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12 December 2020

The receptor-binding domain of human apolipoprotein E. Monoclonal antibody inhibition of binding

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12 December 2020

The human LDL receptor: a cysteine-rich protein with multiple Alu sequences in its mRNA

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12 December 2020

Localization of mRNA for low density lipoprotein receptor and a cholesterol synthetic enzyme in rabbit nervous system by in situ hybridization

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12 December 2020

Subcellular localization of the low density lipoprotein receptor-related protein (alpha 2-macroglobulin receptor) in human brain.

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12 December 2020

Differential effects of apolipoproteins E3 and E4 on neuronal growth in vitro

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12 December 2020

The inhibitory effect of apolipoprotein E4 on neurite outgrowth is associated with microtubule depolymerization

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12 December 2020

Apolipoprotein E in sporadic Alzheimer's disease: allelic variation and receptor interactions

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12 December 2020

Role of heparan sulfate proteoglycans in the binding and uptake of apolipoprotein E-enriched remnant lipoproteins by cultured cells

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12 December 2020

A novel mechanism for controlling the activity of alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein. Multiple regulatory sites for 39-kDa receptor-associated protein

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12 December 2020

Acceleration of Alzheimer's fibril formation by apolipoprotein E in vitro

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12 December 2020

The 39-kDa receptor-associated protein modulates lipoprotein catabolism by binding to LDL receptors

1 reference

12 December 2020

Surface location and high affinity for calcium of a 500-kd liver membrane protein closely related to the LDL-receptor suggest a physiological role as lipoprotein receptor

1 reference

12 December 2020

Comparison of double fluorescence staining and LDH-test for monitoring cell viability in vitro

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12 December 2020

A thrombin cleavage fragment of apolipoprotein E exhibits isoform-specific neurotoxicity

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12 December 2020

39-kDa protein modulates binding of ligands to low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor

1 reference

12 December 2020

Expression of the macrophage scavenger receptor, a multifunctional lipoprotein receptor, in microglia associated with senile plaques in Alzheimer's disease

1 reference

12 December 2020

Rabbit very low density lipoprotein receptor: a low density lipoprotein receptor-like protein with distinct ligand specificity

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12 December 2020

Sequence identity between the alpha 2-macroglobulin receptor and low density lipoprotein receptor-related protein suggests that this molecule is a multifunctional receptor

1 reference

12 December 2020

Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease

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12 December 2020

Characterization and immunohistochemical localization of alpha 2-macroglobulin receptor (low-density lipoprotein receptor-related protein) in human brain

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12 December 2020

Neurodegeneration in the central nervous system of apoE-deficient mice

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12 December 2020

Site-specific mutagenesis of human apolipoprotein E. Receptor binding activity of variants with single amino acid substitutions

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12 December 2020

Human apolipoprotein E. Determination of the heparin binding sites of apolipoprotein E3

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12 December 2020

Phosphorylation of tau in apolipoprotein E-deficient mice

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12 December 2020

The somatic cell-specific low density lipoprotein receptor-related protein of the chicken. Close kinship to mammalian low density lipoprotein receptor gene family members

1 reference

12 December 2020

Association of apolipoprotein E allele epsilon 4 with late-onset familial and sporadic Alzheimer's disease

1 reference

12 December 2020

The LDL-receptor-related protein, LRP, is an apolipoprotein E-binding protein

1 reference

12 December 2020

A gene for a low density lipoprotein receptor-related protein in the nematode Caenorhabditis elegans

1 reference

12 December 2020

Expression and function of the low density lipoprotein receptor-related protein (LRP) in mammalian central neurons.

1 reference

12 December 2020

Tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis for the separation of proteins in the range from 1 to 100 kDa

1 reference

12 December 2020

Stable expression and secretion of apolipoproteins E3 and E4 in mouse neuroblastoma cells produces differential effects on neurite outgrowth

1 reference

12 December 2020

Hypothesis: microtubule instability and paired helical filament formation in the Alzheimer disease brain are related to apolipoprotein E genotype

1 reference

12 December 2020

Low density lipoprotein receptor-related protein and gp330 bind similar ligands, including plasminogen activator-inhibitor complexes and lactoferrin, an inhibitor of chylomicron remnant clearance

1 reference

12 December 2020

Only multimers of a synthetic peptide of human apolipoprotein E are biologically active.

1 reference

12 December 2020

1 reference

12 December 2020

The laying hen expresses two different low density lipoprotein receptor-related proteins.

1 reference

12 December 2020

Genetic association of the very low density lipoprotein (VLDL) receptor gene with sporadic Alzheimer's disease

1 reference

12 December 2020

Expression and distribution of low density lipoprotein receptor-related protein mRNA in the rat central nervous system.

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12 December 2020

The low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor binds and mediates catabolism of bovine milk lipoprotein lipase

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12 December 2020

10.1523/JNEUROSCI.17-15-05678.1997

Identifiers

DOI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9221767%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9221767%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

PubMed publication ID

9221767

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