Regulation of the system x(C)- cystine/glutamate exchanger by intracellular glutathione levels in rat astrocyte primary cultures (Q84136583)

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1 February 2020

title

Regulation of the system x(C)- cystine/glutamate exchanger by intracellular glutathione levels in rat astrocyte primary cultures (English)

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1 February 2020

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Todd Michael Seib

1

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Sarjubhai Amratbhai Patel

series ordinal

2

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1 February 2020

Richard James Bridges

series ordinal

3

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publication date

17 May 2011

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1 February 2020

volume

59

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issue

10

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page(s)

1387-1401

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Methylmercury inhibits the in vitro uptake of the glutathione precursor, cystine, in astrocytes, but not in neurons

1 February 2020

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Determination of glutathione and glutathione disulfide in biological samples

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Neuroadaptations in cystine-glutamate exchange underlie cocaine relapse

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Cystine/glutamate exchange serves as the source for extracellular glutamate: modifications by repeated cocaine administration.

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The origin and neuronal function of in vivo nonsynaptic glutamate.

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Transport of cystine and cysteine in mammalian cells

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Activation of microglia by secreted amyloid precursor protein evokes release of glutamate by cystine exchange and attenuates synaptic function.

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Characterization of cystine uptake in cultured astrocytes

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Uptake of glutamate and cysteine in C-6 glioma cells and in cultured astrocytes.

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Inhibition of cystine uptake disrupts the growth of primary brain tumors

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Expression profiling identifies a molecular signature of reactive astrocytes stimulated by cyclic AMP or proinflammatory cytokines

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Targeted activation of astrocytes: a potential neuroprotective strategy.

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Dibutyryl-cAMP (dbcAMP) up-regulates astrocytic chloride-dependent L-[3H]glutamate transport and expression of both system xc(-) subunits

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Sulfasalazine, a potent suppressor of lymphoma growth by inhibition of the x(c)- cystine transporter: a new action for an old drug

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Dopamine-induced oxidative stress in neurons with glutathione deficit: implication for schizophrenia

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Dynamics of sulfur amino acids in mammalian brain: assessment of the astrocytic-neuronal cysteine interaction by a mathematical hybrid model

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Functional studies in cultured astrocytes

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Effects of dopamine on the glutathione metabolism of cultured astroglial cells: implications for Parkinson's disease

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Expression of GABA(A) receptors by reactive astrocytes in explant and primary cultures of rat CNS.

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Enhancement of L-cystine transport activity and its relation to xCT gene induction at the blood-brain barrier by diethyl maleate treatment

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7 January 2021

Transcription factor Nrf2 coordinately regulates a group of oxidative stress-inducible genes in macrophages

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Molecular mechanism activating Nrf2-Keap1 pathway in regulation of adaptive response to electrophiles

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Plasticity of astrocytes in primary cultures: an experimental tool and a reason for methodological caution

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Buthionine sulfoximine-induced cytostasis does not correlate with glutathione depletion

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Cystine/glutamate antiporter expression in retinal Müller glial cells: implications for DL-alpha-aminoadipate toxicity

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Human cystine/glutamate transporter: cDNA cloning and upregulation by oxidative stress in glioma cells

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7 January 2021

Differentiation of substrate and nonsubstrate inhibitors of the high-affinity, sodium-dependent glutamate transporters

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7 January 2021

DBcAMP effect on the expression of GFAP and of its encoding mRNA in astroglial primary cultures

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7 January 2021

Basal levels of eIF2alpha phosphorylation determine cellular antioxidant status by regulating ATF4 and xCT expression

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7 January 2021

Molecular characterization of the cystine/glutamate exchanger and the excitatory amino acid transporters in the rat lens

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7 January 2021

Autocrine glutamate signaling promotes glioma cell invasion.

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Preparation of separate astroglial and oligodendroglial cell cultures from rat cerebral tissue

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Glutathione deficiency produced by inhibition of its synthesis, and its reversal; Applications in research and therapy

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Dibutyryl cAMP, interleukin-1 beta, and macrophage conditioned medium enhance the ability of astrocytes to promote neurite growth

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7 January 2021

Cystine/glutamate exchange regulates metabotropic glutamate receptor presynaptic inhibition of excitatory transmission and vulnerability to cocaine seeking

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Glutamate toxicity in a neuronal cell line involves inhibition of cystine transport leading to oxidative stress

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7 January 2021

Effects of hyperglycemia and oxidative stress on the glutamate transporters GLAST and system xc- in mouse retinal Müller glial cells

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7 January 2021

Transport mechanism for aluminum citrate at the blood-brain barrier: kinetic evidence implies involvement of system Xc- in immortalized rat brain endothelial cells.

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7 January 2021

4F2 (CD98) heavy chain is associated covalently with an amino acid transporter and controls intracellular trafficking and membrane topology of 4F2 heterodimer.

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7 January 2021

Differentiation of substrate and non-substrate inhibitors of transport system xc(-): an obligate exchanger of L-glutamate and L-cystine

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7 January 2021

On the mechanisms of induction of cancer-protective enzymes: a unifying proposal

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Activation of transcription factor Nrf-2 and its downstream targets in response to moloney murine leukemia virus ts1-induced thiol depletion and oxidative stress in astrocytes

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7 January 2021

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7 January 2021

Cloning and expression of a plasma membrane cystine/glutamate exchange transporter composed of two distinct proteins

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7 January 2021

Regulation of the glial Na+-dependent glutamate transporters by cyclic AMP analogs and neurons

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7 January 2021

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7 January 2021

Cystine/glutamate exchange modulates glutathione supply for neuroprotection from oxidative stress and cell proliferation.

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7 January 2021

Coordinate Regulation of Glutathione Biosynthesis and Release by Nrf2-Expressing Glia Potently Protects Neurons from Oxidative Stress

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7 January 2021

The potency of inducers of NAD(P)H:(quinone-acceptor) oxidoreductase parallels their efficiency as substrates for glutathione transferases. Structural and electronic correlations

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7 January 2021

Developmental regulation of glutamate transporters and glutamine synthetase activity in astrocyte cultures differentiated in vitro

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7 January 2021

Neuronal regulation of glutamate transporter subtype expression in astrocytes.

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7 January 2021

Mechanisms of induction of enzymes that protect against chemical carcinogenesis

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7 January 2021

Chemoprotection against cancer by phase 2 enzyme induction

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7 January 2021

Astrocytes provide cysteine to neurons by releasing glutathione

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https://api.crossref.org/works/10.1002%2FGLIA.21176

7 January 2021

Generation of a stable antioxidant response element-driven reporter gene cell line and its use to show redox-dependent activation of nrf2 by cancer chemotherapeutic agents.

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7 January 2021

Characterization of L-glutamic acid transport by glioma cells in culture: evidence for sodium-independent, chloride-dependent high affinity influx

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7 January 2021

The Lathyrus excitotoxin beta-N-oxalyl-L-alpha,beta-diaminopropionic acid is a substrate of the L-cystine/L-glutamate exchanger system xc-.

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7 January 2021

Compromised glutamate transport in human glioma cells: reduction-mislocalization of sodium-dependent glutamate transporters and enhanced activity of cystine-glutamate exchange

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7 January 2021

Identifiers

DOI

10.1002/GLIA.21176

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21590811%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

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