The anticancer effect of oridonin is mediated by fatty acid synthase suppression in human colorectal cancer cells (Q84434166)

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5 February 2020

title

The anticancer effect of oridonin is mediated by fatty acid synthase suppression in human colorectal cancer cells (English)

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1

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Zhijun Yang

2

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5 February 2020

Zhiling Yu

5

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5 February 2020

author name string

Wang-Fun Fong

3

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Yong-Mei Hu

4

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Wen-Luan Wendy Hsiao

6

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publication date

23 June 2012

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Journal of Gastroenterology

5 February 2020

published in

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volume

48

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issue

2

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page(s)

182-192

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Proteomic identification of proteins involved in the anticancer activities of oridonin in HepG2 cells.

5 February 2020

cites work

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12 December 2020

Fatty acid synthase inhibitors are chemopreventive for mammary cancer in neu-N transgenic mice

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12 December 2020

Fas/FasL signaling allows extracelluar-signal regulated kinase to regulate cytochrome c release in oridonin-induced apoptotic U937 cells

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12 December 2020

Androgens stimulate fatty acid synthase in the human prostate cancer cell line LNCaP.

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12 December 2020

Fatty acid synthase inhibition in human breast cancer cells leads to malonyl-CoA-induced inhibition of fatty acid oxidation and cytotoxicity

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12 December 2020

ATP citrate lyase inhibition can suppress tumor cell growth

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12 December 2020

Androgens stimulate lipogenic gene expression in prostate cancer cells by activation of the sterol regulatory element-binding protein cleavage activating protein/sterol regulatory element-binding protein pathway

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12 December 2020

Fatty acid synthase gene is up-regulated by hypoxia via activation of Akt and sterol regulatory element binding protein-1.

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12 December 2020

Control of cell growth and survival by enzymes of the fatty acid synthesis pathway in HCT-116 colon cancer cells.

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12 December 2020

Insulin activates human sterol-regulatory-element-binding protein-1c (SREBP-1c) promoter through SRE motifs

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12 December 2020

Synthesis and antitumor activity of an inhibitor of fatty acid synthase

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12 December 2020

A role of DNA-PK for the metabolic gene regulation in response to insulin

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12 December 2020

Fatty acid synthase (FAS): a target for cytotoxic antimetabolites in HL60 promyelocytic leukemia cells

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12 December 2020

Metformin blocks the stimulative effect of a high-energy diet on colon carcinoma growth in vivo and is associated with reduced expression of fatty acid synthase

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12 December 2020

Genetic epidemiology of mutated K-ras proto-oncogene, altered suppressor genes, and microsatellite instability in colorectal adenomas

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12 December 2020

Sterol regulatory element-binding protein-1 participates in the regulation of fatty acid synthase expression in colorectal neoplasia

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12 December 2020

Inhibition of fatty acid synthesis delays disease progression in a xenograft model of ovarian cancer

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12 December 2020

Oridonin induces apoptosis and senescence in colorectal cancer cells by increasing histone hyperacetylation and regulation of p16, p21, p27 and c-myc

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12 December 2020

Direct interaction between USF and SREBP-1c mediates synergistic activation of the fatty-acid synthase promoter

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12 December 2020

De novo fatty-acid synthesis and related pathways as molecular targets for cancer therapy

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12 December 2020

Mechanism of apoptosis induced by the inhibition of fatty acid synthase in breast cancer cells

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12 December 2020

ATP citrate lyase: activation and therapeutic implications in non-small cell lung cancer.

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12 December 2020

ATP citrate lyase is an important component of cell growth and transformation

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12 December 2020

Fatty-acid synthase and human cancer: new perspectives on its role in tumor biology

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12 December 2020

Inhibition of EGFR signaling augments oridonin-induced apoptosis in human laryngeal cancer cells via enhancing oxidative stress coincident with activation of both the intrinsic and extrinsic apoptotic pathways

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12 December 2020

Oridonin induced A375-S2 cell apoptosis via bax-regulated caspase pathway activation, dependent on the cytochrome c/caspase-9 apoptosome

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12 December 2020

Malonyl-coenzyme-A is a potential mediator of cytotoxicity induced by fatty-acid synthase inhibition in human breast cancer cells and xenografts

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12 December 2020

Metabolism and proliferation share common regulatory pathways in cancer cells

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12 December 2020

Up-regulation of fatty acid synthase promoter by hepatitis C virus core protein: genotype-3a core has a stronger effect than genotype-1b core

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12 December 2020

Co-ordinate activation of lipogenic enzymes in hepatocellular carcinoma

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12 December 2020

Fatty acid synthesis: a potential selective target for antineoplastic therapy

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12 December 2020

Fatty acid synthase, a proficient multifunctional enzyme

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12 December 2020

Genome-wide occupancy of SREBP1 and its partners NFY and SP1 reveals novel functional roles and combinatorial regulation of distinct classes of genes

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12 December 2020

Acetyl-CoA carboxylase alpha is essential to breast cancer cell survival

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12 December 2020

Sterol regulation of fatty acid synthase promoter. Coordinate feedback regulation of two major lipid pathways

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12 December 2020

CNGA2 contributes to ATP-induced noncapacitative Ca2+ influx in vascular endothelial cells.

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12 December 2020

Apoptosis of androgen-independent prostate cell line induced by inhibition of fatty acid synthesis

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12 December 2020

Inhibition of fatty acid synthesis induces programmed cell death in human breast cancer cells

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12 December 2020

Elevated expression of fatty acid synthase and fatty acid synthetic activity in colorectal neoplasia.

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12 December 2020

Sp1 coordinately regulates de novo lipogenesis and proliferation in cancer cells

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12 December 2020

Inhibition of fatty acid synthase induces endoplasmic reticulum stress in tumor cells.

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12 December 2020

Role of glucose-6-phosphate dehydrogenase on enhanced proliferation of pre-neoplastic and neoplastic cells in rat liver induced by N-nitrosomorpholine

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12 December 2020

Increased expression of fatty acid synthase in human aberrant crypt foci: possible target for colorectal cancer prevention

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12 December 2020

Oridonin induced apoptosis through Akt and MAPKs signaling pathways in human osteosarcoma cells

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12 December 2020

Inhibitory effects of flavonoids on animal fatty acid synthase

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12 December 2020

10.1007/S00535-012-0612-1

Identifiers

DOI

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5 February 2020

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