RANKL/RANK: from bone loss to the prevention of breast cancer (Q28075004)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27881737%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

Josef Penninger

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Laundette P Jones

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5 June 2020

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31 July 2019

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28 October 2022

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13 March 2019

24 March 2019

3 April 2019

17 June 2019

31 July 2019

20 November 2019

15 December 2019

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5 June 2020

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cites work

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Osteoclast differentiation factor RANKL controls development of progestin-driven mammary cancer

20 March 2017

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Central control of fever and female body temperature by RANKL/RANK

20 March 2017

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Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results From the Women's Health Initiative randomized controlled trial

20 March 2017

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BRCA1 mediates ligand-independent transcriptional repression of the estrogen receptor

20 March 2017

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RANK is essential for osteoclast and lymph node development

20 March 2017

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A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function

20 March 2017

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Osteoprotegerin: a novel secreted protein involved in the regulation of bone density

20 March 2017

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Breast and ovarian cancer risks due to inherited mutations in BRCA1 and BRCA2

20 March 2017

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RANK-L and RANK: T cells, bone loss, and mammalian evolution

20 March 2017

2 references

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20 March 2017

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The osteoclast differentiation factor osteoprotegerin-ligand is essential for mammary gland development

6 April 2017

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Bench to bedside: elucidation of the OPG-RANK-RANKL pathway and the development of denosumab

20 March 2017

1 reference

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RANK ligand mediates progestin-induced mammary epithelial proliferation and carcinogenesis

20 March 2017

1 reference

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IKKalpha provides an essential link between RANK signaling and cyclin D1 expression during mammary gland development

20 March 2017

1 reference

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OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis

20 March 2017

1 reference

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Triple-Negative Breast Cancer

20 March 2017

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Generation of a functional mammary gland from a single stem cell

7 April 2017

1 reference

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Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies

7 April 2017

1 reference

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Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand

7 April 2017

1 reference

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RANK ligand as a potential target for breast cancer prevention in BRCA1-mutation carriers.

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5133443

Persistent Activation of NF-κB in BRCA1-Deficient Mammary Progenitors Drives Aberrant Proliferation and Accumulation of DNA Damage.

29 September 2017

1 reference

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RANKL/RANK control Brca1 mutation-driven mammary tumors

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5133443

The Role of Risk-Reducing Surgery in Hereditary Breast and Ovarian Cancer

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5133443

Osteoprotegerin (OPG), The Endogenous Inhibitor of Receptor Activator of NF-κB Ligand (RANKL), is Dysregulated in BRCA Mutation Carriers

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5133443

RANK Signaling Amplifies WNT-Responsive Mammary Progenitors through R-SPONDIN1.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5133443

Adjuvant denosumab in breast cancer (ABCSG-18): a multicentre, randomised, double-blind, placebo-controlled trial

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5133443

Association of type and location of BRCA1 and BRCA2 mutations with risk of breast and ovarian cancer

29 September 2017

1 reference

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Osteoclasts: more than 'bone eaters'.

29 September 2017

1 reference

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The mammary stem cell hierarchy.

29 September 2017

1 reference

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How pregnancy at early age protects against breast cancer

29 September 2017

1 reference

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Lgr4 regulates mammary gland development and stem cell activity through the pluripotency transcription factor Sox2.

29 September 2017

1 reference

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Lessons learned from the Women's Health Initiative trials of menopausal hormone therapy.

29 September 2017

1 reference

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Menarche, menopause, and breast cancer risk: individual participant meta-analysis, including 118 964 women with breast cancer from 117 epidemiological studies

29 September 2017

1 reference

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BRCA1 and BRCA2: different roles in a common pathway of genome protection

29 September 2017

1 reference

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Clinical practice. Breast-cancer screening

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5133443

Receptor activator of NF-kappaB (RANK) stimulates the proliferation of epithelial cells of the epidermo-pilosebaceous unit

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5133443

Tumour-infiltrating regulatory T cells stimulate mammary cancer metastasis through RANKL-RANK signalling

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5133443

Repression of mammary stem/progenitor cells by p53 is mediated by Notch and separable from apoptotic activity

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5133443

From milk to malignancy: the role of mammary stem cells in development, pregnancy and breast cancer

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5133443

Osteoimmunology: crosstalk between the immune and bone systems

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5133443

BRCA1, hormone, and tissue-specific tumor suppression

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5133443

Linking the cellular functions of BRCA genes to cancer pathogenesis and treatment

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5133443

Genetic predisposition to breast cancer: past, present, and future

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5133443

BRCA1 regulates human mammary stem/progenitor cell fate

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5133443

International variation in rates of uptake of preventive options in BRCA1 and BRCA2 mutation carriers

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5133443

IkappaB kinase alpha kinase activity is required for self-renewal of ErbB2/Her2-transformed mammary tumor-initiating cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5133443

Prevention of Brca1-mediated mammary tumorigenesis in mice by a progesterone antagonist

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5133443

Mouse models of BRCA1 and BRCA2 deficiency: past lessons, current understanding and future prospects

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5133443

The role of BRCA1 in transcriptional regulation and cell cycle control

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5133443

Distinction between hereditary and sporadic breast cancer on the basis of clinicopathological data

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5133443

The breast cancer susceptibility gene BRCA1 regulates progesterone receptor signaling in mammary epithelial cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5133443

BRCA1 inhibits membrane estrogen and growth factor receptor signaling to cell proliferation in breast cancer

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5133443

Soluble RANKL and risk of nontraumatic fracture

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5133443

Breast cancer and hormone-replacement therapy in the Million Women Study

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5133443

The effects of estrogen on osteoprotegerin, RANKL, and estrogen receptor expression in human osteoblasts

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5133443

Risk-reducing salpingo-oophorectomy in women with a BRCA1 or BRCA2 mutation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5133443

Signaling pathways in mammary gland development.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5133443

The mechanisms of estrogen regulation of bone resorption

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5133443

Localization of a breast cancer susceptibility gene, BRCA2, to chromosome 13q12-13.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5133443

Progesterone induces adult mammary stem cell expansion

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5133443

RANK signals from CD4(+)3(-) inducer cells regulate development of Aire-expressing epithelial cells in the thymic medulla

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5133443

LGR4 is a receptor for RANKL and negatively regulates osteoclast differentiation and bone resorption.

2 June 2018

1 reference

https://api.crossref.org/works/10.1098%2FRSOB.160230

Control of mammary stem cell function by steroid hormone signalling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1098%2FRSOB.160230

Clinical outcomes of breast cancer in carriers of BRCA1 and BRCA2 mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1098%2FRSOB.160230

"The race" to clone BRCA1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1098%2FRSOB.160230

The tumor suppressor p53 regulates polarity of self-renewing divisions in mammary stem cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1098%2FRSOB.160230

The sex hormone system in carriers of BRCA1/2 mutations: a case-control study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1098%2FRSOB.160230

Pharmacological properties of mifepristone: toxicology and safety in animal and human studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1098%2FRSOB.160230

A role for Brca1 in chromosome end maintenance

21 January 2018

1 reference

https://api.crossref.org/works/10.1098%2FRSOB.160230

Abnormal bone remodeling process is due to an imbalance in the receptor activator of nuclear factor–κB ligand (RANKL)/osteoprotegerin (OPG) axis in patients with solid tumors metastatic to the skeleton

21 January 2018

1 reference

https://api.crossref.org/works/10.1098%2FRSOB.160230

Pregnancy and risk of early breast cancer in carriers of BRCA1 and BRCA2

21 January 2018

1 reference

https://api.crossref.org/works/10.1098%2FRSOB.160230

Bone loss in relation to serum levels of osteoprotegerin and nuclear factor-kappaB ligand: the Tromsø Study

21 January 2018

1 reference

12 December 2020

Clinical implications of genetic testing for BRCA1 and BRCA2 mutations in Austria

1 reference

12 December 2020

BRCA1 Inhibition of Estrogen Receptor Signaling in Transfected Cells

1 reference

12 December 2020

Osteoprotegerin, RANKL and bone turnover in postmenopausal osteoporosis

1 reference

12 December 2020

Identifiers

DOI

10.1098/RSOB.160230

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27881737%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27881737%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

2 references