Oxidative Stress-Related Mechanisms and Antioxidant Therapy in Diabetic Retinopathy (Q29248994)

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11 October 2020

Oxidative Stress-Related Mechanisms and Antioxidant Therapy in Diabetic Retinopathy (English)

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8 April 2017

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physiological phenomenon

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Xiao Miao

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10 references

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Oxidative medicine and cellular longevity

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2017

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Activation of PKC-delta and SHP-1 by hyperglycemia causes vascular cell apoptosis and diabetic retinopathy

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Diabetes regulates small molecular weight G-protein, H-Ras, in the microvasculature of the retina: implication in the development of retinopathy

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High glucose increases angiopoietin-2 transcription in microvascular endothelial cells through methylglyoxal modification of mSin3A

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Multiorgan autoimmune inflammation, enhanced lymphoproliferation, and impaired homeostasis of reactive oxygen species in mice lacking the antioxidant-activated transcription factor Nrf2

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Role of nitrosative stress and peroxynitrite in the pathogenesis of diabetic complications. Emerging new therapeutical strategies

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High glucose mediates pro-oxidant and antioxidant enzyme activities in coronary endothelial cells

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Potential contributory role of H-Ras, a small G-protein, in the development of retinopathy in diabetic rats

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Hyperglycemia increases mitochondrial superoxide in retina and retinal cells

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Killing the messenger: short RNAs that silence gene expression

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Benfotiamine blocks three major pathways of hyperglycemic damage and prevents experimental diabetic retinopathy

8 April 2017

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Characterization of protein kinase C beta isoform's action on retinoblastoma protein phosphorylation, vascular endothelial growth factor-induced endothelial cell proliferation, and retinal neovascularization

8 April 2017

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The absence of diabetic retinopathy in patients with retinitis pigmentosa: implications for pathophysiology and possible treatment

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Oxidative stress and diabetic complications

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Peroxynitrite: biochemistry, pathophysiology and development of therapeutics

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Dynamic DNA methylation of matrix metalloproteinase-9 in the development of diabetic retinopathy

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PRMT1 and PRMT4 Regulate Oxidative Stress-Induced Retinal Pigment Epithelial Cell Damage in SIRT1-Dependent and SIRT1-Independent Manners.

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High glucose induces renal tubular epithelial injury via Sirt1/NF-kappaB/microR-29/Keap1 signal pathway

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Epigenetic Modification of Mitochondrial DNA in the Development of Diabetic Retinopathy

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Fenoﬁbrate suppresses cellular metabolic memory of high glucose in diabetic retinopathy via a sirtuin 1-dependent signalling pathway

3 June 2018

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Vitamin D Deficiency Is Associated with the Presence and Severity of Diabetic Retinopathy in Type 2 Diabetes Mellitus

3 June 2018

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Potential drugs which activate nuclear factor E2-related factor 2 signaling to prevent diabetic cardiovascular complications: A focus on fumaric acid esters

3 June 2018

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Oxidative stress and epigenetic modifications in the pathogenesis of diabetic retinopathy.

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Increased O-GlcNAcylation of NF-κB Enhances Retinal Ganglion Cell Death in Streptozotocin-induced Diabetic Retinopathy.

3 June 2018

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High glucose enhances microRNA-26a to activate mTORC1 for mesangial cell hypertrophy and matrix protein expression

3 June 2018

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Sirtuins in vascular diseases: Emerging roles and therapeutic potential.

3 June 2018

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Nitric oxide and oxidative stress is associated with severity of diabetic retinopathy and retinal structural alterations

3 June 2018

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Oxidative stress and light-evoked responses of the posterior segment in a mouse model of diabetic retinopathy

3 June 2018

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Polyphenol-enriched cocoa protects the diabetic retina from glial reaction through the sirtuin pathway

3 June 2018

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Epigenetic modifications of Keap1 regulate its interaction with the protective factor Nrf2 in the development of diabetic retinopathy

3 June 2018

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Alpha-lipoic acid as a pleiotropic compound with potential therapeutic use in diabetes and other chronic diseases

3 June 2018

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High-glucose-induced CARM1 expression regulates apoptosis of human retinal pigment epithelial cells via histone 3 arginine 17 dimethylation: role in diabetic retinopathy

3 June 2018

1 reference

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Epigenetic modifications of Nrf2-mediated glutamate-cysteine ligase: implications for the development of diabetic retinopathy and the metabolic memory phenomenon associated with its continued progression

3 June 2018

1 reference

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Role of epigenetic mechanisms in the development of chronic complications of diabetes.

3 June 2018

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Parp inhibition prevents ten-eleven translocase enzyme activation and hyperglycemia-induced DNA demethylation

3 June 2018

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Antioxidant therapy for retinal disease

3 June 2018

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Tonicity-responsive enhancer binding protein regulates the expression of aldose reductase and protein kinase C δ in a mouse model of diabetic retinopathy

3 June 2018

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Association of tea consumption and the risk of oral cancer: a meta-analysis

3 June 2018

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Requirement of NOX2 expression in both retina and bone marrow for diabetes-induced retinal vascular injury

3 June 2018

1 reference

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NRF2 plays a protective role in diabetic retinopathy in mice

3 June 2018

1 reference

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Photoreceptor cells are major contributors to diabetes-induced oxidative stress and local inflammation in the retina

3 June 2018

1 reference

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Ten-eleven translocation (Tet) and thymine DNA glycosylase (TDG), components of the demethylation pathway, are direct targets of miRNA-29a

3 June 2018

1 reference

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Resveratrol protects vascular endothelial cells from high glucose-induced apoptosis through inhibition of NADPH oxidase activation-driven oxidative stress

3 June 2018

1 reference

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Transcription factor Nrf2-mediated antioxidant defense system in the development of diabetic retinopathy

3 June 2018

1 reference

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Regulation of SIRT1 by oxidative stress-responsive miRNAs and a systematic approach to identify its role in the endothelium

3 June 2018

1 reference

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Identification of a SIRT1 mutation in a family with type 1 diabetes

3 June 2018

1 reference

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Regulation of matrix metalloproteinase-9 by epigenetic modifications and the development of diabetic retinopathy

3 June 2018

1 reference

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MicroRNA-200b downregulates oxidation resistance 1 (Oxr1) expression in the retina of type 1 diabetes model

3 June 2018

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3 June 2018

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A possible gene silencing mechanism: hypermethylation of the Keap1 promoter abrogates binding of the transcription factor Sp1 in lung cancer cells

3 June 2018

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A compensatory mechanism protects retinal mitochondria from initial insult in diabetic retinopathy

3 June 2018

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The worldwide epidemic of diabetic retinopathy.

3 June 2018

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Metabolic memory and chronic diabetes complications: potential role for epigenetic mechanisms

3 June 2018

1 reference

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Aberrant DNA methylation and prostate cancer

3 June 2018

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Diabetes and alpha lipoic Acid.

3 June 2018

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Sirtuin 1-mediated cellular metabolic memory of high glucose via the LKB1/AMPK/ROS pathway and therapeutic effects of metformin

3 June 2018

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Roles of AMP-activated protein kinase in diabetes-induced retinal inflammation

3 June 2018

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miR-200a regulates Nrf2 activation by targeting Keap1 mRNA in breast cancer cells

3 June 2018

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Sirtuin-3 (Sirt3) regulates skeletal muscle metabolism and insulin signaling via altered mitochondrial oxidation and reactive oxygen species production

3 June 2018

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Pathophysiological roles of NADPH oxidase/nox family proteins in the vascular system. -Review and perspective-.

3 June 2018

1 reference

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Nrf2 has a protective role against neuronal and capillary degeneration in retinal ischemia-reperfusion injury

3 June 2018

1 reference

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SIRT1 as a potential therapeutic target for treatment of nonalcoholic fatty liver disease.

3 June 2018

1 reference

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AGEs and diabetic retinopathy.

3 June 2018

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TNF-α signals through PKCζ/NF-κB to alter the tight junction complex and increase retinal endothelial cell permeability

3 June 2018

1 reference

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Epigenetic regulation of high glucose-induced proinflammatory cytokine production in monocytes by curcumin

3 June 2018

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Plasma microRNA profiling reveals loss of endothelial miR-126 and other microRNAs in type 2 diabetes

3 June 2018

1 reference

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Resveratrol decreases the levels of miR-155 by upregulating miR-663, a microRNA targeting JunB and JunD

3 June 2018

1 reference

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Role of histone acetylation in the development of diabetic retinopathy and the metabolic memory phenomenon

3 June 2018

1 reference

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Role of protein kinase Czeta in thrombin-induced RhoA activation and inter-endothelial gap formation of human dermal microvessel endothelial cell monolayers

3 June 2018

1 reference

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The role of vitamin E and oxidative stress in diabetes complications

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5317113

Role of matrix metalloproteinase-9 in the development of diabetic retinopathy and its regulation by H-Ras

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5317113

Role of mitochondrial DNA damage in the development of diabetic retinopathy, and the metabolic memory phenomenon associated with its progression

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5317113

Translocation of H-Ras and its implications in the development of diabetic retinopathy

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5317113

Regulation of hypoxia-inducible factor 2alpha signaling by the stress-responsive deacetylase sirtuin 1.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5317113

BTG3 tumor suppressor gene promoter demethylation, histone modification and cell cycle arrest by genistein in renal cancer

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5317113

Hyperglycemia induces a dynamic cooperativity of histone methylase and demethylase enzymes associated with gene-activating epigenetic marks that coexist on the lysine tail

3 June 2018

1 reference

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Epigallocatechin-3-gallate, a histone acetyltransferase inhibitor, inhibits EBV-induced B lymphocyte transformation via suppression of RelA acetylation

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5317113

Overexpression of SIRT1 protects pancreatic beta-cells against cytokine toxicity by suppressing the nuclear factor-kappaB signaling pathway

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5317113

p38MAPK and ERK promote nitric oxide production in cultured human retinal pigmented epithelial cells induced by high concentration glucose.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5317113

Rho kinase inhibition by fasudil ameliorates diabetes-induced microvascular damage

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5317113

PKC inhibition and diabetic microvascular complications

3 June 2018

1 reference

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Inducible nitric oxide synthase isoform is a key mediator of leukostasis and blood-retinal barrier breakdown in diabetic retinopathy

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5317113

Oxidative stress and diabetic retinopathy

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5317113

Increased oxidative stress in diabetes regulates activation of a small molecular weight G-protein, H-Ras, in the retina

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5317113

Long-term effects of oral vitamin C supplementation on the endothelial dysfunction in the iris microvessels of diabetic rats

3 June 2018

1 reference

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Genome-wide analysis of histone lysine methylation variations caused by diabetic conditions in human monocytes

3 June 2018

1 reference

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Deregulated Ras signaling in developmental disorders: new tricks for an old dog.

3 June 2018

1 reference

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Advanced glycation end products: sparking the development of diabetic vascular injury

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5317113

H-Ras selectively up-regulates MMP-9 and COX-2 through activation of ERK1/2 and NF-kappaB: an implication for invasive phenotype in rat liver epithelial cells

3 June 2018

1 reference

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Nonproliferative retinopathy in diabetes type 2. Initial stages and characterization of phenotypes

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5317113

Pericytes and the prevention of diabetic retinopathy

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5317113

Rho activity critically and selectively regulates endothelial cell organization during angiogenesis

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5317113

Inhibition of GAPDH activity by poly(ADP-ribose) polymerase activates three major pathways of hyperglycemic damage in endothelial cells

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5317113

ROS generation by nonphagocytic NADPH oxidase: potential relevance in diabetic nephropathy

3 June 2018

1 reference

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Improved arterial compliance by a novel advanced glycation end-product crosslink breaker

3 June 2018

1 reference

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Rho-Rho-kinase pathway in smooth muscle contraction and cytoskeletal reorganization of non-muscle cells

3 June 2018

1 reference

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Chemistry and pathobiology of advanced glycation end products.

3 June 2018

1 reference

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Overview of matrix metalloproteinase expression in cultured human cells

3 June 2018

1 reference

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Mitogenic signaling mediated by oxidants in Ras-transformed fibroblasts

3 June 2018

1 reference

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Nitric oxide: a review of its role in retinal function and disease.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5317113

NIH conference. Aldose reductase and complications of diabetes

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5317113

Light-induced free radical oxidation of membrane lipids in photoreceptors of frog retina

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5317113

The sorbitol pathway and the complications of diabetes

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5317113

The function of myosin and myosin light chain kinase phosphorylation in smooth muscle

3 June 2018

1 reference

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The role of Raf-1 kinase in diabetic retinopathy.

3 June 2018

1 reference

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Downregulation of fibronectin overexpression reduces basement membrane thickening and vascular lesions in retinas of galactose-fed rats.

21 January 2018

1 reference

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Methylglyoxal induces hyperpermeability of the blood-retinal barrier via the loss of tight junction proteins and the activation of matrix metalloproteinases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2017%2F9702820

Diabetes-induced activation of caspase-3 in retina: effect of antioxidant therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2017%2F9702820

Diabetes-induced activation of nuclear transcriptional factor in the retina, and its inhibition by antioxidants.

21 January 2018

1 reference

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Retinopathy is reduced during experimental diabetes in a mouse model of outer retinal degeneration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2017%2F9702820

High glucose-induced tyrosine nitration in endothelial cells: role of eNOS uncoupling and aldose reductase activation

21 January 2018

1 reference

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Helicobacter pylori modulates cisplatin sensitivity in gastric cancer by down-regulating miR-141 expression

21 January 2018

1 reference

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Reactive oxygen species mediate cyclic strain-induced endothelin-1 gene expression via Ras/Raf/extracellular signal-regulated kinase pathway in endothelial cells

21 January 2018

1 reference

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Protection of human endothelial cells from oxidative stress: role of Ras-ERK1/2 signaling.

21 January 2018

1 reference

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Activated Ras induces a proangiogenic phenotype in primary endothelial cells.

21 January 2018

1 reference

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The involvement of the rho-kinase pathway and its regulation in cytokine-induced collagen gel contraction by hyalocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2017%2F9702820

Thioredoxin interacting protein (TXNIP) induces inflammation through chromatin modification in retinal capillary endothelial cells under diabetic conditions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2017%2F9702820

The glucagon like peptide 1 analogue, exendin-4, attenuates oxidative stress-induced retinal cell death in early diabetic rats through promoting Sirt1 and Sirt3 expression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2017%2F9702820

Green tea prevents hyperglycemia-induced retinal oxidative stress and inflammation in streptozotocin-induced diabetic rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2017%2F9702820

Effect of R-(+)-alpha-lipoic acid on experimental diabetic retinopathy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2017%2F9702820

Thiamine and benfotiamine prevent apoptosis induced by high glucose-conditioned extracellular matrix in human retinal pericytes

21 January 2018

1 reference

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Apoptosis and cell proliferation in proliferative retinal disorders: PCNA, Ki-67, caspase-3, and PARP expression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2017%2F9702820

PARP activation and the alteration of vasoactive factors and extracellular matrix protein in retina and kidney in diabetes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2017%2F9702820

Poly(ADP-ribose) polymerase is involved in the development of diabetic retinopathy via regulation of nuclear factor-kappaB.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2017%2F9702820

Endothelial MnSOD overexpression prevents retinal VEGF expression in diabetic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2017%2F9702820

Exogenous SOD mimetic tempol ameliorates the early retinal changes reestablishing the redox status in diabetic hypertensive rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2017%2F9702820

Zinc might protect oxidative changes in the retina and pancreas at the early stage of diabetic rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2017%2F9702820

Sulforaphane induces thioredoxin through the antioxidant-responsive element and attenuates retinal light damage in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2017%2F9702820

Role of Zinc Supplementation in Testicular and Epididymal Damages in Diabetic Rat: Involvement of Nrf2, SOD1, and GPX5.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2017%2F9702820

Oltipraz upregulates the nuclear factor (erythroid-derived 2)-like 2 [corrected](NRF2) antioxidant system and prevents insulin resistance and obesity induced by a high-fat diet in C57BL/6J mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2017%2F9702820

Overexpression of mitochondrial superoxide dismutase in mice protects the retina from diabetes-induced oxidative stress

21 January 2018

1 reference

12 December 2020

Retinal neovascularization is suppressed with a matrix metalloproteinase inhibitor

1 reference

12 December 2020

Vitamin E prevents diabetes-induced abnormal retinal blood flow via the diacylglycerol-protein kinase C pathway

1 reference

12 December 2020

Antioxidant treatment of experimental diabetic retinopathy in rats with nicanartine

1 reference

12 December 2020

Pharmacologic induction of heme oxygenase-1 plays a protective role in diabetic retinopathy in rats

1 reference

12 December 2020

Does dark adaptation exacerbate diabetic retinopathy? Evidence and a linking hypothesis

1 reference

12 December 2020

Oxidative stress and increased eNOS and NADPH oxidase expression in mouse microvessel endothelial cells

1 reference

12 December 2020

1 reference

12 December 2020

Curcumin inhibits hypoxia-induced angiogenesis via down-regulation of HIF-1

1 reference

12 December 2020

The impact of 1,25-dihydroxy vitamin D3 on the expressions of vascular endothelial growth factor and transforming growth factor-β₁ in the retinas of rats with diabetes

1 reference

12 December 2020

Serum markers of oxidative stress and severity of diabetic retinopathy

1 reference

12 December 2020

Mitochondrial DNA mutations, oxidative stress, and aging

1 reference

12 December 2020

Q&A: Five questions on the 2015 IDF Diabetes Atlas

1 reference

12 December 2020

Pigment epithelium-derived factor inhibits advanced glycation end product-induced retinal vascular hyperpermeability by blocking reactive oxygen species-mediated vascular endothelial growth factor expression

1 reference

12 December 2020

Increased vitreous concentrations of MCP-1 and IL-6 after vitrectomy in patients with proliferative diabetic retinopathy: possible association with postoperative macular oedema

1 reference

12 December 2020

Effect of curcumin on hyperglycemia-induced vascular endothelial growth factor expression in streptozotocin-induced diabetic rat retina

1 reference

12 December 2020

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pmc&retmode=json&id=5317113

Identifiers

2 references

8 April 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28265339%20AND%20SRC:MED&resulttype=core&format=json

4 April 2020

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pmc&retmode=json&id=5317113

8 April 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28265339%20AND%20SRC:MED&resulttype=core&format=json

4 April 2020

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pmc&retmode=json&id=5317113

8 April 2017