Microglia activation due to obesity programs metabolic failure leading to type two diabetes (Q37737776)

22 August 2017

7 references

13 March 2019

14 March 2019

19 March 2019

24 March 2019

12 September 2019

4 February 2021

29 April 2021

Microglia activation due to obesity programs metabolic failure leading to type two diabetes (English)

1 reference

22 August 2017

0 references

5 references

13 March 2019

14 March 2019

19 March 2019

24 March 2019

12 September 2019

2 references

12 September 2019

4 February 2021

1 reference

12 September 2019

1 reference

29 April 2021

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28319103%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

Alberto Camacho-Morales

series ordinal

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28319103%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

author name string

L Montalvo-Martínez

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28319103%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

L Fuentes-Mera

series ordinal

3

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1 June 2020

publication date

20 March 2017

8 references

22 August 2017

13 March 2019

14 March 2019

19 March 2019

24 March 2019

12 September 2019

4 February 2021

29 April 2021

8 references

13 March 2019

14 March 2019

19 March 2019

24 March 2019

12 September 2019

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28319103%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

4 February 2021

29 April 2021

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28319103%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

page(s)

e254

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28319103%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

issue

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28319103%20AND%20SRC:MED&resulttype=core&format=json

Creative Commons Attribution 4.0 International

1 June 2020

copyright license

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13 March 2019

14 March 2019

19 March 2019

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12 September 2019

4 February 2021

on focus list of Wikimedia project

29 April 2021

copyright status

copyrighted

0 references

ScienceSource

0 references

exact match

https://scigraph.springernature.com/pub.10.1038/nutd.2017.10

0 references

cites work

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Brain Lipotoxicity of Phytanic Acid and Very Long-chain Fatty Acids. Harmful Cellular/Mitochondrial Activities in Refsum Disease and X-Linked Adrenoleukodystrophy

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22 August 2017

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Roles of Chemokines and Chemokine Receptors in Obesity-Associated Insulin Resistance and Nonalcoholic Fatty Liver Disease

22 August 2017

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Is interleukin-1β a culprit in macrophage-adipocyte crosstalk in obesity?

22 August 2017

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Brain innate immunity regulates hypothalamic arcuate neuronal activity and feeding behavior

22 August 2017

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Neonatal overfeeding attenuates acute central pro-inflammatory effects of short-term high fat diet

22 August 2017

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A subcutaneous adipose tissue-liver signalling axis controls hepatic gluconeogenesis

22 August 2017

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Microglia dictate the impact of saturated fat consumption on hypothalamic inflammation and neuronal function.

22 August 2017

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Targeting inflammation in diabetes: Newer therapeutic options

22 August 2017

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Reduced immune cell infiltration and increased pro-inflammatory mediators in the brain of Type 2 diabetic mouse model infected with West Nile virus

22 August 2017

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Central inflammation and leptin resistance are attenuated by ginsenoside Rb1 treatment in obese mice fed a high-fat diet

22 August 2017

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Deficient neuron-microglia signaling results in impaired functional brain connectivity and social behavior.

22 August 2017

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Sustained, neuron-specific IKK/NF-κB activation generates a selective neuroinflammatory response promoting local neurodegeneration with aging

22 August 2017

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Adipokines mediate inflammation and insulin resistance

22 August 2017

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Acute-phase serum amyloid a in osteoarthritis: regulatory mechanism and proinflammatory properties

22 August 2017

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An inhibitor of the protein kinases TBK1 and IKK-ɛ improves obesity-related metabolic dysfunctions in mice

22 August 2017

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Expression of novel Alzheimer's disease risk genes in control and Alzheimer's disease brains

22 August 2017

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Saturated fatty acids activate TLR-mediated proinflammatory signaling pathways.

22 August 2017

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Microglia sculpt postnatal neural circuits in an activity and complement-dependent manner

22 August 2017

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Molecular basis of Tank-binding kinase 1 activation by transautophosphorylation

22 August 2017

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Obesity is associated with hypothalamic injury in rodents and humans

22 August 2017

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Remodeling of the arcuate nucleus energy-balance circuit is inhibited in obese mice

22 August 2017

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NLRP3 inflammasomes link inflammation and metabolic disease

22 August 2017

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Association of lipidome remodeling in the adipocyte membrane with acquired obesity in humans

22 August 2017

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Inflammatory links between obesity and metabolic disease

22 August 2017

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B cells promote insulin resistance through modulation of T cells and production of pathogenic IgG antibodies

22 August 2017

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Differential lipid partitioning between adipocytes and tissue macrophages modulates macrophage lipotoxicity and M2/M1 polarization in obese mice

22 August 2017

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Inflammation of the hypothalamus leads to defective pancreatic islet function.

22 August 2017

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The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance

22 August 2017

1 reference

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The inflammasome-mediated caspase-1 activation controls adipocyte differentiation and insulin sensitivity

22 August 2017

1 reference

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IL-6 and IL-10 anti-inflammatory activity links exercise to hypothalamic insulin and leptin sensitivity through IKKbeta and ER stress inhibition

22 August 2017

1 reference

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The nuclear factor NF-kappaB pathway in inflammation

22 August 2017

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Central administration of interleukin-4 exacerbates hypothalamic inflammation and weight gain during high-fat feeding

22 August 2017

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Adipose tissue expandability, lipotoxicity and the Metabolic Syndrome--an allostatic perspective

22 August 2017

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Saturated fatty acids produce an inflammatory response predominantly through the activation of TLR4 signaling in hypothalamus: implications for the pathogenesis of obesity

22 August 2017

1 reference

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Hypothalamic proinflammatory lipid accumulation, inflammation, and insulin resistance in rats fed a high-fat diet

22 August 2017

1 reference

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Hypothalamic IKKbeta/NF-kappaB and ER stress link overnutrition to energy imbalance and obesity

22 August 2017

1 reference

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It's not how fat you are, it's what you do with it that counts

22 August 2017

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The classical complement cascade mediates CNS synapse elimination

22 August 2017

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Expression of serum amyloid A transcripts in human bone tissues, differentiated osteoblast-like stem cells and human osteosarcoma cell lines

22 August 2017

1 reference

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Relationship of metabolic risk factors and development of cardiovascular disease and diabetes.

22 August 2017

1 reference

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Role of complement in neurodegeneration and neuroinflammation.

22 August 2017

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Recent advances in the relationship between obesity, inflammation, and insulin resistance.

22 August 2017

1 reference

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Role of endoplasmic reticulum stress and c-Jun NH2-terminal kinase pathways in inflammation and origin of obesity and diabetes

22 August 2017

1 reference

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Hypothalamic K(ATP) channels control hepatic glucose production

22 August 2017

1 reference

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The adipocyte as an endocrine cell

22 August 2017

1 reference

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Obesity is associated with macrophage accumulation in adipose tissue

22 August 2017

1 reference

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The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus

22 August 2017

2 references

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22 August 2017

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Adiponectin expression from human adipose tissue: relation to obesity, insulin resistance, and tumor necrosis factor-alpha expression

1 September 2018

1 reference

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NF-kappaB activation by a signaling complex containing TRAF2, TANK and TBK1, a novel IKK-related kinase

22 August 2017

1 reference

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Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance

22 August 2017

1 reference

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Ceramides - Lipotoxic Inducers of Metabolic Disorders

22 August 2017

1 reference

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Neuroinflammation and neurodegeneration in overnutrition-induced diseases

22 August 2017

1 reference

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Microglia: actively surveying and shaping neuronal circuit structure and function.

22 August 2017

1 reference

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Obesity and C-reactive protein in various populations: a systematic review and meta-analysis.

22 August 2017

1 reference

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The nuclear factor kappa B signaling pathway: integrating metabolism with inflammation

22 August 2017

1 reference

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Protection from high fat diet-induced increase in ceramide in mice lacking plasminogen activator inhibitor 1.

22 August 2017

1 reference

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Tissue resident macrophages: Key players in the pathogenesis of type 2 diabetes and its complications

22 August 2017

1 reference

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Lipid signaling and lipotoxicity in metaflammation: indications for metabolic disease pathogenesis and treatment

6 September 2017

1 reference

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Palmitic acid induces interleukin-1β secretion via NLRP3 inflammasomes and inflammatory responses through ROS production in human placental cells

6 September 2017

1 reference

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Effects of cholesterol oxides on cell death induction and calcium increase in human neuronal cells (SK-N-BE) and evaluation of the protective effects of docosahexaenoic acid (DHA; C22:6 n-3).

6 September 2017

1 reference

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Central inhibition of IKKβ/NF-κB signaling attenuates high-fat diet-induced obesity and glucose intolerance.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5380893

Saturated fatty acids activate microglia via Toll-like receptor 4/NF-κB signalling

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5380893

Low-grade hypothalamic inflammation leads to defective thermogenesis, insulin resistance, and impaired insulin secretion

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5380893

Neuroprotective Effects of Endurance Exercise Against High-Fat Diet-Induced Hippocampal Neuroinflammation

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5380893

IL-6 plays a critical role in the synergistic induction of human serum amyloid A (SAA) gene when stimulated with proinflammatory cytokines as analyzed with an SAA isoform real-time quantitative RT-PCR assay system

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5380893

Inhibition of de novo ceramide synthesis reverses diet-induced insulin resistance and enhances whole-body oxygen consumption

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5380893

The effect of abscisic acid chronic treatment on neuroinflammatory markers and memory in a rat model of high-fat diet induced neuroinflammation

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5380893

Genetic obesity alters recruitment of TANK-binding kinase 1 and AKT into hypothalamic lipid rafts domains.

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5380893

Neonatal overfeeding alters hypothalamic microglial profiles and central responses to immune challenge long-term

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5380893

Obesity induced by a high-fat diet is associated with increased immune cell entry into the central nervous system.

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5380893

IKKβ/NF-κB disrupts adult hypothalamic neural stem cells to mediate a neurodegenerative mechanism of dietary obesity and pre-diabetes

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5380893

Inhibition of hypothalamic inflammation reverses diet-induced insulin resistance in the liver.

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5380893

Ceramide content is increased in skeletal muscle from obese insulin-resistant humans

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5380893

Secretion of adiponectin and regulation of apM1 gene expression in human visceral adipose tissue

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5380893

Canagliflozin, a sodium glucose cotransporter 2 inhibitor, attenuates obesity-induced inflammation in the nodose ganglion, hypothalamus, and skeletal muscle of mice.

23 June 2018

1 reference

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Effects of liraglutide in hypothalamic arcuate nucleus of obese mice.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5380893

PCR array and protein array studies demonstrate that IL-1β (interleukin-1β) stimulates the expression and secretion of multiple cytokines and chemokines in human adipocytes.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5380893

Fractalkine (CX3CL1) is involved in the early activation of hypothalamic inflammation in experimental obesity.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5380893

IKKε is key to induction of insulin resistance in the hypothalamus, and its inhibition reverses obesity.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5380893

Microglial CR3 activation triggers long-term synaptic depression in the hippocampus via NADPH oxidase.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5380893

Adipose tissue expandability, lipotoxicity and the metabolic syndrome.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5380893

The effects of dietary saturated fat on basal hypothalamic neuroinflammation in rats

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5380893

A distinct vagal anti-inflammatory pathway modulates intestinal muscularis resident macrophages independent of the spleen.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5380893

[Development of main disturbances of hemostasis in patients with obesity].

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5380893

XOMA 052, an anti-IL-1{beta} monoclonal antibody, improves glucose control and {beta}-cell function in the diet-induced obesity mouse model

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5380893

TANK-binding kinase 1 mediates phosphorylation of insulin receptor at serine residue 994: a potential link between inflammation and insulin resistance

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5380893

Serum saturated fatty acids containing triacylglycerols are better markers of insulin resistance than total serum triacylglycerol concentrations.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5380893

Lower expression of adiponectin mRNA in visceral adipose tissue in lean and obese subjects.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5380893

C-reactive protein activates complement in infarcted human myocardium

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5380893

Insulin resistance and adiposity correlate with acute-phase reaction and soluble cell adhesion molecules in type 2 diabetes

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5380893

Hypothalamic insulin signaling is required for inhibition of glucose production

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5380893

PPARgamma ligands increase expression and plasma concentrations of adiponectin, an adipose-derived protein

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5380893

Interleukin-6 stimulates hepatic triglyceride secretion in rats

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5380893

Comparative Perspectives on Oxytocin and Vasopressin Receptor Research in Rodents and Primates: Translational Implications

1 September 2018

1 reference

https://api.crossref.org/works/10.1038%2FNUTD.2017.10

Plasma ceramide and lysophosphatidylcholine inversely correlate with mortality in sepsis patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNUTD.2017.10

Serum amyloid A: production by human white adipocyte and regulation by obesity and nutrition

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNUTD.2017.10

Systemic low-grade inflammation is related to both circulating and adipose tissue TNFalpha, leptin and IL-6 levels in obese women

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNUTD.2017.10

31 March 2020

Identifiers

DOI

10.1038/NUTD.2017.10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28319103%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

1 June 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28319103%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

1 reference