Why are Functional Amyloids Non-Toxic in Humans? (Q46302841)

19 February 2018

3 references

24 March 2019

16 November 2019

20 November 2019

Why are Functional Amyloids Non-Toxic in Humans? (English)

1 reference

19 February 2018

macromolecular substances

3 references

24 March 2019

16 November 2019

20 November 2019

1 reference

16 November 2019

1 reference

20 November 2019

amyloid fibril formation

1 reference

Gene Ontology release 2020-05-02

Eric W Hewitt

2

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author name string

Matthew P Jackson

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1

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19 February 2018

language of work or name

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22 September 2017

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19 February 2018

full work available at URL

24 March 2019

16 November 2019

20 November 2019

http://eprints.whiterose.ac.uk/122038/

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White Rose Research Online

object has role

published version

copyright license

Creative Commons Attribution 4.0 International

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published in

Biomolecules

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19 February 2018

24 March 2019

16 November 2019

20 November 2019

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19 February 2018

issue

4

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19 February 2018

Creative Commons Attribution

copyright license

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24 March 2019

16 November 2019

20 November 2019

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on focus list of Wikimedia project

ScienceSource

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cites work

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Semen amyloids participate in spermatozoa selection and clearance

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Complex Pathologic Roles of RIPK1 and RIPK3: Moving Beyond Necroptosis

24 May 2018

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24 May 2018

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24 May 2018

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Amyloidogenic amyloid-β-peptide variants induce microbial agglutination and exert antimicrobial activity

24 May 2018

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PMEL Amyloid Fibril Formation: The Bright Steps of Pigmentation

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Historical and Current Concepts of Fibrillogenesis and In vivo Amyloidogenesis: Implications of Amyloid Tissue Targeting

24 May 2018

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Amyloid-β peptide protects against microbial infection in mouse and worm models of Alzheimer's disease

24 May 2018

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The Role of Amyloid-β Oligomers in Toxicity, Propagation, and Immunotherapy

24 May 2018

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An outline of necrosome triggers

24 May 2018

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Amyloid Fibres: Inert End-Stage Aggregates or Key Players in Disease?

24 May 2018

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24 May 2018

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pH-induced molecular shedding drives the formation of amyloid fibril-derived oligomers

24 May 2018

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ADAM protease inhibitors reduce melanogenesis by regulating PMEL17 processing in human melanocytes

24 May 2018

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Bioactive TTR105-115-based amyloid fibrils reduce the viability of mammalian cells

24 May 2018

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β2-Microglobulin amyloid fibril-induced membrane disruption is enhanced by endosomal lipids and acidic pH

24 May 2018

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SEVI, the semen enhancer of HIV infection along with fragments from its central region, form amyloid fibrils that are toxic to neuronal cells

24 May 2018

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Proteostasis impairment in protein-misfolding and -aggregation diseases

24 May 2018

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The amyloid state and its association with protein misfolding diseases.

24 May 2018

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Functional amyloids in the mouse sperm acrosome

24 May 2018

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Aggregation modulators interfere with membrane interactions of β2-microglobulin fibrils

24 May 2018

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BACE2 processes PMEL to form the melanosome amyloid matrix in pigment cells

24 May 2018

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Proliferation of amyloid-β42 aggregates occurs through a secondary nucleation mechanism

24 May 2018

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Common mechanism unites membrane poration by amyloid and antimicrobial peptides

24 May 2018

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The antimicrobial peptide LL-37 alters human osteoblast Ca2+ handling and induces Ca2+-independent apoptosis.

24 May 2018

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PMEL: a pigment cell-specific model for functional amyloid formation

24 May 2018

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Molecular structures of amyloid and prion fibrils: consensus versus controversy

24 May 2018

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Antimicrobial activity and molecular mechanism of the CRES protein

24 May 2018

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Direct three-dimensional visualization of membrane disruption by amyloid fibrils

24 May 2018

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The RIP1/RIP3 necrosome forms a functional amyloid signaling complex required for programmed necrosis

24 May 2018

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Direct observation of the interconversion of normal and toxic forms of α-synuclein

24 May 2018

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Nonpathological extracellular amyloid is present during normal epididymal sperm maturation

24 May 2018

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Membrane lipid composition and its physicochemical properties define cell vulnerability to aberrant protein oligomers

24 May 2018

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A molecular history of the amyloidoses

24 May 2018

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Acrosome biogenesis: Revisiting old questions to yield new insights

24 May 2018

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Peptides released by physiological cleavage of semen coagulum proteins form amyloids that enhance HIV infection

24 May 2018

1 reference

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Binding with nucleic acids or glycosaminoglycans converts soluble protein oligomers to amyloid

24 May 2018

1 reference

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Probing fibril dissolution of the repeat domain of a functional amyloid, Pmel17, on the microscopic and residue level

24 May 2018

1 reference

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Antimicrobial properties of amyloid peptides

24 May 2018

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Mutations in or near the transmembrane domain alter PMEL amyloid formation from functional to pathogenic

24 May 2018

1 reference

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Inactivation of Pmel alters melanosome shape but has only a subtle effect on visible pigmentation

24 May 2018

1 reference

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Heparin induces harmless fibril formation in amyloidogenic W7FW14F apomyoglobin and amyloid aggregation in wild-type protein in vitro

24 May 2018

1 reference

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Antimicrobial protegrin-1 forms amyloid-like fibrils with rapid kinetics suggesting a functional link

24 May 2018

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Amyloid precursor protein processing and Alzheimer's disease

24 May 2018

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Proprotein convertases process Pmel17 during secretion

24 May 2018

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Alterations in the testis and epididymis associated with loss of function of the cystatin-related epididymal spermatogenic (CRES) protein

24 May 2018

1 reference

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Biochemical and biophysical features of both oligomer/fibril and cell membrane in amyloid cytotoxicity.

24 May 2018

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Functional amyloid: turning swords into plowshares

24 May 2018

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Reduced fertility in vitro in mice lacking the cystatin CRES (cystatin-related epididymal spermatogenic): rescue by exposure of spermatozoa to dibutyryl cAMP and isobutylmethylxanthine

24 May 2018

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Resveratrol selectively remodels soluble oligomers and fibrils of amyloid Abeta into off-pathway conformers

24 May 2018

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Structural conversion of neurotoxic amyloid-beta(1-42) oligomers to fibrils

24 May 2018

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The Alzheimer's disease-associated amyloid beta-protein is an antimicrobial peptide

24 May 2018

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Comparison of aggregation enhancement and inhibition as strategies for reducing the cytotoxicity of the aortic amyloid polypeptide medin.

24 May 2018

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The human cathelicidin LL-37 preferentially promotes apoptosis of infected airway epithelium

24 May 2018

1 reference

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A causative link between the structure of aberrant protein oligomers and their toxicity.

24 May 2018

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Fibril fragmentation enhances amyloid cytotoxicity

24 May 2018

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24 May 2018

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The repeat domain of the melanosome fibril protein Pmel17 forms the amyloid core promoting melanin synthesis

24 May 2018

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Secondary necrosis of apoptotic neutrophils induced by the human cathelicidin LL-37 is not proinflammatory to phagocytosing macrophages

24 May 2018

1 reference

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Functional amyloids as natural storage of peptide hormones in pituitary secretory granules

24 May 2018

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Formation of Pmel17 amyloid is regulated by juxtamembrane metalloproteinase cleavage, and the resulting C-terminal fragment is a substrate for gamma-secretase

24 May 2018

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Neutrophil secondary necrosis is induced by LL-37 derived from cathelicidin

24 May 2018

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Membrane damage by human islet amyloid polypeptide through fibril growth at the membrane

24 May 2018

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Functionalised amyloid fibrils for roles in cell adhesion

24 May 2018

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Semen-derived amyloid fibrils drastically enhance HIV infection

24 May 2018

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Fibril specific, conformation dependent antibodies recognize a generic epitope common to amyloid fibrils and fibrillar oligomers that is absent in prefibrillar oligomers

24 May 2018

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Human antimicrobial peptide LL-37 is present in atherosclerotic plaques and induces death of vascular smooth muscle cells: a laboratory study

24 May 2018

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Solution state characterization of amyloid beta-derived diffusible ligands

24 May 2018

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Protein misfolding, functional amyloid, and human disease

24 May 2018

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A specific amyloid-beta protein assembly in the brain impairs memory

24 May 2018

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Functional amyloid formation within mammalian tissue

24 May 2018

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Amyloid: toward terminology clarification. Report from the Nomenclature Committee of the International Society of Amyloidosis.

24 May 2018

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Calcium dysregulation and membrane disruption as a ubiquitous neurotoxic mechanism of soluble amyloid oligomers

24 May 2018

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Self-propagating, molecular-level polymorphism in Alzheimer's beta-amyloid fibrils

24 May 2018

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The Dominant white, Dun and Smoky color variants in chicken are associated with insertion/deletion polymorphisms in the PMEL17 gene

24 May 2018

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Prefibrillar amyloid protein aggregates share common features of cytotoxicity.

24 May 2018

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Proprotein convertase cleavage liberates a fibrillogenic fragment of a resident glycoprotein to initiate melanosome biogenesis

24 May 2018

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Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis

24 May 2018

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Inherent toxicity of aggregates implies a common mechanism for protein misfolding diseases

24 May 2018

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Conformational Abs recognizing a generic amyloid fibril epitope

24 May 2018

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Review: history of the amyloid fibril

24 May 2018

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Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins

24 May 2018

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Molecular organization of prolactin granules. II. Characterization of glycosaminoglycans and glycoproteins of the bovine prolactin matrix

24 May 2018

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Amyloid fibril proteins and amyloidosis: chemical identification and clinical classification International Society of Amyloidosis 2016 Nomenclature Guidelines.

24 May 2018

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Functional amyloid: widespread in Nature, diverse in purpose.

15 August 2018

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Amyloid-hydroxyapatite bone biomimetic composites.

15 August 2018

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Binding of LL-37 to model biomembranes: insight into target vs host cell recognition.

15 August 2018

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Prefibrillar amyloid aggregates could be generic toxins in higher organisms.

15 August 2018

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Distinct early folding and aggregation properties of Alzheimer amyloid-beta peptides Abeta40 and Abeta42: stable trimer or tetramer formation by Abeta42.

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5745454

Permeabilization of lipid bilayers is a common conformation-dependent activity of soluble amyloid oligomers in protein misfolding diseases

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5745454

The oligomerization of amyloid beta-protein begins intracellularly in cells derived from human brain

15 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/28937655

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.3390/BIOM7040071

1 reference

19 February 2018

Dimensions Publication ID

0 references

0 references

0 references

1 reference

19 February 2018

PubMed ID

28937655

1 reference

19 February 2018