Implications of HIV-1 Nef for "Shock and Kill" Strategies to Eliminate Latent Viral Reservoirs (Q60925679)

12 December 2020

Serine phosphorylation-independent downregulation of cell-surface CD4 by nef

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12 December 2020

Structure and expression of tat-, rev-, and nef-specific transcripts of human immunodeficiency virus type 1 in infected lymphocytes and macrophages

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12 December 2020

Temporal aspects of DNA and RNA synthesis during human immunodeficiency virus infection: evidence for differential gene expression

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12 December 2020

Apoptosis occurs predominantly in bystander cells and not in productively infected cells of HIV- and SIV-infected lymph nodes

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12 December 2020

Extracellular Nef protein regulates productive HIV-1 infection from latency.

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12 December 2020

Nef induces CD4 endocytosis: requirement for a critical dileucine motif in the membrane-proximal CD4 cytoplasmic domain

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12 December 2020

Temporal association of cellular immune responses with the initial control of viremia in primary human immunodeficiency virus type 1 syndrome

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12 December 2020

Endocytosis of major histocompatibility complex class I molecules is induced by the HIV–1 Nef protein

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12 December 2020

Soluble Nef antigen of HIV-1 is cytotoxic for human CD4+ T cells

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12 December 2020

Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways

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12 December 2020

Antiviral pressure exerted by HIV-1-specific cytotoxic T lymphocytes (CTLs) during primary infection demonstrated by rapid selection of CTL escape virus

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12 December 2020

Nef protein of HIV-1 induces apoptotic cytolysis of murine lymphoid cells independently of CD95 (Fas) and its suppression by serine/threonine protein kinase inhibitors

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12 December 2020

HIV-1 Nef protein protects infected primary cells against killing by cytotoxic T lymphocytes.

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12 December 2020

Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1.

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12 December 2020

Nef interacts with the mu subunit of clathrin adaptor complexes and reveals a cryptic sorting signal in MHC I molecules

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12 December 2020

Activation of apoptosis signal-regulating kinase 1 (ASK1) by the adapter protein Daxx

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12 December 2020

ASK1 is essential for JNK/SAPK activation by TRAF2

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12 December 2020

Nef-induced CD4 and major histocompatibility complex class I (MHC-I) down-regulation are governed by distinct determinants: N-terminal alpha helix and proline repeat of Nef selectively regulate MHC-I trafficking

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12 December 2020

HIV-1 Nef plays an essential role in two independent processes in CD4 down-regulation: dissociation of the CD4-p56(lck) complex and targeting of CD4 to lysosomes.

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12 December 2020

Induction of Fas ligand expression by HIV involves the interaction of Nef with the T cell receptor zeta chain

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12 December 2020

Inhibition of HIV-1 progeny virion release by cell-surface CD4 is relieved by expression of the viral Nef protein

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12 December 2020

Cell-surface expression of CD4 reduces HIV-1 infectivity by blocking Env incorporation in a Nef- and Vpu-inhibitable manner

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12 December 2020

Activation of Vav by Nef induces cytoskeletal rearrangements and downstream effector functions

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12 December 2020

The selective downregulation of class I major histocompatibility complex proteins by HIV-1 protects HIV-infected cells from NK cells

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12 December 2020

Effect of long-term infection with nef-defective attenuated HIV type 1 on CD4+ and CD8+ T lymphocytes: increased CD45RO+CD4+ T lymphocytes and limited activation of CD8+ T lymphocytes

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12 December 2020

Regulation of BAD phosphorylation at serine 112 by the Ras-mitogen-activated protein kinase pathway

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12 December 2020

Synergistic activation of NFAT by HIV-1 nef and the Ras/MAPK pathway

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12 December 2020

T-tropic human immunodeficiency virus (HIV) type 1 Nef protein enters human monocyte-macrophages and induces resistance to HIV replication: a possible mechanism of HIV T-tropic emergence in AIDS.

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12 December 2020

Mechanism for down-regulation of CD28 by Nef.

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12 December 2020

HIV-1 Nef inhibits ASK1-dependent death signalling providing a potential mechanism for protecting the infected host cell

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12 December 2020

The pathogenicity of human immunodeficiency virus (HIV) type 1 Nef in CD4C/HIV transgenic mice is abolished by mutation of its SH3-binding domain, and disease development is delayed in the absence of Hck.

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12 December 2020

HIV-1 Nef activates STAT1 in human monocytes/macrophages through the release of soluble factors

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12 December 2020

HIV-1 Nef associated PAK and PI3-kinases stimulate Akt-independent Bad-phosphorylation to induce anti-apoptotic signals

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12 December 2020

Human immunodeficiency virus type 1 Nef binds to tumor suppressor p53 and protects cells against p53-mediated apoptosis.

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12 December 2020

HIV-1 Nef interacts with inositol trisphosphate receptor to activate calcium signaling in T cells

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12 December 2020

Extracellular Nef protein activates signal transduction pathway from Ras to mitogen-activated protein kinase cascades that leads to activation of human immunodeficiency virus from latency

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12 December 2020

HIV preferentially infects HIV-specific CD4+ T cells

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12 December 2020

TNF-R1 signaling: a beautiful pathway

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12 December 2020

Effects of interleukin-2 plus highly active antiretroviral therapy on HIV-1 replication and proviral DNA (COSMIC trial).

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12 December 2020

Effects of prostratin on T-cell activation and human immunodeficiency virus latency

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12 December 2020

Exogenous Nef protein activates NF-kappa B, AP-1, and c-Jun N-terminal kinase and stimulates HIV transcription in promonocytic cells. Role in AIDS pathogenesis

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12 December 2020

Enhanced CD4 down-modulation by late stage HIV-1 nef alleles is associated with increased Env incorporation and viral replication.

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12 December 2020

Dominant influence of HLA-B in mediating the potential co-evolution of HIV and HLA.

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12 December 2020

CD4 down-regulation by HIV-1 and simian immunodeficiency virus (SIV) Nef proteins involves both internalization and intracellular retention mechanisms.

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12 December 2020

HIV-1 Nef-induced FasL induction and bystander killing requires p38 MAPK activation

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12 December 2020

Human immunodeficiency virus type-1 infection impairs the formation of the immunological synapse

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12 December 2020

Contribution of Vpu, Env, and Nef to CD4 down-modulation and resistance of human immunodeficiency virus type 1-infected T cells to superinfection

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12 December 2020

HLA Alleles Associated with Delayed Progression to AIDS Contribute Strongly to the Initial CD8(+) T Cell Response against HIV-1.

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12 December 2020

Modulation of the immunological synapse: a key to HIV-1 pathogenesis?

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12 December 2020

HIV-1 Nef employs two distinct mechanisms to modulate Lck subcellular localization and TCR induced actin remodeling

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12 December 2020

Human immunodeficiency virus type 1 Nef recruits the guanine exchange factor Vav1 via an unexpected interface into plasma membrane microdomains for association with p21-activated kinase 2 activity

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12 December 2020

Induction of HIV transcription by Nef involves Lck activation and protein kinase C theta raft recruitment leading to activation of ERK1/2 but not NF kappa B.

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12 December 2020

Long-term control of HIV by CCR5 Delta32/Delta32 stem-cell transplantation

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12 December 2020

IL-7 administration drives T cell-cycle entry and expansion in HIV-1 infection

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12 December 2020

Nef-induced CD4 endocytosis in human immunodeficiency virus type 1 host cells: role of p56lck kinase

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12 December 2020

HIV-1 Nef interferes with host cell motility by deregulation of Cofilin

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12 December 2020

Inhibition of T-cell receptor-induced actin remodeling and relocalization of Lck are evolutionarily conserved activities of lentiviral Nef proteins

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12 December 2020

Massive Secretion by T Cells Is Caused by HIV Nef in Infected Cells and by Nef Transfer to Bystander Cells

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12 December 2020

HIV Nef is secreted in exosomes and triggers apoptosis in bystander CD4+ T cells

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12 December 2020

Lentiviral Nef proteins utilize PAK2-mediated deregulation of cofilin as a general strategy to interfere with actin remodeling

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12 December 2020

ADAM-17: the enzyme that does it all.

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12 December 2020

Bryostatin modulates latent HIV-1 infection via PKC and AMPK signaling but inhibits acute infection in a receptor independent manner

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12 December 2020

HIV Type 1 Nef is released from infected cells in CD45(+) microvesicles and is present in the plasma of HIV-infected individuals

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12 December 2020

HIV-1 Nef compensates for disorganization of the immunological synapse by inducing trans-Golgi network-associated Lck signaling

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12 December 2020

Stimulation of HIV-1-specific cytolytic T lymphocytes facilitates elimination of latent viral reservoir after virus reactivation

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12 December 2020

Disulfiram reactivates latent HIV-1 expression through depletion of the phosphatase and tensin homolog

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12 December 2020

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12 December 2020

Administration of vorinostat disrupts HIV-1 latency in patients on antiretroviral therapy

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12 December 2020

HIV Nef, paxillin, and Pak1/2 regulate activation and secretion of TACE/ADAM10 proteases

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12 December 2020

Challenges in detecting HIV persistence during potentially curative interventions: a study of the Berlin patient

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12 December 2020

Replication-competent noninduced proviruses in the latent reservoir increase barrier to HIV-1 cure.

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12 December 2020

Interaction with cellular CD4 exposes HIV-1 envelope epitopes targeted by antibody-dependent cell-mediated cytotoxicity

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12 December 2020

Histone deacetylase inhibitors and cell death

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12 December 2020

Antiretroviral-free HIV-1 remission and viral rebound after allogeneic stem cell transplantation: report of 2 cases

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12 December 2020

Histone deacetylase inhibitors impair the elimination of HIV-infected cells by cytotoxic T-lymphocytes

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12 December 2020

The HIV-1 gp120 CD4-bound conformation is preferentially targeted by antibody-dependent cellular cytotoxicity-mediating antibodies in sera from HIV-1-infected individuals

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12 December 2020

Activation of HIV transcription with short-course vorinostat in HIV-infected patients on suppressive antiretroviral therapy

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12 December 2020

HIV-1 Nef: a master manipulator of the membrane trafficking machinery mediating immune evasion

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12 December 2020

The Depsipeptide Romidepsin Reverses HIV-1 Latency In Vivo

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12 December 2020

SERINC3 and SERINC5 restrict HIV-1 infectivity and are counteracted by Nef

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12 December 2020

HIV-1 Nef promotes infection by excluding SERINC5 from virion incorporation

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12 December 2020

Panobinostat, a histone deacetylase inhibitor, for latent-virus reactivation in HIV-infected patients on suppressive antiretroviral therapy: a phase 1/2, single group, clinical trial

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12 December 2020

Latent HIV-1 is activated by exosomes from cells infected with either replication-competent or defective HIV-1.

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12 December 2020

Nef Proteins from HIV-1 Elite Controllers Are Inefficient at Preventing Antibody-Dependent Cellular Cytotoxicity

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12 December 2020

Bryostatin-1 for latent virus reactivation in HIV-infected patients on antiretroviral therapy

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12 December 2020

Tuning of AKT-pathway by Nef and its blockade by protease inhibitors results in limited recovery in latently HIV infected T-cell line

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12 December 2020

HIV-1 Nef: Taking Control of Protein Trafficking

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12 December 2020

The Effect of Latency Reversal Agents on Primary CD8+ T Cells: Implications for Shock and Kill Strategies for Human Immunodeficiency Virus Eradication

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12 December 2020

The differential short- and long-term effects of HIV-1 latency-reversing agents on T cell function

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12 December 2020

The Antagonism of HIV-1 Nef to SERINC5 Particle Infectivity Restriction Involves the Counteraction of Virion-Associated Pools of the Restriction Factor

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12 December 2020

Ongoing Clinical Trials of Human Immunodeficiency Virus Latency-Reversing and Immunomodulatory Agents

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12 December 2020

HIV cure strategists: ignore the central nervous system at your patients' peril

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12 December 2020

SERINC5 protein inhibits HIV-1 fusion pore formation by promoting functional inactivation of envelope glycoproteins.

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12 December 2020

Identification of SERINC5-001 as the Predominant Spliced Isoform for HIV-1 Restriction.

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12 December 2020

Short-Course Toll-Like Receptor 9 Agonist Treatment Impacts Innate Immunity and Plasma Viremia in Individuals With Human Immunodeficiency Virus Infection

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12 December 2020

The host-cell restriction factor SERINC5 restricts HIV-1 infectivity without altering the lipid composition and organization of viral particles

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12 December 2020

Landscape review of current HIV 'kick and kill' cure research - some kicking, not enough killing.

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12 December 2020

Pharmacologic HIV-1 Nef blockade promotes CD8 T cell-mediated elimination of latently HIV-1-infected cells in vitro

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12 December 2020

Making Sense of Multifunctional Proteins: Human Immunodeficiency Virus Type 1 Accessory and Regulatory Proteins and Connections to Transcription

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12 December 2020

Latent HIV reservoirs exhibit inherent resistance to elimination by CD8+ T cells.

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12 December 2020

Incomplete Downregulation of CD4 Expression Affects HIV-1 Env Conformation and Antibody-Dependent Cellular Cytotoxicity Responses.

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12 December 2020

SIV Latency in Macrophages in the CNS.

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12 December 2020