Role of Forkhead Box O Transcription Factors in Oxidative Stress-Induced Chondrocyte Dysfunction: Possible Therapeutic Target for Osteoarthritis? (Q60932159)

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scientific article published on 28 November 2018

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English	Role of Forkhead Box O Transcription Factors in Oxidative Stress-Induced Chondrocyte Dysfunction: Possible Therapeutic Target for Osteoarthritis?	scientific article published on 28 November 2018

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Role of Forkhead Box O Transcription Factors in Oxidative Stress-Induced Chondrocyte Dysfunction: Possible Therapeutic Target for Osteoarthritis? (English)

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DNA-binding protein

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transcription factor

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Rikang Wang

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Shuai Zhang

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Di Chen

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Yi Jin

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Upregulation of insulin-like growth factor I gene expression in the lesions of osteoarthritic human articular cartilage

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The mechanism of chondrocyte hydrogen peroxide damage. Depletion of intracellular ATP due to suppression of glycolysis caused by oxidation of glyceraldehyde-3-phosphate dehydrogenase.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human osteoarthritic chondrocytes possess an increased number of insulin-like growth factor 1 binding sites but are unresponsive to its stimulation. Possible role of IGF-1-binding proteins

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https://pubmed.ncbi.nlm.nih.gov/30487470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Extension of life-span by overexpression of superoxide dismutase and catalase in Drosophila melanogaster.

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https://pubmed.ncbi.nlm.nih.gov/30487470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reactive oxygen species mediate cytokine activation of c-Jun NH2-terminal kinases

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https://pubmed.ncbi.nlm.nih.gov/30487470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Localization of insulin-like growth factor-1 receptor in human normal and osteoarthritic cartilage in relation to proteoglycan synthesis and content

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https://pubmed.ncbi.nlm.nih.gov/30487470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Superinduction of cyclooxygenase-2 activity in human osteoarthritis-affected cartilage. Influence of nitric oxide.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differences in nitric oxide production by superficial and deep human articular chondrocytes: implications for proteoglycan turnover in inflammatory joint diseases

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Extended life-span and stress resistance in the Drosophila mutant methuselah

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

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https://pubmed.ncbi.nlm.nih.gov/30487470

12 December 2020

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Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487470

12 December 2020

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Diverse and dynamic functions of the Sir silencing complex

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https://pubmed.ncbi.nlm.nih.gov/30487470

12 December 2020

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Insulin-like growth factor-1-induced phosphorylation of the forkhead family transcription factor FKHRL1 is mediated by Akt kinase in PC12 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nitric oxide inhibits chondrocyte response to IGF-I: inhibition of IGF-IRbeta tyrosine phosphorylation

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Collective inhibition of pRB family proteins by phosphorylation in cells with p16INK4a loss or cyclin E overexpression

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chondrocyte death in experimental osteoarthritis is mediated by MEK 1/2 and p38 pathways: role of cyclooxygenase-2 and inducible nitric oxide synthase

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

DNA repair pathway stimulated by the forkhead transcription factor FOXO3a through the Gadd45 protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The in situ up-regulation of chondrocyte interleukin-1-converting enzyme and interleukin-18 levels in experimental osteoarthritis is mediated by nitric oxide

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of reactive oxygen species in homeostasis and degradation of cartilage

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased oxidative stress with aging reduces chondrocyte survival: correlation with intracellular glutathione levels

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

FoxOs at the crossroads of cellular metabolism, differentiation, and transformation

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p53-dependent inhibition of FKHRL1 in response to DNA damage through protein kinase SGK1

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

FOXO transcription factor activation by oxidative stress mediated by the small GTPase Ral and JNK.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Potential predictive markers for proliferative capacity of cultured human articular chondrocytes: PCNA and p21.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Functional interaction between beta-catenin and FOXO in oxidative stress signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxygen and reactive oxygen species in cartilage degradation: friends or foes?

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487470

12 December 2020

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Vulnerability to ROS-induced cell death in ageing articular cartilage: the role of antioxidant enzyme activity.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

SIRT1 is critical regulator of FOXO-mediated transcription in response to oxidative stress

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

FOXO transcription factors at the interface between longevity and tumor suppression

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Serotonin targets the DAF-16/FOXO signaling pathway to modulate stress responses

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inactivation of Pten in osteo-chondroprogenitor cells leads to epiphyseal growth plate abnormalities and skeletal overgrowth

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of the flavonoids kaempferol and fisetin on thermotolerance, oxidative stress and FoxO transcription factor DAF-16 in the model organism Caenorhabditis elegans

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reactive oxygen species induce chondrocyte hypertrophy in endochondral ossification.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of forkhead box class O family member transcription factors in rheumatoid synovial tissue

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxidative stress antagonizes Wnt signaling in osteoblast precursors by diverting beta-catenin from T cell factor- to forkhead box O-mediated transcription.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reactive nitrogen and oxygen species in interleukin-1-mediated DNA damage associated with osteoarthritis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Wnt/beta-catenin signaling in adipogenesis and metabolism.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

FoxO3 coordinately activates protein degradation by the autophagic/lysosomal and proteasomal pathways in atrophying muscle cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Joint fluid antioxidants are decreased in osteoarthritic joints compared to joints with macroscopically intact cartilage and subacute injury.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Coordinate activation of autophagy and the proteasome pathway by FoxO transcription factor.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interaction of FOXO with beta-catenin inhibits beta-catenin/T cell factor activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mitochondrial dysregulation of osteoarthritic human articular chondrocytes analyzed by proteomics: a decrease in mitochondrial superoxide dismutase points to a redox imbalance

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

RNAi screening for kinases and phosphatases identifies FoxO regulators

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Conditional loss of PTEN leads to skeletal abnormalities and lipoma formation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

SIRT1: regulation of longevity via autophagy

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rhein, the metabolite of diacerhein, reduces the proliferation of osteoarthritic chondrocytes and synoviocytes without inducing apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Aging and osteoarthritis: the role of chondrocyte senescence and aging changes in the cartilage matrix

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Akt regulates skeletal development through GSK3, mTOR, and FoxOs.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Smurf2 induces degradation of GSK-3beta and upregulates beta-catenin in chondrocytes: a potential mechanism for Smurf2-induced degeneration of articular cartilage.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

SIRT1 regulation of apoptosis of human chondrocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxidative stress inhibits insulin-like growth factor-I induction of chondrocyte proteoglycan synthesis through differential regulation of phosphatidylinositol 3-Kinase-Akt and MEK-ERK MAPK signaling pathways

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

MAPKs are essential upstream signaling pathways in proteolytic cartilage degradation--divergence in pathways leading to aggrecanase and MMP-mediated articular cartilage degradation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rotenone prevents impact-induced chondrocyte death

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

FoxO-mediated defense against oxidative stress in osteoblasts is indispensable for skeletal homeostasis in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

FoxO1 is a positive regulator of bone formation by favoring protein synthesis and resistance to oxidative stress in osteoblasts

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

TNF-alpha mediates diabetes-enhanced chondrocyte apoptosis during fracture healing and stimulates chondrocyte apoptosis through FOXO1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Superoxide dismutase downregulation in osteoarthritis progression and end-stage disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

FoxO, autophagy, and cardiac remodeling

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Forkhead homeobox type O transcription factors in the responses to oxidative stress

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction of hypertrophic chondrocyte-like phenotypes by oxidized LDL in cultured bovine articular chondrocytes through increase in oxidative stress.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Are FoxO transcription factors implicated in osteoarthritis? Influence of Diacerhein

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Linking Alzheimer's disease to insulin resistance: the FoxO response to oxidative stress

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxidative stress induces senescence in chondrocytes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects and relationship of ERK1 and ERK2 in interleukin-1β-induced alterations in MMP3, MMP13, type II collagen and aggrecan expression in human chondrocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of ubiquitin-proteasome system in ageing.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Osteoarthritis year 2010 in review: pathomechanisms

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Senescence of chondrocytes in aging articular cartilage: GADD45β mediates p21 expression in association with C/EBPβ in senescence-accelerated mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of Foxo-dependent transcription by post-translational modifications

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The PKB/FOXO switch in aging and cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of Gsk3β in cartilage induces osteoarthritic features through activation of the canonical Wnt signaling pathway.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Behavioral stress-induced activation of FoxO3a in the cerebral cortex of mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Resveratrol inhibits interleukin 1β-mediated inducible nitric oxide synthase expression in articular chondrocytes by activating SIRT1 and thereby suppressing nuclear factor-κB activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Autophagy activation by rapamycin reduces severity of experimental osteoarthritis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Autophagy modulates osteoarthritis-related gene expression in human chondrocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Current overview of functions of FoxO proteins, with special regards to cellular homeostasis, cell response to stress, as well as inflammation and aging.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sirtuins' modulation of autophagy

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

FOXOs attenuate bone formation by suppressing Wnt signaling.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Production of reactive oxygen species by withaferin A causes loss of type collagen expression and COX-2 expression through the PI3K/Akt, p38, and JNK pathways in rabbit articular chondrocytes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The dual role of autophagy in chondrocyte responses in the pathogenesis of articular cartilage degeneration in osteoarthritis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Diagnosis and treatment of osteoarthritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dysregulated FOXO transcription factors in articular cartilage in aging and osteoarthritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nitric oxide inhibits autophagy via suppression of JNK in meniscal cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

c-Jun N-terminal kinase - c-Jun pathway transactivates Bim to promote osteoarthritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p16INK4a and its regulator miR-24 link senescence and chondrocyte terminal differentiation-associated matrix remodeling in osteoarthritis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glycogen synthase kinase 3 inhibition stimulates human cartilage destruction and exacerbates murine osteoarthritis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The ECM-cell interaction of cartilage extracellular matrix on chondrocytes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sirtuin1 (Sirt1) promotes cortical bone formation by preventing β-catenin sequestration by FoxO transcription factors in osteoblast progenitors.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Age-related degeneration of articular cartilage in the pathogenesis of osteoarthritis: molecular markers of senescent chondrocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Physical activity ameliorates cartilage degeneration in a rat model of aging: a study on lubricin expression

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Peroxisome proliferator-activated receptor γ coactivator 1α and FoxO3A mediate chondroprotection by AMP-activated protein kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Withaferin A-caused production of intracellular reactive oxygen species modulates apoptosis via PI3K/Akt and JNKinase in rabbit articular chondrocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Defective autophagy in chondrocytes with Kashin-Beck disease but higher than osteoarthritis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

FoxO transcription factors support oxidative stress resistance in human chondrocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Emerging regulators of the inflammatory process in osteoarthritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Biosynthesis of collagen I, II, RUNX2 and lubricin at different time points of chondrogenic differentiation in a 3D in vitro model of human mesenchymal stem cells derived from adipose tissue

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Local intra-articular injection of rapamycin delays articular cartilage degeneration in a murine model of osteoarthritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The thymoquinone-induced production of reactive oxygen species promotes dedifferentiation through the ERK pathway and inflammation through the p38 and PI3K pathways in rabbit articular chondrocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxidative stress-induced apoptosis and matrix loss of chondrocytes is inhibited by eicosapentaenoic acid.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chondrosenescence: definition, hallmarks and potential role in the pathogenesis of osteoarthritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ameliorative effects of PACAP against cartilage degeneration. Morphological, immunohistochemical and biochemical evidence from in vivo and in vitro models of rat osteoarthritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Autophagy protects chondrocytes from glucocorticoids-induced apoptosis via ROS/Akt/FOXO3 signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Matrix cross-linking-mediated mechanotransduction promotes posttraumatic osteoarthritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of senescence associated signaling mechanisms in chondrocytes for cartilage tissue regeneration

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Forkhead box O transcription factors in chondrocytes regulate endochondral bone formation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sirtuin1 Suppresses Osteoclastogenesis by Deacetylating FoxOs

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sam68 Promotes NF-κB Activation and Apoptosis Signaling in Articular Chondrocytes during Osteoarthritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Autophagy in osteoarthritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ROS/oxidative stress signaling in osteoarthritis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxidative Stress Promotes Peroxiredoxin Hyperoxidation and Attenuates Pro-survival Signaling in Aging Chondrocytes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Age-Related Alterations in Signaling Pathways in Articular Chondrocytes: Implications for the Pathogenesis and Progression of Osteoarthritis - A Mini-Review.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cellular senescence in aging and osteoarthritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Age-related reduction in the expression of FOXO transcription factors and correlations with intervertebral disc degeneration.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Aging and osteoarthritis: Central role of the extracellular matrix.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glycogen Synthase Kinase-3β Inhibition Links Mitochondrial Dysfunction, Extracellular Matrix Remodelling and Terminal Differentiation in Chondrocytes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Serum microRNA array analysis identifies miR-140-3p, miR-33b-3p and miR-671-3p as potential osteoarthritis biomarkers involved in metabolic processes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A Role for Soluble IL-6 Receptor in Osteoarthritis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of Forkhead Box O (FOXO) transcription factor in aging and diseases.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

FoxO transcription factors modulate autophagy and proteoglycan 4 in cartilage homeostasis and osteoarthritis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.3390/IJMS19123794

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30487470%20AND%20SRC:MED&resulttype=core&format=json

5 May 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30487470%20AND%20SRC:MED&resulttype=core&format=json

5 May 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30487470%20AND%20SRC:MED&resulttype=core&format=json

5 May 2020

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