TNF alpha induced protein 3 (Q21109230)

http://www.ebi.ac.uk/interpro/protein/P21580

OTU domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Zinc finger, A20-type, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

2 references

cysteine-type peptidase activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21580

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21580

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21580

ubiquitin-protein transferase activity

1 reference

8 April 2019

De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaB signalling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21580

1 reference

8 April 2019

T cell antigen receptor stimulation induces MALT1 paracaspase-mediated cleavage of the NF-kappaB inhibitor A20

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21580

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21580

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21580&geneProductId=UniProtKB:P21580

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21580

K63-linked polyubiquitin modification-dependent protein binding

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21580

1 reference

8 April 2019

Identification of polyubiquitin binding proteins involved in NF-kappaB signaling using protein arrays

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21580

13 references

8 April 2019

A20 inhibits NF-kappaB activation independently of binding to 14-3-3 proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21580

8 April 2019

A20 inhibits LUBAC-mediated NF-κB activation by binding linear polyubiquitin chains via its zinc finger 7

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21580

8 April 2019

The ubiquitin-editing enzyme A20 requires RNF11 to downregulate NF-kappaB signalling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21580

8 April 2019

Functional proteomics mapping of a human signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21580

8 April 2019

A protein-protein interaction map of the TNF-induced NF-κB signal transduction pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21580

8 April 2019

A proteome-scale map of the human interactome network

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21580

8 April 2019

ABIN-2 forms a ternary complex with TPL-2 and NF-kappa B1 p105 and is essential for TPL-2 protein stability

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21580

8 April 2019

Toward an understanding of the protein interaction network of the human liver

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21580

8 April 2019

ABIN-1 is a ubiquitin sensor that restricts cell death and sustains embryonic development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21580

8 April 2019

Isolation and characterization of two novel A20-like proteins

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21580

8 April 2019

A20 is a potent inhibitor of TLR3- and Sendai virus-induced activation of NF-kappaB and ISRE and IFN-beta promoter

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21580

8 April 2019

A20 inhibits toll-like receptor 2- and 4-mediated interleukin-8 synthesis in airway epithelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21580

8 April 2019

The A20 deubiquitinase activity negatively regulates LMP1 activation of IRF7

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21580

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21580

thiol-dependent deubiquitinase

3 references

17 October 2017

The A20 deubiquitinase activity negatively regulates LMP1 activation of IRF7

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21580&geneProductId=UniProtKB:P21580

17 October 2017

OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21580&geneProductId=UniProtKB:P21580

17 October 2017

De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaB signalling

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21580&geneProductId=UniProtKB:P21580

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21580

thiol-dependent deubiquitinase

4 references

8 April 2019

The A20 deubiquitinase activity negatively regulates LMP1 activation of IRF7

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21580

8 April 2019

De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaB signalling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21580

8 April 2019

OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21580

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21580

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21580

3 references

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21580

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21580

MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis

extracellular exosome

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21580&geneProductId=UniProtKB:P21580

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21580

8 April 2019

Isolation and characterization of two novel A20-like proteins

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21580

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21580

intracellular membrane-bounded organelle

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21580

MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis

extracellular exosome

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21580

positive regulation of hepatocyte proliferation

HDA

biological process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21580

negative regulation of endothelial cell apoptotic process

1 reference

8 April 2019

A20 protects from CD40-CD40 ligand-mediated endothelial cell activation and apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21580

negative regulation of interleukin-1 beta production

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21580

negative regulation of smooth muscle cell proliferation

1 reference

8 April 2019

A20, a modulator of smooth muscle cell proliferation and apoptosis, prevents and induces regression of neointimal hyperplasia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21580

regulation of vascular wound healing

1 reference

8 April 2019

A20, a modulator of smooth muscle cell proliferation and apoptosis, prevents and induces regression of neointimal hyperplasia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21580

protein K48-linked deubiquitination

1 reference

8 April 2019

OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21580

positive regulation of protein catabolic process

1 reference

8 April 2019

Role of the A20-TRAF6 axis in lipopolysaccharide-mediated osteoclastogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21580

negative regulation of cyclin-dependent protein serine/threonine kinase activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21580

regulation of defense response to virus by host

1 reference

8 April 2019

A20 inhibits toll-like receptor 2- and 4-mediated interleukin-8 synthesis in airway epithelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21580

protein deubiquitination involved in ubiquitin-dependent protein catabolic process

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21580

negative regulation of toll-like receptor 2 signaling pathway

1 reference

8 April 2019

A20 inhibits toll-like receptor 2- and 4-mediated interleukin-8 synthesis in airway epithelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21580

negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21580

regulation of tumor necrosis factor-mediated signaling pathway

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21580

negative regulation of toll-like receptor 5 signaling pathway

TAS

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21580

tolerance induction to lipopolysaccharide

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21580

response to muramyl dipeptide

IMP

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21580

negative regulation of chronic inflammatory response

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21580

negative regulation of cell death

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21580

negative regulation of I-kappaB kinase/NF-kappaB signaling

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21580

8 April 2019

De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaB signalling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21580

8 April 2019

Isolation and characterization of two novel A20-like proteins

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21580

8 April 2019

Role of the A20-TRAF6 axis in lipopolysaccharide-mediated osteoclastogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21580

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21580

establishment of protein localization to vacuole

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21580

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21580

protein deubiquitination

4 references

8 April 2019

8 April 2019

The A20 deubiquitinase activity negatively regulates LMP1 activation of IRF7

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21580

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21580

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21580

negative regulation of protein ubiquitination

1 reference

8 April 2019

The A20 deubiquitinase activity negatively regulates LMP1 activation of IRF7

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21580

protein K48-linked ubiquitination

1 reference

8 April 2019

De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaB signalling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21580

negative regulation of CD40 signaling pathway

1 reference

8 April 2019

A20 protects from CD40-CD40 ligand-mediated endothelial cell activation and apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21580

negative regulation of extrinsic apoptotic signaling pathway via death domain receptors

IMP

1 reference

8 April 2019

A20 inhibits tumor necrosis factor (TNF) alpha-induced apoptosis by disrupting recruitment of TRADD and RIP to the TNF receptor 1 complex in Jurkat T cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21580

protein complex oligomerization

1 reference

8 April 2019

A20 is a potent inhibitor of TLR3- and Sendai virus-induced activation of NF-kappaB and ISRE and IFN-beta promoter

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21580

protein K11-linked deubiquitination

1 reference

8 April 2019

OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21580

regulation of inflammatory response

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21580&geneProductId=UniProtKB:P21580

negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21580

negative regulation of osteoclast proliferation

1 reference

8 April 2019

Role of the A20-TRAF6 axis in lipopolysaccharide-mediated osteoclastogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21580

negative regulation of type I interferon production

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21580

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21580

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21580

inflammatory response

1 reference

8 April 2019

negative regulation of NF-kappaB transcription factor activity

1 reference

8 April 2019

T cell antigen receptor stimulation induces MALT1 paracaspase-mediated cleavage of the NF-kappaB inhibitor A20

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21580

negative regulation of interleukin-2 production

1 reference

8 April 2019

T cell antigen receptor stimulation induces MALT1 paracaspase-mediated cleavage of the NF-kappaB inhibitor A20

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21580

negative regulation of toll-like receptor 3 signaling pathway

IMP

1 reference

8 April 2019

A20 is a potent inhibitor of TLR3- and Sendai virus-induced activation of NF-kappaB and ISRE and IFN-beta promoter

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21580

nucleotide-binding oligomerization domain containing signaling pathway

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21580

cellular response to lipopolysaccharide

TAS

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21580

8 April 2019

Role of the A20-TRAF6 axis in lipopolysaccharide-mediated osteoclastogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21580

8 April 2019

A20 is an early responding negative regulator of Toll-like receptor 5 signalling in intestinal epithelial cells during inflammation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21580

negative regulation of toll-like receptor 4 signaling pathway

1 reference

8 April 2019

A20 inhibits toll-like receptor 2- and 4-mediated interleukin-8 synthesis in airway epithelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21580

negative regulation of bone resorption

1 reference

8 April 2019

Role of the A20-TRAF6 axis in lipopolysaccharide-mediated osteoclastogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21580

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21580

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21580

protein ubiquitination

1 reference

8 April 2019

cytoskeleton organization

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21580

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21580

positive regulation of Wnt signaling pathway

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21580

protein K29-linked deubiquitination

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21580

protein K33-linked deubiquitination

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21580

has part(s)

Zinc finger, A20-type

1 reference

stated in

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P21580

OTU domain

1 reference

stated in

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P21580

Identifiers

MeSH descriptor ID

C076529

subject named as

TNFAIP3 protein, human

0 references

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

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9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016