Glutamate ionotropic receptor NMDA type subunit 2C (Q21115819)

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q14957

ionotropic glutamate receptor, metazoa

2 references

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q14957

Transporter Classification Database ID

1.A.10.1.3

2 October 2019

hierarchical database ID heuristic

Receptor, ligand binding region, protein family

1 reference

Ionotropic glutamate receptor domain, protein family

1 reference

Glutamate [NMDA] receptor, epsilon subunit, C-terminal domain, protein family

1 reference

Ionotropic glutamate receptor, L-glutamate and glycine-binding domain, protein family

1 reference

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14957

1 reference

13 November 2019

1 reference

13 November 2019

1 reference

8 April 2019

ionotropic glutamate receptor activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14957

cation channel activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14957

extracellularly glutamate-gated ion channel activity

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14957&geneProductId=UniProtKB:Q14957

NMDA glutamate receptor activity

3 references

1 January 2018

The human N-methyl-D-aspartate receptor 2C subunit: genomic analysis, distribution in human brain, and functional expression

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14957&geneProductId=UniProtKB:Q14957

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14957&geneProductId=UniProtKB:Q14957

1 January 2018

Discovery of GluN2A-Selective NMDA Receptor Positive Allosteric Modulators (PAMs): Tuning Deactivation Kinetics via Structure-Based Design

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14957&geneProductId=UniProtKB:Q14957

glutamate-gated calcium ion channel activity

1 reference

8 April 2019

Positive Allosteric Modulators of GluN2A-Containing NMDARs with Distinct Modes of Action and Impacts on Circuit Function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14957

NMDA glutamate receptor activity

5 references

8 April 2019

The human N-methyl-D-aspartate receptor 2C subunit: genomic analysis, distribution in human brain, and functional expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14957

8 April 2019

Fyn-mediated phosphorylation of NR2B Tyr-1336 controls calpain-mediated NR2B cleavage in neurons and heterologous systems

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14957

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14957

8 April 2019

Discovery of GluN2A-Selective NMDA Receptor Positive Allosteric Modulators (PAMs): Tuning Deactivation Kinetics via Structure-Based Design

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14957

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14957

signaling receptor activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14957

transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14957

integral component of membrane

cell component

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14957

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14957

postsynaptic membrane

1 reference

8 April 2019

2 references

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14957&geneProductId=UniProtKB:Q14957

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14957

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14957

intracellular anatomical structure

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14957&geneProductId=UniProtKB:Q14957

integral component of plasma membrane

3 references

8 April 2019

The human N-methyl-D-aspartate receptor 2C subunit: genomic analysis, distribution in human brain, and functional expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14957

8 April 2019

Discovery of GluN2A-Selective NMDA Receptor Positive Allosteric Modulators (PAMs): Tuning Deactivation Kinetics via Structure-Based Design

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14957

8 April 2019

Positive Allosteric Modulators of GluN2A-Containing NMDARs with Distinct Modes of Action and Impacts on Circuit Function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14957

NMDA selective glutamate receptor complex

3 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14957&geneProductId=UniProtKB:Q14957

1 January 2018

Discovery of GluN2A-Selective NMDA Receptor Positive Allosteric Modulators (PAMs): Tuning Deactivation Kinetics via Structure-Based Design

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14957&geneProductId=UniProtKB:Q14957

1 January 2018

Positive Allosteric Modulators of GluN2A-Containing NMDARs with Distinct Modes of Action and Impacts on Circuit Function

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14957&geneProductId=UniProtKB:Q14957

NMDA selective glutamate receptor complex

5 references

8 April 2019

Fyn-mediated phosphorylation of NR2B Tyr-1336 controls calpain-mediated NR2B cleavage in neurons and heterologous systems

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14957

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14957

8 April 2019

Discovery of GluN2A-Selective NMDA Receptor Positive Allosteric Modulators (PAMs): Tuning Deactivation Kinetics via Structure-Based Design

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14957

8 April 2019

Positive Allosteric Modulators of GluN2A-Containing NMDARs with Distinct Modes of Action and Impacts on Circuit Function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14957

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14957

postsynaptic density membrane

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14957

glutamatergic synapse

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14957

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14957&geneProductId=UniProtKB:Q14957

glutamate receptor signaling pathway

1 reference

8 April 2019

The human N-methyl-D-aspartate receptor 2C subunit: genomic analysis, distribution in human brain, and functional expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14957

neuromuscular process controlling balance

TAS

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14957

negative regulation of protein catabolic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14957

regulation of membrane potential

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14957

directional locomotion

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14957

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14957&geneProductId=UniProtKB:Q14957

ionotropic glutamate receptor signaling pathway

TAS

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14957

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14957

excitatory postsynaptic potential

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14957&geneProductId=UniProtKB:Q14957

calcium-mediated signaling

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14957

calcium ion transmembrane import into cytosol

1 reference

8 April 2019

Positive Allosteric Modulators of GluN2A-Containing NMDARs with Distinct Modes of Action and Impacts on Circuit Function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14957

regulation of molecular function

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14957&geneProductId=UniProtKB:Q14957

1 reference

1 January 2018

The human N-methyl-D-aspartate receptor 2C subunit: genomic analysis, distribution in human brain, and functional expression

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14957&geneProductId=UniProtKB:Q14957

1 reference

8 April 2019

Fyn-mediated phosphorylation of NR2B Tyr-1336 controls calpain-mediated NR2B cleavage in neurons and heterologous systems

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14957

regulation of synaptic plasticity

NAS

1 reference

8 April 2019

Fyn-mediated phosphorylation of NR2B Tyr-1336 controls calpain-mediated NR2B cleavage in neurons and heterologous systems

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14957

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

NAS

long-term potentiation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14957

excitatory chemical synaptic transmission

1 reference

8 April 2019

Fyn-mediated phosphorylation of NR2B Tyr-1336 controls calpain-mediated NR2B cleavage in neurons and heterologous systems

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14957

protein localization to postsynaptic membrane

NAS

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14957

physically interacts with

1 reference

727

17 August 2016

1 reference

3309

17 August 2016

1 reference

4216

17 August 2016

1 reference

4068

English

17 August 2016

N-methyl-D-aspartic acid

has use

agonist

1 reference

4268

English

5,7-dichlorokynurenic acid

17 August 2016

has use

antagonist

1 reference

2361

17 August 2016

1 reference

4170

17 August 2016

1 reference

4155

17 August 2016

1 reference

4128

17 August 2016

1 reference

6953

17 August 2016

1 reference

2403

17 August 2016

1 reference

4233

17 August 2016

1 reference

7595

17 August 2016

1 reference

4282

17 August 2016

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL467084

neboglamine

positive allosteric modullator

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1255840

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL2107771

esketamine

negative allosteric modulator

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL395091

ketamine

negative allosteric modulator

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL742

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL41306

ketamine hydrochloride

negative allosteric modulator

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1714

amantadine hydrochloride

antagonist

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1569

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1200395

Identifiers

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

Transporter Classification Database ID

1.A.10.1.3

2 references

Transporter Classification database

13 March 2020

Transporter Classification database