Serine/threonine kinase 4 (Q21116513)

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mammalian protein found in Homo sapiens
  • serine/threonine-protein kinase 4
  • MST-1
  • mammalian sterile 20-like 1
  • STE20-like kinase MST1
  • serine/threonine-protein kinase Krs-2
  • STK4
  • kinase responsive to stress 2
  • mammalian STE20-like protein kinase 1
edit
Language Label Description Also known as
English
Serine/threonine kinase 4
mammalian protein found in Homo sapiens
  • serine/threonine-protein kinase 4
  • MST-1
  • mammalian sterile 20-like 1
  • STE20-like kinase MST1
  • serine/threonine-protein kinase Krs-2
  • STK4
  • kinase responsive to stress 2
  • mammalian STE20-like protein kinase 1

Statements

molecular function
protein serine/threonine kinase activity
determination method
EXP
IDA
IEA
15 references
retrieved
27 March 2018
stated in
GOA
curator
UniProt
UniProt protein ID
Q13043
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13043&geneProductId=UniProtKB:Q13043
determination method
IEA
retrieved
27 March 2018
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13043&geneProductId=UniProtKB:Q13043
determination method
IEA
retrieved
27 March 2018
stated in
MST1 is a multifunctional caspase-independent inhibitor of androgenic signaling
GOA
curator
UniProt
UniProt protein ID
Q13043
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13043&geneProductId=UniProtKB:Q13043
determination method
IDA
retrieved
27 March 2018
stated in
MST1 promotes apoptosis through regulating Sirt1-dependent p53 deacetylation
GOA
curator
UniProt
UniProt protein ID
Q13043
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13043&geneProductId=UniProtKB:Q13043
determination method
IDA
retrieved
27 March 2018
stated in
A conserved MST-FOXO signaling pathway mediates oxidative-stress responses and extends life span
GOA
curator
UniProt
UniProt protein ID
Q13043
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13043&geneProductId=UniProtKB:Q13043
determination method
IDA
retrieved
27 March 2018
stated in
RASSF2 associates with and stabilizes the proapoptotic kinase MST2
GOA
curator
UniProt
UniProt protein ID
Q13043
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13043&geneProductId=UniProtKB:Q13043
determination method
IDA
retrieved
27 March 2018
stated in
Cloning and characterization of a member of the MST subfamily of Ste20-like kinases
GOA
curator
UniProt
UniProt protein ID
Q13043
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13043&geneProductId=UniProtKB:Q13043
determination method
IDA
retrieved
27 March 2018
stated in
Phosphorylation of cardiac troponin I by mammalian sterile 20-like kinase 1
GOA
curator
UniProt
UniProt protein ID
Q13043
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13043&geneProductId=UniProtKB:Q13043
determination method
IDA
retrieved
27 March 2018
stated in
MOBKL1A/MOBKL1B phosphorylation by MST1 and MST2 inhibits cell proliferation
GOA
curator
UniProt
UniProt protein ID
Q13043
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13043&geneProductId=UniProtKB:Q13043
determination method
IDA
retrieved
27 March 2018
stated in
Phosphorylation and dimerization regulate nucleocytoplasmic shuttling of mammalian STE20-like kinase (MST)
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13043&geneProductId=UniProtKB:Q13043
determination method
IDA
retrieved
27 March 2018
stated in
Caspase-mediated activation and induction of apoptosis by the mammalian Ste20-like kinase Mst1
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13043&geneProductId=UniProtKB:Q13043
determination method
EXP
retrieved
27 March 2018
stated in
MST, a physiological caspase substrate, highly sensitizes apoptosis both upstream and downstream of caspase activation
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13043&geneProductId=UniProtKB:Q13043
determination method
EXP
retrieved
27 March 2018
stated in
The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13043&geneProductId=UniProtKB:Q13043
determination method
EXP
retrieved
27 March 2018
stated in
Association of mammalian sterile twenty kinases, Mst1 and Mst2, with hSalvador via C-terminal coiled-coil domains, leads to its stabilization and phosphorylation
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13043&geneProductId=UniProtKB:Q13043
determination method
EXP
retrieved
27 March 2018
stated in
Regulation of the MST1 kinase by autophosphorylation, by the growth inhibitory proteins, RASSF1 and NORE1, and by Ras
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13043&geneProductId=UniProtKB:Q13043
determination method
EXP
protein binding
determination method
IPI
22 references
retrieved
8 April 2019
stated in
MST1 promotes apoptosis through regulating Sirt1-dependent p53 deacetylation
GOA
curator
UniProt
UniProt protein ID
Q13043
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13043
determination method
IPI
retrieved
8 April 2019
stated in
The pro-apoptotic kinase Mst1 and its caspase cleavage products are direct inhibitors of Akt1
GOA
curator
UniProt
UniProt protein ID
Q13043
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13043
determination method
IPI
retrieved
8 April 2019
stated in
Phosphorylation of cardiac troponin I by mammalian sterile 20-like kinase 1
GOA
curator
UniProt
UniProt protein ID
Q13043
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13043
determination method
IPI
retrieved
8 April 2019
stated in
The tumor suppressor RASSF1A prevents dephosphorylation of the mammalian STE20-like kinases MST1 and MST2.
GOA
curator
UniProt
UniProt protein ID
Q13043
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13043
determination method
IPI
retrieved
8 April 2019
stated in
DLG5 connects cell polarity and Hippo signaling protein networks by linking PAR-1 with MST1/2
GOA
curator
UniProt
UniProt protein ID
Q13043
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13043
determination method
IPI
retrieved
8 April 2019
stated in
Loss of DLG5 promotes breast cancer malignancy by inhibiting the Hippo signaling pathway
GOA
curator
UniProt
UniProt protein ID
Q13043
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13043
determination method
IPI
retrieved
8 April 2019
stated in
MST1 is a multifunctional caspase-independent inhibitor of androgenic signaling
GOA
curator
UniProt
UniProt protein ID
Q13043
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13043
determination method
IPI
retrieved
8 April 2019
stated in
RASSF2 associates with and stabilizes the proapoptotic kinase MST2
GOA
curator
UniProt
UniProt protein ID
Q13043
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13043
determination method
IPI
retrieved
8 April 2019
stated in
Network organization of the human autophagy system
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13043
determination method
IPI
retrieved
8 April 2019
stated in
The pro-apoptotic kinase Mst1 and its caspase cleavage products are direct inhibitors of Akt1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13043
determination method
IPI
retrieved
8 April 2019
stated in
Frequent epigenetic inactivation of RASSF2 in thyroid cancer and functional consequences
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13043
determination method
IPI
retrieved
8 April 2019
stated in
Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13043
determination method
IPI
retrieved
8 April 2019
stated in
The tumor suppressor Mst1 promotes changes in the cellular redox state by phosphorylation and inactivation of peroxiredoxin-1 protein
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13043
determination method
IPI
retrieved
8 April 2019
stated in
Association of mammalian sterile twenty kinases, Mst1 and Mst2, with hSalvador via C-terminal coiled-coil domains, leads to its stabilization and phosphorylation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13043
determination method
IPI
retrieved
8 April 2019
stated in
MICAL-1 is a negative regulator of MST-NDR kinase signaling and apoptosis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13043
determination method
IPI
retrieved
8 April 2019
stated in
Regulation of the MST1 kinase by autophosphorylation, by the growth inhibitory proteins, RASSF1 and NORE1, and by Ras
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13043
determination method
IPI
retrieved
8 April 2019
stated in
Identification of the E1A-regulated transcription factor p120 E4F as an interacting partner of the RASSF1A candidate tumor suppressor gene
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13043
determination method
IPI
retrieved
8 April 2019
stated in
Interaction proteome of human Hippo signaling: modular control of the co-activator YAP1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13043
determination method
IPI
retrieved
8 April 2019
stated in
Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13043
determination method
IPI
retrieved
8 April 2019
stated in
Spatiotemporal regulation of the kinase Mst1 by binding protein RAPL is critical for lymphocyte polarity and adhesion
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13043
determination method
IPI
retrieved
8 April 2019
stated in
Oligomeric peroxiredoxin-I is an essential intermediate for p53 to activate MST1 kinase and apoptosis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13043
determination method
IPI
retrieved
8 April 2019
stated in
Regulation of the Hippo-YAP pathway by G-protein-coupled receptor signaling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13043
determination method
IPI
protein serine/threonine kinase activity
determination method
EXP
IBA
IDA
IEA
16 references
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q13043
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13043
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13043
determination method
IEA
retrieved
8 April 2019
stated in
MST1 promotes apoptosis through regulating Sirt1-dependent p53 deacetylation
GOA
curator
UniProt
UniProt protein ID
Q13043
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13043
determination method
IDA
retrieved
8 April 2019
stated in
Phosphorylation of cardiac troponin I by mammalian sterile 20-like kinase 1
GOA
curator
UniProt
UniProt protein ID
Q13043
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13043
determination method
IDA
retrieved
8 April 2019
stated in
Cloning and characterization of a member of the MST subfamily of Ste20-like kinases
GOA
curator
UniProt
UniProt protein ID
Q13043
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13043
determination method
IDA
retrieved
8 April 2019
stated in
A conserved MST-FOXO signaling pathway mediates oxidative-stress responses and extends life span
GOA
curator
UniProt
UniProt protein ID
Q13043
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13043
determination method
IDA
retrieved
8 April 2019
stated in
MOBKL1A/MOBKL1B phosphorylation by MST1 and MST2 inhibits cell proliferation
GOA
curator
UniProt
UniProt protein ID
Q13043
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13043
determination method
IDA
retrieved
8 April 2019
stated in
MST1 is a multifunctional caspase-independent inhibitor of androgenic signaling
GOA
curator
UniProt
UniProt protein ID
Q13043
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13043
determination method
IDA
retrieved
8 April 2019
stated in
RASSF2 associates with and stabilizes the proapoptotic kinase MST2
GOA
curator
UniProt
UniProt protein ID
Q13043
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13043
determination method
IDA
retrieved
8 April 2019
stated in
Phosphorylation and dimerization regulate nucleocytoplasmic shuttling of mammalian STE20-like kinase (MST)
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13043
determination method
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13043
determination method
IBA
retrieved
8 April 2019
stated in
The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13043
determination method
EXP
retrieved
8 April 2019
stated in
Association of mammalian sterile twenty kinases, Mst1 and Mst2, with hSalvador via C-terminal coiled-coil domains, leads to its stabilization and phosphorylation
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13043
determination method
EXP
retrieved
8 April 2019
stated in
Regulation of the MST1 kinase by autophosphorylation, by the growth inhibitory proteins, RASSF1 and NORE1, and by Ras
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13043
determination method
EXP
retrieved
8 April 2019
stated in
MST, a physiological caspase substrate, highly sensitizes apoptosis both upstream and downstream of caspase activation
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13043
determination method
EXP
retrieved
8 April 2019
stated in
Caspase-mediated activation and induction of apoptosis by the mammalian Ste20-like kinase Mst1
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13043
determination method
EXP
cell component
cytoplasm
determination method
IBA
IDA
IEA
6 references
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q13043
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13043
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13043
determination method
IEA
retrieved
8 April 2019
stated in
RASSF2 associates with and stabilizes the proapoptotic kinase MST2
GOA
curator
UniProt
UniProt protein ID
Q13043
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13043
determination method
IDA
retrieved
8 April 2019
stated in
The pro-apoptotic kinase Mst1 and its caspase cleavage products are direct inhibitors of Akt1
GOA
curator
UniProt
UniProt protein ID
Q13043
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13043
determination method
IDA
retrieved
8 April 2019
stated in
MST1 is a multifunctional caspase-independent inhibitor of androgenic signaling
GOA
curator
UniProt
UniProt protein ID
Q13043
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13043
determination method
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13043
determination method
IBA
biological process

Identifiers

 
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                    Retrieved from "https://www.wikidata.org/w/index.php?title=Q21116513&oldid=2022966897"