activating transcription factor 6 (Q21116808)

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mammalian protein found in Homo sapiens

cAMP-dependent transcription factor ATF-6 alpha
ATF6
cyclic AMP-dependent transcription factor ATF-6 alpha
Activating transcription factor 6 alpha
ATF6-alpha
ATF6 protein, human

Language	Label	Description	Also known as
English	activating transcription factor 6	mammalian protein found in Homo sapiens	cAMP-dependent transcription factor ATF-6 alpha ATF6 cyclic AMP-dependent transcription factor ATF-6 alpha Activating transcription factor 6 alpha ATF6-alpha ATF6 protein, human

Statements

1 reference

13 November 2019

UniProt protein ID

cAMP-dependent transcription factor ATF-6 alpha

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P18850

Basic-leucine zipper domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18850

determination method

RNA polymerase II transcription regulatory region sequence-specific DNA binding

determination method

1 reference

8 April 2019

XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18850

determination method

DNA-binding transcription factor activity

determination method

4 references

8 April 2019

Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stress

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18850

determination method

8 April 2019

Interaction of ATF6 and serum response factor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18850

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18850

determination method

8 April 2019

ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18850

determination method

transcription coactivator activity

determination method

1 reference

8 April 2019

ATF6 as a transcription activator of the endoplasmic reticulum stress element: thapsigargin stress-induced changes and synergistic interactions with NF-Y and YY1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18850

determination method

transcription cis-regulatory region binding

determination method

1 reference

8 April 2019

Endoplasmic reticulum stress activates cleavage of CREBH to induce a systemic inflammatory response

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18850

determination method

protein binding

determination method

5 references

8 April 2019

A thrombospondin-dependent pathway for a protective ER stress response

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18850

determination method

8 April 2019

Compounds Triggering ER Stress Exert Anti-Melanoma Effects and Overcome BRAF Inhibitor Resistance

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18850

determination method

8 April 2019

Endoplasmic reticulum stress activates cleavage of CREBH to induce a systemic inflammatory response

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18850

determination method

8 April 2019

Identification of bZIP interaction partners of viral proteins HBZ, MEQ, BZLF1, and K-bZIP using coiled-coil arrays

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18850

determination method

8 April 2019

The CREB coactivator CRTC2 links hepatic ER stress and fasting gluconeogenesis

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18850

determination method

protein heterodimerization activity

determination method

1 reference

8 April 2019

Endoplasmic reticulum stress activates cleavage of CREBH to induce a systemic inflammatory response

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18850

determination method

ubiquitin protein ligase binding

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18850

determination method

cAMP response element binding

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18850

determination method

RNA polymerase II cis-regulatory region sequence-specific DNA binding

determination method

1 reference

8 April 2019

ATF6 upregulates XBP1S and inhibits ER stress-mediated apoptosis in osteoarthritis cartilage

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18850

determination method

sequence-specific DNA binding

determination method

1 reference

8 April 2019

Impact of cytosine methylation on DNA binding specificities of human transcription factors.

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18850

determination method

DNA-binding transcription factor activity, RNA polymerase II-specific

determination method

3 references

8 April 2019

A census of human transcription factors: function, expression and evolution

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18850

determination method

8 April 2019

A census of human transcription factors: function, expression and evolution

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18850

determination method

8 April 2019

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18850

determination method

integral component of membrane

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18850

determination method

Golgi apparatus

determination method

1 reference

8 April 2019

CREB4, a transmembrane bZip transcription factor and potential new substrate for regulation and cleavage by S1P.

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18850

determination method

nuclear envelope

determination method

1 reference

8 April 2019

ATF6 as a transcription activator of the endoplasmic reticulum stress element: thapsigargin stress-induced changes and synergistic interactions with NF-Y and YY1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18850

determination method

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18850

determination method

integral component of endoplasmic reticulum membrane

determination method

2 references

8 April 2019

Identification of the G13 (cAMP-response-element-binding protein-related protein) gene product related to activating transcription factor 6 as a transcriptional activator of the mammalian unfolded protein response

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18850

determination method

8 April 2019

Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stress

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18850

determination method

endoplasmic reticulum

determination method

3 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18850

determination method

8 April 2019

CREB4, a transmembrane bZip transcription factor and potential new substrate for regulation and cleavage by S1P.

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18850

determination method

8 April 2019

Identification of the G13 (cAMP-response-element-binding protein-related protein) gene product related to activating transcription factor 6 as a transcriptional activator of the mammalian unfolded protein response

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18850

determination method

determination method

7 references

8 April 2019

Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stress

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18850

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18850

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18850

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18850

determination method

8 April 2019

ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18850

determination method

8 April 2019

CREB4, a transmembrane bZip transcription factor and potential new substrate for regulation and cleavage by S1P.

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18850

determination method

8 April 2019

Identification of the G13 (cAMP-response-element-binding protein-related protein) gene product related to activating transcription factor 6 as a transcriptional activator of the mammalian unfolded protein response

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18850

determination method

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18850

determination method

biological process

eye development

determination method

1 reference

8 April 2019

Mutations in the unfolded protein response regulator ATF6 cause the cone dysfunction disorder achromatopsia

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18850

determination method

regulation of transcription, DNA-templated

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18850

determination method

positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress

determination method

4 references

27 March 2018

The unfolded protein response: integrating stress signals through the stress sensor IRE1α

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18850&geneProductId=UniProtKB:P18850

determination method

27 March 2018

ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18850&geneProductId=UniProtKB:P18850

determination method

27 March 2018

Endoplasmic reticulum stress activates cleavage of CREBH to induce a systemic inflammatory response

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18850&geneProductId=UniProtKB:P18850

determination method

27 March 2018

Identification of the G13 (cAMP-response-element-binding protein-related protein) gene product related to activating transcription factor 6 as a transcriptional activator of the mammalian unfolded protein response

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18850&geneProductId=UniProtKB:P18850

determination method

regulation of transcription by RNA polymerase II

determination method

1 reference

8 April 2019

Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stress

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18850

determination method

transcription, DNA-templated

determination method

1 reference

27 March 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18850&geneProductId=UniProtKB:P18850

determination method

response to unfolded protein

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18850

determination method

protein folding

determination method

1 reference

8 April 2019

Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stress

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18850

determination method

signal transduction

determination method

1 reference

8 April 2019

Interaction of ATF6 and serum response factor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18850

determination method

visual perception

determination method

1 reference

8 April 2019

Mutations in the unfolded protein response regulator ATF6 cause the cone dysfunction disorder achromatopsia

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18850

determination method

positive regulation of apoptotic process

determination method

1 reference

8 April 2019

hsp70-DnaJ chaperone pair prevents nitric oxide- and CHOP-induced apoptosis by inhibiting translocation of Bax to mitochondria

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18850

determination method

transcription by RNA polymerase II

determination method

1 reference

27 March 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18850&geneProductId=UniProtKB:P18850

determination method

positive regulation of transcription by RNA polymerase II

determination method

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18850

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18850

determination method

8 April 2019

Opposing roles for ATF6alpha and ATF6beta in endoplasmic reticulum stress response gene induction

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18850

determination method

positive regulation of ATF6-mediated unfolded protein response

determination method

1 reference

8 April 2019

Identification of the cis-acting endoplasmic reticulum stress response element responsible for transcriptional induction of mammalian glucose-regulated proteins. Involvement of basic leucine zipper transcription factors

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18850

determination method

positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress

determination method

3 references

8 April 2019

Endoplasmic reticulum stress activates cleavage of CREBH to induce a systemic inflammatory response

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18850

determination method

8 April 2019

ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18850

determination method

8 April 2019

Identification of the G13 (cAMP-response-element-binding protein-related protein) gene product related to activating transcription factor 6 as a transcriptional activator of the mammalian unfolded protein response

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18850

determination method

Basic-leucine zipper domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P18850

Identifiers

MeSH descriptor ID

subject named as

ATF6 protein, human

0 references

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000356919

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000356919

1 reference

based on heuristic

inferred by common MeSH mappings on source and on Wikidata

25 May 2023

Sitelinks

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Wikivoyage(0 entries)

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