NADH:ubiquinone oxidoreductase subunit S4 (Q21120100)

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mammalian protein found in Homo sapiens

complex I 18kDa subunit
CI-AQDQ
CI-18 kDa
NDUFS4
complex I-AQDQ
NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial
NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase)
NADH-ubiquinone oxidoreductase 18 kDa subunit
mitochondrial respiratory chain complex I (18-KD subunit)
Complex I-18 kDa

Language	Label	Description	Also known as
English	NADH:ubiquinone oxidoreductase subunit S4	mammalian protein found in Homo sapiens	complex I 18kDa subunit CI-AQDQ CI-18 kDa NDUFS4 complex I-AQDQ NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase) NADH-ubiquinone oxidoreductase 18 kDa subunit mitochondrial respiratory chain complex I (18-KD subunit) Complex I-18 kDa

Statements

1 reference

13 November 2019

UniProt protein ID

NADH dehydrogenase ubiquinone Fe-S protein 4, mitochondrial

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O43181

NADH dehydrogenase ubiquinone Fe-S protein 4-like superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O43181

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

oxidoreductase activity, acting on NAD(P)H

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43181

determination method

NADH dehydrogenase (ubiquinone) activity

determination method

4 references

27 March 2018

Dysfunctions of cellular oxidative metabolism in patients with mutations in the NDUFS1 and NDUFS4 genes of complex I

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O43181&geneProductId=UniProtKB:O43181

determination method

27 March 2018

Respiratory complex I in brain development and genetic disease

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O43181&geneProductId=UniProtKB:O43181

determination method

27 March 2018

cAMP controls oxygen metabolism in mammalian cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O43181&geneProductId=UniProtKB:O43181

determination method

27 March 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=O43181&geneProductId=UniProtKB:O43181

determination method

NADH dehydrogenase (ubiquinone) activity

determination method

5 references

10 September 2018

Dysfunctions of cellular oxidative metabolism in patients with mutations in the NDUFS1 and NDUFS4 genes of complex I

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O43181&geneProductId=UniProtKB:O43181

determination method

10 September 2018

cAMP controls oxygen metabolism in mammalian cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O43181&geneProductId=UniProtKB:O43181

determination method

10 September 2018

Respiratory complex I in brain development and genetic disease

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O43181&geneProductId=UniProtKB:O43181

determination method

10 September 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=O43181&geneProductId=UniProtKB:O43181

determination method

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=O43181&geneProductId=UniProtKB:O43181

determination method

NADH dehydrogenase (ubiquinone) activity

determination method

4 references

8 April 2019

Dysfunctions of cellular oxidative metabolism in patients with mutations in the NDUFS1 and NDUFS4 genes of complex I

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43181

determination method

8 April 2019

cAMP controls oxygen metabolism in mammalian cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43181

determination method

8 April 2019

Respiratory complex I in brain development and genetic disease

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43181

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43181

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43181

determination method

respiratory chain complex I

determination method

1 reference

10 September 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=O43181&geneProductId=UniProtKB:O43181

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43181

determination method

mitochondrial respiratory chain complex I

determination method

4 references

27 March 2018

Human complex I defects can be resolved by monoclonal antibody analysis into distinct subunit assembly patterns

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O43181&geneProductId=UniProtKB:O43181

determination method

27 March 2018

Dysfunctions of cellular oxidative metabolism in patients with mutations in the NDUFS1 and NDUFS4 genes of complex I

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O43181&geneProductId=UniProtKB:O43181

determination method

27 March 2018

The subunit composition of the human NADH dehydrogenase obtained by rapid one-step immunopurification

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O43181&geneProductId=UniProtKB:O43181

determination method

27 March 2018

Accessory subunits are integral for assembly and function of human mitochondrial complex I.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O43181&geneProductId=UniProtKB:O43181

determination method

mitochondrial respiratory chain complex I

determination method

5 references

8 April 2019

Dysfunctions of cellular oxidative metabolism in patients with mutations in the NDUFS1 and NDUFS4 genes of complex I

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43181

determination method

8 April 2019

Human complex I defects can be resolved by monoclonal antibody analysis into distinct subunit assembly patterns

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43181

determination method

8 April 2019

Accessory subunits are integral for assembly and function of human mitochondrial complex I.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43181

determination method

8 April 2019

The subunit composition of the human NADH dehydrogenase obtained by rapid one-step immunopurification

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43181

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43181

determination method

biological process

regulation of protein phosphorylation

determination method

1 reference

8 April 2019

Mutation in the NDUFS4 gene of complex I abolishes cAMP-dependent activation of the complex in a child with fatal neurological syndrome

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43181

determination method

positive regulation of fibroblast proliferation

determination method

1 reference

8 April 2019

Dysfunctions of cellular oxidative metabolism in patients with mutations in the NDUFS1 and NDUFS4 genes of complex I

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43181

determination method

reactive oxygen species metabolic process

determination method

1 reference

8 April 2019

cAMP controls oxygen metabolism in mammalian cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43181

determination method

mitochondrial respiratory chain complex I assembly

determination method

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43181

determination method

8 April 2019

Respiratory complex I in brain development and genetic disease

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43181

determination method

8 April 2019

Human complex I defects can be resolved by monoclonal antibody analysis into distinct subunit assembly patterns

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43181

determination method

brain development

determination method

1 reference

8 April 2019

Clinical heterogeneity in patients with mutations in the NDUFS4 gene of mitochondrial complex I

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43181

determination method

cellular respiration

determination method

1 reference

8 April 2019

Dysfunctions of cellular oxidative metabolism in patients with mutations in the NDUFS1 and NDUFS4 genes of complex I

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43181

determination method

response to cAMP

determination method

2 references

8 April 2019

Mutation in the NDUFS4 gene of complex I abolishes cAMP-dependent activation of the complex in a child with fatal neurological syndrome

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43181

determination method

8 April 2019

A nonsense mutation in the NDUFS4 gene encoding the 18 kDa (AQDQ) subunit of complex I abolishes assembly and activity of the complex in a patient with Leigh-like syndrome

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43181

determination method

cAMP-mediated signaling

determination method

2 references

8 April 2019

Mutation in the NDUFS4 gene of complex I abolishes cAMP-dependent activation of the complex in a child with fatal neurological syndrome

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43181

determination method

8 April 2019

A nonsense mutation in the NDUFS4 gene encoding the 18 kDa (AQDQ) subunit of complex I abolishes assembly and activity of the complex in a patient with Leigh-like syndrome

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43181

determination method

electron transport chain

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43181

determination method

mitochondrial electron transport, NADH to ubiquinone

determination method

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43181

determination method

8 April 2019

Demonstration of a new pathogenic mutation in human complex I deficiency: a 5-bp duplication in the nuclear gene encoding the 18-kD (AQDQ) subunit

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43181

determination method

8 April 2019

cDNA of eight nuclear encoded subunits of NADH:ubiquinone oxidoreductase: human complex I cDNA characterization completed

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43181

determination method

mitochondrial electron transport, NADH to ubiquinone

determination method

2 references

1 January 2018

Demonstration of a new pathogenic mutation in human complex I deficiency: a 5-bp duplication in the nuclear gene encoding the 18-kD (AQDQ) subunit

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O43181&geneProductId=UniProtKB:O43181

determination method

1 January 2018

cDNA of eight nuclear encoded subunits of NADH:ubiquinone oxidoreductase: human complex I cDNA characterization completed

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O43181&geneProductId=UniProtKB:O43181

determination method

physically interacts with

object has role

reaction inhibitor

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1431

metformin hydrochloride

object has role

reaction inhibitor

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1703

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000296684

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000296684

ENSP00000422177

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000422177

ENSP00000424570

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000424570

ENSP00000424993

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000424993

ENSP00000425967

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000425967

Sitelinks

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Wikisource(0 entries)

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Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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