VPS35 retromer complex component (Q21125246)

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mammalian protein found in Homo sapiens
  • VPS35
  • Vesicle protein sorting 35
  • vacuolar protein sorting 35 homolog
  • hVPS35
  • vacuolar protein sorting-associated protein 35
  • maternal-embryonic 3
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Language Label Description Also known as
English
VPS35 retromer complex component
mammalian protein found in Homo sapiens
  • VPS35
  • Vesicle protein sorting 35
  • vacuolar protein sorting 35 homolog
  • hVPS35
  • vacuolar protein sorting-associated protein 35
  • maternal-embryonic 3

Statements

molecular function
protein binding
determination method
IPI
23 references
retrieved
8 April 2019
stated in
Retriever is a multiprotein complex for retromer-independent endosomal cargo recycling.
GOA
curator
UniProt
UniProt protein ID
Q96QK1
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96QK1
determination method
IPI
retrieved
8 April 2019
stated in
The retromer coat complex coordinates endosomal sorting and dynein-mediated transport, with carrier recognition by the trans-Golgi network
GOA
curator
UniProt
UniProt protein ID
Q96QK1
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96QK1
determination method
IPI
retrieved
8 April 2019
stated in
SNX12 role in endosome membrane transport
GOA
curator
UniProt
UniProt protein ID
Q96QK1
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96QK1
determination method
IPI
retrieved
8 April 2019
stated in
Regulation of WASH-dependent actin polymerization and protein trafficking by ubiquitination
GOA
curator
UniProt
UniProt protein ID
Q96QK1
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96QK1
determination method
IPI
retrieved
8 April 2019
stated in
A SNX3-dependent retromer pathway mediates retrograde transport of the Wnt sorting receptor Wntless and is required for Wnt secretion
GOA
curator
UniProt
UniProt protein ID
Q96QK1
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96QK1
determination method
IPI
retrieved
8 April 2019
stated in
Endosomal recruitment of the WASH complex: active sequences and mutations impairing interaction with the retromer
GOA
curator
UniProt
UniProt protein ID
Q96QK1
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96QK1
determination method
IPI
retrieved
8 April 2019
stated in
Human orthologs of yeast vacuolar protein sorting proteins Vps26, 29, and 35: assembly into multimeric complexes
GOA
curator
UniProt
UniProt protein ID
Q96QK1
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96QK1
determination method
IPI
retrieved
8 April 2019
stated in
A mechanism for retromer endosomal coat complex assembly with cargo
GOA
curator
UniProt
UniProt protein ID
Q96QK1
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96QK1
determination method
IPI
retrieved
8 April 2019
stated in
Identification of molecular heterogeneity in SNX27-retromer-mediated endosome-to-plasma-membrane recycling
GOA
curator
UniProt
UniProt protein ID
Q96QK1
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96QK1
determination method
IPI
retrieved
8 April 2019
stated in
GOLPH3 modulates mTOR signalling and rapamycin sensitivity in cancer
GOA
curator
UniProt
UniProt protein ID
Q96QK1
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96QK1
determination method
IPI
retrieved
8 April 2019
stated in
Parkinson's disease-associated mutant VPS35 causes mitochondrial dysfunction by recycling DLP1 complexes
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96QK1
determination method
IPI
retrieved
8 April 2019
stated in
Parkinson Disease-linked Vps35 R524W Mutation Impairs the Endosomal Association of Retromer and Induces α-Synuclein Aggregation
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96QK1
determination method
IPI
retrieved
8 April 2019
stated in
VPS35 regulates cell surface recycling and signaling of dopamine receptor D1
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96QK1
determination method
IPI
retrieved
8 April 2019
stated in
The retromer complex influences Wnt secretion by recycling wntless from endosomes to the trans-Golgi network
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96QK1
determination method
IPI
retrieved
8 April 2019
stated in
Role of the mammalian retromer in sorting of the cation-independent mannose 6-phosphate receptor
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96QK1
determination method
IPI
retrieved
8 April 2019
stated in
Pharmacological chaperones stabilize retromer to limit APP processing
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96QK1
determination method
IPI
retrieved
8 April 2019
stated in
The retromer subunit Vps26 has an arrestin fold and binds Vps35 through its C-terminal domain
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96QK1
determination method
IPI
retrieved
8 April 2019
stated in
A human interactome in three quantitative dimensions organized by stoichiometries and abundances
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96QK1
determination method
IPI
retrieved
8 April 2019
stated in
A proteome-scale map of the human interactome network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96QK1
determination method
IPI
retrieved
8 April 2019
stated in
The cargo-selective retromer complex is a recruiting hub for protein complexes that regulate endosomal tubule dynamics
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96QK1
determination method
IPI
retrieved
8 April 2019
stated in
Human orthologs of yeast vacuolar protein sorting proteins Vps26, 29, and 35: assembly into multimeric complexes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96QK1
determination method
IPI
retrieved
8 April 2019
stated in
Functional architecture of the retromer cargo-recognition complex
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96QK1
determination method
IPI
retrieved
8 April 2019
stated in
Cellular cofactors affecting hepatitis C virus infection and replication
GOA
curator
AgBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96QK1
determination method
IPI
cell component
retromer complex
determination method
NAS
IDA
TAS
IEA
6 references
retrieved
17 October 2017
stated in
The vacuolar-ATPase inhibitor bafilomycin and mutant VPS35 inhibit canonical Wnt signaling
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96QK1&geneProductId=UniProtKB:Q96QK1
determination method
TAS
retrieved
17 October 2017
stated in
The regulation and deregulation of Wnt signaling by PARK genes in health and disease
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96QK1&geneProductId=UniProtKB:Q96QK1
determination method
TAS
retrieved
17 October 2017
stated in
Wingless secretion requires endosome-to-Golgi retrieval of Wntless/Evi/Sprinter by the retromer complex
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96QK1&geneProductId=UniProtKB:Q96QK1
determination method
NAS
retrieved
17 October 2017
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96QK1&geneProductId=UniProtKB:Q96QK1
determination method
IEA
retrieved
17 October 2017
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96QK1&geneProductId=UniProtKB:Q96QK1
determination method
IEA
retrieved
17 October 2017
stated in
Human orthologs of yeast vacuolar protein sorting proteins Vps26, 29, and 35: assembly into multimeric complexes
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96QK1&geneProductId=UniProtKB:Q96QK1
determination method
IDA
retromer complex
determination method
IBA
IDA
IEA
NAS
TAS
7 references
retrieved
8 April 2019
stated in
The regulation and deregulation of Wnt signaling by PARK genes in health and disease
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96QK1
determination method
TAS
retrieved
8 April 2019
stated in
The vacuolar-ATPase inhibitor bafilomycin and mutant VPS35 inhibit canonical Wnt signaling
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96QK1
determination method
TAS
retrieved
8 April 2019
stated in
Wingless secretion requires endosome-to-Golgi retrieval of Wntless/Evi/Sprinter by the retromer complex
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96QK1
determination method
NAS
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96QK1
determination method
IEA
retrieved
8 April 2019
stated in
Retriever is a multiprotein complex for retromer-independent endosomal cargo recycling.
GOA
curator
UniProt
UniProt protein ID
Q96QK1
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96QK1
determination method
IDA
retrieved
8 April 2019
stated in
Human orthologs of yeast vacuolar protein sorting proteins Vps26, 29, and 35: assembly into multimeric complexes
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96QK1
determination method
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96QK1
determination method
IBA
biological process
retrograde transport, endosome to Golgi
determination method
NAS
IEA
IMP
8 references
retrieved
17 October 2017
stated in
Human orthologs of yeast vacuolar protein sorting proteins Vps26, 29, and 35: assembly into multimeric complexes
GOA
curator
UniProt
UniProt protein ID
Q96QK1
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96QK1&geneProductId=UniProtKB:Q96QK1
determination method
NAS
retrieved
17 October 2017
stated in
Retromer: Structure, function, and roles in mammalian disease
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96QK1&geneProductId=UniProtKB:Q96QK1
determination method
NAS
retrieved
17 October 2017
stated in
Wingless secretion requires endosome-to-Golgi retrieval of Wntless/Evi/Sprinter by the retromer complex
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96QK1&geneProductId=UniProtKB:Q96QK1
determination method
NAS
retrieved
17 October 2017
stated in
Role of the mammalian retromer in sorting of the cation-independent mannose 6-phosphate receptor
GOA
curator
UniProt
UniProt protein ID
Q96QK1
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96QK1&geneProductId=UniProtKB:Q96QK1
determination method
IMP
retrieved
17 October 2017
stated in
Parkinson Disease-linked Vps35 R524W Mutation Impairs the Endosomal Association of Retromer and Induces α-Synuclein Aggregation
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96QK1&geneProductId=UniProtKB:Q96QK1
determination method
IMP
retrieved
17 October 2017
stated in
Parkinson's disease-associated mutant VPS35 causes mitochondrial dysfunction by recycling DLP1 complexes
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96QK1&geneProductId=UniProtKB:Q96QK1
determination method
IMP
retrieved
17 October 2017
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96QK1&geneProductId=UniProtKB:Q96QK1
determination method
IEA
retrieved
17 October 2017
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96QK1&geneProductId=UniProtKB:Q96QK1
determination method
IEA
retrograde transport, endosome to Golgi
determination method
IBA
IEA
IMP
NAS
9 references
retrieved
8 April 2019
stated in
Human orthologs of yeast vacuolar protein sorting proteins Vps26, 29, and 35: assembly into multimeric complexes
GOA
curator
UniProt
UniProt protein ID
Q96QK1
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96QK1
determination method
NAS
retrieved
8 April 2019
stated in
Retromer: Structure, function, and roles in mammalian disease
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96QK1
determination method
NAS
retrieved
8 April 2019
stated in
Wingless secretion requires endosome-to-Golgi retrieval of Wntless/Evi/Sprinter by the retromer complex
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96QK1
determination method
NAS
retrieved
8 April 2019
stated in
Role of the mammalian retromer in sorting of the cation-independent mannose 6-phosphate receptor
GOA
curator
UniProt
UniProt protein ID
Q96QK1
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96QK1
determination method
IMP
retrieved
8 April 2019
stated in
Parkinson's disease-associated mutant VPS35 causes mitochondrial dysfunction by recycling DLP1 complexes
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96QK1
determination method
IMP
retrieved
8 April 2019
stated in
Parkinson Disease-linked Vps35 R524W Mutation Impairs the Endosomal Association of Retromer and Induces α-Synuclein Aggregation
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96QK1
determination method
IMP
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96QK1
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96QK1
determination method
IEA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96QK1
determination method
IBA

Identifiers

 
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