Arachidonate 12-lipoxygenase, 12S type (Q21133173)

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mammalian protein found in Homo sapiens

platelet 12-LOX
arachidonate 15-lipoxygenase,15S-type
platelet-type 12-lipoxygenase
3.3.2.-
platelet-type lipoxygenase 12
ALOX12
Arachidonate 12-lipoxygenase, 12S-type
arachidonate (12S)-lipoxygenase
polyunsaturated fatty acid lipoxygenase ALOX12
linoleate 13S-lipoxygenase
12(S)-lipoxygenase
lipoxin synthase 12-LO
arachidonate (15S)-lipoxygenase
12S-lipoxygenase

Language	Label	Description	Also known as
English	Arachidonate 12-lipoxygenase, 12S type	mammalian protein found in Homo sapiens	platelet 12-LOX arachidonate 15-lipoxygenase,15S-type platelet-type 12-lipoxygenase 3.3.2.- platelet-type lipoxygenase 12 ALOX12 Arachidonate 12-lipoxygenase, 12S-type arachidonate (12S)-lipoxygenase polyunsaturated fatty acid lipoxygenase ALOX12 linoleate 13S-lipoxygenase 12(S)-lipoxygenase lipoxin synthase 12-LO arachidonate (15S)-lipoxygenase 12S-lipoxygenase

Statements

1 reference

13 November 2019

UniProt protein ID

Lipoxigenase, C-terminal domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P18054

PLAT/LH2 domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P18054

Lipoxygenase, mammalian

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P18054

membrane protein

1 reference

based on heuristic

inferred from GOA cell component → membrane

Lipoxygenase, C-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Lipoxygenase, iron binding site, protein family

1 reference

based on heuristic

inferred from protein domain or family

PLAT/LH2 domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Lipoxygenase, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

hepoxilin A3 synthase activity

determination method

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18054&geneProductId=UniProtKB:P18054

determination method

iron ion binding

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18054

determination method

arachidonate 12(S)-lipoxygenase activity

determination method

7 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18054&geneProductId=UniProtKB:P18054

determination method

1 January 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18054&geneProductId=UniProtKB:P18054

determination method

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18054&geneProductId=UniProtKB:P18054

determination method

1 January 2018

Catalytic properties of human platelet 12-lipoxygenase as compared with the enzymes of other origins

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18054&geneProductId=UniProtKB:P18054

determination method

1 January 2018

Purification and characterization of recombinant histidine-tagged human platelet 12-lipoxygenase expressed in a baculovirus/insect cell system

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18054&geneProductId=UniProtKB:P18054

determination method

1 January 2018

Molecular cloning, primary structure, and expression of the human platelet/erythroleukemia cell 12-lipoxygenase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18054&geneProductId=UniProtKB:P18054

determination method

1 January 2018

Cloning of the cDNA for human 12-lipoxygenase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18054&geneProductId=UniProtKB:P18054

determination method

dioxygenase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18054

determination method

hepoxilin-epoxide hydrolase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18054

determination method

protein binding

determination method

1 reference

8 April 2019

Identification of 12-lipoxygenase interaction with cellular proteins by yeast two-hybrid screening

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18054

determination method

linoleate 13S-lipoxygenase activity

determination method

1 reference

8 April 2019

Purification and characterization of recombinant histidine-tagged human platelet 12-lipoxygenase expressed in a baculovirus/insect cell system

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18054

determination method

oxidoreductase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18054

determination method

hydrolase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18054

determination method

arachidonate 12(S)-lipoxygenase activity

determination method

6 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18054

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18054

determination method

8 April 2019

Catalytic properties of human platelet 12-lipoxygenase as compared with the enzymes of other origins

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18054

determination method

8 April 2019

Molecular cloning, primary structure, and expression of the human platelet/erythroleukemia cell 12-lipoxygenase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18054

determination method

8 April 2019

Purification and characterization of recombinant histidine-tagged human platelet 12-lipoxygenase expressed in a baculovirus/insect cell system

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18054

determination method

8 April 2019

Cloning of the cDNA for human 12-lipoxygenase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18054

determination method

oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18054

determination method

determination method

3 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18054

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18054

determination method

8 April 2019

Purification and characterization of recombinant histidine-tagged human platelet 12-lipoxygenase expressed in a baculovirus/insect cell system

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18054

determination method

determination method

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18054

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18054

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18054

determination method

8 April 2019

Lipoxygenase-dependent superoxide release in skeletal muscle

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18054

determination method

8 April 2019

12-Lipoxygenase in A431 cells: genetic identity, modulation of expression, and intracellular localization

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18054

determination method

determination method

1 reference

1 January 2018

Lipoxygenase-dependent superoxide release in skeletal muscle

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18054&geneProductId=UniProtKB:P18054

determination method

extracellular exosome

determination method

1 reference

26 September 2017

Large-scale proteomics and phosphoproteomics of urinary exosomes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18054&geneProductId=UniProtKB:P18054

determination method

extracellular exosome

determination method

1 reference

8 April 2019

Large-scale proteomics and phosphoproteomics of urinary exosomes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18054

determination method

biological process

linoleic acid metabolic process

determination method

positive regulation of cell death

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18054

determination method

positive regulation of endothelial cell differentiation

determination method

1 reference

26 September 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18054&geneProductId=UniProtKB:P18054

determination method

lipoxin A4 biosynthetic process

determination method

1 reference

8 April 2019

Lipoxin synthase activity of human platelet 12-lipoxygenase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18054

determination method

lipid metabolism

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18054

determination method

positive regulation of cell migration

determination method

1 reference

26 September 2017

Up-regulation of 12(S)-lipoxygenase induces a migratory phenotype in colorectal cancer cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18054&geneProductId=UniProtKB:P18054

determination method

lipoxin B4 biosynthetic process

determination method

1 reference

8 April 2019

Lipoxin synthase activity of human platelet 12-lipoxygenase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18054

determination method

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18054

determination method

negative regulation of apoptotic process

determination method

3 references

26 September 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18054&geneProductId=UniProtKB:P18054

determination method

26 September 2017

Molecular identification, localization and function of platelet-type 12-lipoxygenase in human melanoma progression, under experimental and clinical conditions

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18054&geneProductId=UniProtKB:P18054

determination method

26 September 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18054&geneProductId=UniProtKB:P18054

determination method

negative regulation of muscle cell apoptotic process

determination method

1 reference

8 April 2019

12S-Lipoxygenase is necessary for human vascular smooth muscle cell survival

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18054

determination method

fatty acid metabolic process

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18054

determination method

positive regulation of angiogenesis

determination method

1 reference

26 September 2017

Platelet-type 12-lipoxygenase in a human prostate carcinoma stimulates angiogenesis and tumor growth

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18054&geneProductId=UniProtKB:P18054

determination method

reactive oxygen species metabolic process

determination method

1 reference

26 September 2017

Mechanisms of free-radical induction in relation to fenretinide-induced apoptosis of neuroblastoma

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18054&geneProductId=UniProtKB:P18054

determination method

superoxide anion generation

determination method

1 reference

8 April 2019

Lipoxygenase-dependent superoxide release in skeletal muscle

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18054

determination method

positive regulation of endothelial cell migration

determination method

1 reference

26 September 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18054&geneProductId=UniProtKB:P18054

determination method

lipoxygenase pathway

determination method

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18054

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18054

determination method

8 April 2019

Purification and characterization of recombinant histidine-tagged human platelet 12-lipoxygenase expressed in a baculovirus/insect cell system

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18054

determination method

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18054

determination method

positive regulation of cell growth

determination method

1 reference

26 September 2017

Relationship between lipoxygenase and human testicular cancer

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18054&geneProductId=UniProtKB:P18054

determination method

positive regulation of gene expression

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18054

determination method

positive regulation of mitochondrial depolarization

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18054

determination method

fatty acid oxidation

determination method

1 reference

8 April 2019

12/15-lipoxygenase is increased in Alzheimer's disease: possible involvement in brain oxidative stress

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18054

determination method

positive regulation of cell population proliferation

determination method

5 references

26 September 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18054&geneProductId=UniProtKB:P18054

determination method

26 September 2017

Up-regulation of 12(S)-lipoxygenase induces a migratory phenotype in colorectal cancer cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18054&geneProductId=UniProtKB:P18054

determination method

26 September 2017

Platelet-type 12-lipoxygenase in a human prostate carcinoma stimulates angiogenesis and tumor growth

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18054&geneProductId=UniProtKB:P18054

determination method

26 September 2017

Expression of lipoxygenase in human prostate cancer and growth reduction by its inhibitors

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18054&geneProductId=UniProtKB:P18054

determination method

26 September 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18054&geneProductId=UniProtKB:P18054

determination method

positive regulation of apoptotic process

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18054

determination method

cellular response to lipid

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18054

determination method

hepoxilin metabolic process

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18054

determination method

lipoxin metabolic process

determination method

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18054&geneProductId=UniProtKB:P18054

determination method

positive regulation of cell adhesion

determination method

1 reference

26 September 2017

Increased metastatic potential in human prostate carcinoma cells by overexpression of arachidonate 12-lipoxygenase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18054&geneProductId=UniProtKB:P18054

determination method

positive regulation of smooth muscle cell proliferation

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18054

determination method

arachidonic acid metabolic process

determination method

4 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18054

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18054

determination method

8 April 2019

Catalytic properties of human platelet 12-lipoxygenase as compared with the enzymes of other origins

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18054

determination method

8 April 2019

Purification and characterization of recombinant histidine-tagged human platelet 12-lipoxygenase expressed in a baculovirus/insect cell system

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18054

determination method

long-chain fatty acid biosynthetic process

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18054

determination method

negative regulation of apoptotic process

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18054

determination method

positive regulation of blood vessel endothelial cell migration

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18054

determination method

positive regulation of endothelial tube morphogenesis

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18054

determination method

lipoxin biosynthetic process

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18054

determination method

EC enzyme number

3.3.2.-

1 reference

14 November 2015

http://www.uniprot.org/uniprot/P18054.txt?version=173

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000251535

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000251535

ENSP00000467033

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000467033

PDB structure ID

1 reference

UniProt protein ID

4 August 2016

language of work or name

Sitelinks

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