Insulin-degrading enzyme regulates extracellular levels of amyloid beta-protein by degradation (Q22008492)

insulin catabolic process

GOA release 2020-03-11

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GOA release 2020-03-11

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W Q Qiu

1

W Q

Qiu

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7 February 2023

D M Walsh

2

D M

Walsh

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7 February 2023

Z Ye

3

Z

Ye

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7 February 2023

K Vekrellis

4

K

Vekrellis

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7 February 2023

J Zhang

5

J

Zhang

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7 February 2023

M B Podlisny

6

M B

Podlisny

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7 February 2023

M R Rosner

7

M R

Rosner

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7 February 2023

A Safavi

8

A

Safavi

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7 February 2023

L B Hersh

9

L B

Hersh

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7 February 2023

D J Selkoe

10

D J

Journal of Biological Chemistry

Selkoe

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7 February 2023

language of work or name

English

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publication date

4 December 1998

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published in

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volume

273

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issue

49

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page(s)

32730-8

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cites work

Overexpression of insulin degrading enzyme: cellular localization and effects on insulin signaling

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Alzheimer's beta-amyloid peptide specifically interacts with and is degraded by insulin degrading enzyme

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Insulysin and pitrilysin: insulin-degrading enzymes of mammals and bacteria

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Seeding "one-dimensional crystallization" of amyloid: a pathogenic mechanism in Alzheimer's disease and scrapie?

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Expression, purification, and characterization of the Kunitz-type proteinase inhibitor domain of the amyloid beta-protein precursor-like protein-2.

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7 January 2021

Hydrolysis of amyloid precursor protein-derived peptides by cysteine proteinases and extracts of rat brain clathrin-coated vesicles.

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7 January 2021

Neutral endopeptidase can hydrolyze beta-amyloid(1-40) but shows no effect on beta-amyloid precursor protein metabolism

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Characterization of an insulin degrading enzyme from cultured human lymphocytes

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7 January 2021

The carboxy terminus of the beta amyloid protein is critical for the seeding of amyloid formation: implications for the pathogenesis of Alzheimer's disease

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7 January 2021

Identification of gamma-endorphin-generating enzyme as insulin-degrading enzyme

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Oligomerization of endogenous and synthetic amyloid beta-protein at nanomolar levels in cell culture and stabilization of monomer by Congo red.

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7 January 2021

Degradation of Alzheimer's beta-amyloid protein by human and rat brain peptidases: involvement of insulin-degrading enzyme.

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7 January 2021

Amyloid beta-peptide is produced by cultured cells during normal metabolism

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Gelatinase A not alpha-secretase?

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Proteolytic degradation of Alzheimer's disease amyloid beta-peptide by a metalloproteinase from microglia cells.

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7 January 2021

Degradation of the cleaved leader peptide of thiolase by a peroxisomal proteinase

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Aggregation of secreted amyloid beta-protein into sodium dodecyl sulfate-stable oligomers in cell culture

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Amino-terminal deletions enhance aggregation of beta-amyloid peptides in vitro

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7 January 2021

Degradation of amyloid beta-protein by a serine protease-alpha2-macroglobulin complex.

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Degradation of amyloid beta-protein by a metalloprotease secreted by microglia and other neural and non-neural cells

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Slow degradation of aggregates of the Alzheimer's disease amyloid beta-protein by microglial cells.

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An insulin epidermal growth factor-binding protein from Drosophila has insulin-degrading activity

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Processing and presentation of insulin. III. Insulin degrading enzyme: a neutral metalloendoproteinase that is non-homologous to classical endoproteinases mediates the processing of insulin epitopes for helper T cells

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Alzheimer's disease: genotypes, phenotypes, and treatments

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7 January 2021

Conservation of brain amyloid proteins in aged mammals and humans with Alzheimer's disease.

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7 January 2021

Insulin-degrading enzyme does not require peroxisomal localization for insulin degradation

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7 January 2021

Characterization of insulin-degrading activity of intact and subcellular components of human fibroblasts

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7 January 2021

Insulin and cognitive function in an elderly population. The Rotterdam Study.

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7 January 2021