Developing master keys to brain pathology, cancer and aging from the structural biology of proteins controlling reactive oxygen species and DNA repair. (Q35865533)

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scientific article published on 15 December 2006

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English	Developing master keys to brain pathology, cancer and aging from the structural biology of proteins controlling reactive oxygen species and DNA repair.	scientific article published on 15 December 2006

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scholarly article

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23 December 2019

3 references

Europe PubMed Central

24 January 2021

14 July 2021

Developing master keys to brain pathology, cancer and aging from the structural biology of proteins controlling reactive oxygen species and DNA repair (English)

1 reference

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23 December 2019

3 references

25 April 2019

28 September 2019

4 November 2019

1 reference

28 September 2019

inorganic compound

1 reference

4 November 2019

reactive oxygen species

1 reference

based on heuristic

inferred from title

1 reference

24 January 2021

1 reference

14 July 2021

structural biology

1 reference

based on heuristic

inferred from title

3

1 reference

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23 December 2019

author name string

J J P Perry

1

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23 December 2019

L Fan

2

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publication date

15 December 2006

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23 December 2019

14 April 2007

2 references

24 January 2021

14 July 2021

6 references

25 April 2019

28 September 2019

4 November 2019

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17174478%20AND%20SRC:MED&resulttype=core&format=json

23 December 2019

24 January 2021

14 July 2021

145

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23 December 2019

4

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23 December 2019

1280-1299

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23 December 2019

Sit down, relax and unwind: structural insights into RecQ helicase mechanisms

1 reference

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Mechanisms of RecQ helicases in pathways of DNA metabolism and maintenance of genomic stability

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NO chimeras as therapeutic agents in Alzheimer's disease

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WRN exonuclease structure and molecular mechanism imply an editing role in DNA end processing

1 reference

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Conserved XPB core structure and motifs for DNA unwinding: implications for pathway selection of transcription or excision repair

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A novel processive mechanism for DNA synthesis revealed by structure, modeling and mutagenesis of the accessory subunit of human mitochondrial DNA polymerase

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p8/TTD-A as a repair-specific TFIIH subunit

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Solution structure of a multifunctional DNA- and protein-binding motif of human Werner syndrome protein

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Functional human mitochondrial DNA polymerase gamma forms a heterotrimer

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Protein mimicry of DNA and pathway regulation

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Hydrogen bonding in human manganese superoxide dismutase containing 3-fluorotyrosine.

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The physiology and pathophysiology of nitric oxide in the brain.

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An introduction to NO-related therapeutic agents

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Conferring substrate specificity to DNA helicases: role of the RecQ HRDC domain.

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DNA helicases as targets for anti-cancer drugs.

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11 July 2018

Current advances in unraveling the function of the Werner syndrome protein

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Deficient DNA repair in the human progeroid disorder, Werner syndrome

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Ageing and PARP.

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Pathways and functions of the Werner syndrome protein

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11 July 2018

Phosphorylation of XPB helicase regulates TFIIH nucleotide excision repair activity

1 reference

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Complex genetics of amyotrophic lateral sclerosis

1 reference

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The Werner syndrome protein at the crossroads of DNA repair and apoptosis

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MRE11/RAD50/NBS1: complex activities

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Oxidative stress in neurodegeneration: cause or consequence?

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Poly(ADP-ribose) polymerase 1 regulates both the exonuclease and helicase activities of the Werner syndrome protein

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The Mre11 complex and the metabolism of chromosome breaks: the importance of communicating and holding things together

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11 July 2018

Nitric oxide pathways in Alzheimer's disease and other neurodegenerative dementias

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Is nitric oxide a key target in the pathogenesis of brain lesions during the development of Alzheimer's disease?

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DNA polymerase gamma, the mitochondrial replicase

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Type IV pilus structure and bacterial pathogenicity

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Linkage between Werner syndrome protein and the Mre11 complex via Nbs1.

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11 July 2018

Identification and biochemical characterization of a Werner's syndrome protein complex with Ku70/80 and poly(ADP-ribose) polymerase-1

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DNA repair-deficient diseases, xeroderma pigmentosum, Cockayne syndrome and trichothiodystrophy

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Structural basis for FEN-1 substrate specificity and PCNA-mediated activation in DNA replication and repair

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Amino acid substitution at the dimeric interface of human manganese superoxide dismutase

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11 July 2018

Central Role for the Werner Syndrome Protein/Poly(ADP-Ribose) Polymerase 1 Complex in the Poly(ADP-Ribosyl)ation Pathway after DNA Damage

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High-resolution structure of the E.coli RecQ helicase catalytic core

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ALS mutants of human superoxide dismutase form fibrous aggregates via framework destabilization

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The MRN complex: coordinating and mediating the response to broken chromosomes

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Full-length archaeal Rad51 structure and mutants: mechanisms for RAD51 assembly and control by BRCA2

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Nitric-oxide synthase (NOS) reductase domain models suggest a new control element in endothelial NOS that attenuates calmodulin-dependent activity

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Werner syndrome and the function of the Werner protein; what they can teach us about the molecular aging process.

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WRN interacts physically and functionally with the recombination mediator protein RAD52

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The Werner syndrome protein stimulates DNA polymerase beta strand displacement synthesis via its helicase activity

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Chromosomal cohesin forms a ring

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RecQ helicases: caretakers of the genome

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Extensive conformational sampling in a ternary electron transfer complex

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A nucleolar targeting sequence in the Werner syndrome protein resides within residues 949-1092.

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Displacement of DNA-PKcs from DNA ends by the Werner syndrome protein

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Telomere-binding protein TRF2 binds to and stimulates the Werner and Bloom syndrome helicases

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Ku heterodimer binds to both ends of the Werner protein and functional interaction occurs at the Werner N-terminus

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Intrinsic and extrinsic modulation of nitric oxide synthase activity.

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Catalytic pathway of manganese superoxide dismutase by direct observation of superoxide

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Werner protein is a target of DNA-dependent protein kinase in vivo and in vitro, and its catalytic activities are regulated by phosphorylation

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DNA double-strand break repair from head to tail

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Human Rad50/Mre11 is a flexible complex that can tether DNA ends

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Promotion of Dnl4-catalyzed DNA end-joining by the Rad50/Mre11/Xrs2 and Hdf1/Hdf2 complexes

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From Charcot to Lou Gehrig: deciphering selective motor neuron death in ALS

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11 July 2018

Werner syndrome protein interacts with human flap endonuclease 1 and stimulates its cleavage activity

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Protein folding and its links with human disease

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11 July 2018

Coordinate action of the helicase and 3' to 5' exonuclease of Werner syndrome protein

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11 July 2018

Werner syndrome protein is regulated and phosphorylated by DNA-dependent protein kinase

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Current status of SOD1 mutations in familial amyotrophic lateral sclerosis

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Genetics of sporadic ALS.

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11 July 2018

Nitric oxide synthases: structure, function and inhibition

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11 July 2018

p53 Modulates the exonuclease activity of Werner syndrome protein

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Protein misfolding and disease; protein refolding and therapy

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11 July 2018

Werner helicase relocates into nuclear foci in response to DNA damaging agents and co-localizes with RPA and Rad51.

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Structural biochemistry and interaction architecture of the DNA double-strand break repair Mre11 nuclease and Rad50-ATPase

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11 July 2018

Genome maintenance mechanisms for preventing cancer

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11 July 2018

A functional interaction of Ku with Werner exonuclease facilitates digestion of damaged DNA

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11 July 2018

Multiple regions of subunit interaction in Drosophila mitochondrial DNA polymerase: three functional domains in the accessory subunit

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11 July 2018

DNA double-strand breaks: signaling, repair and the cancer connection

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11 July 2018

Human DNA repair genes

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11 July 2018

Cerebral ischemia and inflammation

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11 July 2018

Crystal structure and deletion analysis show that the accessory subunit of mammalian DNA polymerase gamma, Pol gamma B, functions as a homodimer

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11 July 2018

Unwinding the 'Gordian knot' of helicase action.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1904427

11 July 2018

Requirements for the nucleolytic processing of DNA ends by the Werner syndrome protein-Ku70/80 complex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1904427

11 July 2018

Formation of high molecular weight complexes of mutant Cu, Zn-superoxide dismutase in a mouse model for familial amyotrophic lateral sclerosis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1904427

11 July 2018

Crystal structures of mismatch repair protein MutS and its complex with a substrate DNA

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1904427

11 July 2018

Werner protein recruits DNA polymerase delta to the nucleolus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1904427

11 July 2018

Molecular structure of human TFIIH

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1904427

11 July 2018

Protein aggregation in Huntington's and Parkinson's disease: implications for therapy.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1904427

11 July 2018

A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1904427

11 July 2018

Twists in catalysis: alternating conformations of Escherichia coli thioredoxin reductase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1904427

11 July 2018

Functional interaction between Ku and the werner syndrome protein in DNA end processing

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1904427

11 July 2018

Characterization of the human and mouse WRN 3'-->5' exonuclease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1904427

11 July 2018

Multiple replacements of glutamine 143 in human manganese superoxide dismutase: effects on structure, stability, and catalysis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1904427

11 July 2018

Mechanism of ATP-dependent promoter melting by transcription factor IIH

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1904427

11 July 2018

Ku complex interacts with and stimulates the Werner protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1904427

11 July 2018

DNA helicases: 'inching forward'.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1904427

11 July 2018

Active and inhibited human catalase structures: ligand and NADPH binding and catalytic mechanism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1904427

11 July 2018

The three-dimensional structure of the HRDC domain and implications for the Werner and Bloom syndrome proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1904427

11 July 2018

Cellular Werner phenotypes in mice expressing a putative dominant-negative human WRN gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1904427

11 July 2018

The Werner syndrome gene product co-purifies with the DNA replication complex and interacts with PCNA and topoisomerase I.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1904427

11 July 2018

WRN helicase expression in Werner syndrome cell lines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1904427

11 July 2018

Natural engineering principles of electron tunnelling in biological oxidation-reduction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1904427

11 July 2018

N-terminal domain swapping and metal ion binding in nitric oxide synthase dimerization.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1904427

11 July 2018

Physical and functional interaction between p53 and the Werner's syndrome protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1904427

11 July 2018

Disruption of mRad50 causes embryonic stem cell lethality, abnormal embryonic development, and sensitivity to ionizing radiation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1904427

11 July 2018

Functional and physical interaction between WRN helicase and human replication protein A

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1904427

11 July 2018

Oligomeric ring structure of the Bloom's syndrome helicase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1904427

11 July 2018

Molecular mechanism of nucleotide excision repair.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1904427

11 July 2018

Protein mimicry of DNA from crystal structures of the uracil-DNA glycosylase inhibitor protein and its complex with Escherichia coli uracil-DNA glycosylase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1904427

11 July 2018

Structural characterization of nitric oxide synthase isoforms reveals striking active-site conservation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1904427

11 July 2018

Structure of a cytochrome P450-redox partner electron-transfer complex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1904427

11 July 2018

Reconstitution of the transcription factor TFIIH: assignment of functions for the three enzymatic subunits, XPB, XPD, and cdk7

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1904427

11 July 2018

Resistance to nitric oxide-mediated apoptosis in HL-60 variant cells is associated with increased activities of Cu,Zn-superoxide dismutase and catalase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1904427

11 July 2018

Crystal structure of constitutive endothelial nitric oxide synthase: a paradigm for pterin function involving a novel metal center

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1904427

11 July 2018

Structure of the DNA repair and replication endonuclease and exonuclease FEN-1: coupling DNA and PCNA binding to FEN-1 activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1904427

11 July 2018

The premature ageing syndrome protein, WRN, is a 3'-->5' exonuclease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1904427

11 July 2018

Aggregation and Motor Neuron Toxicity of an ALS-Linked SOD1 Mutant Independent from Wild-Type SOD1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1904427

11 July 2018

Characterization of Werner syndrome protein DNA helicase activity: directionality, substrate dependence and stimulation by replication protein A

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1904427

11 July 2018

Electron transfer by domain movement in cytochrome bc1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1904427

11 July 2018

Crystal structure of Y34F mutant human mitochondrial manganese superoxide dismutase and the functional role of tyrosine 34

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1904427

11 July 2018

Structure of nitric oxide synthase oxygenase dimer with pterin and substrate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1904427

11 July 2018

Expression of long-patch and short-patch DNA mismatch repair proteins in the embryonic and adult mammalian brain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1904427

11 July 2018

A novel neurological phenotype in mice lacking mitochondrial manganese superoxide dismutase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1904427

11 July 2018

Biosynthesis and action of nitric oxide in mammalian cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1904427

11 July 2018

The proofreading domain of Escherichia coli DNA polymerase I and other DNA and/or RNA exonuclease domains

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1904427

11 July 2018

DNA replication and postreplication mismatch repair in cell-free extracts from cultured human neuroblastoma and fibroblast cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1904427

11 July 2018

The structure of nitric oxide synthase oxygenase domain and inhibitor complexes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1904427

11 July 2018

The Werner syndrome protein is a DNA helicase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1904427

11 July 2018

Three-dimensional structure of NADPH-cytochrome P450 reductase: prototype for FMN- and FAD-containing enzymes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1904427

11 July 2018

Conditional gene targeted deletion by Cre recombinase demonstrates the requirement for the double-strand break repair Mre11 protein in murine embryonic stem cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1904427

11 July 2018

Positionally cloned human disease genes: patterns of evolutionary conservation and functional motifs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1904427

11 July 2018

A mutation in the XPB/ERCC3 DNA repair transcription gene, associated with trichothiodystrophy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1904427

11 July 2018

Identification of a novel growth-promoting factor with a wide target cell spectrum from various tumor cells as catalase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1904427

11 July 2018

A novel human catalase mutation (358 T-->del) causing Japanese-type acatalasemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1904427

11 July 2018

Heme iron reduction and catalysis by a nitric oxide synthase heterodimer containing one reductase and two oxygenase domains

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1904427

11 July 2018

Positional cloning of the Werner's syndrome gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1904427

11 July 2018

Lethality induced by a single site-specific double-strand break in a dispensable yeast plasmid

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1904427

11 July 2018

DNA repair helicase: a component of BTF2 (TFIIH) basic transcription factor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1904427

11 July 2018

Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1904427

11 July 2018

Amyotrophic lateral sclerosis and structural defects in Cu,Zn superoxide dismutase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1904427

11 July 2018

DNA excision-repair defect of xeroderma pigmentosum prevents removal of a class of oxygen free radical-induced base lesions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1904427

11 July 2018

Crystal structure of human uracil-DNA glycosylase in complex with a protein inhibitor: protein mimicry of DNA

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1904427

11 July 2018

The Bloom's syndrome gene product is homologous to RecQ helicases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1904427

11 July 2018

Nucleotide mimicry in the crystal structure of the uracil-DNA glycosylase-uracil glycosylase inhibitor protein complex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1904427

11 July 2018

Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese superoxide dismutase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1904427

11 July 2018

Oxygen toxicity, oxygen radicals, transition metals and disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1904427

11 July 2018

Catalase: Physical and chemical properties, mechanism of catalysis, and physiological role

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1904427

11 July 2018

Changes in crystallographic structure and thermostability of a Cu,Zn superoxide dismutase mutant resulting from the removal of a buried cysteine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1904427

11 July 2018

Thermostabilization of recombinant human and bovine CuZn superoxide dismutases by replacement of free cysteines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1904427

11 July 2018

Atomic structures of wild-type and thermostable mutant recombinant human Cu,Zn superoxide dismutase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1904427

11 July 2018

The structure of human mitochondrial manganese superoxide dismutase reveals a novel tetrameric interface of two 4-helix bundles

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1904427

11 July 2018

Type IV pilus structure by cryo-electron microscopy and crystallography: implications for pilus assembly and functions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1904427

24 September 2018

Modifications of platelet from Alzheimer disease patients: a possible relation between membrane properties and NO metabolites.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1904427

24 September 2018

A nanomachine for making ends meet: MRN is a flexing scaffold for the repair of DNA double-strand breaks.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1904427

24 September 2018

Structural basis for isozyme-specific regulation of electron transfer in nitric-oxide synthase.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1904427

24 September 2018

Role of hydrogen bonding in the active site of human manganese superoxide dismutase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1904427

24 September 2018

MR evidence of structural and metabolic changes in brains of patients with Werner's syndrome.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1904427

24 September 2018

Werner syndrome protein contains three structure-specific DNA binding domains

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1904427

24 September 2018

Molecular disruption of the MRN(95) complex induces radiation sensitivity in head and neck cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1904427

24 September 2018

Oxidation-induced misfolding and aggregation of superoxide dismutase and its implications for amyotrophic lateral sclerosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1904427

24 September 2018

p52 Mediates XPB function within the transcription/repair factor TFIIH.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1904427

24 September 2018

Targeted disruption of the Nijmegen breakage syndrome gene NBS1 leads to early embryonic lethality in mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1904427

24 September 2018

Electron crystal structure of the transcription factor and DNA repair complex, core TFIIH.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1904427

24 September 2018

Oxidative stress in bacterial meningitis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1904427

24 September 2018

Distribution and kinetics of ethanol metabolism in rat brain.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1904427

24 September 2018

Detection of excision nuclease in cell-free extracts from the adult mammalian brain.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1904427

24 September 2018

Rejoining of DNA by the RAG1 and RAG2 proteins.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1904427

24 September 2018

Colocalization of NOS and SOD1 in neurofilament accumulation within motor neurons of amyotrophic lateral sclerosis: an immunohistochemical study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1904427

24 September 2018

Intense superoxide dismutase-1 immunoreactivity in intracytoplasmic hyaline inclusions of familial amyotrophic lateral sclerosis with posterior column involvement.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1904427

24 September 2018

DNA mismatch repair and DNA methylation in adult brain neurons.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1904427

24 September 2018

Electrostatic recognition between superoxide and copper, zinc superoxide dismutase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1904427

24 September 2018

Isolation and genetic characterization of a thymineless death-resistant mutant of Escherichia coli K12: identification of a new mutation (recQ1) that blocks the RecF recombination pathway.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1904427

24 September 2018

Aggregation of mutant Cu/Zn superoxide dismutase proteins in a culture model of ALS

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1904427

24 September 2018

Mitochondrial disorders

1 reference

https://pubmed.ncbi.nlm.nih.gov/17174478

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A minimal exonuclease domain of WRN forms a hexamer on DNA and possesses both 3'- 5' exonuclease and 5'-protruding strand endonuclease activities

1 reference

https://pubmed.ncbi.nlm.nih.gov/17174478

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Superoxide dismutases

1 reference

https://pubmed.ncbi.nlm.nih.gov/17174478

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Subunit dissociation and unfolding of macrophage NO synthase: relationship between enzyme structure, prosthetic group binding, and catalytic function

1 reference

https://pubmed.ncbi.nlm.nih.gov/17174478

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The pilus and porin of Neisseria gonorrhoeae cooperatively induce Ca(2+) transients in infected epithelial cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/17174478

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Further genetic heterogeneity in acatalasemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/17174478

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Rad50 hook domain is a critical determinant of Mre11 complex functions

1 reference

https://pubmed.ncbi.nlm.nih.gov/17174478

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structural analysis of flexible proteins in solution by small angle X-ray scattering combined with crystallography

1 reference

https://pubmed.ncbi.nlm.nih.gov/17174478

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Distribution and kainate-mediated induction of the DNA mismatch repair protein MSH2 in rat brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/17174478

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rapid kinetic studies of electron transfer in the three isoforms of nitric oxide synthase

1 reference

https://pubmed.ncbi.nlm.nih.gov/17174478

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Heterogeneity of erythrocyte catalase II. Isolation and characterization of normal and variant erythrocyte catalase and their subunits

1 reference

https://pubmed.ncbi.nlm.nih.gov/17174478

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Copper chaperone for superoxide dismutase co-aggregates with superoxide dismutase 1 (SOD1) in neuronal Lewy body-like hyaline inclusions: an immunohistochemical study on familial amyotrophic lateral sclerosis with SOD1 gene mutation

1 reference

https://pubmed.ncbi.nlm.nih.gov/17174478

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of reductase domain cluster 1 acidic residues in neuronal nitric-oxide synthase. Characterization of the FMN-FREE enzyme

1 reference

https://pubmed.ncbi.nlm.nih.gov/17174478

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of tryptophan 161 in catalysis by human manganese superoxide dismutase

1 reference

https://pubmed.ncbi.nlm.nih.gov/17174478

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Impaired nuclear localization of defective DNA helicases in Werner's syndrome

1 reference

https://pubmed.ncbi.nlm.nih.gov/17174478

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hierarchical deterioration of body systems in Werner's syndrome: implications for normal ageing

1 reference

https://pubmed.ncbi.nlm.nih.gov/17174478

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1016/J.NEUROSCIENCE.2006.10.045

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17174478%20AND%20SRC:MED&resulttype=core&format=json

23 December 2019

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17174478%20AND%20SRC:MED&resulttype=core&format=json

23 December 2019

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17174478%20AND%20SRC:MED&resulttype=core&format=json

23 December 2019

ResearchGate publication ID

0 references

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