Calcitonin receptor (Q3931282)

GPCR, family 2, calcitonin receptor

1 reference

G protein-coupled receptor

1 reference

Transporter Classification Database ID

9.A.14.4.1

2 October 2019

hierarchical database ID heuristic

GPCR, family 2, extracellular hormone receptor domain, protein family

1 reference

inferred from protein domain or family

GPCR, family 2-like

1 reference

inferred from protein domain or family

GPCR, family 2, secretin-like, conserved site, protein family

1 reference

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

3 references

8 April 2019

Molecular characterization of two novel isoforms of the human calcitonin receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30988

8 April 2019

Molecular characterization of two novel isoforms of the human calcitonin receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30988

8 April 2019

Cloning and characterization of an abundant subtype of the human calcitonin receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30988

signal transducer activity

1 reference

3 January 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P30988

2 references

transmembrane signaling receptor activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30988

1 reference

8 April 2019

Amyloid β (Aβ) peptide directly activates amylin-3 receptor subtype by triggering multiple intracellular signaling pathways

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30988

calcitonin gene-related peptide receptor activity

IC

1 reference

8 April 2019

Characterization of the human calcitonin gene-related peptide receptor subtypes associated with receptor activity-modifying proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30988

Characterization of the human calcitonin gene-related peptide receptor subtypes associated with receptor activity-modifying proteins

IPI

amylin receptor activity

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30988

8 April 2019

Amyloid β (Aβ) peptide directly activates amylin-3 receptor subtype by triggering multiple intracellular signaling pathways

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30988

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30988

2 references

2 references

integral component of plasma membrane

1 reference

8 April 2019

Molecular cloning and functional expression of a third isoform of the human calcitonin receptor and partial characterization of the calcitonin receptor gene

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30988

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30988

amylin receptor complex 1

IBA

1 reference

8 April 2019

Amyloid β (Aβ) peptide directly activates amylin-3 receptor subtype by triggering multiple intracellular signaling pathways

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30988

amylin receptor complex 2

1 reference

8 April 2019

Amyloid β (Aβ) peptide directly activates amylin-3 receptor subtype by triggering multiple intracellular signaling pathways

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30988

amylin receptor complex 3

1 reference

8 April 2019

Amyloid β (Aβ) peptide directly activates amylin-3 receptor subtype by triggering multiple intracellular signaling pathways

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30988

positive regulation of adenylate cyclase activity

biological process

3 references

3 January 2017

Expression of two human skeletal calcitonin receptor isoforms cloned from a giant cell tumor of bone. The first intracellular domain modulates ligand binding and signal transduction

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P30988

3 January 2017

Molecular characterization of two novel isoforms of the human calcitonin receptor

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P30988

3 January 2017

Molecular cloning and functional expression of a third isoform of the human calcitonin receptor and partial characterization of the calcitonin receptor gene

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P30988

adenylate cyclase-activating G protein-coupled receptor signaling pathway

NAS

positive regulation of cytosolic calcium ion concentration

1 reference

3 January 2017

Cloning and characterization of an abundant subtype of the human calcitonin receptor

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P30988

Visualization of the calcitonin receptor-like receptor and its receptor activity-modifying proteins during internalization and recycling

receptor internalization

1 reference

3 January 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P30988

response to glucocorticoid

1 reference

8 April 2019

Regulation of calcitonin receptor by glucocorticoid in human osteoclast-like cells prepared in vitro using receptor activator of nuclear factor-kappaB ligand and macrophage colony-stimulating factor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30988

activation of phospholipase C activity

1 reference

3 January 2017

Hemolytic anemia associated with Wilson's disease

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P30988

activation of adenylate cyclase activity

1 reference

8 April 2019

Molecular characterization of two novel isoforms of the human calcitonin receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30988

cell surface receptor signaling pathway

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30988

1 reference

3 January 2017

Characterization of the human calcitonin gene-related peptide receptor subtypes associated with receptor activity-modifying proteins

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P30988

protein localization to plasma membrane

1 reference

3 January 2017

Characterization of the human calcitonin gene-related peptide receptor subtypes associated with receptor activity-modifying proteins

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P30988

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30988

G protein-coupled receptor signaling pathway

IEA

adenylate cyclase-activating G protein-coupled receptor signaling pathway

IEA

3 references

5 references

8 April 2019

Cloning, characterization, and expression of a human calcitonin receptor from an ovarian carcinoma cell line

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30988

8 April 2019

Amyloid β (Aβ) peptide directly activates amylin-3 receptor subtype by triggering multiple intracellular signaling pathways

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30988

8 April 2019

Characterization of the human calcitonin gene-related peptide receptor subtypes associated with receptor activity-modifying proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30988

8 April 2019

Identification of multiple human calcitonin receptor isoforms: heterologous expression and pharmacological characterization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30988

8 April 2019

Molecular characterization of two novel isoforms of the human calcitonin receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30988

positive regulation of cytosolic calcium ion concentration

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30988

positive regulation of gene expression

IBA

1 reference

8 April 2019

Amyloid β (Aβ) peptide directly activates amylin-3 receptor subtype by triggering multiple intracellular signaling pathways

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30988

positive regulation of protein kinase A signaling

1 reference

8 April 2019

Amyloid β (Aβ) peptide directly activates amylin-3 receptor subtype by triggering multiple intracellular signaling pathways

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30988

positive regulation of cell death

1 reference

8 April 2019

Amyloid β (Aβ) peptide directly activates amylin-3 receptor subtype by triggering multiple intracellular signaling pathways

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30988

positive regulation of peptidyl-serine phosphorylation

1 reference

8 April 2019

Amyloid β (Aβ) peptide directly activates amylin-3 receptor subtype by triggering multiple intracellular signaling pathways

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30988

cross-receptor inhibition within G protein-coupled receptor heterodimer

1 reference

8 April 2019

Characterization of the human calcitonin gene-related peptide receptor subtypes associated with receptor activity-modifying proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30988

positive regulation of protein kinase B signaling

IPI

1 reference

8 April 2019

Amyloid β (Aβ) peptide directly activates amylin-3 receptor subtype by triggering multiple intracellular signaling pathways

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30988

positive regulation of ERK1 and ERK2 cascade

1 reference

8 April 2019

Amyloid β (Aβ) peptide directly activates amylin-3 receptor subtype by triggering multiple intracellular signaling pathways

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30988

amylin receptor signaling pathway

Amyloid β (Aβ) peptide directly activates amylin-3 receptor subtype by triggering multiple intracellular signaling pathways

response to amyloid-beta

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30988

positive regulation of calcium ion import across plasma membrane

1 reference

8 April 2019

Amyloid β (Aβ) peptide directly activates amylin-3 receptor subtype by triggering multiple intracellular signaling pathways

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30988

physically interacts with

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

685

language of work or name

17 August 2016

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL2103758

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1201661

Gene Atlas image

PBB GE CALCR 207886 s at fs.png
732 × 530; 12 KB

0 references

has part(s)

GPCR, family 2, extracellular hormone receptor domain

1 reference

GPCR, family 2, secretin-like, conserved site

1 reference

GPCR, family 2-like

1 reference

Transporter Classification Database ID

Identifiers

MeSH descriptor ID

D018003

subject named as

Receptors, Calcitonin

0 references

MeSH tree code

D12.776.543.750.695.100

0 references

D12.776.543.750.750.200

0 references

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

9 August 2016

language of work or name

English

9.A.14.4.1

2 references

Transporter Classification database

13 March 2020

Transporter Classification database

29 April 2020

1 reference

inferred by common MeSH mappings on source and on Wikidata

UMLS 2023