Leucine rich repeat kinase 2 (Q409961)

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mammalian protein found in Homo sapiens
  • Dardarin
  • augmented in rheumatoid arthritis 17
  • leucine-rich repeat serine/threonine-protein kinase 2
  • LRRK2
edit
Language Label Description Also known as
English
Leucine rich repeat kinase 2
mammalian protein found in Homo sapiens
  • Dardarin
  • augmented in rheumatoid arthritis 17
  • leucine-rich repeat serine/threonine-protein kinase 2
  • LRRK2

Statements

part of
molecular function
protein kinase activity
determination method
IEA
IDA
7 references
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S007
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S007
determination method
IEA
retrieved
8 April 2019
stated in
Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity
GOA
curator
UniProt
UniProt protein ID
Q5S007
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S007
determination method
IDA
retrieved
8 April 2019
stated in
Mutations in LRRK2 increase phosphorylation of peroxiredoxin 3 exacerbating oxidative stress-induced neuronal death
GOA
curator
UniProt
UniProt protein ID
Q5S007
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S007
determination method
IDA
retrieved
8 April 2019
stated in
The R1441C mutation of LRRK2 disrupts GTP hydrolysis
GOA
curator
UniProt
UniProt protein ID
Q5S007
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S007
determination method
IDA
retrieved
8 April 2019
stated in
The Parkinson disease causing LRRK2 mutation I2020T is associated with increased kinase activity
GOA
curator
UniProt
UniProt protein ID
Q5S007
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S007
determination method
IDA
retrieved
8 April 2019
stated in
Phosphorylation of LRRK2 by casein kinase 1α regulates trans-Golgi clustering via differential interaction with ARHGEF7
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S007
determination method
IDA
identical protein binding
determination method
IPI
IEA
18 references
retrieved
8 April 2019
stated in
The Parkinson's disease kinase LRRK2 autophosphorylates its GTPase domain at multiple sites
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S007
determination method
IPI
retrieved
8 April 2019
stated in
Structure of the ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2 reveals a dimeric GTPase
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S007
determination method
IPI
retrieved
8 April 2019
stated in
Parkinson disease-associated mutation R1441H in LRRK2 prolongs the "active state" of its GTPase domain
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S007
determination method
IPI
retrieved
8 April 2019
stated in
Homo- and heterodimerization of ROCO kinases: LRRK2 kinase inhibition by the LRRK2 ROCO fragment
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S007
determination method
IPI
retrieved
8 April 2019
stated in
The Parkinson disease causing LRRK2 mutation I2020T is associated with increased kinase activity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S007
determination method
IPI
retrieved
8 April 2019
stated in
Protective LRRK2 R1398H Variant Enhances GTPase and Wnt Signaling Activity.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S007
determination method
IPI
retrieved
8 April 2019
stated in
LRRK2 kinase activity regulates synaptic vesicle trafficking and neurotransmitter release through modulation of LRRK2 macro-molecular complex
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S007
determination method
IPI
retrieved
8 April 2019
stated in
Structural model of the dimeric Parkinson's protein LRRK2 reveals a compact architecture involving distant interdomain contacts
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S007
determination method
IPI
retrieved
8 April 2019
stated in
GTPase activity regulates kinase activity and cellular phenotypes of Parkinson's disease-associated LRRK2
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S007
determination method
IPI
retrieved
8 April 2019
stated in
Dominant-negative effects of LRRK2 heterodimers: a possible mechanism of neurodegeneration in Parkinson's disease caused by LRRK2 I2020T mutation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S007
determination method
IPI
retrieved
8 April 2019
stated in
Biochemical characterization of highly purified leucine-rich repeat kinases 1 and 2 demonstrates formation of homodimers
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S007
determination method
IPI
retrieved
8 April 2019
stated in
The Parkinson disease-associated leucine-rich repeat kinase 2 (LRRK2) is a dimer that undergoes intramolecular autophosphorylation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S007
determination method
IPI
retrieved
8 April 2019
stated in
GTPase activity and neuronal toxicity of Parkinson's disease-associated LRRK2 is regulated by ArfGAP1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S007
determination method
IPI
retrieved
8 April 2019
stated in
Membrane localization of LRRK2 is associated with increased formation of the highly active LRRK2 dimer and changes in its phosphorylation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S007
determination method
IPI
retrieved
8 April 2019
stated in
Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPases
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S007
determination method
IPI
retrieved
8 April 2019
stated in
A direct interaction between leucine-rich repeat kinase 2 and specific β-tubulin isoforms regulates tubulin acetylation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S007
determination method
IPI
retrieved
8 April 2019
stated in
Insight into the mode of action of the LRRK2 Y1699C pathogenic mutant
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S007
determination method
IPI
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S007
determination method
IEA
protein serine/threonine kinase activity
determination method
IEA
IDA
TAS
9 references
retrieved
17 October 2017
stated in
LRRK2 functions as a Wnt signaling scaffold, bridging cytosolic proteins and membrane-localized LRP6
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q5S007&geneProductId=UniProtKB:Q5S007
determination method
TAS
retrieved
17 October 2017
stated in
GOA
curator
UniProt
UniProt protein ID
Q5S007
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q5S007&geneProductId=UniProtKB:Q5S007
determination method
IEA
retrieved
17 October 2017
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q5S007&geneProductId=UniProtKB:Q5S007
determination method
IEA
retrieved
17 October 2017
stated in
Parkinson's disease-associated mutations in LRRK2 link enhanced GTP-binding and kinase activities to neuronal toxicity
GOA
curator
UniProt
UniProt protein ID
Q5S007
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q5S007&geneProductId=UniProtKB:Q5S007
determination method
IDA
retrieved
17 October 2017
stated in
LRRK2 phosphorylates Snapin and inhibits interaction of Snapin with SNAP-25
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q5S007&geneProductId=UniProtKB:Q5S007
determination method
IDA
retrieved
17 October 2017
stated in
Mutations in LRRK2 increase phosphorylation of peroxiredoxin 3 exacerbating oxidative stress-induced neuronal death
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q5S007&geneProductId=UniProtKB:Q5S007
determination method
IDA
retrieved
17 October 2017
stated in
ArfGAP1 is a GTPase activating protein for LRRK2: reciprocal regulation of ArfGAP1 by LRRK2
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q5S007&geneProductId=UniProtKB:Q5S007
determination method
IDA
retrieved
17 October 2017
stated in
ARHGEF7 (Beta-PIX) acts as guanine nucleotide exchange factor for leucine-rich repeat kinase 2
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q5S007&geneProductId=UniProtKB:Q5S007
determination method
IDA
retrieved
17 October 2017
stated in
Lrrk2 phosphorylates alpha synuclein at serine 129: Parkinson disease implications
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q5S007&geneProductId=UniProtKB:Q5S007
determination method
IDA
GTP binding
determination method
IEA
IDA
TAS
6 references
retrieved
8 April 2019
stated in
LRRK2 functions as a Wnt signaling scaffold, bridging cytosolic proteins and membrane-localized LRP6
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S007
determination method
TAS
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q5S007
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S007
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S007
determination method
IEA
retrieved
8 April 2019
stated in
The R1441C mutation of LRRK2 disrupts GTP hydrolysis
GOA
curator
UniProt
UniProt protein ID
Q5S007
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S007
determination method
IDA
retrieved
8 April 2019
stated in
Kinase activity of mutant LRRK2 mediates neuronal toxicity
GOA
curator
UniProt
UniProt protein ID
Q5S007
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S007
determination method
IDA
retrieved
8 April 2019
stated in
GTP binding is essential to the protein kinase activity of LRRK2, a causative gene product for familial Parkinson's disease
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S007
determination method
IDA
protein binding
determination method
IPI
72 references
retrieved
8 April 2019
stated in
LRRK2 Promotes Tau Accumulation, Aggregation and Release.
GOA
curator
UniProt
UniProt protein ID
Q5S007
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S007
determination method
IPI
retrieved
8 April 2019
stated in
Leucine-rich repeat kinase 2 (LRRK2) interacts with parkin, and mutant LRRK2 induces neuronal degeneration
GOA
curator
UniProt
UniProt protein ID
Q5S007
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S007
determination method
IPI
retrieved
8 April 2019
stated in
Phosphorylation of amyloid precursor protein by mutant LRRK2 promotes AICD activity and neurotoxicity in Parkinson's disease.
GOA
curator
UniProt
UniProt protein ID
Q5S007
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S007
determination method
IPI
retrieved
8 April 2019
stated in
Mutations in LRRK2 increase phosphorylation of peroxiredoxin 3 exacerbating oxidative stress-induced neuronal death
GOA
curator
UniProt
UniProt protein ID
Q5S007
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S007
determination method
IPI
retrieved
8 April 2019
stated in
LRRK2 and the stress response: interaction with MKKs and JNK-interacting proteins
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S007
determination method
IPI
retrieved
8 April 2019
stated in
LRRK2 controls synaptic vesicle storage and mobilization within the recycling pool
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S007
determination method
IPI
retrieved
8 April 2019
stated in
LRRK2 regulates synaptic vesicle endocytosis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S007
determination method
IPI
retrieved
8 April 2019
stated in
Structural model of the dimeric Parkinson's protein LRRK2 reveals a compact architecture involving distant interdomain contacts
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S007
determination method
IPI
retrieved
8 April 2019
stated in
Inhibition of excessive mitochondrial fission reduced aberrant autophagy and neuronal damage caused by LRRK2 G2019S mutation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S007
determination method
IPI
retrieved
8 April 2019
stated in
A Parkinson's disease gene regulatory network identifies the signaling protein RGS2 as a modulator of LRRK2 activity and neuronal toxicity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S007
determination method
IPI
retrieved
8 April 2019
stated in
Ubiqutination via K27 and K29 chains signals aggregation and neuronal protection of LRRK2 by WSB1.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S007
determination method
IPI
retrieved
8 April 2019
stated in
Identification of protein phosphatase 1 as a regulator of the LRRK2 phosphorylation cycle
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S007
determination method
IPI
retrieved
8 April 2019
stated in
LRRK2 directly phosphorylates Akt1 as a possible physiological substrate: impairment of the kinase activity by Parkinson's disease-associated mutations
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S007
determination method
IPI
retrieved
8 April 2019
stated in
LRRK2 kinase activity regulates synaptic vesicle trafficking and neurotransmitter release through modulation of LRRK2 macro-molecular complex
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S007
determination method
IPI
retrieved
8 April 2019
stated in
Threonine 56 phosphorylation of Bcl-2 is required for LRRK2 G2019S-induced mitochondrial depolarization and autophagy
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S007
determination method
IPI
retrieved
8 April 2019
stated in
Differential protein-protein interactions of LRRK1 and LRRK2 indicate roles in distinct cellular signaling pathways
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S007
determination method
IPI
retrieved
8 April 2019
stated in
Parkinson-related LRRK2 mutation R1441C/G/H impairs PKA phosphorylation of LRRK2 and disrupts its interaction with 14-3-3
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S007
determination method
IPI
retrieved
8 April 2019
stated in
LRRK2 interactions with α-synuclein in Parkinson's disease brains and in cell models
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S007
determination method
IPI
retrieved
8 April 2019
stated in
Mutations in LRRK2 increase phosphorylation of peroxiredoxin 3 exacerbating oxidative stress-induced neuronal death
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S007
determination method
IPI
retrieved
8 April 2019
stated in
The G2385R variant of leucine-rich repeat kinase 2 associated with Parkinson's disease is a partial loss-of-function mutation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S007
determination method
IPI
retrieved
8 April 2019
stated in
GTPase activity regulates kinase activity and cellular phenotypes of Parkinson's disease-associated LRRK2
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S007
determination method
IPI
retrieved
8 April 2019
stated in
LRRK2 phosphorylates novel tau epitopes and promotes tauopathy
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S007
determination method
IPI
retrieved
8 April 2019
stated in
Functional interaction of Parkinson's disease-associated LRRK2 with members of the dynamin GTPase superfamily
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S007
determination method
IPI
retrieved
8 April 2019
stated in
RAB7L1 interacts with LRRK2 to modify intraneuronal protein sorting and Parkinson's disease risk
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S007
determination method
IPI
retrieved
8 April 2019
stated in
Rac1 protein rescues neurite retraction caused by G2019S leucine-rich repeat kinase 2 (LRRK2)
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S007
determination method
IPI
retrieved
8 April 2019
stated in
MAP1B rescues LRRK2 mutant-mediated cytotoxicity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S007
determination method
IPI
retrieved
8 April 2019
stated in
The kinase LRRK2 is a regulator of the transcription factor NFAT that modulates the severity of inflammatory bowel disease
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S007
determination method
IPI
retrieved
8 April 2019
stated in
The Parkinson disease causing LRRK2 mutation I2020T is associated with increased kinase activity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S007
determination method
IPI
retrieved
8 April 2019
stated in
Protective LRRK2 R1398H Variant Enhances GTPase and Wnt Signaling Activity.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S007
determination method
IPI
retrieved
8 April 2019
stated in
An early endosome regulator, Rab5b, is an LRRK2 kinase substrate
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S007
determination method
IPI
retrieved
8 April 2019
stated in
G2385R and I2020T Mutations Increase LRRK2 GTPase Activity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S007
determination method
IPI
retrieved
8 April 2019
stated in
Comparative Protein Interaction Network Analysis Identifies Shared and Distinct Functions for the Human ROCO Proteins.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S007
determination method
IPI
retrieved
8 April 2019
stated in
Phosphorylation of LRRK2 by casein kinase 1α regulates trans-Golgi clustering via differential interaction with ARHGEF7
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S007
determination method
IPI
retrieved
8 April 2019
stated in
ARHGEF7 (Beta-PIX) acts as guanine nucleotide exchange factor for leucine-rich repeat kinase 2
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S007
determination method
IPI
retrieved
8 April 2019
stated in
A direct interaction between leucine-rich repeat kinase 2 and specific β-tubulin isoforms regulates tubulin acetylation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S007
determination method
IPI
retrieved
8 April 2019
stated in
Ribosomal protein s15 phosphorylation mediates LRRK2 neurodegeneration in Parkinson's disease
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S007
determination method
IPI
retrieved
8 April 2019
stated in
Leucine-rich repeat kinase 2 regulates tau phosphorylation through direct activation of glycogen synthase kinase-3β
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S007
determination method
IPI
retrieved
8 April 2019
stated in
LRRK2 functions as a Wnt signaling scaffold, bridging cytosolic proteins and membrane-localized LRP6
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S007
determination method
IPI
retrieved
8 April 2019
stated in
The Parkinson disease protein leucine-rich repeat kinase 2 transduces death signals via Fas-associated protein with death domain and caspase-8 in a cellular model of neurodegeneration
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S007
determination method
IPI
retrieved
8 April 2019
stated in
LRRK2 phosphorylates Snapin and inhibits interaction of Snapin with SNAP-25
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S007
determination method
IPI
retrieved
8 April 2019
stated in
Leucine-rich repeat kinase 2 disturbs mitochondrial dynamics via Dynamin-like protein
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S007
determination method
IPI
retrieved
8 April 2019
stated in
Pathogenic LRRK2 negatively regulates microRNA-mediated translational repression
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S007
determination method
IPI
retrieved
8 April 2019
stated in
Interplay of LRRK2 with chaperone-mediated autophagy
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S007
determination method
IPI
retrieved
8 April 2019
stated in
CHIP regulates leucine-rich repeat kinase-2 ubiquitination, degradation, and toxicity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S007
determination method
IPI
retrieved
8 April 2019
stated in
Unbiased screen for interactors of leucine-rich repeat kinase 2 supports a common pathway for sporadic and familial Parkinson disease
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S007
determination method
IPI
retrieved
8 April 2019
stated in
Homo- and heterodimerization of ROCO kinases: LRRK2 kinase inhibition by the LRRK2 ROCO fragment
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S007
determination method
IPI
retrieved
8 April 2019
stated in
LRRK2 regulates mitochondrial dynamics and function through direct interaction with DLP1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S007
determination method
IPI
retrieved
8 April 2019
stated in
Biochemical characterization of highly purified leucine-rich repeat kinases 1 and 2 demonstrates formation of homodimers
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S007
determination method
IPI
retrieved
8 April 2019
stated in
GTPase activity and neuronal toxicity of Parkinson's disease-associated LRRK2 is regulated by ArfGAP1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S007
determination method
IPI
retrieved
8 April 2019
stated in
LRRK2 functions in synaptic vesicle endocytosis through a kinase-dependent mechanism
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S007
determination method
IPI
retrieved
8 April 2019
stated in
LRRK2 transport is regulated by its novel interacting partner Rab32
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S007
determination method
IPI
retrieved
8 April 2019
stated in
LRRK2 kinase activity and biology are not uniformly predicted by its autophosphorylation and cellular phosphorylation site status
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S007
determination method
IPI
retrieved
8 April 2019
stated in
Identification of potential protein interactors of Lrrk2
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S007
determination method
IPI
retrieved
8 April 2019
stated in
The Parkinson disease-linked LRRK2 protein mutation I2020T stabilizes an active state conformation leading to increased kinase activity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S007
determination method
IPI
retrieved
8 April 2019
stated in
LRRK2 phosphorylates tubulin-associated tau but not the free molecule: LRRK2-mediated regulation of the tau-tubulin association and neurite outgrowth
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S007
determination method
IPI
retrieved
8 April 2019
stated in
14-3-3 binding to LRRK2 is disrupted by multiple Parkinson's disease-associated mutations and regulates cytoplasmic localization
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S007
determination method
IPI
retrieved
8 April 2019
stated in
MKK6 binds and regulates expression of Parkinson's disease-related protein LRRK2
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S007
determination method
IPI
retrieved
8 April 2019
stated in
LRRK2 regulates synaptogenesis and dopamine receptor activation through modulation of PKA activity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S007
determination method
IPI
retrieved
8 April 2019
stated in
Leucine-rich repeat kinase 2 binds to neuronal vesicles through protein interactions mediated by its C-terminal WD40 domain
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S007
determination method
IPI
retrieved
8 April 2019
stated in
Thiol peroxidases ameliorate LRRK2 mutant-induced mitochondrial and dopaminergic neuronal degeneration in Drosophila
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S007
determination method
IPI
retrieved
8 April 2019
stated in
LRRK2 controls synaptic vesicle storage and mobilization within the recycling pool
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S007
determination method
IPI
retrieved
8 April 2019
stated in
LRRK2 and the stress response: interaction with MKKs and JNK-interacting proteins
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S007
determination method
IPI
retrieved
8 April 2019
stated in
Leucine-rich repeat kinase 2 (LRRK2) interacts with parkin, and mutant LRRK2 induces neuronal degeneration
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S007
determination method
IPI
retrieved
8 April 2019
stated in
Mutations in the LRRK2 Roc-COR tandem domain link Parkinson's disease to Wnt signalling pathways
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S007
determination method
IPI
retrieved
8 April 2019
stated in
Heterodimerization of Lrrk1-Lrrk2: Implications for LRRK2-associated Parkinson disease
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S007
determination method
IPI
retrieved
8 April 2019
stated in
Leucine-rich repeat kinase 2 regulates Sec16A at ER exit sites to allow ER-Golgi export
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S007
determination method
IPI
retrieved
8 April 2019
stated in
LRRK2 controls an EndoA phosphorylation cycle in synaptic endocytosis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S007
determination method
IPI
retrieved
8 April 2019
stated in
Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPases
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S007
determination method
IPI
retrieved
8 April 2019
stated in
Progressive degeneration of human neural stem cells caused by pathogenic LRRK2
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S007
determination method
IPI
retrieved
8 April 2019
stated in
Expression of leucine-rich repeat kinase 2 (LRRK2) inhibits the processing of uMtCK to induce cell death in a cell culture model system
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S007
determination method
IPI
retrieved
8 April 2019
stated in
ARHGEF7 (Beta-PIX) acts as guanine nucleotide exchange factor for leucine-rich repeat kinase 2
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S007
determination method
IPI
retrieved
8 April 2019
stated in
LRRK2 kinase regulates synaptic morphology through distinct substrates at the presynaptic and postsynaptic compartments of the Drosophila neuromuscular junction
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S007
determination method
IPI
protein serine/threonine kinase activity
determination method
IDA
IEA
IMP
TAS
10 references
retrieved
8 April 2019
stated in
LRRK2 functions as a Wnt signaling scaffold, bridging cytosolic proteins and membrane-localized LRP6
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S007
determination method
TAS
retrieved
8 April 2019
stated in
Phosphorylation of amyloid precursor protein by mutant LRRK2 promotes AICD activity and neurotoxicity in Parkinson's disease.
GOA
curator
UniProt
UniProt protein ID
Q5S007
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S007
determination method
IMP
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q5S007
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S007
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S007
determination method
IEA
retrieved
8 April 2019
stated in
Parkinson's disease-associated mutations in LRRK2 link enhanced GTP-binding and kinase activities to neuronal toxicity
GOA
curator
UniProt
UniProt protein ID
Q5S007
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S007
determination method
IDA
retrieved
8 April 2019
stated in
LRRK2 phosphorylates Snapin and inhibits interaction of Snapin with SNAP-25
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S007
determination method
IDA
retrieved
8 April 2019
stated in
Mutations in LRRK2 increase phosphorylation of peroxiredoxin 3 exacerbating oxidative stress-induced neuronal death
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S007
determination method
IDA
retrieved
8 April 2019
stated in
ArfGAP1 is a GTPase activating protein for LRRK2: reciprocal regulation of ArfGAP1 by LRRK2
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S007
determination method
IDA
retrieved
8 April 2019
stated in
ARHGEF7 (Beta-PIX) acts as guanine nucleotide exchange factor for leucine-rich repeat kinase 2
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S007
determination method
IDA
retrieved
8 April 2019
stated in
Lrrk2 phosphorylates alpha synuclein at serine 129: Parkinson disease implications
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S007
determination method
IDA
cell component
cytosol
determination method
IDA
TAS
5 references
retrieved
17 October 2017
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q5S007&geneProductId=UniProtKB:Q5S007
determination method
TAS
retrieved
17 October 2017
stated in
LRRK2 functions as a Wnt signaling scaffold, bridging cytosolic proteins and membrane-localized LRP6
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q5S007&geneProductId=UniProtKB:Q5S007
determination method
IDA
retrieved
17 October 2017
stated in
G2019S leucine-rich repeat kinase 2 causes uncoupling protein-mediated mitochondrial depolarization
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q5S007&geneProductId=UniProtKB:Q5S007
determination method
IDA
retrieved
17 October 2017
stated in
Mutations in LRRK2 increase phosphorylation of peroxiredoxin 3 exacerbating oxidative stress-induced neuronal death
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q5S007&geneProductId=UniProtKB:Q5S007
determination method
IDA
retrieved
17 October 2017
stated in
Mutant LRRK2 toxicity in neurons depends on LRRK2 levels and synuclein but not kinase activity or inclusion bodies
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q5S007&geneProductId=UniProtKB:Q5S007
determination method
IDA
cytoplasm
determination method
IDA
IEA
IMP
6 references
retrieved
8 April 2019
stated in
LRRK2 Promotes Tau Accumulation, Aggregation and Release.
GOA
curator
UniProt
UniProt protein ID
Q5S007
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S007
determination method
IMP
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q5S007
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S007
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S007
determination method
IEA
retrieved
8 April 2019
stated in
Leucine-rich repeat kinase 2 (LRRK2) interacts with parkin, and mutant LRRK2 induces neuronal degeneration
GOA
curator
UniProt
UniProt protein ID
Q5S007
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S007
determination method
IDA
retrieved
8 April 2019
stated in
The Parkinson disease causing LRRK2 mutation I2020T is associated with increased kinase activity
GOA
curator
UniProt
UniProt protein ID
Q5S007
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S007
determination method
IDA
retrieved
8 April 2019
stated in
Mutations in the LRRK2 Roc-COR tandem domain link Parkinson's disease to Wnt signalling pathways
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S007
determination method
IDA
cytosol
determination method
IBA
IDA
TAS
6 references
retrieved
8 April 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S007
determination method
TAS
retrieved
8 April 2019
stated in
LRRK2 functions as a Wnt signaling scaffold, bridging cytosolic proteins and membrane-localized LRP6
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S007
determination method
IDA
retrieved
8 April 2019
stated in
Mutant LRRK2 toxicity in neurons depends on LRRK2 levels and synuclein but not kinase activity or inclusion bodies
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S007
determination method
IDA
retrieved
8 April 2019
stated in
G2019S leucine-rich repeat kinase 2 causes uncoupling protein-mediated mitochondrial depolarization
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S007
determination method
IDA
retrieved
8 April 2019
stated in
Mutations in LRRK2 increase phosphorylation of peroxiredoxin 3 exacerbating oxidative stress-induced neuronal death
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S007
determination method
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S007
determination method
IBA
biological process
Gene Atlas image
PBB GE LRRK2 gnf1h07577 s at fs.png
732 × 530; 12 KB
0 references

Identifiers

 
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                  Retrieved from "https://www.wikidata.org/w/index.php?title=Q409961&oldid=2022901161"