Plant Ribosome-Inactivating Proteins: Progesses, Challenges and Biotechnological Applications (and a Few Digressions). (Q41918293)

23 December 2017

3 references

28 September 2019

22 October 2019

20 December 2019

Plant Ribosome-Inactivating Proteins: Progesses, Challenges and Biotechnological Applications (and a Few Digressions). (English)

1 reference

23 December 2017

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1 reference

28 September 2019

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22 October 2019

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20 December 2019

Riccardo Vago

4

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author name string

Maria Serena Fabbrini

series ordinal

1

1 reference

23 December 2017

Miku Katayama

series ordinal

2

1 reference

23 December 2017

Ikuhiko Nakase

series ordinal

3

1 reference

23 December 2017

publication date

12 October 2017

4 references

23 December 2017

28 September 2019

22 October 2019

20 December 2019

4 references

23 December 2017

28 September 2019

22 October 2019

20 December 2019

9

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23 December 2017

issue

10

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23 December 2017

Creative Commons Attribution

copyright license

3 references

28 September 2019

22 October 2019

20 December 2019

0 references

Two Saporin-Containing Immunotoxins Specific for CD20 and CD22 Show Different Behavior in Killing Lymphoma Cells

1 reference

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1 reference

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Optimization of construct design and fermentation strategy for the production of bioactive ATF-SAP, a saporin based anti-tumoral uPAR-targeted chimera.

5 June 2018

1 reference

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1 reference

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1 reference

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5 June 2018

1 reference

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Structural analysis of a type 1 ribosome inactivating protein reveals multiple L‑asparagine‑N‑acetyl‑D‑glucosamine monosaccharide modifications: Implications for cytotoxicity

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1 reference

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Two complementary approaches for intracellular delivery of exogenous enzymes

5 June 2018

1 reference

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Active macropinocytosis induction by stimulation of epidermal growth factor receptor and oncogenic Ras expression potentiates cellular uptake efficacy of exosomes

5 June 2018

1 reference

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Combined treatment with a pH-sensitive fusogenic peptide and cationic lipids achieves enhanced cytosolic delivery of exosomes

5 June 2018

1 reference

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Ribosome-inactivating and related proteins.

5 June 2018

1 reference

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Thermostable ricin vaccine protects rhesus macaques against aerosolized ricin: Epitope-specific neutralizing antibodies correlate with protection

5 June 2018

1 reference

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Light-controlled endosomal escape of the novel CD133-targeting immunotoxin AC133-saporin by photochemical internalization - A minimally invasive cancer stem cell-targeting strategy.

5 June 2018

1 reference

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Pokeweed antiviral protein: its cytotoxicity mechanism and applications in plant disease resistance

5 June 2018

1 reference

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Ebulin from dwarf elder (Sambucus ebulus L.): a mini-review

5 June 2018

1 reference

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Design of an EGFR-targeting toxin for photochemical delivery: in vitro and in vivo selectivity and efficacy

5 June 2018

1 reference

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Dianthin-EGF is an effective tumor targeted toxin in combination with saponins in a xenograft model for colon carcinoma

5 June 2018

1 reference

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Immunotoxins constructed with ribosome-inactivating proteins and their enhancers: a lethal cocktail with tumor specific efficacy

5 June 2018

1 reference

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Photochemical internalization augments tumor vascular cytotoxicity and specificity of VEGF(121)/rGel fusion toxin.

5 June 2018

1 reference

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Combinatorially designed lipid-like nanoparticles for intracellular delivery of cytotoxic protein for cancer therapy.

5 June 2018

1 reference

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The role of EDEM2 compared with EDEM1 in ricin transport from the endoplasmic reticulum to the cytosol

5 June 2018

1 reference

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Intrathecal substance P-saporin in the dog: efficacy in bone cancer pain

5 June 2018

1 reference

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Saporin-S6: a useful tool in cancer therapy

5 June 2018

1 reference

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Chemically and biologically synthesized CPP-modified gelonin for enhanced anti-tumor activity

5 June 2018

1 reference

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Visualization and in vivo tracking of the exosomes of murine melanoma B16-BL6 cells in mice after intravenous injection

5 June 2018

1 reference

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Ribosome-inactivating proteins: from toxins to useful proteins

5 June 2018

1 reference

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Synergistic antitumor activity from two-stage delivery of targeted toxins and endosome-disrupting nanoparticles

5 June 2018

1 reference

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A systematic mammalian genetic interaction map reveals pathways underlying ricin susceptibility

5 June 2018

1 reference

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5 June 2018

1 reference

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Cell-penetrating peptides (CPPs) as a vector for the delivery of siRNAs into cells.

5 June 2018

1 reference

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Targeted tumor therapy by epidermal growth factor appended toxin and purified saponin: an evaluation of toxicity and therapeutic potential in syngeneic tumor bearing mice.

5 June 2018

1 reference

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Pilot phase IB clinical trial of an alhydrogel-adsorbed recombinant ricin vaccine

5 June 2018

1 reference

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Exosomes as nano-theranostic delivery platforms for gene therapy

5 June 2018

1 reference

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Eukaryotic expression vectors bearing genes encoding cytotoxic proteins for cancer gene therapy

5 June 2018

1 reference

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Exosomes: current knowledge of their composition, biological functions, and diagnostic and therapeutic potentials.

5 June 2018

1 reference

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Microvesicles and exosomes: opportunities for cell-derived membrane vesicles in drug delivery

5 June 2018

1 reference

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Ricin trafficking in plant and mammalian cells

5 June 2018

1 reference

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Ribosome-inactivating proteins: from plant defense to tumor attack

5 June 2018

1 reference

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5 June 2018

1 reference

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Engineered toxins "zymoxins" are activated by the HCV NS3 protease by removal of an inhibitory protein domain

5 June 2018

1 reference

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Endosomal escape pathways for delivery of biologicals

5 June 2018

1 reference

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5 June 2018

1 reference

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Photochemical internalization provides time- and space-controlled endolysosomal escape of therapeutic molecules

5 June 2018

1 reference

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Intradermal administration of RiVax protects mice from mucosal and systemic ricin intoxication

5 June 2018

1 reference

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5 June 2018

1 reference

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Exosomes account for vesicle-mediated transcellular transport of activatable phospholipases and prostaglandins.

5 June 2018

1 reference

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Ricin poisoning and forensic toxicology

5 June 2018

1 reference

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Intracellular transduction using cell-penetrating peptides

5 June 2018

1 reference

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5 June 2018

1 reference

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Pichia pastoris as a host for secretion of toxic saporin chimeras

5 June 2018

1 reference

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Transition state analogues rescue ribosomes from saporin-L1 ribosome inactivating protein

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5666361

Saporin suicide gene therapy

5 June 2018

1 reference

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Inhibition of tumor growth by targeted toxins in mice is dramatically improved by saponinum album in a synergistic way.

5 June 2018

1 reference

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Characterization and comprehensive proteome profiling of exosomes secreted by hepatocytes

5 June 2018

1 reference

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Ricin A chain insertion into endoplasmic reticulum membranes is triggered by a temperature increase to 37 {degrees}C

5 June 2018

1 reference

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Cytosolic chaperones influence the fate of a toxin dislocated from the endoplasmic reticulum

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5666361

5 June 2018

1 reference

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Ribosome inactivating protein saporin induces apoptosis through mitochondrial cascade, independent of translation inhibition

5 June 2018

1 reference

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Endoplasmic reticulum quality control and the unfolded protein response: insights from plants

5 June 2018

1 reference

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The role of CDC48 in the retro-translocation of non-ubiquitinated toxin substrates in plant cells.

5 June 2018

1 reference

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Enhanced cytotoxicity of saporin by polyamidoamine dendrimer conjugation and photochemical internalization

5 June 2018

1 reference

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Epidermal growth factor stimulates Rac activation through Src and phosphatidylinositol 3-kinase to promote colonic epithelial cell migration

5 June 2018

1 reference

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Lipopolyamine treatment increases the efficacy of intoxication with saporin and an anticancer saporin conjugate

5 June 2018

1 reference

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chFRP5-ZZ-PE38, a large IgG-toxin immunoconjugate outperforms the corresponding smaller FRP5(Fv)-ETA immunotoxin in eradicating ErbB2-expressing tumor xenografts.

5 June 2018

1 reference

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Evidence for the importance of electrostatics in the function of two distinct families of ribosome inactivating toxins

5 June 2018

1 reference

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Syntaxin 16 and syntaxin 5 are required for efficient retrograde transport of several exogenous and endogenous cargo proteins

5 June 2018

1 reference

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Targeting of human renal tumor-derived endothelial cells with peptides obtained by phage display

5 June 2018

1 reference

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A cleavable molecular adapter reduces side effects and concomitantly enhances efficacy in tumor treatment by targeted toxins in mice

5 June 2018

1 reference

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Effect of 3-methyladenine on the fusion process of macropinosomes in EGF-stimulated A431 cells

5 June 2018

1 reference

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Substrate-specific translocational attenuation during ER stress defines a pre-emptive quality control pathway

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5666361

Conditions of endoplasmic reticulum stress favor the accumulation of cytosolic prion protein

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5666361

A pilot clinical trial of a recombinant ricin vaccine in normal humans.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5666361

Saporin and ricin A chain follow different intracellular routes to enter the cytosol of intoxicated cells

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5666361

Ribosome inactivating proteins and apoptosis

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5666361

Sugar-responsive gene expression, invertase activity, and senescence in aborting maize ovaries at low water potentials

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5666361

Protein disulphide-isomerase reduces ricin to its A and B chains in the endoplasmic reticulum

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5666361

Reductive activation of ricin and ricin A-chain immunotoxins by protein disulfide isomerase and thioredoxin reductase

5 June 2018

1 reference

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GALA: a designed synthetic pH-responsive amphipathic peptide with applications in drug and gene delivery

5 June 2018

1 reference

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The effect of mutations surrounding and within the active site on the catalytic activity of ricin A chain

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5666361

Inhibition of endoplasmic reticulum-associated degradation in CHO cells resistant to cholera toxin, Pseudomonas aeruginosa exotoxin A, and ricin

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5666361

In vitro and in vivo studies of a VEGF121/rGelonin chimeric fusion toxin targeting the neovasculature of solid tumors

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5666361

The low lysine content of ricin A chain reduces the risk of proteolytic degradation after translocation from the endoplasmic reticulum to the cytosol

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5666361

Ricin A chain without its partner B chain is degraded after retrotranslocation from the endoplasmic reticulum to the cytosol in plant cells.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5666361

Electrostatics of nanosystems: application to microtubules and the ribosome

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5666361

Ribosome-inactivating proteins from plants: more than RNA N-glycosidases?

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5666361

An insight into the mechanism of cytotoxicity of ricin to hepatoma cell: roles of Bcl-2 family proteins, caspases, Ca(2+)-dependent proteases and protein kinase C.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5666361

Reactive oxygen species involved in trichosanthin-induced apoptosis of human choriocarcinoma cells

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5666361

Abrin triggers cell death by inactivating a thiol-specific antioxidant protein

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5666361

Pivotal phase III trial of two dose levels of denileukin diftitox for the treatment of cutaneous T-cell lymphoma

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5666361

Analysis of the genome sequence of the flowering plant Arabidopsis thaliana

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5666361

Endocytosis of a chimera between human pro-urokinase and the plant toxin saporin: an unusual internalization mechanism.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5666361

Phase I trial of recombinant immunotoxin anti-Tac(Fv)-PE38 (LMB-2) in patients with hematologic malignancies

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5666361

Preparation of highly purified momordin II without ribonuclease activity.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5666361

Release of caspase-9 from mitochondria during neuronal apoptosis and cerebral ischemia

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5666361

Photochemical internalization: a novel technology for delivery of macromolecules into cytosol

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5666361

Targeted delivery of DNA encoding cytotoxic proteins through high-affinity fibroblast growth factor receptors

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5666361

Evaluation of immunotoxins containing single-chain ribosome-inactivating proteins and an anti-CD22 monoclonal antibody (OM124): in vitro and in vivo studies

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5666361

The amino-terminal fragment of human urokinase directs a recombinant chimeric toxin to target cells: internalization is toxin mediated.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5666361

Systemic therapy with 3BIT, a triple combination cocktail of anti-CD19, -CD22, and -CD38-saporin immunotoxins, is curative of human B-cell lymphoma in severe combined immunodeficient mice.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5666361

Ribotoxic stress response: activation of the stress-activated protein kinase JNK1 by inhibitors of the peptidyl transferase reaction and by sequence-specific RNA damage to the alpha-sarcin/ricin loop in the 28S rRNA.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5666361

Characterization of a saporin isoform with lower ribosome-inhibiting activity

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5666361

Retrograde transport of mutant ricin to the endoplasmic reticulum with subsequent translocation to cytosol

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5666361

Morphology of ricin and abrin exposed endothelial cells is consistent with apoptotic cell death

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5666361

alpha-2 Macroglobulin receptor/Ldl receptor-related protein(Lrp)-dependent internalization of the urokinase receptor

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5666361

Broad-spectrum virus resistance in transgenic plants expressing pokeweed antiviral protein

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5666361

A conjugate between human urokinase and saporin, a type-1 ribosome-inactivating protein, is selectively cytotoxic to urokinase receptor-expressing cells

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5666361

Ricin: structure, mode of action, and some current applications.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5666361

Antitumor activity of anti-CD30 immunotoxin (Ber-H2/saporin) in vitro and in severe combined immunodeficiency disease mice xenografted with human CD30+ anaplastic large-cell lymphoma.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5666361

A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5666361

Different biological properties of the two constituent peptide chains of ricin a toxic protein inhibiting protein synthesis

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5666361

The mechanism of action of ricin and related toxic lectins on eukaryotic ribosomes. The site and the characteristics of the modification in 28 S ribosomal RNA caused by the toxins.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5666361

RNA N-glycosidase activity of ricin A-chain. Mechanism of action of the toxic lectin ricin on eukaryotic ribosomes

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5666361

Routing of internalized ricin and ricin conjugates to the Golgi complex

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5666361

pH-dependent bilayer destabilization by an amphipathic peptide.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5666361

Nucleotide sequence of cDNA coding for saporin-6, a type-1 ribosome-inactivating protein from Saponaria officinalis

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5666361

Cytotoxicity of a recombinant ricin-A-chain fusion protein containing a proteolytically-cleavable spacer sequence

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5666361

Disruption of the Golgi apparatus by brefeldin A inhibits the cytotoxicity of ricin, modeccin, and Pseudomonas toxin

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5666361

Immunolesioning: selective destruction of neurons using immunotoxin to rat NGF receptor

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5666361

Type 1 ribosome-inactivating proteins depurinate plant 25S rRNA without species specificity

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5666361

Adenine depurination and inactivation of plant ribosomes by an antiviral protein of Mirabilis jalapa (MAP)

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5666361

X-ray analysis of substrate analogs in the ricin A-chain active site

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5666361

Addition of an ER retention signal to the ricin A chain increases the cytotoxicity of the holotoxin

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5666361

Ricin--a potent homicidal poison

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5666361

Cytosolic antibody delivery by lipid-sensitive endosomolytic peptide.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5666361

Glycosylated Triterpenoids as Endosomal Escape Enhancers in Targeted Tumor Therapies.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5666361

SMI-Ribosome inactivating protein conjugates selectively inhibit tumor cell growth.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5666361

Cathepsin B-degradable, NIR-responsive nanoparticulate platform for target-specific cancer therapy.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5666361

Fate and action of ricin in rat liver in vivo: translocation of endocytosed ricin into cytosol and induction of intrinsic apoptosis by ricin B-chain.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5666361

Cholinergic immunotoxin 192 IgG-SAPORIN alters subicular theta-gamma activity and impairs spatial learning in rats.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5666361

Depletion of inflammatory dendritic cells with anti-CD209 conjugated to saporin toxin

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5666361

Molecular interplays involved in the cellular uptake of octaarginine on cell surfaces and the importance of syndecan-4 cytoplasmic V domain for the activation of protein kinase Cα.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5666361

DNA based therapy with diphtheria toxin-A BC-819: a phase 2b marker lesion trial in patients with intermediate risk nonmuscle invasive bladder cancer

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5666361

Intrathecal substance P-saporin in the dog: distribution, safety, and spinal neurokinin-1 receptor ablation

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5666361

CXCR4 stimulates macropinocytosis: implications for cellular uptake of arginine-rich cell-penetrating peptides and HIV.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5666361

Accumulation of arginine-rich cell-penetrating peptides in tumors and the potential for anticancer drug delivery in vivo.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5666361

Protective effect of two recombinant ricin subunit vaccines in the New Zealand white rabbit subjected to a lethal aerosolized ricin challenge: survival, immunological response, and histopathological findings.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5666361

Characterisation of exosomes derived from human cells by nanoparticle tracking analysis and scanning electron microscopy.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5666361

Signal peptide-regulated toxicity of a plant ribosome-inactivating protein during cell stress.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5666361

Application of a fusiogenic peptide GALA for intracellular delivery

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5666361

Cytosolic targeting of macromolecules using a pH-dependent fusogenic peptide in combination with cationic liposomes.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5666361

Improved formulation of a recombinant ricin A-chain vaccine increases its stability and effective antigenicity.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5666361

Saporin as a novel suicide gene in anticancer gene therapy.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5666361

Safety evaluation of intrathecal substance P-saporin, a targeted neurotoxin, in dogs

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5666361

Expression and characterisation in E. coli of mutant forms of saporin.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5666361

The type-1 and type-2 ribosome-inactivating proteins from Iris confer transgenic tobacco plants local but not systemic protection against viruses.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5666361

Finding a new vaccine in the ricin protein fold

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5666361

Cytotoxicity of ribosome-inactivating protein saporin is not mediated through alpha2-macroglobulin receptor.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5666361

The cytotoxic activity of ribosome-inactivating protein saporin-6 is attributed to its rRNA N-glycosidase and internucleosomal DNA fragmentation activities

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5666361

Binding of ricin A-chain to negatively charged phospholipid vesicles leads to protein structural changes and destabilizes the lipid bilayer

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5666361

Polynucleotide:Adenosine glycosidase is the sole activity of ribosome-inactivating proteins on DNA.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5666361

Cancer gene therapy by thyroid hormone-mediated expression of toxin genes

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5666361

Role of poly(ADP-ribose) polymerase (PARP) cleavage in apoptosis. Caspase 3-resistant PARP mutant increases rates of apoptosis in transfected cells.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5666361

An abscisic-acid- and salt-stress-responsive rice cDNA from a novel plant gene family.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5666361

Addition of an endoplasmic reticulum retrieval sequence to ricin A chain significantly increases its cytotoxicity to mammalian cells.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5666361

Correlation between the activities of five ribosome-inactivating proteins in depurination of tobacco ribosomes and inhibition of tobacco mosaic virus infection

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5666361

Alpha 2-macroglobulin receptor mediates binding and cytotoxicity of plant ribosome-inactivating proteins.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5666361

Characterization and molecular cloning of a proenzyme form of a ribosome-inactivating protein from maize. Novel mechanism of proenzyme activation by proteolytic removal of a 2.8-kilodalton internal peptide segment

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5666361

Antitumor activity of basic fibroblast growth factor-saporin mitotoxin in vitro and in vivo

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5666361

Ricin. Mechanisms of cytotoxicity.

18 August 2018

1 reference

Crossref

https://api.crossref.org/works/10.3390%2FTOXINS9100314

The Unusual Stability of Saporin, a Candidate for the Synthesis of Immunotoxins

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.3390%2FTOXINS9100314

A Small-Molecule Drug Conjugate for the Treatment of Carbonic Anhydrase IX Expressing Tumors

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.3390%2FTOXINS9100314

Genetic grafting of membrane-acting peptides to the cytotoxin dianthin augments its ability to de-stabilize lipid bilayers and enhances its cytotoxic potential as the component of transferrin-toxin conjugates

21 January 2018

1 reference

12 December 2020

The toxic plant proteins ricin and abrin induce apoptotic changes in mammalian lymphoid tissues and intestine

1 reference

12 December 2020

Recombinant toxins that bind to the urokinase receptor are cytotoxic without requiring binding to the alpha(2)-macroglobulin receptor

1 reference

12 December 2020

Trichosanthin interacts with and enters cells via LDL receptor family members

1 reference

12 December 2020

Depletion of Alloreactive T-Cells by Anti-CD137-Saporin Immunotoxin

1 reference

12 December 2020

Effect of chemical deglycosylation of ricin A chain on the in vivo fate and cytotoxic activity of an immunotoxin composed of ricin A chain and anti-Thy 1.1 antibody

1 reference

12 December 2020

The RNA N-glycosidase activity of ricin A-chain

1 reference

12 December 2020

The deoxyribonuclease activity attributed to ribosome-inactivating proteins is due to contamination

1 reference

12 December 2020

Targeting tumor cellsvia EGF receptors: Selective toxicity of an HBEGF-toxin fusion protein

1 reference

12 December 2020

Exosomes released by melanoma cells prepare sentinel lymph nodes for tumor metastasis

1 reference

12 December 2020

Design, expression, purification, and characterization, in vitro and in vivo, of an antimelanoma single-chain Fv antibody fused to the toxin gelonin

1 reference

12 December 2020

A single point mutation in ricin A-chain increases toxin degradation and inhibits EDEM1-dependent ER retrotranslocation

1 reference

12 December 2020

The effect of a monoclonal antibody coupled to ricin A chain-derived peptides on endothelial cells in vitro: insights into toxin-mediated vascular damage

1 reference

12 December 2020

Free ricin A chain reaches an early compartment of the secretory pathway before it enters the cytosol

1 reference

12 December 2020

Modeling and alanine scanning mutagenesis studies of recombinant pokeweed antiviral protein

1 reference

12 December 2020

Depletion of intracellular NAD(+) and ATP levels during ricin-induced apoptosis through the specific ribosomal inactivation results in the cytolysis of U937 cells

1 reference

12 December 2020

Genetic engineering of an immunotoxin to eliminate pulmonary vascular leak in mice

1 reference

12 December 2020

Pokeweed antiviral protein inactivates pokeweed ribosomes; implications for the antiviral mechanism

1 reference

12 December 2020

Dependence of ricin toxicity on translocation of the toxin A-chain from the endoplasmic reticulum to the cytosol

1 reference

12 December 2020

A novel strategy for the invasive toxin: hijacking exosome-mediated intercellular trafficking

1 reference

12 December 2020

Identifiers

DOI

10.3390/TOXINS9100314

1 reference

23 December 2017

release_mqin57h7pvam5fg5vnfoybamua

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/mqin57h7pvam5fg5vnfoybamua

24 November 2022

mapped directly with Wikidata item

PMCID

5666361

1 reference

23 December 2017

PubMed ID

29023422

1 reference

23 December 2017