Potassium voltage-gated channel subfamily Q member 1 (Q6449560)

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P51787

KCNQ potassium channel

1 reference

Transporter Classification Database ID

1.A.1.15.6

hierarchical database ID heuristic

2 October 2019

based on heuristic

Ion transport domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Potassium channel, voltage dependent, KCNQ, C-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization

Phosphorylation of the A-kinase-anchoring protein Yotiao contributes to protein kinase A regulation of a heart potassium channel

scaffold protein binding

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787

8 April 2019

Mutation of an A-kinase-anchoring protein causes long-QT syndrome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787

8 April 2019

Requirement of a macromolecular signaling complex for beta adrenergic receptor modulation of the KCNQ1-KCNE1 potassium channel

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787

protein kinase A regulatory subunit binding

IPI

1 reference

8 April 2019

Requirement of a macromolecular signaling complex for beta adrenergic receptor modulation of the KCNQ1-KCNE1 potassium channel

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787

voltage-gated potassium channel activity

7 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51787&geneProductId=UniProtKB:P51787

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51787&geneProductId=UniProtKB:P51787

24 April 2018

Functional assembly of Kv7.1/Kv7.5 channels with emerging properties on vascular muscle physiology

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51787&geneProductId=UniProtKB:P51787

24 April 2018

Suppression of slow delayed rectifier current by a truncated isoform of KvLQT1 cloned from normal human heart

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51787&geneProductId=UniProtKB:P51787

24 April 2018

The KCNQ1 potassium channel is down-regulated by ubiquitylating enzymes of the Nedd4/Nedd4-like family

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51787&geneProductId=UniProtKB:P51787

24 April 2018

Coassembly of K(V)LQT1 and minK (IsK) proteins to form cardiac I(Ks) potassium channel

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51787&geneProductId=UniProtKB:P51787

24 April 2018

Phosphorylation of the A-kinase-anchoring protein Yotiao contributes to protein kinase A regulation of a heart potassium channel

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51787&geneProductId=UniProtKB:P51787

transmembrane transporter binding

5 references

8 April 2019

Functional assembly of Kv7.1/Kv7.5 channels with emerging properties on vascular muscle physiology

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787

8 April 2019

KCNE2 confers background current characteristics to the cardiac KCNQ1 potassium channel

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787

8 April 2019

Analysis of the interactions between the C-terminal cytoplasmic domains of KCNQ1 and KCNE1 channel subunits

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787

8 April 2019

Long QT mutations at the interface between KCNQ1 helix C and KCNE1 disrupt I(KS) regulation by PKA and PIP₂

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787

8 April 2019

KCNE5 induces time- and voltage-dependent modulation of the KCNQ1 current

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787

outward rectifier potassium channel activity

IPI

3 references

24 April 2018

Cellular mechanisms of mutations in Kv7.1: auditory functions in Jervell and Lange-Nielsen syndrome vs. Romano-Ward syndrome

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51787&geneProductId=UniProtKB:P51787

24 April 2018

KCNE2 confers background current characteristics to the cardiac KCNQ1 potassium channel

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51787&geneProductId=UniProtKB:P51787

24 April 2018

Properties of KvLQT1 K+ channel mutations in Romano-Ward and Jervell and Lange-Nielsen inherited cardiac arrhythmias

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51787&geneProductId=UniProtKB:P51787

delayed rectifier potassium channel activity

9 references

24 April 2018

A molecular mechanism for adrenergic-induced long QT syndrome

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51787&geneProductId=UniProtKB:P51787

24 April 2018

A KCNQ1 mutation contributes to the concealed type 1 long QT phenotype by limiting the Kv7.1 channel conformational changes associated with protein kinase A phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51787&geneProductId=UniProtKB:P51787

24 April 2018

Long QT mutations at the interface between KCNQ1 helix C and KCNE1 disrupt I(KS) regulation by PKA and PIP₂

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51787&geneProductId=UniProtKB:P51787

24 April 2018

Mutations in the hminK gene cause long QT syndrome and suppress IKs function

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51787&geneProductId=UniProtKB:P51787

24 April 2018

Cellular dysfunction of LQT5-minK mutants: abnormalities of IKs, IKr and trafficking in long QT syndrome

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51787&geneProductId=UniProtKB:P51787

24 April 2018

KCNQ1 gain-of-function mutation in familial atrial fibrillation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51787&geneProductId=UniProtKB:P51787

24 April 2018

Augmented potassium current is a shared phenotype for two genetic defects associated with familial atrial fibrillation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51787&geneProductId=UniProtKB:P51787

24 April 2018

Coassembly of K(V)LQT1 and minK (IsK) proteins to form cardiac I(Ks) potassium channel

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51787&geneProductId=UniProtKB:P51787

24 April 2018

AKAP proteins anchor cAMP-dependent protein kinase to KvLQT1/IsK channel complex

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51787&geneProductId=UniProtKB:P51787

potassium channel activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787

5 references

8 April 2019

Distinct subdomains of the KCNQ1 S6 segment determine channel modulation by different KCNE subunits

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787

8 April 2019

Impact of KCNE subunits on KCNQ1 (Kv7.1) channel membrane surface targeting

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787

8 April 2019

Deubiquitylating enzyme USP2 counteracts Nedd4-2-mediated downregulation of KCNQ1 potassium channels

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787

8 April 2019

Oestrogen promotes KCNQ1 potassium channel endocytosis and postendocytic trafficking in colonic epithelium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787

8 April 2019

Intracellular domains interactions and gated motions of I(KS) potassium channel subunits

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787

phosphatidylinositol-4,5-bisphosphate binding

IPI

1 reference

8 April 2019

Long QT mutations at the interface between KCNQ1 helix C and KCNE1 disrupt I(KS) regulation by PKA and PIP₂

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787

protein kinase A catalytic subunit binding

1 reference

8 April 2019

Requirement of a macromolecular signaling complex for beta adrenergic receptor modulation of the KCNQ1-KCNE1 potassium channel

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787

voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization

1 reference

8 April 2019

KCNQ1 gain-of-function mutation in familial atrial fibrillation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787

protein phosphatase 1 binding

1 reference

8 April 2019

Requirement of a macromolecular signaling complex for beta adrenergic receptor modulation of the KCNQ1-KCNE1 potassium channel

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787

voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization

1 reference

24 April 2018

Positional cloning of a novel potassium channel gene: KVLQT1 mutations cause cardiac arrhythmias

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51787&geneProductId=UniProtKB:P51787

voltage-gated ion channel activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787

voltage-gated potassium channel activity

7 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787

8 April 2019

Functional assembly of Kv7.1/Kv7.5 channels with emerging properties on vascular muscle physiology

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787

8 April 2019

Phosphorylation of the A-kinase-anchoring protein Yotiao contributes to protein kinase A regulation of a heart potassium channel

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787

8 April 2019

The KCNQ1 potassium channel is down-regulated by ubiquitylating enzymes of the Nedd4/Nedd4-like family

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787

8 April 2019

Coassembly of K(V)LQT1 and minK (IsK) proteins to form cardiac I(Ks) potassium channel

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787

delayed rectifier potassium channel activity

10 references

8 April 2019

A molecular mechanism for adrenergic-induced long QT syndrome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787

8 April 2019

Long QT mutations at the interface between KCNQ1 helix C and KCNE1 disrupt I(KS) regulation by PKA and PIP₂

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787

8 April 2019

A KCNQ1 mutation contributes to the concealed type 1 long QT phenotype by limiting the Kv7.1 channel conformational changes associated with protein kinase A phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787

8 April 2019

Coassembly of K(V)LQT1 and minK (IsK) proteins to form cardiac I(Ks) potassium channel

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787

8 April 2019

Cellular dysfunction of LQT5-minK mutants: abnormalities of IKs, IKr and trafficking in long QT syndrome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787

8 April 2019

KCNQ1 gain-of-function mutation in familial atrial fibrillation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787

8 April 2019

Mutations in the hminK gene cause long QT syndrome and suppress IKs function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787

8 April 2019

Augmented potassium current is a shared phenotype for two genetic defects associated with familial atrial fibrillation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787

8 April 2019

AKAP proteins anchor cAMP-dependent protein kinase to KvLQT1/IsK channel complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787

8 April 2019

The KCNQ1 (Kv7.1) COOH terminus, a multitiered scaffold for subunit assembly and protein interaction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787

outward rectifier potassium channel activity

4 references

8 April 2019

KCNE2 confers background current characteristics to the cardiac KCNQ1 potassium channel

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787

8 April 2019

Properties of KvLQT1 K+ channel mutations in Romano-Ward and Jervell and Lange-Nielsen inherited cardiac arrhythmias

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787

8 April 2019

Cellular mechanisms of mutations in Kv7.1: auditory functions in Jervell and Lange-Nielsen syndrome vs. Romano-Ward syndrome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787

voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization

3 references

8 April 2019

IKs Gain- and Loss-of-Function in Early-Onset Lone Atrial Fibrillation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787

8 April 2019

KCNQ1 gain-of-function mutation in familial atrial fibrillation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787

voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization

integral component of membrane

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51787&geneProductId=UniProtKB:P51787

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787

cytoplasmic vesicle membrane

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787

voltage-gated potassium channel complex

5 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51787&geneProductId=UniProtKB:P51787

24 April 2018

The KCNQ1 potassium channel is down-regulated by ubiquitylating enzymes of the Nedd4/Nedd4-like family

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51787&geneProductId=UniProtKB:P51787

24 April 2018

Augmented potassium current is a shared phenotype for two genetic defects associated with familial atrial fibrillation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51787&geneProductId=UniProtKB:P51787

24 April 2018

Phosphorylation of the A-kinase-anchoring protein Yotiao contributes to protein kinase A regulation of a heart potassium channel

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51787&geneProductId=UniProtKB:P51787

24 April 2018

Coassembly of K(V)LQT1 and minK (IsK) proteins to form cardiac I(Ks) potassium channel

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51787&geneProductId=UniProtKB:P51787

2 references

1 reference

8 April 2019

AMP-activated protein kinase downregulates Kv7.1 cell surface expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787

Functional assembly of Kv7.1/Kv7.5 channels with emerging properties on vascular muscle physiology

endoplasmic reticulum

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787

8 April 2019

Functional assembly of Kv7.1/Kv7.5 channels with emerging properties on vascular muscle physiology

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787

8 April 2019

Kv7.1 surface expression is regulated by epithelial cell polarization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787

8 April 2019

Functional assembly of Kv7.1/Kv7.5 channels with emerging properties on vascular muscle physiology

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787

8 April 2019

Impact of KCNE subunits on KCNQ1 (Kv7.1) channel membrane surface targeting

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787

basolateral plasma membrane

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787

8 April 2019

Kv7.1 surface expression is regulated by epithelial cell polarization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787

8 April 2019

AMP-activated protein kinase downregulates Kv7.1 cell surface expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787

9 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787

8 April 2019

Deubiquitylating enzyme USP2 counteracts Nedd4-2-mediated downregulation of KCNQ1 potassium channels

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787

8 April 2019

Kv7.1 surface expression is regulated by epithelial cell polarization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787

8 April 2019

A constitutively open potassium channel formed by KCNQ1 and KCNE3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787

8 April 2019

Cellular mechanisms of mutations in Kv7.1: auditory functions in Jervell and Lange-Nielsen syndrome vs. Romano-Ward syndrome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787

8 April 2019

Long QT mutations at the interface between KCNQ1 helix C and KCNE1 disrupt I(KS) regulation by PKA and PIP₂

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787

8 April 2019

Oestrogen promotes KCNQ1 potassium channel endocytosis and postendocytic trafficking in colonic epithelium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787

8 April 2019

A molecular mechanism for adrenergic-induced long QT syndrome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787

1 reference

8 April 2019

Functional assembly of Kv7.1/Kv7.5 channels with emerging properties on vascular muscle physiology

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787

1 reference

8 April 2019

Long QT mutations at the interface between KCNQ1 helix C and KCNE1 disrupt I(KS) regulation by PKA and PIP₂

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787

1 reference

8 April 2019

AMP-activated protein kinase downregulates Kv7.1 cell surface expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787

3 references

8 April 2019

Oestrogen promotes KCNQ1 potassium channel endocytosis and postendocytic trafficking in colonic epithelium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787

8 April 2019

AMP-activated protein kinase downregulates Kv7.1 cell surface expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787

voltage-gated potassium channel complex

6 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787

8 April 2019

Phosphorylation of the A-kinase-anchoring protein Yotiao contributes to protein kinase A regulation of a heart potassium channel

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787

8 April 2019

Augmented potassium current is a shared phenotype for two genetic defects associated with familial atrial fibrillation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787

8 April 2019

The KCNQ1 potassium channel is down-regulated by ubiquitylating enzymes of the Nedd4/Nedd4-like family

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787

8 April 2019

Coassembly of K(V)LQT1 and minK (IsK) proteins to form cardiac I(Ks) potassium channel

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787

regulation of ventricular cardiac muscle cell membrane repolarization

biological process

1 reference

8 April 2019

Positional cloning of a novel potassium channel gene: KVLQT1 mutations cause cardiac arrhythmias

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787

negative regulation of delayed rectifier potassium channel activity

1 reference

24 April 2018

Suppression of slow delayed rectifier current by a truncated isoform of KvLQT1 cloned from normal human heart

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51787&geneProductId=UniProtKB:P51787

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787

intestinal absorption

1 reference

8 April 2019

regulation of atrial cardiac muscle cell membrane repolarization

ISS

1 reference

8 April 2019

KCNQ1 gain-of-function mutation in familial atrial fibrillation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787

positive regulation of cardiac muscle contraction

1 reference

8 April 2019

Augmented potassium current is a shared phenotype for two genetic defects associated with familial atrial fibrillation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787

cellular response to epinephrine stimulus

1 reference

8 April 2019

Requirement of a macromolecular signaling complex for beta adrenergic receptor modulation of the KCNQ1-KCNE1 potassium channel

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787

positive regulation of potassium ion transmembrane transport

TAS

1 reference

8 April 2019

Coassembly of K(V)LQT1 and minK (IsK) proteins to form cardiac I(Ks) potassium channel

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787

negative regulation of voltage-gated potassium channel activity

1 reference

24 April 2018

Suppression of slow delayed rectifier current by a truncated isoform of KvLQT1 cloned from normal human heart

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51787&geneProductId=UniProtKB:P51787

cardiac muscle contraction

1 reference

8 April 2019

Positional cloning of a novel potassium channel gene: KVLQT1 mutations cause cardiac arrhythmias

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787

regulation of gene expression by genetic imprinting

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787

sensory perception of sound

1 reference

8 April 2019

A novel mutation in the potassium channel gene KVLQT1 causes the Jervell and Lange-Nielsen cardioauditory syndrome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787

atrial cardiac muscle cell action potential

TAS

1 reference

8 April 2019

KCNQ1 gain-of-function mutation in familial atrial fibrillation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787

regulation of heart rate by cardiac conduction

1 reference

8 April 2019

Positional cloning of a novel potassium channel gene: KVLQT1 mutations cause cardiac arrhythmias

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787

cellular response to cAMP

3 references

8 April 2019

Mutation of an A-kinase-anchoring protein causes long-QT syndrome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787

8 April 2019

Phosphorylation of the A-kinase-anchoring protein Yotiao contributes to protein kinase A regulation of a heart potassium channel

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787

8 April 2019

AKAP proteins anchor cAMP-dependent protein kinase to KvLQT1/IsK channel complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787

transmembrane transport

1 reference

8 April 2019

ventricular cardiac muscle cell action potential

1 reference

8 April 2019

Positional cloning of a novel potassium channel gene: KVLQT1 mutations cause cardiac arrhythmias

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787

regulation of ion transmembrane transport

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787

potassium ion export across plasma membrane

1 reference

24 April 2018

The KCNQ1 potassium channel is down-regulated by ubiquitylating enzymes of the Nedd4/Nedd4-like family

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51787&geneProductId=UniProtKB:P51787

positive regulation of heart rate

1 reference

8 April 2019

Augmented potassium current is a shared phenotype for two genetic defects associated with familial atrial fibrillation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787

potassium ion transmembrane transport

5 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51787&geneProductId=UniProtKB:P51787

24 April 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51787&geneProductId=UniProtKB:P51787

24 April 2018

Mutations in the hminK gene cause long QT syndrome and suppress IKs function

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51787&geneProductId=UniProtKB:P51787

24 April 2018

AKAP proteins anchor cAMP-dependent protein kinase to KvLQT1/IsK channel complex

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51787&geneProductId=UniProtKB:P51787

24 April 2018

Phosphorylation of the A-kinase-anchoring protein Yotiao contributes to protein kinase A regulation of a heart potassium channel

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51787&geneProductId=UniProtKB:P51787

regulation of heart contraction

1 reference

8 April 2019

Coassembly of K(V)LQT1 and minK (IsK) proteins to form cardiac I(Ks) potassium channel

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787

IC

membrane repolarization

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787

membrane repolarization during action potential

3 references

8 April 2019

Augmented potassium current is a shared phenotype for two genetic defects associated with familial atrial fibrillation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787

8 April 2019

AKAP proteins anchor cAMP-dependent protein kinase to KvLQT1/IsK channel complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787

8 April 2019

Coassembly of K(V)LQT1 and minK (IsK) proteins to form cardiac I(Ks) potassium channel

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787

membrane repolarization during ventricular cardiac muscle cell action potential

1 reference

8 April 2019

Positional cloning of a novel potassium channel gene: KVLQT1 mutations cause cardiac arrhythmias

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787

potassium ion transmembrane transport

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787

8 April 2019

Phosphorylation of the A-kinase-anchoring protein Yotiao contributes to protein kinase A regulation of a heart potassium channel

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787

8 April 2019

AKAP proteins anchor cAMP-dependent protein kinase to KvLQT1/IsK channel complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787

8 April 2019

Mutations in the hminK gene cause long QT syndrome and suppress IKs function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787

potassium ion export across plasma membrane

4 references

8 April 2019

The KCNQ1 potassium channel is down-regulated by ubiquitylating enzymes of the Nedd4/Nedd4-like family

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787

8 April 2019

Cellular dysfunction of LQT5-minK mutants: abnormalities of IKs, IKr and trafficking in long QT syndrome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787

8 April 2019

Coassembly of K(V)LQT1 and minK (IsK) proteins to form cardiac I(Ks) potassium channel

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787

physically interacts with

TAS

mefenamic acid

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

2593

IUPHAR/BPS Guide to PHARMACOLOGY

17 August 2016

1 reference

Guide to Pharmacology Ligand ID

2439

17 August 2016

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL821

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL41355

Gene Atlas image

PBB GE CD44 204490 s at tn.png
255 × 135; 847 bytes

1 reference

imported from Wikimedia project

English Wikipedia

exact match

http://purl.uniprot.org/uniprot/P51787

1 reference

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P51787

Potassium channel, voltage dependent, KCNQ, C-terminal

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P51787

Identifiers

0 references

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

Transporter Classification Database ID

English

1.A.1.15.6

2 references

Transporter Classification database

13 March 2020

Transporter Classification database

29 April 2020

1 reference

inferred by common MeSH mappings on source and on Wikidata

UMLS 2023