SMAD family member 3 (Q6917575)

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mammalian protein found in Homo sapiens
  • SMA- and MAD-related protein 3
  • hMAD-3
  • SMAD 3
  • mad homolog JV15-2
  • mad protein homolog
  • mothers against DPP homolog 3
  • mothers against decapentaplegic homolog 3
  • hSMAD3
  • MAD homolog 3
  • SMAD, mothers against DPP homolog 3
  • mad3
  • SMAD3
  • JV15-2
  • MAD, mothers against decapentaplegic homolog 3
  • Smad3 Protein
edit
Language Label Description Also known as
English
SMAD family member 3
mammalian protein found in Homo sapiens
  • SMA- and MAD-related protein 3
  • hMAD-3
  • SMAD 3
  • mad homolog JV15-2
  • mad protein homolog
  • mothers against DPP homolog 3
  • mothers against decapentaplegic homolog 3
  • hSMAD3
  • MAD homolog 3
  • SMAD, mothers against DPP homolog 3
  • mad3
  • SMAD3
  • JV15-2
  • MAD, mothers against decapentaplegic homolog 3
  • Smad3 Protein

Statements

instance of
R-SMAD
0 references
molecular function
DNA-binding transcription factor activity
determination method
IDA
IEA
6 references
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P84022
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P84022
determination method
IEA
retrieved
8 April 2019
stated in
USP15 is a deubiquitylating enzyme for receptor-activated SMADs
GOA
curator
UniProt
UniProt protein ID
P84022
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P84022
determination method
IDA
retrieved
8 April 2019
stated in
Heteromeric and homomeric interactions correlate with signaling activity and functional cooperativity of Smad3 and Smad4/DPC4
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P84022
determination method
IDA
retrieved
8 April 2019
stated in
Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-beta-induced transcription
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P84022
determination method
IDA
retrieved
8 April 2019
stated in
Transforming growth factor beta -inducible independent binding of SMAD to the Smad7 promoter
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P84022
determination method
IDA
protein binding
determination method
IPI
55 references
retrieved
8 April 2019
stated in
Cloning and functional characterization of a new Ski homolog, Fussel-18, specifically expressed in neuronal tissues
GOA
curator
UniProt
UniProt protein ID
P84022
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P84022
determination method
IPI
retrieved
8 April 2019
stated in
SARA, a FYVE domain protein that recruits Smad2 to the TGFbeta receptor
GOA
curator
UniProt
UniProt protein ID
P84022
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P84022
determination method
IPI
retrieved
8 April 2019
stated in
C18 ORF1, a novel negative regulator of transforming growth factor-β signaling
GOA
curator
UniProt
UniProt protein ID
P84022
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P84022
determination method
IPI
retrieved
8 April 2019
stated in
HMGA2 and Smads co-regulate SNAIL1 expression during induction of epithelial-to-mesenchymal transition
GOA
curator
UniProt
UniProt protein ID
P84022
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P84022
determination method
IPI
retrieved
8 April 2019
stated in
Identification and characterization of a PDZ protein that interacts with activin type II receptors
GOA
curator
UniProt
UniProt protein ID
P84022
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P84022
determination method
IPI
retrieved
8 April 2019
stated in
Potentiation of Smad-mediated transcriptional activation by the RNA-binding protein RBPMS
GOA
curator
UniProt
UniProt protein ID
P84022
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P84022
determination method
IPI
retrieved
8 April 2019
stated in
Hsp70 and Hsp90 oppositely regulate TGF-β signaling through CHIP/Stub1
GOA
curator
UniProt
UniProt protein ID
P84022
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P84022
determination method
IPI
retrieved
8 April 2019
stated in
TMEPAI, a transmembrane TGF-beta-inducible protein, sequesters Smad proteins from active participation in TGF-beta signaling
GOA
curator
UniProt
UniProt protein ID
P84022
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P84022
determination method
IPI
retrieved
8 April 2019
stated in
Involvement of the constitutive complex formation of c-Ski/SnoN with Smads in the impaired negative feedback regulation of transforming growth factor beta signaling in scleroderma fibroblasts
GOA
curator
UniProt
UniProt protein ID
P84022
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P84022
determination method
IPI
retrieved
8 April 2019
stated in
TAZ controls Smad nucleocytoplasmic shuttling and regulates human embryonic stem-cell self-renewal
GOA
curator
UniProt
UniProt protein ID
P84022
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P84022
determination method
IPI
retrieved
8 April 2019
stated in
Roles of pathway-specific and inhibitory Smads in activin receptor signaling
GOA
curator
UniProt
UniProt protein ID
P84022
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P84022
determination method
IPI
retrieved
8 April 2019
stated in
Nuclear export of Smad2 and Smad3 by RanBP3 facilitates termination of TGF-beta signaling
GOA
curator
UniProt
UniProt protein ID
P84022
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P84022
determination method
IPI
retrieved
8 April 2019
stated in
Oligomerization of Evi-1 regulated by the PR domain contributes to recruitment of corepressor CtBP
GOA
curator
UniProt
UniProt protein ID
P84022
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P84022
determination method
IPI
retrieved
8 April 2019
stated in
USP15 is a deubiquitylating enzyme for receptor-activated SMADs
GOA
curator
UniProt
UniProt protein ID
P84022
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P84022
determination method
IPI
retrieved
8 April 2019
stated in
The Smad3 linker region contains a transcriptional activation domain
GOA
curator
UniProt
UniProt protein ID
P84022
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P84022
determination method
IPI
retrieved
8 April 2019
stated in
The integral inner nuclear membrane protein MAN1 physically interacts with the R-Smad proteins to repress signaling by the transforming growth factor-{beta} superfamily of cytokines
GOA
curator
UniProt
UniProt protein ID
P84022
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P84022
determination method
IPI
retrieved
8 April 2019
stated in
Fussel-15, a novel Ski/Sno homolog protein, antagonizes BMP signaling
GOA
curator
UniProt
UniProt protein ID
P84022
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P84022
determination method
IPI
retrieved
8 April 2019
stated in
SKI and MEL1 cooperate to inhibit transforming growth factor-beta signal in gastric cancer cells
GOA
curator
UniProt
UniProt protein ID
P84022
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P84022
determination method
IPI
retrieved
8 April 2019
stated in
Inactivation of menin, a Smad3-interacting protein, blocks transforming growth factor type beta signaling
GOA
curator
UniProt
UniProt protein ID
P84022
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P84022
determination method
IPI
retrieved
8 April 2019
stated in
Hepatitis C virus core variants isolated from liver tumor but not from adjacent non-tumor tissue interact with Smad3 and inhibit the TGF-beta pathway
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P84022
determination method
IPI
retrieved
8 April 2019
stated in
Functional proteomics mapping of a human signaling pathway
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P84022
determination method
IPI
retrieved
8 April 2019
stated in
Antagonistic regulation of EMT by TIF1γ and Smad4 in mammary epithelial cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P84022
determination method
IPI
retrieved
8 April 2019
stated in
ShcA Protects against Epithelial-Mesenchymal Transition through Compartmentalized Inhibition of TGF-β-Induced Smad Activation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P84022
determination method
IPI
retrieved
8 April 2019
stated in
MiR-1 suppresses tumor cell proliferation in colorectal cancer by inhibition of Smad3-mediated tumor glycolysis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P84022
determination method
IPI
retrieved
8 April 2019
stated in
Nodal enhances the activity of FoxO3a and its synergistic interaction with Smads to regulate cyclin G2 transcription in ovarian cancer cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P84022
determination method
IPI
retrieved
8 April 2019
stated in
Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P84022
determination method
IPI
retrieved
8 April 2019
stated in
Ski-interacting protein interacts with Smad proteins to augment transforming growth factor-beta-dependent transcription
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P84022
determination method
IPI
retrieved
8 April 2019
stated in
Smad3 allostery links TGF-beta receptor kinase activation to transcriptional control
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P84022
determination method
IPI
retrieved
8 April 2019
stated in
Ablation of Smurf2 reveals an inhibition in TGF-β signalling through multiple mono-ubiquitination of Smad3
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P84022
determination method
IPI
retrieved
8 April 2019
stated in
Ski co-repressor complexes maintain the basal repressed state of the TGF-beta target gene, SMAD7, via HDAC3 and PRMT5
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P84022
determination method
IPI
retrieved
8 April 2019
stated in
HEB and E2A function as SMAD/FOXH1 cofactors
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P84022
determination method
IPI
retrieved
8 April 2019
stated in
Homeodomain protein DLX4 counteracts key transcriptional control mechanisms of the TGF-β cytostatic program and blocks the antiproliferative effect of TGF-β
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P84022
determination method
IPI
retrieved
8 April 2019
stated in
DACH1 inhibits transforming growth factor-beta signaling through binding Smad4
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P84022
determination method
IPI
retrieved
8 April 2019
stated in
SMAD proteins control DROSHA-mediated microRNA maturation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P84022
determination method
IPI
retrieved
8 April 2019
stated in
FAM/USP9x, a deubiquitinating enzyme essential for TGFbeta signaling, controls Smad4 monoubiquitination
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P84022
determination method
IPI
retrieved
8 April 2019
stated in
Identification of novel Smad2 and Smad3 associated proteins in response to TGF-beta1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P84022
determination method
IPI
retrieved
8 April 2019
stated in
Selective targeting of activating and inhibitory Smads by distinct WWP2 ubiquitin ligase isoforms differentially modulates TGFβ signalling and EMT
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P84022
determination method
IPI
retrieved
8 April 2019
stated in
LuTHy: a double-readout bioluminescence-based two-hybrid technology for quantitative mapping of protein-protein interactions in mammalian cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P84022
determination method
IPI
retrieved
8 April 2019
stated in
Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P84022
determination method
IPI
retrieved
8 April 2019
stated in
Intercellular variation in signaling through the TGF-β pathway and its relation to cell density and cell cycle phase
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P84022
determination method
IPI
retrieved
8 April 2019
stated in
14-3-3ζ turns TGF-β's function from tumor suppressor to metastasis promoter in breast cancer by contextual changes of Smad partners from p53 to Gli2
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P84022
determination method
IPI
retrieved
8 April 2019
stated in
Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P84022
determination method
IPI
retrieved
8 April 2019
stated in
A proteome-scale map of the human interactome network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P84022
determination method
IPI
retrieved
8 April 2019
stated in
Widespread macromolecular interaction perturbations in human genetic disorders
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P84022
determination method
IPI
retrieved
8 April 2019
stated in
The adaptor molecule Disabled-2 links the transforming growth factor beta receptors to the Smad pathway
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P84022
determination method
IPI
retrieved
8 April 2019
stated in
Toward an understanding of the protein interaction network of the human liver
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P84022
determination method
IPI
retrieved
8 April 2019
stated in
Structural basis of heteromeric smad protein assembly in TGF-beta signaling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P84022
determination method
IPI
retrieved
8 April 2019
stated in
Pooled-matrix protein interaction screens using Barcode Fusion Genetics
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P84022
determination method
IPI
retrieved
8 April 2019
stated in
MTMR4 attenuates transforming growth factor beta (TGFbeta) signaling by dephosphorylating R-Smads in endosomes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P84022
determination method
IPI
retrieved
8 April 2019
stated in
A Novel E1A-like Inhibitor of Differentiation (EID) Family Member, EID-2, Suppresses Transforming Growth Factor (TGF)-β Signaling by Blocking TGF-β-induced Formation of Smad3-Smad4 Complexes
GOA
curator
HUGO Gene Nomenclature Committee
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P84022
determination method
IPI
retrieved
8 April 2019
stated in
SMAD proteins control DROSHA-mediated microRNA maturation
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P84022
determination method
IPI
retrieved
8 April 2019
stated in
Response gene to complement 32 interacts with Smad3 to promote epithelial-mesenchymal transition of human renal tubular cells
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P84022
determination method
IPI
retrieved
8 April 2019
stated in
Pin1 down-regulates transforming growth factor-beta (TGF-beta) signaling by inducing degradation of Smad proteins
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P84022
determination method
IPI
retrieved
8 April 2019
stated in
Hepatitis C virus core variants isolated from liver tumor but not from adjacent non-tumor tissue interact with Smad3 and inhibit the TGF-beta pathway
GOA
curator
AgBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P84022
determination method
IPI
retrieved
8 April 2019
stated in
New host factors important for respiratory syncytial virus (RSV) replication revealed by a novel microfluidics screen for interactors of matrix (M) protein
GOA
curator
AgBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P84022
determination method
IPI
cell component
nucleus
determination method
IDA
IEA
7 references
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P84022
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P84022
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P84022
determination method
IEA
retrieved
8 April 2019
stated in
USP15 is a deubiquitylating enzyme for receptor-activated SMADs
GOA
curator
UniProt
UniProt protein ID
P84022
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P84022
determination method
IDA
retrieved
8 April 2019
stated in
Syntenin regulates TGF-β1-induced Smad activation and the epithelial-to-mesenchymal transition by inhibiting caveolin-mediated TGF-β type I receptor internalization
GOA
curator
UniProt
UniProt protein ID
P84022
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P84022
determination method
IDA
retrieved
8 April 2019
stated in
TGF-beta receptor-mediated signalling through Smad2, Smad3 and Smad4
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P84022
determination method
IDA
retrieved
8 April 2019
stated in
TGFbeta-Smad signalling in postoperative human lens epithelial cells
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P84022
determination method
IDA
retrieved
8 April 2019
stated in
Hepatitis C virus core variants isolated from liver tumor but not from adjacent non-tumor tissue interact with Smad3 and inhibit the TGF-beta pathway
GOA
curator
AgBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P84022
determination method
IDA
biological process
Gene Atlas image
PBB GE SMAD3 205396 at fs.png
732 × 530; 12 KB
0 references

Identifiers

MeSH descriptor ID
D051900
subject named as
Smad3 Protein
0 references
 
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