Telomerase reverse transcriptase (Q7697809)

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mammalian protein found in Homo sapiens
  • telomerase-associated protein 2
  • TP2
  • telomerase reverse transcriptase
  • telomerase catalytic subunit
  • TERT
  • HEST2
  • TERT protein, human
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Language Label Description Also known as
English
Telomerase reverse transcriptase
mammalian protein found in Homo sapiens
  • telomerase-associated protein 2
  • TP2
  • telomerase reverse transcriptase
  • telomerase catalytic subunit
  • TERT
  • HEST2
  • TERT protein, human

Statements

molecular function
telomerase RNA reverse transcriptase activity
determination method
IDA
TAS
IMP
IEA
7 references
retrieved
16 July 2018
stated in
Modulation of human telomerase reverse transcriptase in hepatocellular carcinoma
GOA
curator
UniProt
UniProt protein ID
O14746
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O14746&geneProductId=UniProtKB:O14746
determination method
TAS
retrieved
16 July 2018
stated in
Hypoxia extends the life span of vascular smooth muscle cells through telomerase activation.
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O14746&geneProductId=UniProtKB:O14746
determination method
IMP
retrieved
16 July 2018
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O14746&geneProductId=UniProtKB:O14746
determination method
IEA
retrieved
16 July 2018
stated in
Reconstitution of human telomerase with the template RNA component hTR and the catalytic protein subunit hTRT
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O14746&geneProductId=UniProtKB:O14746
determination method
IDA
retrieved
16 July 2018
stated in
An RNA-dependent RNA polymerase formed by TERT and the RMRP RNA
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O14746&geneProductId=UniProtKB:O14746
determination method
IDA
retrieved
16 July 2018
stated in
Human protection of telomeres 1 (POT1) is a negative regulator of telomerase activity in vitro
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O14746&geneProductId=UniProtKB:O14746
determination method
IDA
retrieved
16 July 2018
stated in
Protein RNA and protein protein interactions mediate association of human EST1A/SMG6 with telomerase
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O14746&geneProductId=UniProtKB:O14746
determination method
IDA
protein binding
determination method
IPI
23 references
retrieved
8 April 2019
stated in
The AAA-ATPase NVL2 is a telomerase component essential for holoenzyme assembly
GOA
curator
UniProt
UniProt protein ID
O14746
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
determination method
IPI
retrieved
8 April 2019
stated in
Characterization of interactions between PinX1 and human telomerase subunits hTERT and hTR
GOA
curator
UniProt
UniProt protein ID
O14746
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
determination method
IPI
retrieved
8 April 2019
stated in
The DEAH-box RNA helicase RHAU binds an intramolecular RNA G-quadruplex in TERC and associates with telomerase holoenzyme
GOA
curator
UniProt
UniProt protein ID
O14746
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
determination method
IPI
retrieved
8 April 2019
stated in
A human telomerase holoenzyme protein required for Cajal body localization and telomere synthesis
GOA
curator
UniProt
UniProt protein ID
O14746
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
determination method
IPI
retrieved
8 April 2019
stated in
Human UPF1 interacts with TPP1 and telomerase and sustains telomere leading-strand replication
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
determination method
IPI
retrieved
8 April 2019
stated in
Identification of ATPases pontin and reptin as telomerase components essential for holoenzyme assembly
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
determination method
IPI
retrieved
8 April 2019
stated in
Involvement of telomerase reverse transcriptase in heterochromatin maintenance
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
determination method
IPI
retrieved
8 April 2019
stated in
HPV E6 protein interacts physically and functionally with the cellular telomerase complex
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
determination method
IPI
retrieved
8 April 2019
stated in
TPP1 is a homologue of ciliate TEBP-beta and interacts with POT1 to recruit telomerase
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
determination method
IPI
retrieved
8 April 2019
stated in
Telomerase modulates Wnt signalling by association with target gene chromatin
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
determination method
IPI
retrieved
8 April 2019
stated in
PML-IV functions as a negative regulator of telomerase by interacting with TERT
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
determination method
IPI
retrieved
8 April 2019
stated in
Functional conservation of the telomerase protein Est1p in humans
GOA
curator
HUGO Gene Nomenclature Committee
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
determination method
IPI
retrieved
8 April 2019
stated in
The shelterin component TPP1 is a binding partner and substrate for the deubiquitinating enzyme USP7
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
determination method
IPI
retrieved
8 April 2019
stated in
Protein RNA and protein protein interactions mediate association of human EST1A/SMG6 with telomerase
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
determination method
IPI
retrieved
8 April 2019
stated in
Human UPF1 interacts with TPP1 and telomerase and sustains telomere leading-strand replication
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
determination method
IPI
retrieved
8 April 2019
stated in
Single-strand DNA-binding protein SSB1 facilitates TERT recruitment to telomeres and maintains telomere G-overhangs
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
determination method
IPI
retrieved
8 April 2019
stated in
Human MCRS2, a cell-cycle-dependent protein, associates with LPTS/PinX1 and reduces the telomere length
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
determination method
IPI
retrieved
8 April 2019
stated in
Telomerase inhibitor PinX1 provides a link between TRF1 and telomerase to prevent telomere elongation
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
determination method
IPI
retrieved
8 April 2019
stated in
Human Ku70/80 associates physically with telomerase through interaction with hTERT
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
determination method
IPI
retrieved
8 April 2019
stated in
The TPR-containing domain within Est1 homologs exhibits species-specific roles in telomerase interaction and telomere length homeostasis
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
determination method
IPI
retrieved
8 April 2019
stated in
TPP1 is a homologue of ciliate TEBP-beta and interacts with POT1 to recruit telomerase
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
determination method
IPI
retrieved
8 April 2019
stated in
GNL3L stabilizes the TRF1 complex and promotes mitotic transition
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
determination method
IPI
retrieved
8 April 2019
stated in
Purification of human telomerase complexes identifies factors involved in telomerase biogenesis and telomere length regulation
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
determination method
IPI
telomerase RNA binding
determination method
IDA
IEA
IPI
7 references
retrieved
16 July 2018
stated in
Specificity and stoichiometry of subunit interactions in the human telomerase holoenzyme assembled in vivo
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O14746&geneProductId=UniProtKB:O14746
determination method
IPI
retrieved
16 July 2018
stated in
Purification of human telomerase complexes identifies factors involved in telomerase biogenesis and telomere length regulation
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O14746&geneProductId=UniProtKB:O14746
determination method
IPI
retrieved
16 July 2018
stated in
An RNA-dependent RNA polymerase formed by TERT and the RMRP RNA
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O14746&geneProductId=UniProtKB:O14746
determination method
IPI
retrieved
16 July 2018
stated in
Regulation of cellular immortalization and steady-state levels of the telomerase reverse transcriptase through its carboxy-terminal domain
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O14746&geneProductId=UniProtKB:O14746
determination method
IPI
retrieved
16 July 2018
stated in
Protein RNA and protein protein interactions mediate association of human EST1A/SMG6 with telomerase
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O14746&geneProductId=UniProtKB:O14746
determination method
IPI
retrieved
16 July 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O14746&geneProductId=UniProtKB:O14746
determination method
IEA
retrieved
16 July 2018
stated in
Human telomerase contains two cooperating telomerase RNA molecules
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O14746&geneProductId=UniProtKB:O14746
determination method
IDA
telomerase activity
determination method
IEA
IDA
TAS
14 references
retrieved
8 April 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
determination method
TAS
retrieved
8 April 2019
stated in
Endothelial cell senescence in human atherosclerosis: role of telomere in endothelial dysfunction
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
determination method
TAS
retrieved
8 April 2019
stated in
HTLV-1 bZIP factor impedes the menin tumor suppressor and upregulates JunD-mediated transcription of the hTERT gene
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
determination method
TAS
retrieved
8 April 2019
stated in
Structure of active dimeric human telomerase
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
determination method
TAS
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
determination method
IEA
retrieved
8 April 2019
stated in
Cryo-EM structure of substrate-bound human telomerase holoenzyme.
GOA
curator
UniProt
UniProt protein ID
O14746
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
determination method
IDA
retrieved
8 April 2019
stated in
Differential regulation of telomerase activity by six telomerase subunits
GOA
curator
UniProt
UniProt protein ID
O14746
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
determination method
IDA
retrieved
8 April 2019
stated in
Reconstitution of human telomerase with the template RNA component hTR and the catalytic protein subunit hTRT
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
determination method
IDA
retrieved
8 April 2019
stated in
Reconstitution of human telomerase activity in vitro
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
determination method
IDA
retrieved
8 April 2019
stated in
Protein RNA and protein protein interactions mediate association of human EST1A/SMG6 with telomerase
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
determination method
IDA
retrieved
8 April 2019
stated in
Human POT1 disrupts telomeric G-quadruplexes allowing telomerase extension in vitro
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
determination method
IDA
retrieved
8 April 2019
stated in
High-throughput RNAi screening reveals novel regulators of telomerase
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
determination method
IDA
retrieved
8 April 2019
stated in
Regulation of cellular immortalization and steady-state levels of the telomerase reverse transcriptase through its carboxy-terminal domain
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
determination method
IDA
retrieved
8 April 2019
stated in
Purification of human telomerase complexes identifies factors involved in telomerase biogenesis and telomere length regulation
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
determination method
IDA
RNA binding
determination method
IEA
IPI
6 references
retrieved
8 April 2019
stated in
Protein RNA and protein protein interactions mediate association of human EST1A/SMG6 with telomerase
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
determination method
IPI
retrieved
8 April 2019
stated in
Specificity and stoichiometry of subunit interactions in the human telomerase holoenzyme assembled in vivo
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
determination method
IPI
retrieved
8 April 2019
stated in
An RNA-dependent RNA polymerase formed by TERT and the RMRP RNA
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
determination method
IPI
retrieved
8 April 2019
stated in
Regulation of cellular immortalization and steady-state levels of the telomerase reverse transcriptase through its carboxy-terminal domain
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
determination method
IPI
retrieved
8 April 2019
stated in
Purification of human telomerase complexes identifies factors involved in telomerase biogenesis and telomere length regulation
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
determination method
IPI
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
determination method
IEA
telomerase RNA reverse transcriptase activity
determination method
IBA
IDA
IEA
IMP
TAS
8 references
retrieved
8 April 2019
stated in
Modulation of human telomerase reverse transcriptase in hepatocellular carcinoma
GOA
curator
UniProt
UniProt protein ID
O14746
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
determination method
TAS
retrieved
8 April 2019
stated in
Hypoxia extends the life span of vascular smooth muscle cells through telomerase activation.
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
determination method
IMP
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
determination method
IEA
retrieved
8 April 2019
stated in
Reconstitution of human telomerase with the template RNA component hTR and the catalytic protein subunit hTRT
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
determination method
IDA
retrieved
8 April 2019
stated in
Human protection of telomeres 1 (POT1) is a negative regulator of telomerase activity in vitro
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
determination method
IDA
retrieved
8 April 2019
stated in
Protein RNA and protein protein interactions mediate association of human EST1A/SMG6 with telomerase
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
determination method
IDA
retrieved
8 April 2019
stated in
An RNA-dependent RNA polymerase formed by TERT and the RMRP RNA
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
determination method
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
determination method
IBA
telomerase RNA binding
determination method
IBA
IDA
IEA
IPI
8 references
retrieved
8 April 2019
stated in
Protein RNA and protein protein interactions mediate association of human EST1A/SMG6 with telomerase
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
determination method
IPI
retrieved
8 April 2019
stated in
Specificity and stoichiometry of subunit interactions in the human telomerase holoenzyme assembled in vivo
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
determination method
IPI
retrieved
8 April 2019
stated in
An RNA-dependent RNA polymerase formed by TERT and the RMRP RNA
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
determination method
IPI
retrieved
8 April 2019
stated in
Regulation of cellular immortalization and steady-state levels of the telomerase reverse transcriptase through its carboxy-terminal domain
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
determination method
IPI
retrieved
8 April 2019
stated in
Purification of human telomerase complexes identifies factors involved in telomerase biogenesis and telomere length regulation
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
determination method
IPI
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
determination method
IEA
retrieved
8 April 2019
stated in
Human telomerase contains two cooperating telomerase RNA molecules
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
determination method
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
determination method
IBA
cell component
telomerase catalytic core complex
determination method
IDA
IEA
IMP
IPI
8 references
retrieved
16 July 2018
stated in
An RNA-dependent RNA polymerase formed by TERT and the RMRP RNA
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O14746&geneProductId=UniProtKB:O14746
determination method
IPI
retrieved
16 July 2018
stated in
Hypoxia extends the life span of vascular smooth muscle cells through telomerase activation.
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O14746&geneProductId=UniProtKB:O14746
determination method
IMP
retrieved
16 July 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O14746&geneProductId=UniProtKB:O14746
determination method
IEA
retrieved
16 July 2018
stated in
Reconstitution of human telomerase activity in vitro
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O14746&geneProductId=UniProtKB:O14746
determination method
IDA
retrieved
16 July 2018
stated in
Reconstitution of human telomerase with the template RNA component hTR and the catalytic protein subunit hTRT
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O14746&geneProductId=UniProtKB:O14746
determination method
IDA
retrieved
16 July 2018
stated in
Purification of human telomerase complexes identifies factors involved in telomerase biogenesis and telomere length regulation
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O14746&geneProductId=UniProtKB:O14746
determination method
IDA
retrieved
16 July 2018
stated in
Regulation of cellular immortalization and steady-state levels of the telomerase reverse transcriptase through its carboxy-terminal domain
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O14746&geneProductId=UniProtKB:O14746
determination method
IDA
retrieved
16 July 2018
stated in
Protein RNA and protein protein interactions mediate association of human EST1A/SMG6 with telomerase
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O14746&geneProductId=UniProtKB:O14746
determination method
IDA
telomerase holoenzyme complex
determination method
IDA
IPI
TAS
6 references
retrieved
8 April 2019
stated in
In vitro assembly of human H/ACA small nucleolar RNPs reveals unique features of U17 and telomerase RNAs
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
determination method
TAS
retrieved
8 April 2019
stated in
An enhanced H/ACA RNP assembly mechanism for human telomerase RNA
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
determination method
TAS
retrieved
8 April 2019
stated in
An RNA-dependent RNA polymerase formed by TERT and the RMRP RNA
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
determination method
IPI
retrieved
8 April 2019
stated in
Cryo-EM structure of substrate-bound human telomerase holoenzyme.
GOA
curator
UniProt
UniProt protein ID
O14746
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
determination method
IDA
retrieved
8 April 2019
stated in
Differential regulation of telomerase activity by six telomerase subunits
GOA
curator
UniProt
UniProt protein ID
O14746
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
determination method
IDA
retrieved
8 April 2019
stated in
Purification of human telomerase complexes identifies factors involved in telomerase biogenesis and telomere length regulation
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
determination method
IDA
telomerase catalytic core complex
determination method
IBA
IDA
IEA
IMP
IPI
9 references
retrieved
8 April 2019
stated in
An RNA-dependent RNA polymerase formed by TERT and the RMRP RNA
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
determination method
IPI
retrieved
8 April 2019
stated in
Hypoxia extends the life span of vascular smooth muscle cells through telomerase activation.
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
determination method
IMP
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
determination method
IEA
retrieved
8 April 2019
stated in
Reconstitution of human telomerase with the template RNA component hTR and the catalytic protein subunit hTRT
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
determination method
IDA
retrieved
8 April 2019
stated in
Reconstitution of human telomerase activity in vitro
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
determination method
IDA
retrieved
8 April 2019
stated in
Protein RNA and protein protein interactions mediate association of human EST1A/SMG6 with telomerase
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
determination method
IDA
retrieved
8 April 2019
stated in
Regulation of cellular immortalization and steady-state levels of the telomerase reverse transcriptase through its carboxy-terminal domain
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
determination method
IDA
retrieved
8 April 2019
stated in
Purification of human telomerase complexes identifies factors involved in telomerase biogenesis and telomere length regulation
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
determination method
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
determination method
IBA
biological process
telomere maintenance via telomerase
determination method
NAS
IDA
TAS
IMP
9 references
retrieved
16 July 2018
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O14746&geneProductId=UniProtKB:O14746
determination method
TAS
retrieved
16 July 2018
stated in
The human telomere terminal transferase enzyme is a ribonucleoprotein that synthesizes TTAGGG repeats
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O14746&geneProductId=UniProtKB:O14746
determination method
NAS
retrieved
16 July 2018
stated in
Extension of life-span by introduction of telomerase into normal human cells
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O14746&geneProductId=UniProtKB:O14746
determination method
IMP
retrieved
16 July 2018
stated in
Cryo-EM structure of substrate-bound human telomerase holoenzyme.
GOA
curator
UniProt
UniProt protein ID
O14746
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O14746&geneProductId=UniProtKB:O14746
determination method
IDA
retrieved
16 July 2018
stated in
Reconstitution of human telomerase activity in vitro
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O14746&geneProductId=UniProtKB:O14746
determination method
IDA
retrieved
16 July 2018
stated in
High-throughput RNAi screening reveals novel regulators of telomerase
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O14746&geneProductId=UniProtKB:O14746
determination method
IDA
retrieved
16 July 2018
stated in
Human POT1 disrupts telomeric G-quadruplexes allowing telomerase extension in vitro
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O14746&geneProductId=UniProtKB:O14746
determination method
IDA
retrieved
16 July 2018
stated in
An RNA-dependent RNA polymerase formed by TERT and the RMRP RNA
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O14746&geneProductId=UniProtKB:O14746
determination method
IDA
retrieved
16 July 2018
stated in
Protein RNA and protein protein interactions mediate association of human EST1A/SMG6 with telomerase
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O14746&geneProductId=UniProtKB:O14746
determination method
IDA
telomere maintenance via telomerase
determination method
IBA
IDA
IMP
NAS
TAS
10 references
retrieved
8 April 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
determination method
TAS
retrieved
8 April 2019
stated in
The human telomere terminal transferase enzyme is a ribonucleoprotein that synthesizes TTAGGG repeats
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
determination method
NAS
retrieved
8 April 2019
stated in
Extension of life-span by introduction of telomerase into normal human cells
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
determination method
IMP
retrieved
8 April 2019
stated in
Cryo-EM structure of substrate-bound human telomerase holoenzyme.
GOA
curator
UniProt
UniProt protein ID
O14746
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
determination method
IDA
retrieved
8 April 2019
stated in
Reconstitution of human telomerase activity in vitro
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
determination method
IDA
retrieved
8 April 2019
stated in
Protein RNA and protein protein interactions mediate association of human EST1A/SMG6 with telomerase
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
determination method
IDA
retrieved
8 April 2019
stated in
Human POT1 disrupts telomeric G-quadruplexes allowing telomerase extension in vitro
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
determination method
IDA
retrieved
8 April 2019
stated in
High-throughput RNAi screening reveals novel regulators of telomerase
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
determination method
IDA
retrieved
8 April 2019
stated in
An RNA-dependent RNA polymerase formed by TERT and the RMRP RNA
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
determination method
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746
determination method
IBA

Identifiers

MeSH descriptor ID
C509186
subject named as
TERT protein, human
0 references
 
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